KEGG   ORTHOLOGY: K12318
Entry
K12318                      KO                                     

Name
GUCY1A
Definition
guanylate cyclase soluble subunit alpha [EC:4.6.1.2]
Pathway
ko00230  Purine metabolism
ko01100  Metabolic pathways
ko04022  cGMP-PKG signaling pathway
ko04270  Vascular smooth muscle contraction
ko04540  Gap junction
ko04611  Platelet activation
ko04713  Circadian entrainment
ko04730  Long-term depression
ko04921  Oxytocin signaling pathway
ko04924  Renin secretion
ko04970  Salivary secretion
Disease
H01396  Moyamoya disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
   04924 Renin secretion
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
  09154 Digestive system
   04970 Salivary secretion
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
  09156 Nervous system
   04730 Long-term depression
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
  09159 Environmental adaptation
   04713 Circadian entrainment
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.2  guanylate cyclase
     K12318  GUCY1A; guanylate cyclase soluble subunit alpha
Other DBs
RN: R00434
GO: 0004383
Genes
HSA: 2977(GUCY1A2) 2982(GUCY1A1)
PTR: 100608597(GUCY1A1) 466769(GUCY1A2)
PPS: 100985928(GUCY1A3) 100987635(GUCY1A2)
GGO: 101139175(GUCY1A1) 101146114(GUCY1A2)
PON: 100172608(GUCY1A1) 100445361(GUCY1A2)
NLE: 100581660(GUCY1A1) 100592351(GUCY1A2)
MCC: 699365(GUCY1A1) 706615(GUCY1A2)
MCF: 101866366(GUCY1A3) 102127299(GUCY1A2)
CSAB: 103236428(GUCY1A3) 103248387(GUCY1A2)
RRO: 104655958(GUCY1A2) 104658100(GUCY1A1)
RBB: 108513181(GUCY1A2) 108527520 108529026(GUCY1A3)
CJC: 100387768(GUCY1A2) 100396127(GUCY1A3)
SBQ: 101040779(GUCY1A3) 101040955(GUCY1A2)
MMU: 234889(Gucy1a2) 60596(Gucy1a1)
MCAL: 110291186(Gucy1a3) 110301665(Gucy1a2)
MPAH: 110320296(Gucy1a3) 110327749(Gucy1a2)
RNO: 497757(Gucy1a3) 66012(Gucy1a2)
MUN: 110566017(Gucy1a3)
CGE: 100768699(Gucy1a1) 100769238(Gucy1a2)
NGI: 103731324(Gucy1a2) 103751001(Gucy1a3)
HGL: 101702803(Gucy1a2) 101712487(Gucy1a3)
CCAN: 109676102(Gucy1a3) 109684240(Gucy1a2)
OCU: 100350099(GUCY1A3) 100357621(GUCY1A2)
TUP: 102469297(GUCY1A2) 102483882(GUCY1A3)
CFA: 479455(GUCY1A2) 482663(GUCY1A1)
VVP: 112925911(GUCY1A2) 112933458(GUCY1A1)
AML: 100483617(GUCY1A1)
UMR: 103658044(GUCY1A3) 103662433(GUCY1A2)
UAH: 113255781(GUCY1A1) 113260215(GUCY1A2)
ORO: 101369879(GUCY1A2) 101381618(GUCY1A3)
FCA: 101098377(GUCY1A1) 101099494(GUCY1A2)
PTG: 102956040(GUCY1A2) 102969669(GUCY1A3)
PPAD: 109262490(GUCY1A3) 109278730(GUCY1A2)
AJU: 106982463(GUCY1A1) 106983909
BTA: 281216(GUCY1A1) 613600(GUCY1A2)
BOM: 102280817(GUCY1A2) 102281834(GUCY1A3)
BIU: 109570022(GUCY1A2) 109571318(GUCY1A3)
BBUB: 102390736(GUCY1A2) 102394541(GUCY1A1)
CHX: 102169692(GUCY1A3) 102184168(GUCY1A2)
OAS: 101104339(GUCY1A2) 101110000(GUCY1A1)
SSC: 100522091(GUCY1A2) 553100(GUCY1A3)
CFR: 102508002(GUCY1A1) 102523651(GUCY1A2)
CDK: 105099193(GUCY1A2) 105101181(GUCY1A1)
BACU: 103007177(GUCY1A2) 103020991
LVE: 103069938(GUCY1A2) 103075302
OOR: 101275975(GUCY1A2) 101279277(GUCY1A3)
DLE: 111167557(GUCY1A2) 111179006(GUCY1A1)
PCAD: 102978888(GUCY1A2) 102994352(GUCY1A1)
ECB: 100069474(GUCY1A2) 100069573(GUCY1A1)
EPZ: 103562610(GUCY1A3) 103563826
EAI: 106832984(GUCY1A3) 106837662(GUCY1A2)
MYB: 102250686(GUCY1A3) 102260196(GUCY1A2)
MYD: 102764771(GUCY1A3) 102767033(GUCY1A2)
MNA: 107527534(GUCY1A3) 107532921(GUCY1A2)
HAI: 109371447(GUCY1A2) 109377496(GUCY1A3)
DRO: 112312473(GUCY1A1) 112314356(GUCY1A2)
PALE: 102889502(GUCY1A1) 102896673(GUCY1A2)
RAY: 107507549(GUCY1A3) 107518221(GUCY1A2)
MJV: 108408486(GUCY1A3)
LAV: 100662779(GUCY1A2) 100663946(GUCY1A1)
MDO: 100017038(GUCY1A3) 100027037(GUCY1A2)
SHR: 100928661(GUCY1A1) 100929308(GUCY1A2)
PCW: 110213640(GUCY1A3) 110214955(GUCY1A2)
OAA: 100075186(GUCY1A1) 100077965(GUCY1A2)
GGA: 422407(GUCY1A3) 771678(GUCY1A2)
MGP: 100542159(GUCY1A2) 100547213(GUCY1A1)
CJO: 107308362(GUCY1A2) 107313055(GUCY1A1)
NMEL: 110398017(GUCY1A3) 110403886(GUCY1A2)
APLA: 101790692(GUCY1A2) 101799600(GUCY1A1)
ACYG: 106032273(GUCY1A3) 106047549(GUCY1A2)
TGU: 100217644(GUCY1A2) 100223563(GUCY1A1)
LSR: 110470028(GUCY1A2) 110478231(GUCY1A1)
SCAN: 103812526(GUCY1A2) 103825957(GUCY1A1)
GFR: 102043874(GUCY1A3) 102044723(GUCY1A2)
FAB: 101812872(GUCY1A2) 101814320(GUCY1A3)
PHI: 102106220(GUCY1A3) 102113474(GUCY1A2)
PMAJ: 107203218(GUCY1A3) 107210410(GUCY1A2)
CCAE: 111924184(GUCY1A2) 111927848(GUCY1A1)
CCW: 104690109(GUCY1A2) 104697178(GUCY1A3)
ETL: 114065469(GUCY1A1) 114066011(GUCY1A2)
FPG: 101914436(GUCY1A2) 101922339(GUCY1A3)
FCH: 102046999(GUCY1A1) 102059430(GUCY1A2)
CLV: 102090855(GUCY1A3) 102097143(GUCY1A2)
EGZ: 104124168(GUCY1A3) 104130062(GUCY1A2)
NNI: 104021238(GUCY1A3) 104023120(GUCY1A2)
ACUN: 113479562(GUCY1A1) 113484388(GUCY1A2)
PADL: 103915456(GUCY1A2) 103921780(GUCY1A3)
AAM: 106492053(GUCY1A3)
ASN: 102383277(GUCY1A2) 102383335(GUCY1A1)
AMJ: 102569074(GUCY1A3) 106737232(GUCY1A2)
PSS: 102444454(GUCY1A2) 102446826(GUCY1A1)
CMY: 102934622(GUCY1A2) 102938442(GUCY1A3)
CPIC: 101945080(GUCY1A2) 101948053(GUCY1A3)
ACS: 100554615(gucy1a2) 100563220(gucy1a3)
PVT: 110072775(GUCY1A3) 110084083(GUCY1A2)
PBI: 103052921(GUCY1A2) 103063344(GUCY1A1)
PMUR: 107287977(GUCY1A1) 107294718 107294950
TSR: 106553741(GUCY1A3) 106555835(GUCY1A2)
PMUA: 114595672(GUCY1A2) 114603793(GUCY1A1)
GJA: 107109446(GUCY1A3) 107123339(GUCY1A2)
XLA: 108704686 108706648(gucy1a3.S) 108709988
XTR: 100145454(gucy1a2) 100496677(gucy1a1)
NPR: 108789645(GUCY1A3) 108798037
DRE: 100330875(gucy1a2) 550420(gucy1a1)
IPU: 108260481(gucy1a3) 108278235(gucy1a2)
PHYP: 113524511(gucy1a1) 113544642(gucy1a2)
AMEX: 103040541(gucy1a2) 103041681(gucy1a3)
EEE: 113578734(gucy1a2) 113583870(gucy1a1)
TRU: 101068334(gucy1a2) 446059(gucy1a1)
LCO: 104928518(gucy1a2) 104930192(gucy1a1)
NCC: 104945126(gucy1a2) 104949644(gucy1a3)
MZE: 101471149(gucy1a2) 101483862(gucy1a1)
ONL: 100705742(gucy1a2) 100710791(gucy1a1)
OLA: 100049248(gucy1a2)
XMA: 102218476(gucy1a2) 102228906(gucy1a1)
XCO: 114133238(gucy1a2) 114145011(gucy1a1)
PRET: 103466154(gucy1a3) 103474497(gucy1a2)
CVG: 107093944(gucy1a2) 107097704(gucy1a3)
NFU: 107375309(gucy1a3) 107380439(gucy1a2)
KMR: 108244641(gucy1a2) 108250689(gucy1a1)
ALIM: 106517183 106521477(gucy1a2)
AOCE: 111575320(gucy1a1) 111580973(gucy1a2)
CSEM: 103378532(gucy1a2) 103383661(gucy1a3)
POV: 109630163(gucy1a2) 109637781(gucy1a3)
LCF: 108890865(gucy1a2) 108896510(gucy1a3)
SDU: 111224115(gucy1a2) 111231447(gucy1a3)
SLAL: 111651815(gucy1a2) 111654817 111664043(gucy1a1)
HCQ: 109511512(gucy1a3) 109525417(gucy1a2)
BPEC: 110165413(gucy1a3) 110174338(gucy1a2)
MALB: 109961420(gucy1a3) 109971610(gucy1a2)
SALP: 111959269(gucy1a2) 111971540(gucy1a1) 112068693 112080371
ELS: 105024076(gucy1a2) 105028905(gucy1a1)
SFM: 108924492(gucy1a1) 108924639(gucy1a2)
PKI: 111833824(gucy1a2) 111837347(gucy1a1)
LCM: 102362175(GUCY1A3)
CMK: 103185780(gucy1a2) 103187183(gucy1a3)
BFO: 118419466
CIN: 100178591
SPU: 100889569
APLC: 110983731
DME: Dmel_CG1912(Gycalpha99B)
DER: 6554597
DSE: 6612719
DSI: Dsimw501_GD21450(Dsim_GD21450)
DAN: 6506001
DSR: 110186477
DPE: 6595164
DMN: 108157189
DWI: 6647577
DAZ: 108610366
DNV: 108656204
DHE: 111599443
DVI: 6632721
LCQ: 111690487
AAG: 5570698
AME: 408879(sGC-alpha1)
BIM: 100749092
BTER: 100647693
CCAL: 108624087
SOC: 105196464
MPHA: 105831031
AEC: 105146046
ACEP: 105617197
PBAR: 105432005
VEM: 105564904
HST: 105180850
DQU: 106751694
CFO: 105254454
LHU: 105668450
PGC: 109854999
OBO: 105279309
PCF: 106785349
NVI: 100118554
CSOL: 105363410
MDL: 103570076
TCA: 659086
ATD: 109609386
NVL: 108562076
BMOR: 100642185(GC-a1)
BMAN: 114242746
PMAC: 106711336
PRAP: 110997097
HAW: 110373281
TNL: 113500001
PXY: 105383491
API: 100167238
DNX: 107167885
AGS: 114119225
RMD: 113556210
BTAB: 109029770
CLEC: 106663391
ZNE: 110840164
FCD: 110858207
PVM: 113823998
TUT: 107363705
DPTE: 113791936
PTEP: 107436806
PCAN: 112560072
CRG: 105333172
MYI: 110452448
OBI: 106869877
EPA: 110248038
DGT: 114523321
HMG: 100197914
 » show all
Reference
PMID:1683630
  Authors
Harteneck C, Wedel B, Koesling D, Malkewitz J, Bohme E, Schultz G
  Title
Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme.
  Journal
FEBS Lett 292:217-22 (1991)
DOI:10.1016/0014-5793(91)80871-Y
  Sequence
[hsa:2977]
LinkDB

KEGG   ORTHOLOGY: K12319
Entry
K12319                      KO                                     

Name
GUCY1B
Definition
guanylate cyclase soluble subunit beta [EC:4.6.1.2]
Pathway
ko00230  Purine metabolism
ko01100  Metabolic pathways
ko04022  cGMP-PKG signaling pathway
ko04270  Vascular smooth muscle contraction
ko04540  Gap junction
ko04611  Platelet activation
ko04713  Circadian entrainment
ko04730  Long-term depression
ko04921  Oxytocin signaling pathway
ko04924  Renin secretion
ko04970  Salivary secretion
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K12319  GUCY1B; guanylate cyclase soluble subunit beta
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    K12319  GUCY1B; guanylate cyclase soluble subunit beta
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K12319  GUCY1B; guanylate cyclase soluble subunit beta
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K12319  GUCY1B; guanylate cyclase soluble subunit beta
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K12319  GUCY1B; guanylate cyclase soluble subunit beta
   04924 Renin secretion
    K12319  GUCY1B; guanylate cyclase soluble subunit beta
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K12319  GUCY1B; guanylate cyclase soluble subunit beta
  09154 Digestive system
   04970 Salivary secretion
    K12319  GUCY1B; guanylate cyclase soluble subunit beta
  09156 Nervous system
   04730 Long-term depression
    K12319  GUCY1B; guanylate cyclase soluble subunit beta
  09159 Environmental adaptation
   04713 Circadian entrainment
    K12319  GUCY1B; guanylate cyclase soluble subunit beta
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.2  guanylate cyclase
     K12319  GUCY1B; guanylate cyclase soluble subunit beta
Other DBs
RN: R00434
GO: 0004383
Genes
HSA: 2983(GUCY1B1)
PTR: 452727 461565(GUCY1B1)
PPS: 100980358 100984704(GUCY1B3)
GGO: 101128425 101141380(GUCY1B1)
PON: 100434873(GUCY1B1) 100445008
NLE: 100583335(GUCY1B1) 100600502
MCC: 100424944(GUCY1B1) 114673584
MCF: 101866588(GUCY1B3) 102120445
CSAB: 103214549 103236429(GUCY1B3)
RRO: 104658102(GUCY1B1) 104662724
RBB: 108529025(GUCY1B3) 108530715
CJC: 100390920 100395297(GUCY1B3)
SBQ: 101027848 101040246(GUCY1B3)
MMU: 239134(Gucy1b2) 54195(Gucy1b1)
MCAL: 110291191(Gucy1b3) 110309748
MPAH: 110320110(Gucy1b3) 110325783
RNO: 25202(Gucy1b3) 25206(Gucy1b2)
MUN: 110566016(Gucy1b3) 110566519
CGE: 100752832 100772822(Gucy1b1)
NGI: 103727194 103751002(Gucy1b3)
HGL: 101724888(Gucy1b3) 101726611
CCAN: 109681095 109683638(Gucy1b3)
OCU: 100349851(GUCY1B3)
TUP: 102485635 102488370(GUCY1B3)
CFA: 485435 553102(GUCY1B1)
VVP: 112910844 112933413(GUCY1B1)
AML: 100468070 100481364(GUCY1B1)
UMR: 103658045(GUCY1B3) 103677696
UAH: 113251013 113255783(GUCY1B1)
ORO: 101365290 101380641(GUCY1B3)
FCA: 101089435(GUCY1B1)
PTG: 102963951(GUCY1B3) 102970885
PPAD: 109262488(GUCY1B3)
AJU: 106972647 106982460(GUCY1B1)
BTA: 112449027 282433(GUCY1B1)
BOM: 102282106(GUCY1B3) 102285947
BBUB: 102394244(GUCY1B1) 102400461
CHX: 102169406(GUCY1B3) 102182418
OAS: 443165(GUCY1B1)
SSC: 100625149 444999(GUCY1B3)
CFR: 102508234(GUCY1B1) 102510749
CDK: 105091014 105101179(GUCY1B1)
BACU: 103020709(GUCY1B3) 103020943
LVE: 103075578(GUCY1B3)
OOR: 101279031(GUCY1B3) 101284510
DLE: 111179007(GUCY1B1)
PCAD: 102975653 102994635(GUCY1B1)
ECB: 100054420 100069551(GUCY1B1)
EPZ: 103551994 103562608(GUCY1B3)
EAI: 106833011(GUCY1B3) 106837722
MYB: 102250379(GUCY1B3) 102261219
MYD: 102758657 102769452(GUCY1B3)
MNA: 107527535(GUCY1B3) 107537733
HAI: 109377497(GUCY1B3) 109387114
DRO: 112312386(GUCY1B1)
PALE: 102889391 102889920(GUCY1B1)
RAY: 107507550(GUCY1B3) 107509998
MJV: 108401443 108408488(GUCY1B3)
LAV: 100665374(GUCY1B1) 100676051
MDO: 100024008(GUCY1B3) 100028289
SHR: 100931427(GUCY1B1) 100932257
PCW: 110196646 110213660(GUCY1B3)
OAA: 100079900(GUCY1B1) 100082922
GGA: 422408(GUCY1B3) 429128(GUCY1B4)
MGP: 100539100 100547365(GUCY1B1)
CJO: 107313044(GUCY1B1) 107318030
NMEL: 110397302(GUCY1B3) 110398465
APLA: 101796516 101805193(GUCY1B1)
ACYG: 106032278(GUCY1B3) 106036260
TGU: 100223544(GUCY1B1) 100225337
LSR: 110478232(GUCY1B1) 110483639
SCAN: 103815438 103825956(GUCY1B1)
GFR: 102038841 102043713(GUCY1B3)
FAB: 101815504(GUCY1B3) 101818523
PHI: 102105071 102106413(GUCY1B3)
PMAJ: 107203428(GUCY1B3) 107208956
CCAE: 111927850(GUCY1B1) 111933549
CCW: 104693425 104697179(GUCY1B3)
ETL: 114065470(GUCY1B1) 114070416
FPG: 101915374(GUCY1B3) 101920979
FCH: 102048540(GUCY1B1) 102054518
CLV: 102091284 102091873(GUCY1B3)
EGZ: 104124167(GUCY1B3) 104135463
NNI: 104012992 104021239(GUCY1B3)
ACUN: 113479595(GUCY1B1) 113483585
PADL: 103917858 103921781(GUCY1B3)
ASN: 102375853 102383096(GUCY1B1)
CPIC: 101944882 101947603(GUCY1B3) 101952801
ACS: 100563021(gucy1b3) 100565491
PVT: 110070583 110072778(GUCY1B3)
PMUR: 107287976(GUCY1B1) 107293398 107299885
PMUA: 114593729 114597802 114604018(GUCY1B1)
XLA: 108717066 108717463 108719605(gucy1b3.L) 432281(gucy1b3.S)
XTR: 100379900(gucy1b1) 100496697(gucy1b2)
DRE: 100150304(gucy1b1) 557191(gucy1b2)
PHYP: 113524512(gucy1b1) 113543271 113547436
AMEX: 103028400 103041986(gucy1b3) 103043150
EEE: 113578242 113583871(gucy1b1)
TRU: 105417069 115250535 445898(gucy1b1)
NCC: 104947142 104949643(gucy1b3)
MZE: 101476955 101484121(gucy1b1)
ONL: 100694881 100699589(gucy1b1)
OLA: 100049178(gucy1b1)
XMA: 102229616(gucy1b1)
XCO: 114145012(gucy1b1)
PRET: 103466145(gucy1b3)
CVG: 107097705(gucy1b3)
NFU: 107375310(gucy1b3)
KMR: 108231970(gucy1b1)
ALIM: 106535682(gucy1b3)
AOCE: 111575322(gucy1b1) 111579040
POV: 109637720(gucy1b3) 109639005
SLAL: 111655993 111664044(gucy1b1) 111670291
HCQ: 109511501(gucy1b3)
BPEC: 110165269(gucy1b3) 110175639
MALB: 109951528 109961370(gucy1b3)
ELS: 105019857 105028906(gucy1b1)
SFM: 108924493(gucy1b1) 108933091
PKI: 111837348(gucy1b1) 111859062
CMK: 103187184(gucy1b3) 103187614
CIN: 100178308
DME: Dmel_CG1470(Gycbeta100B)
DER: 6554814
DSE: 6612950
DSI: Dsimw501_GD21561(Dsim_GD21561)
DAN: 6501190
DSR: 110186412
DPE: 6595101
DMN: 108154621
DWI: 6649546
DAZ: 108621345
DNV: 108659933
DHE: 111597882
DVI: 6632917
MDE: 101891503
LCQ: 111681575
AAG: 5567617
AME: 408880(Gycbeta1)
BIM: 100749300
BTER: 100647335
CCAL: 108624073
SOC: 105196463
MPHA: 105831032
AEC: 105146048
PBAR: 105432007
VEM: 105564906
HST: 105180849
DQU: 106751690
CFO: 105254456
LHU: 105668451
PGC: 109855000
OBO: 105279308
PCF: 106785246
NVI: 100118663
CSOL: 105363409
MDL: 103569979
TCA: 659006
DPA: 109535494
ATD: 109598157
NVL: 108561982
BMOR: 100862777(GC-b1)
BMAN: 114242703
PMAC: 106718350
PRAP: 110997360
HAW: 110373283
TNL: 113500121
API: 100160678
DNX: 107169146
AGS: 114119262
RMD: 113549695
BTAB: 109029768
CLEC: 106663282
ZNE: 110840165
FCD: 110858060
TUT: 107363704
DPTE: 113791951
CSCU: 111617914
PTEP: 107436807
CEL: CELE_C06B3.8(gcy-32) CELE_C46E1.2(gcy-36) CELE_T04D3.4(gcy-35)
CBR: CBG04937 CBG06726(Cbr-gcy-34) CBG07710 CBG20390(Cbr-gcy-35)
BMY: Bm1_16095
OBI: 106878947
ADF: 107352951
AMIL: 114960930
HMG: 100212830
AQU: 100633664
 » show all
Reference
PMID:1352257
  Authors
Giuili G, Scholl U, Bulle F, Guellaen G
  Title
Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain.
  Journal
FEBS Lett 304:83-8 (1992)
DOI:10.1016/0014-5793(92)80594-7
  Sequence
[hsa:2983]
LinkDB

KEGG   ORTHOLOGY: K12320
Entry
K12320                      KO                                     

Name
GUCY2C
Definition
heat-stable enterotoxin receptor [EC:4.6.1.2]
Pathway
ko00230  Purine metabolism
ko01100  Metabolic pathways
Disease
H01174  Congenital diarrhea
H01615  Irritable bowel syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K12320  GUCY2C; heat-stable enterotoxin receptor
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K12320  GUCY2C; heat-stable enterotoxin receptor
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.2  guanylate cyclase
     K12320  GUCY2C; heat-stable enterotoxin receptor
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  RGC family [OT]
   K12320  GUCY2C; heat-stable enterotoxin receptor
Other DBs
RN: R00434
GO: 0004383
Genes
HSA: 2984(GUCY2C)
PTR: 473375(GUCY2C)
PPS: 100975209(GUCY2C)
GGO: 101138030(GUCY2C)
PON: 100460918(GUCY2C)
NLE: 100594944(GUCY2C)
MCC: 699191(GUCY2C)
MCF: 102130850(GUCY2C)
CSAB: 103218671(GUCY2C)
RRO: 104666399(GUCY2C)
RBB: 108530463(GUCY2C)
CJC: 100406002(GUCY2C)
SBQ: 101038981(GUCY2C)
MMU: 14917(Gucy2c)
MCAL: 110296529(Gucy2c)
MPAH: 110316487(Gucy2c)
RNO: 25711(Gucy2c)
MUN: 110552758(Gucy2c)
CGE: 100757969(Gucy2c)
NGI: 103752330(Gucy2c)
HGL: 101720874(Gucy2c)
CCAN: 109696930(Gucy2c)
OCU: 100008740(GUCY2C)
TUP: 102495739(GUCY2C)
CFA: 486671(GUCY2C)
VVP: 112917486(GUCY2C)
AML: 100468576(GUCY2C)
UMR: 103677772(GUCY2C)
UAH: 113257858(GUCY2C)
ORO: 101382463(GUCY2C)
ELK: 111142267
FCA: 101095109(GUCY2C)
PTG: 102963095(GUCY2C)
PPAD: 109268647(GUCY2C)
AJU: 106965660(GUCY2C)
BTA: 282244(GUCY2C)
BOM: 102284444(GUCY2C)
BIU: 109559629(GUCY2C)
BBUB: 102402674(GUCY2C)
CHX: 108636048(GUCY2C)
OAS: 101108212
SSC: 397193(GUCY2C)
CFR: 102516411(GUCY2C)
CDK: 105096521(GUCY2C)
BACU: 103006662(GUCY2C)
LVE: 103081407(GUCY2C)
OOR: 101284028(GUCY2C)
DLE: 111176790(GUCY2C)
PCAD: 102978761(GUCY2C)
ECB: 100063810(GUCY2C)
EPZ: 103559389(GUCY2C)
EAI: 106826729(GUCY2C)
MYB: 102247939(GUCY2C)
MYD: 102772626(GUCY2C)
MNA: 107525360(GUCY2C)
HAI: 109383130(GUCY2C)
DRO: 112318447(GUCY2C)
PALE: 102883474(GUCY2C)
RAY: 107508610(GUCY2C)
MJV: 108397788(GUCY2C)
LAV: 100675825(GUCY2C)
TMU: 101340932
MDO: 100016988(GUCY2C)
SHR: 100925538(GUCY2C)
PCW: 110213823(GUCY2C)
OAA: 100091310(GUCY2C)
GGA: 417968(GUCY2C)
MGP: 100550786(GUCY2C)
CJO: 107313537(GUCY2C)
NMEL: 110392293(GUCY2C)
APLA: 101802157(GUCY2C)
ACYG: 106046052(GUCY2C)
TGU: 100228246(GUCY2C)
LSR: 110483071(GUCY2C)
SCAN: 103813321(GUCY2C)
GFR: 102042400(GUCY2C)
FAB: 101816039(GUCY2C)
PHI: 102111535(GUCY2C)
PMAJ: 107204266(GUCY2C)
CCAE: 111934182(GUCY2C)
CCW: 104696375(GUCY2C)
ETL: 114064062(GUCY2C)
FPG: 101913205(GUCY2C)
FCH: 102053014(GUCY2C)
CLV: 102098904(GUCY2C)
EGZ: 104134274(GUCY2C)
NNI: 104021662(GUCY2C)
ACUN: 113491559(GUCY2C)
PADL: 103915916(GUCY2C)
AAM: 106488668(GUCY2C)
ASN: 102374400(GUCY2C)
AMJ: 102558504(GUCY2C)
PSS: 102444148(GUCY2C)
CMY: 102947911(GUCY2C)
CPIC: 101940459 101941251(GUCY2C)
ACS: 100563369(gucy2c)
PVT: 110076095(GUCY2C)
PBI: 103067773(GUCY2C)
PMUR: 107302973(GUCY2C)
TSR: 106539270
PMUA: 114605114(GUCY2C)
GJA: 107118370(GUCY2C)
XLA: 108715011(gucy2c.S) 378662(gucy2c.L)
XTR: 100486678(gucy2c)
DRE: 568219(si:ch73-139e5.4) 572052(gucy2c)
IPU: 108272812(GUCY2C) 108273417
PHYP: 113527433(gucy2c) 113534683
AMEX: 103035855(gucy2c) 103043322
LCO: 104918929 104932052(gucy2c)
OLA: 100125818(olgc9) 100125820(olgc6)
CVG: 107089523 107093098(gucy2c)
NFU: 107376314(gucy2c) 107395148
KMR: 108235883 108236050(gucy2c)
ALIM: 106520689(gucy2c) 106532355
BPEC: 110159629 110162279(gucy2c)
MALB: 109952646
ELS: 105025088 105025779(gucy2c)
LCM: 102346928(GUCY2C)
RTP: 109919097(gucy2c)
 » show all
Reference
PMID:1718270
  Authors
Singh S, Singh G, Heim JM, Gerzer R
  Title
Isolation and expression of a guanylate cyclase-coupled heat stable enterotoxin receptor cDNA from a human colonic cell line.
  Journal
Biochem Biophys Res Commun 179:1455-63 (1991)
DOI:10.1016/0006-291X(91)91736-V
  Sequence
[hsa:2984]
LinkDB

KEGG   ORTHOLOGY: K12321
Entry
K12321                      KO                                     

Name
GUCY2D_E
Definition
guanylate cyclase 2D/E [EC:4.6.1.2]
Pathway
ko00230  Purine metabolism
ko01100  Metabolic pathways
ko04740  Olfactory transduction
ko04744  Phototransduction
Disease
H00481  Cone-rod dystrophy and cone dystrophy
H00837  Leber congenital amaurosis
H01768  Central areolar choroidal dystrophy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K12321  GUCY2D_E; guanylate cyclase 2D/E
 09150 Organismal Systems
  09157 Sensory system
   04744 Phototransduction
    K12321  GUCY2D_E; guanylate cyclase 2D/E
   04740 Olfactory transduction
    K12321  GUCY2D_E; guanylate cyclase 2D/E
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K12321  GUCY2D_E; guanylate cyclase 2D/E
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.2  guanylate cyclase
     K12321  GUCY2D_E; guanylate cyclase 2D/E
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  RGC family [OT]
   K12321  GUCY2D_E; guanylate cyclase 2D/E
Other DBs
RN: R00434
GO: 0004383
Genes
HSA: 3000(GUCY2D)
PTR: 451435 750641(GUCY2D)
PPS: 100976525(GUCY2D)
GGO: 101140749(GUCY2D)
PON: 100443214(GUCY2D)
NLE: 100585866(GUCY2D) 100587777
MCC: 100430188 716734(GUCY2D)
MCF: 102146353(GUCY2D)
CSAB: 103242335(GUCY2D)
RRO: 104661674(GUCY2D)
RBB: 108514277(GUCY2D)
CJC: 100412242(GUCY2D)
SBQ: 101031889(GUCY2D)
MMU: 14918(Gucy2d) 14919(Gucy2e)
MCAL: 110298578 110305918(Gucy2d)
MPAH: 110330114 110332384(Gucy2d)
RNO: 113911(Gucy2d) 79222(Gucy2e)
MUN: 110551701(Gucy2d) 110560570
CGE: 100750501 100754759(Gucy2d)
NGI: 103743062 103752104(Gucy2d)
HGL: 101697777(Gucy2d) 101717731
CCAN: 109688562 109693913(Gucy2d)
OCU: 100344095(GUCY2D)
TUP: 102494681 102496410(GUCY2D)
CFA: 403863(GUCY2D) 485179
VVP: 112924739(GUCY2D) 112928727
AML: 100476540 100480095(GUCY2D)
UMR: 103660485(GUCY2D) 103678130
UAH: 113269343 113271141(GUCY2D)
ORO: 101377149 101383563(GUCY2D)
FCA: 101099582 101101009(GUCY2D)
PTG: 102960287(GUCY2D) 102971963
AJU: 106972445(GUCY2D) 106976443
BTA: 282245(GUCY2D)
BOM: 102267198 102281141(GUCY2D)
BIU: 109574462(GUCY2D)
BBUB: 102406724(GUCY2D)
CHX: 102169418(GUCY2D)
OAS: 101109482 101120932(GUCY2D)
SSC: 100523457 100625536(GUCY2D)
CFR: 102503713(GUCY2D) 102509037
CDK: 105098241 105102998(GUCY2D)
BACU: 103002685 103016360(GUCY2D)
LVE: 103070106(GUCY2D)
OOR: 101274865 101282297(GUCY2D)
DLE: 111185889(GUCY2D)
PCAD: 102991189(GUCY2D)
ECB: 100073037(GUCY2D) 100630860
EPZ: 103548241 103566602(GUCY2D)
EAI: 106840416 106844230(GUCY2D)
MYB: 102242149 102243506(GUCY2D)
MYD: 102751706(GUCY2D) 102760543
MNA: 107524472 107544495(GUCY2D)
HAI: 109395113(GUCY2D)
DRO: 112308750(GUCY2D)
PALE: 102884807 102892708(GUCY2D)
RAY: 107515672(GUCY2D) 107519122
MJV: 108383381(GUCY2D) 108398545
LAV: 100656347 100670740(GUCY2D)
MDO: 100014788(GUCY2D) 100028110
SHR: 100921433(GUCY2D)
PCW: 110194405(GUCY2D) 110210716
NMEL: 110391669
APLA: 101805092
ACYG: 106049690
TGU: 115492653
PHI: 102114027(GUCY2D)
FPG: 101916520
FCH: 102050145
CLV: 102095707
NNI: 104015339
AAM: 106487682
ASN: 102375187(GUCY2D)
AMJ: 102564997(GUCY2D)
PSS: 102451086(GUCY2D)
CMY: 102946484
CPIC: 101953314(GUCY2F)
ACS: 100558820(gucy2d)
PVT: 110087765(GUCY2D)
PBI: 103064925(GUCY2D)
PMUR: 107297126
TSR: 106557179
XLA: 108703527(gucy2d.S) 108711755(gucy2d.L)
XTR: 100496590(gucy2d)
NPR: 108793773(GUCY2D)
DRE: 140426(gucy2d)
SRX: 107734113
SANH: 107661246
IPU: 108259769
PHYP: 113531167
AMEX: 111191814
EEE: 113586825
ONL: 100708131
OLA: 100192404(olgc3)
XMA: 102238353
XCO: 114143094
PRET: 103465677
CVG: 107083206
NFU: 107383747
KMR: 108250633
ALIM: 106534425
AOCE: 111584162
CSEM: 103390041(gucy2d) 103395410
MALB: 109959424
LCM: 102362141(GUCY2D)
 » show all
Reference
PMID:1356371
  Authors
Shyjan AW, de Sauvage FJ, Gillett NA, Goeddel DV, Lowe DG
  Title
Molecular cloning of a retina-specific membrane guanylyl cyclase.
  Journal
Neuron 9:727-37 (1992)
DOI:10.1016/0896-6273(92)90035-C
  Sequence
[hsa:3000]
Reference
  Authors
Venkataraman V, Duda T, Ravichandran S, Sharma RK
  Title
Neurocalcin delta modulation of ROS-GC1, a new model of Ca(2+) signaling.
  Journal
Biochemistry 47:6590-601 (2008)
DOI:10.1021/bi800394s
  Sequence
[hsa:3000]
Reference
  Authors
Coleman JE, Semple-Rowland SL
  Title
GC1 deletion prevents light-dependent arrestin translocation in mouse cone photoreceptor cells.
  Journal
Invest Ophthalmol Vis Sci 46:12-6 (2005)
DOI:10.1167/iovs.04-0691
  Sequence
[mmu:14919]
LinkDB

KEGG   ORTHOLOGY: K12322
Entry
K12322                      KO                                     

Name
GUCY2F
Definition
guanylate cyclase 2F [EC:4.6.1.2]
Pathway
ko00230  Purine metabolism
ko01100  Metabolic pathways
ko04744  Phototransduction
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K12322  GUCY2F; guanylate cyclase 2F
 09150 Organismal Systems
  09157 Sensory system
   04744 Phototransduction
    K12322  GUCY2F; guanylate cyclase 2F
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K12322  GUCY2F; guanylate cyclase 2F
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.2  guanylate cyclase
     K12322  GUCY2F; guanylate cyclase 2F
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  RGC family [OT]
   K12322  GUCY2F; guanylate cyclase 2F
Other DBs
RN: R00434
GO: 0004383
Genes
HSA: 2986(GUCY2F)
PTR: 465806(GUCY2F)
PPS: 100984343(GUCY2F)
GGO: 101134962(GUCY2F)
PON: 100451211(GUCY2F)
NLE: 100588933(GUCY2F)
MCC: 704485(GUCY2F)
MCF: 102129950(GUCY2F)
CSAB: 103232475(GUCY2F)
RBB: 108517394 108531521(GUCY2F)
CJC: 100410561(GUCY2F)
SBQ: 101035077(GUCY2F)
MMU: 245650(Gucy2f)
MCAL: 110286950(Gucy2f)
MPAH: 110313863(Gucy2f)
RNO: 116556(Gucy2f)
MUN: 110542656
CGE: 100755503
NGI: 103750026(Gucy2f)
HGL: 101707903(Gucy2f)
CCAN: 109675363 109698643(Gucy2f)
OCU: 100340698(GUCY2F)
CFA: 481016(GUCY2F)
VVP: 112932078(GUCY2F)
AML: 100469110(GUCY2F)
UMR: 103679746(GUCY2F)
UAH: 113241196(GUCY2F)
ORO: 101371476(GUCY2F)
ELK: 111160977
FCA: 101090242(GUCY2F)
PTG: 102949926(GUCY2F)
PPAD: 109253662(GUCY2F)
AJU: 106973153(GUCY2F)
BTA: 282246(GUCY2F)
BOM: 102274513(GUCY2F)
BIU: 109555058(GUCY2F)
BBUB: 102402009(GUCY2F)
CHX: 102180380(GUCY2F)
OAS: 101112033(GUCY2F)
SSC: 100737736(GUCY2F)
CFR: 102522209(GUCY2F)
CDK: 105093187(GUCY2F)
BACU: 102998599(GUCY2F)
LVE: 103071136(GUCY2F)
OOR: 101269588(GUCY2F)
DLE: 111165760(GUCY2F) 111184892
PCAD: 102978644(GUCY2F) 102987472
ECB: 100054502(GUCY2F)
EPZ: 103563566(GUCY2F)
EAI: 106839735(GUCY2F)
MYB: 102241126(GUCY2F)
MNA: 107526255(GUCY2F)
HAI: 109376730(GUCY2F)
DRO: 112296871(GUCY2F)
PALE: 102878600(GUCY2F)
RAY: 107518569(GUCY2F)
LAV: 100670819(GUCY2F)
TMU: 101350816
GGA: 419089(GUCY2F)
MGP: 100544016(GUCY2F)
CJO: 107308518(GUCY2F)
NMEL: 110391472(GUCY2F)
APLA: 101800833(GUCY2F)
ACYG: 106042382(GUCY2F)
TGU: 100229764(GUCY2F)
LSR: 110472358(GUCY2F)
SCAN: 103812495(GUCY2F)
GFR: 102038803(GUCY2F)
FAB: 101816994(GUCY2F)
PHI: 102099657(GUCY2F)
PMAJ: 107210870(GUCY2F)
CCAE: 111924707(GUCY2F)
CCW: 104690280(GUCY2F)
ETL: 114068652(GUCY2F)
FPG: 101924821(GUCY2F)
FCH: 102055553(GUCY2F)
CLV: 102086091(GUCY2F)
EGZ: 104124743(GUCY2F)
NNI: 104022728(GUCY2F)
ACUN: 113486895(GUCY2F)
PADL: 103915168(GUCY2F)
AAM: 106490807(GUCY2F)
ASN: 102373559(GUCY2F)
AMJ: 102559036(GUCY2F)
ACS: 100556473
PVT: 110070046
PBI: 103062751
PMUA: 114595437(GUCY2F)
GJA: 107122891(GUCY2F)
XLA: 108698903(gucy2f.L) 108700543(gucy2f.S) 108707622
XTR: 100489435 100492820(gucy2f)
NPR: 108798208 108799503(GUCY2F)
DRE: 140424(gucy2f) 140425(gc2)
TRU: 101068241 101074569(gucy2f)
OLA: 100049189(olgc-r1) 100216004(olgc-r2)
ALIM: 106524455(gucy2f) 106525641
LCM: 102366428(GUCY2F)
CMK: 103179559(gucy2f)
CIN: 100177556
APLC: 110981639
SKO: 100377012
DME: Dmel_CG34357(CG34357)
DER: 6552181
DSE: 6613836
DSI: Dsimw501_GD19673(Dsim_GD19673)
DAN: 6501131
DSR: 110187965
DPE: 6591975
DMN: 108157621
DWI: 6650233
DAZ: 108616516
DNV: 108658181
DHE: 111599556
DVI: 6629998
MDE: 101900915
LCQ: 111685298
AAG: 5577087
AME: 409422
BIM: 100741981
BTER: 100642611
CCAL: 108627232
OBB: 114874648
SOC: 105199646
MPHA: 105837175
AEC: 105151608
ACEP: 105617477
PBAR: 105430561
VEM: 105570194
HST: 105182743
DQU: 106745953
CFO: 105250130
LHU: 105676550
PGC: 109851673
OBO: 105277764
PCF: 106793720
NVI: 103316308
TCA: 661745
DPA: 109542730
ATD: 109600478
NVL: 108568708
BMOR: 101740270
BMAN: 114249220
PMAC: 106716277
PRAP: 110994012
HAW: 110377659
TNL: 113493093
BTAB: 109032713
CLEC: 106664618
ZNE: 110831967
TUT: 107371739
CSCU: 111626073
PCAN: 112555351
CRG: 105337771
MYI: 110462614
OBI: 106868455
SHX: MS3_00162
EPA: 110254148
 » show all
Reference
  Authors
Helten A, Saftel W, Koch KW
  Title
Expression level and activity profile of membrane bound guanylate cyclase type 2 in rod outer segments.
  Journal
J Neurochem 103:1439-46 (2007)
DOI:10.1111/j.1471-4159.2007.04923.x
  Sequence
[hsa:2986]
LinkDB

KEGG   ORTHOLOGY: K22600
Entry
K22600                      KO                                     

Name
GUCY2G
Definition
guanylate cyclase 2G [EC:4.6.1.2]
Pathway
ko00230  Purine metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K22600  GUCY2G; guanylate cyclase 2G
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.2  guanylate cyclase
     K22600  GUCY2G; guanylate cyclase 2G
Other DBs
RN: R00434
GO: 0004383
Genes
PTR: 466203
PPS: 100978077
GGO: 101146677
PON: 100460177
NLE: 100605363
MCC: 100423770
MCF: 102136166
RRO: 104664442
RBB: 108538805
SBQ: 101037653
MMU: 73707(Gucy2g)
MCAL: 110285938
MPAH: 110334709
RNO: 245708(Gucy2g)
MUN: 110560937
CGE: 100760728
NGI: 103731771
HGL: 101713282
OCU: 100344092
TUP: 102478622
VVP: 112914554
AML: 100472992
UMR: 103659237
UAH: 113251629
ORO: 101367891
FCA: 101101087
PTG: 102972759
PPAD: 109272691
AJU: 106984748
LVE: 103069064
OOR: 101271659
DLE: 111172649
PCAD: 102980216
ECB: 100068630
EPZ: 103564288
EAI: 106837558
MYB: 102258634
MYD: 102775033
MNA: 107536420
HAI: 109384884
DRO: 112300447
PALE: 102881321
MJV: 108408166
TMU: 101346990
MDO: 100027754
SHR: 105749254
OAA: 100082549
ASN: 106722154
AMJ: 102572749
PSS: 102448215
CMY: 102935364
CPIC: 101944291
ACS: 100564400
PVT: 110072006
PBI: 103060465
PMUR: 107286254
TSR: 106544109
PMUA: 114597481
GJA: 107122702
XTR: 101732806
NPR: 108798364
DRE: 100333350(gucy2g)
IPU: 108273537
PHYP: 113527277
AMEX: 103039360
EEE: 113587535
TRU: 101073658
LCO: 104933166
MZE: 101478879
ONL: 100703815
XMA: 102235007
XCO: 114152432
PRET: 103481687
CVG: 107092998
KMR: 108247651
ALIM: 106535649
AOCE: 111563179
CSEM: 103381679
POV: 109642108
LCF: 108894799
SDU: 111219587
SLAL: 111656132
HCQ: 109512143
BPEC: 110154347
MALB: 109969571
SASA: 106579347
OTW: 112223268
SALP: 111977664
ELS: 105005859
SFM: 108940419
PKI: 111858160
LCM: 102351946
CMK: 103186579
RTP: 109939047
MYI: 110449251
HMG: 101239522
 » show all
Reference
  Authors
Kuhn M, Ng CK, Su YH, Kilic A, Mitko D, Bien-Ly N, Komuves LG, Yang RB
  Title
Identification of an orphan guanylate cyclase receptor selectively expressed in mouse testis.
  Journal
Biochem J 379:385-93 (2004)
DOI:10.1042/BJ20031624
  Sequence
[mmu:73707]
LinkDB

KEGG   ORTHOLOGY: K12323
Entry
K12323                      KO                                     

Name
ANPRA, NPR1
Definition
atrial natriuretic peptide receptor A [EC:4.6.1.2]
Pathway
ko00230  Purine metabolism
ko01100  Metabolic pathways
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04270  Vascular smooth muscle contraction
ko04714  Thermogenesis
ko04921  Oxytocin signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04924  Renin secretion
ko04925  Aldosterone synthesis and secretion
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K12323  ANPRA, NPR1; atrial natriuretic peptide receptor A
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    K12323  ANPRA, NPR1; atrial natriuretic peptide receptor A
   04022 cGMP-PKG signaling pathway
    K12323  ANPRA, NPR1; atrial natriuretic peptide receptor A
 09150 Organismal Systems
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    K12323  ANPRA, NPR1; atrial natriuretic peptide receptor A
   04921 Oxytocin signaling pathway
    K12323  ANPRA, NPR1; atrial natriuretic peptide receptor A
   04924 Renin secretion
    K12323  ANPRA, NPR1; atrial natriuretic peptide receptor A
   04925 Aldosterone synthesis and secretion
    K12323  ANPRA, NPR1; atrial natriuretic peptide receptor A
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K12323  ANPRA, NPR1; atrial natriuretic peptide receptor A
  09159 Environmental adaptation
   04714 Thermogenesis
    K12323  ANPRA, NPR1; atrial natriuretic peptide receptor A
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K12323  ANPRA, NPR1; atrial natriuretic peptide receptor A
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.2  guanylate cyclase
     K12323  ANPRA, NPR1; atrial natriuretic peptide receptor A
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  RGC family [OT]
   K12323  ANPRA, NPR1; atrial natriuretic peptide receptor A
Other DBs
RN: R00434
GO: 0004383
Genes
HSA: 4881(NPR1)
PTR: 457329(NPR1)
PPS: 100983770(NPR1)
GGO: 101131617(NPR1)
PON: 100442459(NPR1)
NLE: 100601694(NPR1)
MCC: 715598(NPR1)
MCF: 102143449(NPR1)
CSAB: 103223952(NPR1)
RRO: 104663522(NPR1)
RBB: 108518838(NPR1)
CJC: 100396371(NPR1)
SBQ: 101044584(NPR1)
MMU: 18160(Npr1)
MCAL: 110291324(Npr1)
MPAH: 110320830(Npr1)
RNO: 24603(Npr1)
MUN: 110554242(Npr1)
CGE: 100752423(Npr1)
NGI: 103751781(Npr1)
HGL: 101714641(Npr1)
CCAN: 109688055(Npr1)
OCU: 100343663(NPR1)
CFA: 490455(NPR1)
VVP: 112918863(NPR1)
AML: 100472771(NPR1)
UAH: 113245333(NPR1)
ORO: 101384059(NPR1)
ELK: 111138909
FCA: 101080682(NPR1)
PPAD: 109256259(NPR1)
AJU: 106987270(NPR1)
BTA: 533048(NPR1)
BOM: 102279810(NPR1)
BIU: 109554550(NPR1)
BBUB: 102407343(NPR1)
CHX: 102186447(NPR1)
OAS: 101123436(NPR1)
SSC: 100153508(NPR1)
CDK: 105089423(NPR1)
BACU: 103006879(NPR1)
LVE: 103088382(NPR1)
OOR: 101288628(NPR1)
DLE: 111167040(NPR1)
PCAD: 102982050(NPR1)
ECB: 100061959(NPR1)
EPZ: 103566725(NPR1)
EAI: 106846257(NPR1)
MYB: 102249825(NPR1)
MNA: 107543755(NPR1)
HAI: 109373524(NPR1)
DRO: 112315464(NPR1)
RAY: 107509091(NPR1)
MJV: 108397230(NPR1)
LAV: 100671961(NPR1)
TMU: 101346019
MDO: 100019736(NPR1)
SHR: 100921526(NPR1)
PCW: 110211999(NPR1)
OAA: 103166385(NPR1)
GGA: 107055115
TGU: 100219844(NPR1)
PHI: 106628815(NPR1)
NNI: 104018278(NPR1)
AMJ: 106736703(NPR1)
CPIC: 101943791(NPR1)
XLA: 397794(xgc-1) 399070(npr1.L)
XTR: 100492092(npr1)
DRE: 555911(npr1b) 560653(npr1a)
IPU: 108273278(npr1) 108273580
LCO: 104935872 104938056(npr1)
MZE: 101481488
ONL: 100695733(npr1)
OLA: 100125799(olgc2)
NFU: 107379009
ALIM: 106532490
AOCE: 111575228(npr1)
SDU: 111223303(npr1) 111234078
SLAL: 111659062(npr1) 111669801
CIN: 100177156
SKO: 100372572
DME: Dmel_CG31183(CG31183) Dmel_CG3216(CG3216)
DSI: Dsimw501_GD20320(Dsim_GD20320) Dsimw501_GD25238(Dsim_GD25238)
MDE: 101888358
LCQ: 111687243
DQU: 106752087
PCF: 106784163
CSOL: 105362022
TCA: 100141543(GLEAN_04747) 664507
ATD: 109594333
BMOR: 692412(Gcy)
BMAN: 114239257
PMAC: 106721157
PRAP: 111000259
HAW: 110371350
TNL: 113499262
PXY: 105389255
API: 100167260
BTAB: 109044685
CLEC: 106670312
ZNE: 110827775
FCD: 110858197
TUT: 107363722
CSCU: 111621704
CEL: CELE_T01A4.1(gcy-28) CELE_W03F11.2(gcy-17)
CBR: CBG14865(Cbr-gcy-28)
BMY: Bm1_18665
TSP: Tsp_10381
PCAN: 112571473
MYI: 110464603
OBI: 106867807
LAK: 106166491
AQU: 100636320
 » show all
Reference
PMID:2569967
  Authors
Lowe DG, Chang MS, Hellmiss R, Chen E, Singh S, Garbers DL, Goeddel DV
  Title
Human atrial natriuretic peptide receptor defines a new paradigm for second messenger signal transduction.
  Journal
EMBO J 8:1377-84 (1989)
DOI:10.1002/j.1460-2075.1989.tb03518.x
  Sequence
[hsa:4881]
LinkDB

KEGG   ORTHOLOGY: K12324
Entry
K12324                      KO                                     

Name
ANPRB, NPR2
Definition
atrial natriuretic peptide receptor B [EC:4.6.1.2]
Pathway
ko00230  Purine metabolism
ko01100  Metabolic pathways
ko04022  cGMP-PKG signaling pathway
ko04270  Vascular smooth muscle contraction
ko04921  Oxytocin signaling pathway
Disease
H00470  Acromesomelic dysplasia, Maroteaux type
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K12324  ANPRB, NPR2; atrial natriuretic peptide receptor B
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    K12324  ANPRB, NPR2; atrial natriuretic peptide receptor B
 09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K12324  ANPRB, NPR2; atrial natriuretic peptide receptor B
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K12324  ANPRB, NPR2; atrial natriuretic peptide receptor B
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K12324  ANPRB, NPR2; atrial natriuretic peptide receptor B
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.2  guanylate cyclase
     K12324  ANPRB, NPR2; atrial natriuretic peptide receptor B
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  RGC family [OT]
   K12324  ANPRB, NPR2; atrial natriuretic peptide receptor B
Other DBs
RN: R00434
GO: 0004383
Genes
HSA: 4882(NPR2)
PTR: 465084(NPR2)
PPS: 100991030(NPR2)
GGO: 101145840(NPR2)
PON: 100437411(NPR2)
NLE: 100595720(NPR2)
MCC: 695750(NPR2)
MCF: 102136908(NPR2)
CSAB: 103219213(NPR2)
RRO: 104672382(NPR2)
RBB: 108518991(NPR2)
CJC: 100410630(NPR2)
SBQ: 101049666(NPR2)
MMU: 230103(Npr2)
MCAL: 110292276(Npr2)
MPAH: 110338739(Npr2)
RNO: 116564(Npr2)
MUN: 110561887(Npr2)
CGE: 100772356(Npr2)
NGI: 103741534(Npr2)
HGL: 101712380(Npr2)
CCAN: 109693375(Npr2)
OCU: 100356598(NPR2)
TUP: 102502023(NPR2)
CFA: 474762(NPR2)
VVP: 112930835(NPR2)
AML: 100472601(NPR2)
UMR: 103667090(NPR2)
UAH: 113260460(NPR2)
ORO: 101385033(NPR2)
ELK: 111146108
FCA: 101094301(NPR2)
PTG: 102949070(NPR2)
PPAD: 109270151(NPR2)
AJU: 106981295(NPR2)
BTA: 281357(NPR2)
BOM: 102278070(NPR2)
BIU: 109563021(NPR2)
BBUB: 102398513(NPR2)
CHX: 100861577(NPR2)
OAS: 101112950(NPR2)
SSC: 100512698(NPR2)
CFR: 102507709(NPR2)
CDK: 105102284(NPR2)
BACU: 103002831(NPR2)
LVE: 103087466(NPR2)
OOR: 101273275(NPR2)
DLE: 111187995(NPR2)
PCAD: 102991665(NPR2)
ECB: 100055416(NPR2)
EPZ: 103541278(NPR2)
EAI: 106846972(NPR2)
MYB: 102238967(NPR2)
MYD: 102771508(NPR2)
MNA: 107544941(NPR2)
HAI: 109393761(NPR2)
DRO: 112304548(NPR2)
PALE: 102885265(NPR2)
RAY: 107502774(NPR2)
MJV: 108406538(NPR2)
LAV: 100676492(NPR2)
TMU: 101351573
MDO: 100020156(NPR2) 100024379
SHR: 100932333(NPR2)
PCW: 110200851 110201433(NPR2)
OAA: 100078016 100087666(NPR2)
GGA: 100859339(NPR2) 431640(NPR1)
MGP: 100539537(NPR2)
CJO: 107305835(NPR2) 107306595
NMEL: 110389689(NPR2) 110390071
APLA: 101804639
ACYG: 106036311(NPR2) 106043048
TGU: 100227153(NPR2)
LSR: 110467768 110484218(NPR2)
GFR: 102039158(NPR2) 102041232
FAB: 101807229(NPR2) 101821431
PHI: 102099290 102105257(NPR2)
PMAJ: 107198475(NPR2) 107215797
CCAE: 111940997(NPR2) 111941232
CCW: 104686575(NPR2) 104690483
ETL: 114068670 114069707(NPR2)
FPG: 101916740(NPR2) 101920659
FCH: 102051925(NPR2)
CLV: 102088233 102098846(NPR2)
EGZ: 104123036 104133897(NPR2)
NNI: 104019848
ACUN: 113489899(NPR2) 113490203
PADL: 103917675(NPR2) 103921085
AAM: 106493342(NPR2)
ASN: 102368327(NPR2) 102369559
AMJ: 102572314
PSS: 102445409
CMY: 102933143(NPR2) 102937891
CPIC: 101939273
ACS: 100566773 100568215(npr2)
PVT: 110082828(NPR2)
PBI: 103052637(NPR2) 103054566
PMUR: 107295817 107299286(NPR2)
PMUA: 114588050 114606224(NPR2)
XTR: 100488543(npr2) 101732477
DRE: 100331745(npr2)
IPU: 108260050(npr2) 108271041
PHYP: 113531491(npr2) 113533698
AMEX: 103046191 103047846(npr2)
EEE: 113588239(npr2)
OLA: 100049174(olgc8) 100049183(npr2)
XMA: 102226281(npr2) 102226340
PRET: 103473991
CVG: 107083749(npr2) 107099068
AOCE: 111581446
POV: 109625491 109640907(npr2)
SDU: 111221111(npr2) 111233435
ELS: 105006247 105015043(npr2)
SFM: 108926017 108929872(npr2)
PKI: 111835585(npr2) 111860506
CMK: 103174800 103181010(npr2)
RTP: 109927210
BFO: 118432137
APLC: 110987241
PTEP: 107451998
PCAN: 112560561
CRG: 105331903
SHX: MS3_01929
ADF: 107357160
 » show all
Reference
  Authors
Rehemudula D, Nakayama T, Soma M, Takahashi Y, Uwabo J, Sato M, Izumi Y, Kanmatsuse K, Ozawa Y
  Title
Structure of the type B human natriuretic peptide receptor gene and association of a novel microsatellite polymorphism with essential hypertension.
  Journal
Circ Res 84:605-10 (1999)
DOI:10.1161/01.res.84.5.605
  Sequence
[hsa:4882]
LinkDB

KEGG   ORTHOLOGY: K01769
Entry
K01769                      KO                                     

Name
E4.6.1.2
Definition
guanylate cyclase, other [EC:4.6.1.2]
Pathway
ko00230  Purine metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K01769  E4.6.1.2; guanylate cyclase, other
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.2  guanylate cyclase
     K01769  E4.6.1.2; guanylate cyclase, other
Other DBs
RN: R00434
GO: 0004383
Genes
SRX: 107715168 107732462 107741773
SANH: 107663441 107678618 107689897 107704631
SGH: 107552331 107587875 107598015
CCAR: 109073494 109081296 109106316
IPU: 108262134 108274535
PHYP: 113530022 113534156
AMEX: 103027224 103038777
TRU: 101070125 101073614
TNG: GSTEN00011672G001
LCO: 104923944 104927073
NCC: 104947122
LCM: 102359843
CMK: 103177390
DME: Dmel_CG14885(Gyc89Da) Dmel_CG14886(Gyc89Db) Dmel_CG33114(Gyc32E) Dmel_CG4154(Gyc88E) Dmel_CG42636(Gyc76C) Dmel_CG42637(CG42637)
DSI: Dsimw501_GD12253(Dsim_GD12253) Dsimw501_GD14452(Dsim_GD14452) Dsimw501_GD18990(Dsim_GD18990) Dsimw501_GD19104(Dsim_GD19104) Dsimw501_GD19105(Dsim_GD19105) Dsimw501_GD22188(Dsim_GD22188)
AME: 411635(sGCbeta-3) 413274 724603
PCF: 106784209
CEL: CELE_AH6.1(gcy-1) CELE_C49H3.1(gcy-8) CELE_F08B1.2(gcy-12) CELE_F21H7.9(gcy-20) CELE_F22E5.3(gcy-21) CELE_F57F5.2(gcy-33) CELE_M04G12.3(gcy-34) CELE_R134.1(gcy-3) CELE_T07D1.1(gcy-31) CELE_T26C12.4(gcy-23) CELE_ZC239.7(gcy-15) CELE_ZC412.2(gcy-14) CELE_ZK896.8(gcy-18) CELE_ZK970.6(gcy-5)
CBR: CBG00850 CBG01631 CBG02110(Cbr-gcy-31) CBG02368(Cbr-gcy-12) CBG04537 CBG10474 CBG17711(Cbr-gcy-8) CBG19543(Cbr-gcy-15) CBG23350(Cbr-gcy-33) CBG24374(Cbr-gcy-18)
TSP: Tsp_05569
HMG: 100214041
AQU: 100633683
PCB: PCHAS_113620(PC000136.03.0)
SMIN: v1.2.030501.t1(symbB.v1.2.030501.t1)
 » show all
Reference
  Authors
Langlais KK, Stewart JA, Morton DB
  Title
Preliminary characterization of two atypical soluble guanylyl cyclases in the central and peripheral nervous system of Drosophila melanogaster.
  Journal
J Exp Biol 207:2323-38 (2004)
DOI:10.1242/jeb.01025
  Sequence
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