KEGG   ORTHOLOGY: K12076
Entry
K12076                      KO                                     

Name
DLG1
Definition
disks large protein 1
Pathway
ko04390  Hippo signaling pathway
ko04391  Hippo signaling pathway - fly
ko04530  Tight junction
ko04660  T cell receptor signaling pathway
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05203  Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    K12076  DLG1; disks large protein 1
   04391 Hippo signaling pathway - fly
    K12076  DLG1; disks large protein 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K12076  DLG1; disks large protein 1
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    K12076  DLG1; disks large protein 1
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K12076  DLG1; disks large protein 1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K12076  DLG1; disks large protein 1
   05165 Human papillomavirus infection
    K12076  DLG1; disks large protein 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K12076  DLG1; disks large protein 1
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Other centriole associated proteins
    K12076  DLG1; disks large protein 1
Genes
HSA: 1739(DLG1)
PTR: 460968(DLG1)
PPS: 100987596(DLG1)
GGO: 101132886(DLG1)
PON: 100444925(DLG1)
NLE: 100603856(DLG1)
MCC: 709572(DLG1)
MCF: 102123600(DLG1)
CSAB: 103241973(DLG1)
RRO: 104676365(DLG1)
RBB: 108530521(DLG1)
CJC: 100401687(DLG1)
SBQ: 101032502(DLG1)
MMU: 13383(Dlg1)
MCAL: 110311707(Dlg1)
MPAH: 110329715(Dlg1)
RNO: 25252(Dlg1)
MUN: 110553298(Dlg1)
CGE: 100774630(Dlg1)
NGI: 103738531(Dlg1)
HGL: 101716409(Dlg1)
CCAN: 109699995
OCU: 100339253(DLG1)
TUP: 102468222(DLG1)
CFA: 488036(DLG1)
VVP: 112913543(DLG1)
AML: 100481489(DLG1)
UMR: 103678920(DLG1)
UAH: 113253232(DLG1)
ORO: 101363847(DLG1)
ELK: 111155042
FCA: 101084051(DLG1)
PTG: 102971040(DLG1)
PPAD: 109266561(DLG1)
AJU: 106976354(DLG1)
BTA: 785291(DLG1)
BOM: 102284602(DLG1)
BIU: 109562672(DLG1)
BBUB: 102396861(DLG1)
CHX: 102178485(DLG1)
OAS: 101103028(DLG1)
SSC: 100157729(DLG1)
CFR: 102508504(DLG1)
CDK: 105101276(DLG1)
BACU: 103001527(DLG1)
LVE: 103079722(DLG1)
OOR: 101270560(DLG1)
DLE: 111172354(DLG1)
PCAD: 102986766(DLG1)
ECB: 100060094(DLG1)
EPZ: 103559183
EAI: 106848317(DLG1)
MYB: 102251241(DLG1)
MYD: 102771948(DLG1)
MNA: 107527282(DLG1)
HAI: 109387512(DLG1)
DRO: 112320513(DLG1)
PALE: 102887557(DLG1)
RAY: 107505282(DLG1)
LAV: 100662117(DLG1)
TMU: 101353387
MDO: 100017371(DLG1)
SHR: 100924037(DLG1)
PCW: 110193183(DLG1)
OAA: 100082103(DLG1)
GGA: 424890(DLG1)
MGP: 100545279(DLG1)
CJO: 107318156(DLG1)
NMEL: 110397341(DLG1)
APLA: 101798182(DLG1)
ACYG: 106039234(DLG1)
TGU: 100220198(DLG1)
LSR: 110473916(DLG1)
SCAN: 103815402(DLG1)
GFR: 102034754(DLG1)
FAB: 101813757(DLG1)
PHI: 102113578(DLG1)
PMAJ: 107208781(DLG1)
CCAE: 111933478(DLG1)
CCW: 104693473(DLG1)
ETL: 114057579(DLG1)
FPG: 101914926(DLG1)
FCH: 102052280(DLG1)
CLV: 102091278(DLG1)
EGZ: 104127125(DLG1)
NNI: 104015686(DLG1)
ACUN: 113483502(DLG1)
PADL: 103913851(DLG1)
AAM: 106485876(DLG1)
ASN: 102388205(DLG1)
AMJ: 102560983(DLG1)
PSS: 102453762(DLG1)
CMY: 102946800(DLG1)
CPIC: 101941940(DLG1)
PVT: 110087113
PBI: 103061777(DLG1)
PMUR: 107291694(DLG1)
TSR: 106551581(DLG1)
PMUA: 114598216(DLG1)
GJA: 107125637(DLG1)
XTR: 733937(dlg1)
NPR: 108795997(DLG1)
DRE: 114446(dlg1) 497648(dlg1l)
IPU: 108271975 108280564(DLG1)
EEE: 113579531 113590541(dlg1)
TRU: 101063550(dlg1) 101067056
NCC: 104946575(dlg1)
MZE: 101468517 101473605(dlg1)
PRET: 103460621 103463088(dlg1)
NFU: 107383683 107392960(dlg1)
AOCE: 111568381(dlg1) 111580207
CSEM: 103396276(dlg1) 103396862
POV: 109636679(dlg1) 109645388
SLAL: 111645407 111649806(dlg1)
LCM: 102359739(DLG1)
CMK: 103181252(dlg1)
BFO: 118427794
CIN: 100177284
SPU: 592591
SKO: 100329000(SAP97)
DME: Dmel_CG1725(dlg1)
DER: 6551603
DSI: Dsimw501_GD17020(Dsim_GD17020)
DAN: 6501841
DSR: 110182043
DPE: 6599195
DMN: 108155488
DWI: 6644661
DAZ: 108619351
DHE: 111601812
LCQ: 111678828
AAG: 23687408
AME: 724292
BIM: 100747372
BTER: 100643982
CCAL: 108629943
SOC: 105201229
MPHA: 105834480
AEC: 105146407
ACEP: 105627778
PBAR: 105425276
HST: 105190839
DQU: 106741986
CFO: 105253961
LHU: 105677469
PGC: 109854966
OBO: 105282675
PCF: 106794038
CSOL: 105368464
MDL: 103573120
TCA: 663521
DPA: 109533899
ATD: 109601412
BMOR: 101744274
PXY: 105388463
BTAB: 109043969
CLEC: 106674408
ZNE: 110831408
FCD: 110852265
PVM: 113809244
DPTE: 113789502
CEL: CELE_C25F6.2(dlg-1)
CBR: CBG14691(Cbr-dlg-1)
BMY: Bm1_32060
TSP: Tsp_08375
PCAN: 112555839
CRG: 105346688
MYI: 110465311
OBI: 106876507
EGL: EGR_02425
NVE: 5518154
EPA: 110232068
ADF: 107337951
AMIL: 114953222
PDAM: 113676184
SPIS: 111330601
DGT: 114524513
HMG: 100209202
 » show all
Reference
  Authors
Round JL, Humphries LA, Tomassian T, Mittelstadt P, Zhang M, Miceli MC
  Title
Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors.
  Journal
Nat Immunol 8:154-61 (2007)
DOI:10.1038/ni1422
Reference
PMID:8678991
  Authors
Burgess DL, Rafael JA, Meisler MH, Chamberlain JS
  Title
Dlgh1, a mouse homolog of the drosophila discs-large gene, is located on chromosome 16.
  Journal
Mamm Genome 7:623-4 (1996)
DOI:10.1007/s003359900187
  Sequence
[mmu:13383]
Reference
PMID:7937897
  Authors
Lue RA, Marfatia SM, Branton D, Chishti AH
  Title
Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1.
  Journal
Proc Natl Acad Sci U S A 91:9818-22 (1994)
DOI:10.1073/pnas.91.21.9818
  Sequence
[hsa:1739]
LinkDB

KEGG   ORTHOLOGY: K12075
Entry
K12075                      KO                                     

Name
DLG2
Definition
discs large protein 2
Pathway
ko04390  Hippo signaling pathway
ko04530  Tight junction
ko05165  Human papillomavirus infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    K12075  DLG2; discs large protein 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K12075  DLG2; discs large protein 2
 09160 Human Diseases
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K12075  DLG2; discs large protein 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K12075  DLG2; discs large protein 2
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K12075  DLG2; discs large protein 2
Genes
HSA: 1740(DLG2)
PTR: 466728(DLG2)
PPS: 100982329(DLG2)
GGO: 101128407(DLG2)
PON: 100440838(DLG2)
NLE: 100590895(DLG2)
MCC: 704826(DLG2)
MCF: 101867199(DLG2)
CSAB: 103248148(DLG2)
RRO: 104662560(DLG2)
RBB: 108512472 108514586(DLG2)
CJC: 100414556(DLG2)
SBQ: 101032013(DLG2)
MMU: 23859(Dlg2)
MCAL: 110299456(Dlg2) 110302744
MPAH: 110333507(Dlg2)
RNO: 64053(Dlg2)
MUN: 110554217(Dlg2)
CGE: 107977363
NGI: 103742979(Dlg2)
HGL: 101712252(Dlg2)
OCU: 100345988(DLG2)
TUP: 102470367(DLG2)
CFA: 485158(DLG2)
VVP: 112932292(DLG2)
AML: 100470083(DLG2)
UMR: 103675333(DLG2)
UAH: 113269385(DLG2)
ORO: 101384686(DLG2)
ELK: 111154393
FCA: 101097912(DLG2)
PTG: 102972156(DLG2)
PPAD: 109267390(DLG2)
AJU: 106976992(DLG2)
BTA: 100851408(DLG2)
BOM: 102270381(DLG2)
BIU: 109554375(DLG2)
BBUB: 102409056(DLG2)
CHX: 102169162(DLG2)
SSC: 100516384(DLG2)
CFR: 102507622(DLG2)
CDK: 105097680(DLG2)
BACU: 103008780(DLG2)
LVE: 103079685(DLG2)
OOR: 101272096(DLG2)
DLE: 111184929(DLG2)
PCAD: 102982626(DLG2)
ECB: 100050929(DLG2)
EPZ: 103563450(DLG2)
EAI: 106830664(DLG2)
MYB: 102260299(DLG2)
MYD: 102755931(DLG2)
MNA: 107532464(DLG2)
HAI: 109383269(DLG2)
DRO: 112316026(DLG2)
PALE: 102886308(DLG2)
RAY: 107518561(DLG2)
MJV: 108402442(DLG2)
TMU: 101352480
MDO: 100026349(DLG2)
SHR: 100922041(DLG2)
PCW: 110213352(DLG2)
OAA: 100083272(DLG2)
GGA: 419024(DLG2)
MGP: 100539081
CJO: 107308468(DLG2)
NMEL: 110390973(DLG2)
APLA: 101792256(DLG2)
ACYG: 106039876(DLG2)
TGU: 100229716(DLG2)
LSR: 110478428(DLG2)
SCAN: 103827238(DLG2)
GFR: 102037252(DLG2)
FAB: 101809577(DLG2)
PHI: 102102230(DLG2)
PMAJ: 107200839(DLG2)
CCAE: 111925133(DLG2)
CCW: 104690308(DLG2)
ETL: 114057774
FPG: 101917502(DLG2)
FCH: 102052581(DLG2)
CLV: 102089077(DLG2)
EGZ: 104129435(DLG2)
NNI: 104017367(DLG2)
ACUN: 113476316(DLG2)
PADL: 103916473(DLG2)
AAM: 106484805(DLG2)
ASN: 102376729
AMJ: 102563139(DLG2)
PSS: 102458555
CMY: 102936277(DLG2)
CPIC: 101941079(DLG2)
ACS: 100567391(dlg2)
PBI: 103067873
PMUR: 107298894
PMUA: 114595591(DLG2)
GJA: 107106938(DLG2)
XTR: 100170164(dlg2)
DRE: 497638(dlg2)
IPU: 108276775(dlg2)
PHYP: 113543460(dlg2)
AMEX: 103046108
EEE: 113579027(dlg2)
TRU: 101064665
LCO: 104932987
MZE: 101476751
ONL: 100710568
OLA: 101168565
XMA: 102228751
XCO: 114153747
PRET: 103476363
CVG: 107100026
NFU: 107386344
KMR: 108247196
AOCE: 111572707
CSEM: 103395064
SDU: 111222161
SLAL: 111654035(dlg2)
BPEC: 110169027
SASA: 106567540(dlg2) 106603804
ELS: 105011021(dlg2)
SFM: 108936168(dlg2)
PKI: 111855821(dlg2)
LCM: 102349031(DLG2)
CMK: 103184532(dlg2)
SKO: 102806997
PCAN: 112555520
 » show all
Reference
  Authors
Tao YX, Rumbaugh G, Wang GD, Petralia RS, Zhao C, Kauer FW, Tao F, Zhuo M, Wenthold RJ, Raja SN, Huganir RL, Bredt DS, Johns RA
  Title
Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein.
  Journal
J Neurosci 23:6703-12 (2003)
DOI:10.1523/JNEUROSCI.23-17-06703.2003
  Sequence
[mmu:23859]
Reference
PMID:8755482
  Authors
Kim E, Cho KO, Rothschild A, Sheng M
  Title
Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins.
  Journal
Neuron 17:103-13 (1996)
DOI:10.1016/S0896-6273(00)80284-6
  Sequence
[hsa:1740]
LinkDB

KEGG   ORTHOLOGY: K21098
Entry
K21098                      KO                                     

Name
DLG3
Definition
discs large protein 3
Pathway
ko04390  Hippo signaling pathway
ko04530  Tight junction
ko05165  Human papillomavirus infection
Disease
H00480  X-linked mental retardation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    K21098  DLG3; discs large protein 3
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K21098  DLG3; discs large protein 3
 09160 Human Diseases
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K21098  DLG3; discs large protein 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K21098  DLG3; discs large protein 3
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K21098  DLG3; discs large protein 3
Genes
HSA: 1741(DLG3)
PTR: 100609853(DLG3)
PPS: 100987358(DLG3)
GGO: 101129823(DLG3)
PON: 100447431(DLG3)
NLE: 100583755(DLG3)
MCC: 697179(DLG3)
MCF: 102136736(DLG3)
CSAB: 103232136(DLG3)
RRO: 104678790(DLG3)
RBB: 108539314(DLG3)
CJC: 100413310(DLG3)
SBQ: 101038838(DLG3)
MMU: 53310(Dlg3)
MCAL: 110286480(Dlg3)
MPAH: 110314132(Dlg3)
RNO: 58948(Dlg3)
MUN: 110541062(Dlg3)
CGE: 100770281(Dlg3)
NGI: 103743164(Dlg3)
HGL: 101708098(Dlg3)
CCAN: 109680747(Dlg3)
OCU: 100349185(DLG3)
TUP: 102483602(DLG3)
CFA: 491942(DLG3)
VVP: 112907643(DLG3)
AML: 100477559(DLG3)
UMR: 103682622(DLG3)
UAH: 113245635(DLG3)
ORO: 101375910(DLG3)
ELK: 111161008
FCA: 101088910(DLG3)
PTG: 102967577(DLG3)
PPAD: 109254604(DLG3)
AJU: 106982389(DLG3)
BTA: 509882(DLG3)
BOM: 102272388(DLG3)
BIU: 109555372(DLG3)
BBUB: 102396743(DLG3)
CHX: 102173541(DLG3)
OAS: 101102123(DLG3)
SSC: 100516124(DLG3)
CFR: 102512967(DLG3)
CDK: 105087977(DLG3)
BACU: 103012048(DLG3)
LVE: 103090204(DLG3)
OOR: 101288833(DLG3)
DLE: 111167775(DLG3)
PCAD: 102980305(DLG3)
ECB: 100146394(DLG3)
EPZ: 103540997(DLG3) 103540999
EAI: 106827110
MYB: 102239063(DLG3)
MYD: 102758577(DLG3)
MNA: 107532901(DLG3)
HAI: 109385608(DLG3)
DRO: 112300117(DLG3)
PALE: 102886812(DLG3)
RAY: 107503831(DLG3)
MJV: 108403637(DLG3)
LAV: 100668545(DLG3)
TMU: 101356813
MDO: 100011645(DLG3)
SHR: 100930826(DLG3)
PCW: 110201058(DLG3)
OAA: 103167833(DLG3)
GGA: 428706(DLG3)
CJO: 107312495(DLG3)
NMEL: 110403165(DLG3)
APLA: 101793279(DLG3)
ACYG: 106037380(DLG3)
TGU: 100218532(DLG3)
LSR: 110472671(DLG3)
SCAN: 103824213(DLG3)
GFR: 102031876(DLG3)
FAB: 101813820(DLG3)
PHI: 102100191(DLG3)
PMAJ: 107203904(DLG3)
CCAE: 111929365(DLG3)
CCW: 104691751
ETL: 114067437(DLG3)
FPG: 101914344(DLG3)
FCH: 102052192(DLG3)
CLV: 102095379(DLG3)
EGZ: 104124284(DLG3)
NNI: 104012969(DLG3)
ACUN: 113479883(DLG3) 113480178
PADL: 103923409(DLG3)
ASN: 102380898(DLG3)
AMJ: 102574566(DLG3)
PSS: 102454109(DLG3)
CMY: 102940428(DLG3)
CPIC: 101950651(DLG3)
ACS: 100565935(dlg1)
PVT: 110080196(DLG3)
PBI: 103064346
PMUR: 107303240(DLG3)
TSR: 106547184(DLG3)
GJA: 107108569(DLG3)
XTR: 100380042(dlg3)
NPR: 108790439
DRE: 564081(dlg3)
SRX: 107744565(dlg3) 107751999
IPU: 108268922(dlg3)
PHYP: 113528964(dlg3)
AMEX: 103039214(dlg3)
EEE: 113582656(dlg3)
TRU: 101070759(dlg3)
LCO: 104923475(dlg3)
NCC: 104958394(dlg3)
MZE: 101479027(dlg3)
ONL: 100707080(dlg3)
OLA: 101169708(dlg3)
XMA: 102229662(dlg3)
XCO: 114139548(dlg3)
PRET: 103471630(dlg3)
CVG: 107092554(dlg3)
NFU: 107378541(dlg3)
KMR: 108231314(dlg3)
ALIM: 106515388
AOCE: 111579652(dlg3)
CSEM: 103390754(dlg3)
POV: 109624949(dlg3)
LCF: 108872512(dlg3)
SDU: 111232358(dlg3)
SLAL: 111666343(dlg3)
HCQ: 109516564(dlg3)
BPEC: 110158846(dlg3)
MALB: 109952324(dlg3)
ELS: 105029493(dlg3)
SFM: 108923077(dlg3) 108928968
LCM: 102355040(DLG3)
CMK: 103189361(dlg3)
RTP: 109919099(dlg3)
 » show all
Reference
PMID:9188857
  Authors
Makino K, Kuwahara H, Masuko N, Nishiyama Y, Morisaki T, Sasaki J, Nakao M, Kuwano A, Nakata M, Ushio Y, Saya H
  Title
Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein.
  Journal
Oncogene 14:2425-33 (1997)
DOI:10.1038/sj.onc.1201087
  Sequence
[hsa:1741]
LinkDB

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