KEGG ORTHOLOGY: K12343

ORTHOLOGY: K12343

Entry

K12343                      KO

Symbol

SRD5A1

Name

3-oxo-5-alpha-steroid 4-dehydrogenase 1 [EC:1.3.1.22]

Pathway

map00140

Steroid hormone biosynthesis

map01100

Metabolic pathways

Module

M00976

C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone

M00977

C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone

Reaction

R02208

5alpha-pregnane-3,20-dione:NADP+ delta4-oxidoreductase

R02497

dihydrotestosterone:NADP+ delta4-oxidoreductase

R08954

5alpha-dihydrodeoxycorticosterone:NADP+ delta4-oxidoreductase

R10242

5alpha-androstane-3,17-dione:NADP+ delta4-oxidoreductase

R13215

5alpha-pregnan-17alpha-ol-3,20-dione:NADP+ Delta4-oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K12343  SRD5A1; 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.22  3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
     K12343  SRD5A1; 3-oxo-5-alpha-steroid 4-dehydrogenase 1

Other DBs

GO:

0047751

Genes

HSA:	6715(SRD5A1)

PTR:	107971060 743740(SRD5A1)

PPS:	100978730(SRD5A1) 117977671

GGO:	101128506 101143956(SRD5A1)

PON:	100444341(SRD5A1)

PPYG:

129036625(SRD5A1)

NLE:	100607932(SRD5A1)

HMH:	116456579(SRD5A1)

SSYN:

129464379(SRD5A1)

MCC:	695103(SRD5A1)

MCF:	102126671(SRD5A1)

MTHB:

126956060

MNI:	105489465(SRD5A1)

CSAB:

103214971(SRD5A1)

CATY:

105585976(SRD5A1)

PANU:

101004666(SRD5A1)

TGE:	112625948(SRD5A1)

MLEU:

105531490(SRD5A1)

RRO:	104674089(SRD5A1)

RBB:	108522884(SRD5A1)

TFN:	117064733(SRD5A1)

PTEH:

111546741(SRD5A1)

CANG:

105510959(SRD5A1)

CJC:	100386366(SRD5A1)

SBQ:	101044295(SRD5A1)

CIMI:

108316246(SRD5A1)

ANAN:

105733046(SRD5A1)

CSYR:

103257156(SRD5A1)

MMUR:

105859939(SRD5A1)

LCAT:

123648395(SRD5A1)

PCOQ:

105816436(SRD5A1)

OGA:	100943716(SRD5A1)

MMU:	78925(Srd5a1)

MCAL:

110307570(Srd5a1)

MPAH:

110329073(Srd5a1)

RNO:	24950(Srd5a1)

MCOC:

116083164(Srd5a1)

ANU:	117724055(Srd5a1)

MUN:	110550393(Srd5a1)

CGE:	100761447(Srd5a1)

MAUA:

101835647(Srd5a1)

PROB:

127220713(Srd5a1)

PLEU:

114696118(Srd5a1)

MORG:

121433562(Srd5a1)

MFOT:

126503186

AAMP:

119809053(Srd5a1)

NGI:	103735348(Srd5a1)

HGL:	101714960(Srd5a1)

CPOC:

100735979(Srd5a1)

CCAN:

109693823(Srd5a1)

DORD:

105983822(Srd5a1)

DSP:	122121008(Srd5a1)

PLOP:

125367670(Srd5a1)

NCAR:

124987411

MMMA:

107146313(Srd5a1)

OCU:

100349876

OPI:	101529408(SRD5A1)

TUP:	102500370(SRD5A1)

GVR:	103605707(SRD5A1)

CFA:	403716(SRD5A1)

CLUD:

112662864(SRD5A1)

VVP:	112934245(SRD5A1)

VLG:	121477366(SRD5A1)

NPO:	129498494(SRD5A1)

AML:	100472194(SRD5A1)

UMR:	103679225(SRD5A1)

UAH:	113260805(SRD5A1)

UAR:	123791262(SRD5A1)

ELK:

111153410

LLV:

125101327

MPUF:

101675468(SRD5A1)

MNP:	132028198(SRD5A1)

MLK:	131831566(SRD5A1)

NVS:	122896103(SRD5A1)

ORO:	101363313(SRD5A1)

EJU:	114223678(SRD5A1)

ZCA:	113928776(SRD5A1)

MLX:	118006292(SRD5A1)

LWW:	102730341(SRD5A1)

FCA:	101098848(SRD5A1)

PYU:	121042390(SRD5A1)

PCOO:

112861562(SRD5A1)

PBG:	122495571(SRD5A1)

PVIV:

125162455(SRD5A1)

LRUF:

124522629

PTG:	102951833(SRD5A1)

PPAD:

109267838(SRD5A1)

PUC:

125934730

AJU:

106971261

HHV:	120224480(SRD5A1)

BTA:	614612(SRD5A1)

BOM:	102273138(SRD5A1)

BIU:	109574873(SRD5A1)

BBUB:

102397031(SRD5A1)

BBIS:

105001000(SRD5A1)

CHX:	102172667(SRD5A1)

OAS:	100642181(SRD5A1)

BTAX:

128066101(SRD5A1)

ODA:	120879381(SRD5A1)

CCAD:

122454566(SRD5A1)

MBEZ:

129553383(SRD5A1)

SSC:	100518046(SRD5A1)

CFR:	102514136(SRD5A1)

CBAI:

105065275 105081231(SRD5A1)

CDK:	105094037(SRD5A1)

VPC:	102542101(SRD5A1)

BACU:

102998118(SRD5A1)

BMUS:

118892116(SRD5A1)

LVE:	103070353(SRD5A1)

OOR:	101287651(SRD5A1)

DLE:	111178554(SRD5A1)

PCAD:

102979400(SRD5A1)

PSIU:

116751299(SRD5A1)

NASI:

112404520(SRD5A1)

ECB:	100071450(SRD5A1)

EPZ:	103550080(SRD5A1)

EAI:	106822987(SRD5A1)

MYB:	102260657(SRD5A1)

MYD:	102762730(SRD5A1)

MMYO:

118655774(SRD5A1)

MLF:	102428937(SRD5A1)

MDT:	132232492 132233860(SRD5A1)

PKL:	118702874(SRD5A1)

EFUS:

103305105(SRD5A1)

MNA:	107540557(SRD5A1)

DRO:	112321085(SRD5A1)

SHON:

118998672(SRD5A1)

AJM:

119043614

PDIC:

114503898(SRD5A1)

PHAS:

123824612(SRD5A1)

MMF:	118642554(SRD5A1)

PPAM:

129074544(SRD5A1)

HAI:	109376001(SRD5A1)

RFQ:	117024788(SRD5A1)

PALE:

102889165(SRD5A1)

PGIG:

120586291(SRD5A1)

PVP:	111731567(SRD5A1)

RAY:	107518894(SRD5A1)

MJV:	108401278(SRD5A1)

TOD:	119261022(SRD5A1)

SARA:

101558043(SRD5A1)

SETR:

126000807(SRD5A1)

LAV:	100673173(SRD5A1)

TMU:

101361021

ETF:	101638733(SRD5A1)

MDO:	100018123(SRD5A1)

GAS:	123252605(SRD5A1)

SHR:	100920954(SRD5A1)

AFZ:

127543613

PCW:	110220445(SRD5A1)

TVP:	118837507(SRD5A1)

OAA:	114807685(SRD5A1)

GGA:	770453(SRD5A1)

PCOC:

116226342(SRD5A1)

MGP:	100540890(SRD5A1)

CJO:	107309501(SRD5A1)

TPAI:

128090846(SRD5A1)

LMUT:

125691414(SRD5A1)

NMEL:

110393802(SRD5A1)

APLA:

101792279(SRD5A1)

ACYG:

106036530(SRD5A1)

CATA:

118250971(SRD5A1)

AFUL:

116485610(SRD5A1)

TGU:	101233999(SRD5A1)

LSR:	110479507(SRD5A1)

SCAN:

103815418(SRD5A1)

PMOA:

120504911(SRD5A1)

OTC:	121339737(SRD5A1)

PRUF:

121358070(SRD5A1)

GFR:	102040059(SRD5A1)

FAB:	101814400(SRD5A1)

OMA:	130249721(SRD5A1)

PHI:	102110867(SRD5A1)

PMAJ:

107200161(SRD5A1)

CCAE:

111925370(SRD5A1)

CCW:	104685924(SRD5A1)

CBRC:

103618791(SRD5A1)

ETL:	114055137(SRD5A1)

ZAB:	102072339(SRD5A1)

ZLE:	135444216(SRD5A1)

ACHL:

103809973(SRD5A1)

SVG:	106850772(SRD5A1)

MMEA:

130576267(SRD5A1)

HRT:	120754411(SRD5A1)

SATI:

136365970(SRD5A1)

FPG:	101911819(SRD5A1)

FCH:	102049514(SRD5A1)

CCRI:

104154808(SRD5A1)

NNT:	104400797(SRD5A1)

SHAB:

115617808(SRD5A1)

TALA:

104356347 122153951

ACHC:

115352982(SRD5A1)

HALD:

104314272(SRD5A1)

HLE:	104834279(SRD5A1)

AGEN:

126048572

GCL:

127013252

CSTI:

104553219(SRD5A1)

LDI:	104344034(SRD5A1)

DPUB:

104305686(SRD5A1)

AVIT:

104281434(SRD5A1)

EGZ:	104126190(SRD5A1)

NNI:	104018889(SRD5A1)

PCRI:

104025869(SRD5A1)

PCAO:

104050403

PADL:

103915155(SRD5A1)

AFOR:

103898442(SRD5A1)

FGA:	104071573(SRD5A1)

GSTE:

104259719(SRD5A1)

CLV:	102086070(SRD5A1)

MUI:	104543917(SRD5A1)

PGUU:

104470622(SRD5A1)

PLET:

104615734(SRD5A1)

CMAC:

104476629(SRD5A1)

CUCA:

104067553(SRD5A1)

TEO:	104384651(SRD5A1)

OHA:	104336668(SRD5A1)

CPEA:

104398277(SRD5A1)

CVF:	104285351(SRD5A1)

RTD:	128904916(SRD5A1)

AAM:	106492345(SRD5A1)

AROW:

112978443(SRD5A1)

NPD:	112955276(SRD5A1)

DNE:	112987298(SRD5A1)

SCAM:

104137841(SRD5A1)

ASN:	102380496(SRD5A1)

AMJ:	102565754(SRD5A1)

CPOO:

109314246(SRD5A1)

GGN:	109300299(SRD5A1)

PSS:	102449134(SRD5A1)

CMY:	102940906(SRD5A1)

CCAY:

125631987(SRD5A1)

DCC:	119852208(SRD5A1)

CPIC:

101931675(SRD5A1)

TST:	117872753(SRD5A1)

CABI:

116833528(SRD5A1)

MRV:	120397089(SRD5A1)

ACS:	100555660(srd5a1)

ASAO:

132774198(SRD5A1)

PVT:	110080024(SRD5A1)

SUND:

121927543(SRD5A1)

PBI:	103065332(SRD5A1)

PMUR:

107289989(SRD5A1)

CTIG:

120301734(SRD5A1)

TSR:

106550141

PGUT:

117662389(SRD5A1)

APRI:

131196188(SRD5A1)

PTEX:

113436474(SRD5A1)

NSS:	113415229(SRD5A1)

VKO:	123029650(SRD5A1)

PMUA:

114601063(SRD5A1)

PRAF:

128417971(SRD5A1)

ZVI:	118079296(SRD5A1)

HCG:	128322435(SRD5A1)

GJA:	107123746(SRD5A1)

STOW:

125443686(SRD5A1)

EMC:	129333381(SRD5A1)

XLA:	100049757(srd5a1.S)

XTR:	448586(srd5a1)

NPR:	108795133(SRD5A1)

RTEM:

120940578(SRD5A1)

BBUF:

121002056(SRD5A1)

BGAR:

122938668(SRD5A1)

MUO:	115474209(SRD5A1)

DRE:	767715(srd5a1)

SRX:	107711310 107754806(srd5a1)

SANH:

107691541 107694335

SGH:

107595623

CCAR:

109074289 109112475

CAUA:

113090833 113119538(srd5a1)

CGIB:

127935090 127978765

PTET:

122323362(srd5a1)

LROH:

127181337(srd5a1)

OMC:	131525757(srd5a1)

PPRM:

120485008(srd5a1)

RKG:	130087758(srd5a1)

MAMB:

125274770(srd5a1)

CIDE:

127500629

CERY:

137037440(srd5a1)

MASI:

127421433

TROS:

130566639(srd5a1)

TDW:	130415696(srd5a1)

MANU:

129454472(srd5a1)

IPU:

108272332

IFU:	128616207(srd5a1)

PHYP:

113543906(srd5a1)

SMEO:

124381786(srd5a1)

TFD:	113634656(srd5a1)

TVC:	132842189(srd5a1)

TRN:	134304015(srd5a1)

AMEX:

103038993(srd5a1)

CMAO:

118805421(srd5a1)

EEE:	113590333(srd5a1)

CHAR:

105892034(srd5a1)

TRU:	101063216(srd5a1)

TFS:	130517978(srd5a1)

TNG:	GSTEN00017584G001

LCO:	104922765(srd5a1)

NCC:

104959824

TBEN:

117477891(srd5a1)

CGOB:

115015530

PGEO:

117455331(srd5a1)

GACU:

117562996(srd5a1)

EMAC:

134875064(srd5a1)

ELY:	117264149(srd5a1)

EFO:	125904613(srd5a1)

PLEP:

121957754(srd5a1)

SLUC:

116041214(srd5a1)

ECRA:

117956554(srd5a1)

ESP:	116701417(srd5a1)

PFLV:

114567717(srd5a1)

GAT:	120826440(srd5a1)

PPUG:

119219022(srd5a1)

AFB:	129097482(srd5a1)

CLUM:

117739529(srd5a1)

PSWI:

130192077(srd5a1)

MSAM:

119884342(srd5a1)

SCHU:

122863987(srd5a1)

CUD:	121524539(srd5a1)

ALAT:

119016494(srd5a1)

ASTR:

137607825(srd5a1)

MZE:	101475598(srd5a1)

ONL:	100694137(srd5a1)

OAU:	116313469(srd5a1)

OLA:	100125491(srd5a1)

OML:	112136253(srd5a1)

CSAI:

133461159(srd5a1)

XMA:	102220105(srd5a1)

XCO:	114156129(srd5a1)

XHE:	116730811(srd5a1)

PRET:

103472068(srd5a1)

PFOR:

103146021(srd5a1)

PLAI:

106961929(srd5a1)

PMEI:

106932853(srd5a1)

GAF:	122844087(srd5a1)

PPRL:

129376279(srd5a1)

CVG:	107091835(srd5a1)

CTUL:

119792938(srd5a1)

GMU:	124878676(srd5a1)

NFU:	107383183(srd5a1)

KMR:	108238724(srd5a1)

ALIM:

106532692(srd5a1)

AOCE:

111569843(srd5a1)

MCEP:

125019953(srd5a1)

CSEM:

103394093(srd5a1)

POV:	109631505(srd5a1)

SSEN:

122786351(srd5a1)

HHIP:

117770489(srd5a1)

HSP:	118125023(srd5a1)

PPLT:

128461878(srd5a1)

SMAU:

118310978(srd5a1)

LCF:

108900396

SDU:	111233184(srd5a1)

SLAL:

111671428(srd5a1)

XGL:	120786960(srd5a1)

HCQ:	109508284(srd5a1)

SSCV:

125986715

SBIA:

133498666(srd5a1)

PEE:	133395540(srd5a1)

PTAO:

133470758(srd5a1)

BPEC:

110167484(srd5a1)

MALB:

109971730(srd5a1)

BSPL:

114865639(srd5a1)

SJO:	128373802(srd5a1)

SASA:

106588696(srd5a1)

STRU:

115173832(srd5a1)

OTW:	112264514(srd5a1)

OMY:	110496471(srd5a1)

OGO:	124013022(srd5a1)

ONE:	115128594(srd5a1)

OKI:

109907345

OKE:	118399537(srd5a1)

SALP:

111956095

SNH:	120022715(srd5a1)

CCLU:

121586594(srd5a1)

ELS:	105012407(srd5a1)

SFM:	108919301(srd5a1)

PKI:	111852637(srd5a1)

AANG:

118234096(srd5a1)

LOC:	102684018(srd5a1)

PSPA:

121314786(srd5a1)

PSEX:

120515895(srd5a1)

LCM:	102346093(SRD5A1)

CMK:	103183194(srd5a1)

RTP:	109926864(srd5a1)

CPLA:

122549723(srd5a1)

HOC:	132815628(srd5a1)

LERI:

129711511(srd5a1)

PMRN:

116945772(SRD5A1)

LRJ:

133339572

BFO:	118421028 118428143

BBEL:

109472328 109477748

CIN:	100176622 100186253

SCLV:

120329569

SPU:	100891309 579782

LPIC:

APLC:

ARUN:

AJC:

SKO:

FCD:	110848858 110848999 110849212 110854015 110858106

DPX:	DAPPUDRAFT_303574 DAPPUDRAFT_315933

DMK:

116924669

DPZ:	124316276 124320789

PVM:	113823899 113823900

PJA:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

HAZT:

TCF:

PPOI:

PMEO:

CEL:	CELE_F19H6.4(srdf-2.1) CELE_F42F12.3(srdf-2.2)

CBR:	CBG_00143 CBG_27819

CRQ:	GCK72_025002

NAI:	NECAME_06352

LOA:	LOAG_07203

HRO:	HELRODRAFT_81976

LGI:	LOTGIDRAFT_194080

PVUL:

126820325

PCAN:

112554453 112570399

BGT:	106060081 106062695

GAE:

121372708

HRF:	124124697 124142409

HRJ:	124272317 124275337

CRG:	105342922 105347041 117690349

CANU:

128173194 128178413

CVN:	111114599 111130679

MYI:	110445242 110456491

PMAX:

117323368 117325433 117327174

MCAF:

127727933 127737224 127739350

MMER:

123545767 123545770

RPHI:

132739246 132739259

DPOL:

127874252 127874624 127874625

MAEA:

128209175 128214455 128214790

OBI:

106875622

OSN:

115217439

LJP:

135468709

LAK:	106180833 112041795

LLON:

135484043

NVE:	5499587 5518934

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114532769 114532770

XEN:

124436990

HSY:	130629824 130630635

RES:

135688944

TAD:	TRIADDRAFT_59840

AQU:

NTA:

NSY:

PVIR:

CRE:	CHLRE_12g528550v5 CHLRE_14g627950v5

VCN:	VOLCADRAFT_109204 VOLCADRAFT_54973

MNG:

MNEG_6120

CSL:	COCSUDRAFT_83645

CVR:	CHLNCDRAFT_18410

APRO:

F751_2320

OLU:	OSTLU_24166

OTA:	OT_ostta03g00610

MIS:	MICPUN_62767

CME:	CYME_CMO284C

GSL:	Gasu_36870

NCR:	NCU03337 NCU16525

SMP:	10804056(SMAC4_12927)

PAN:	PODANSg6407

PBEL:

QC761_305730 QC761_305880

PPSD:

QC762_305730 QC762_305880

PPSP:

QC763_305730 QC763_305880

PPSA:

QC764_305730 QC764_305880

TTT:	THITE_2123426

MTM:	MYCTH_2311708

CTHR:

CTHT_0001600

MGR:

MGG_03905

PPEI:

PpBr36_04374 PpBr36_06364

PGRI:

PgNI_07028 PgNI_09785

TMN:	UCRPA7_873

SSCK:

SPSK_00310

FGR:	FGSG_01618

FPU:	FPSE_07008

FPOA:

FPOAC1_001741

FVN:	FVRRES_01954

FVR:	FVEG_09716

FOX:	FOXG_11084

NHE:	NECHADRAFT_89636

FFC:	NCS54_00015900

FMU:	J7337_000247

TRE:	TRIREDRAFT_82177

TRR:	M419DRAFT_91378

TATV:

25785220(TrAtP1_009335)

TASP:

36615121(TrAFT101_004757)

MAJ:

MAA_09371

MBRN:

26244006(G6M90_00g032740)

PCHM:

VFPPC_13257

CMT:

CCM_02138

AMUS:

LMH87_003214

PLJ:	28889555(PLICBS_008018)

PTKZ:

JDV02_010455

VAL:	VDBG_05809

VDA:	VDAG_07743

CFJ:	CFIO01_07960

CHIG:

CH63R_10697

CDET:

87943771(CDEST_07268)

SAPO:

SAPIO_CDS0920

ELA:	UCREL1_10621

PFY:	PFICI_02767

SSL:	SS1G_10930

BFU:	BCIN_04g06700

MBE:

MBM_07877

PSCO:

LY89DRAFT_709943

GLZ:	GLAREA_09056

AFM:	AFUA_4G07350

ACT:	ACLA_046670

NFI:	NFIA_108870

AOR:	AO090023000838

ANG:	An04g01740

AFV:	AFLA_007188

ALUC:

AKAW2_51204S

ACHE:

ACHE_20637S

PCS:	N7525_004499

PDP:	PDIP_12650

POU:	POX_f07792

TMF:	EYB26_001143

CIM:	CIMG_04063

CPW:	CPC735_003330

ABE:

ARB_01576

TVE:

TRV_03576

PBL:	PAAG_07625

PBN:	PADG_08327

AJE:	HCAG_05566

BGH:	BDBG_02606

PNO:	SNOG_05157

PTE:

PTT_03489

PTRR:

6342434(PtrM4_090560)

BZE:	COCCADRAFT_93429

BSC:	COCSADRAFT_40465

BOR:	COCMIDRAFT_35549

AALT:

CC77DRAFT_1096856

ARAB:

EKO05_0007591

ZTR:	MYCGRDRAFT_77167

PFJ:	MYCFIDRAFT_133929

FFU:	CLAFUR5_13395

CBET:

CB0940_04992

BCOM:

BAUCODRAFT_156204

NPA:	UCRNP2_2482

TML:	GSTUM_00003970001

SPO:	2543655(SPOM_SPAC9.08C)

SOM:	SOMG_01959

CNE:

CNA03510

CNB:

CNBA3370

CNG:	CNAG_00353

CGI:	CGB_B4100W

CDEU:

CNBG_0208

CDEP:

91087838(L203_103627)

KMG:	30166102(I203_103985)

KNE:	92179016(IAR55_001757)

TMS:	TREMEDRAFT_29078

TASA:

A1Q1_00751

CCAC:

CcaHIS019_0406960(CcaverHIS019_0406960)

PPL:	POSPLDRAFT_87541

TVS:	TRAVEDRAFT_74510

DSQ:	DICSQDRAFT_157319 DICSQDRAFT_172414

SHS:	STEHIDRAFT_172351

HIR:	HETIRDRAFT_461496

PSQ:	PUNSTDRAFT_145142

ADL:	AURDEDRAFT_58186

FME:	FOMMEDRAFT_116484

GTR:	GLOTRDRAFT_76409

RSX:	RhiXN_07723

LBC:	LACBIDRAFT_312049

CCI:	CC1G_14953

ABP:	AGABI1DRAFT59271(AGABI1DRAFT_59271)

ABV:	AGABI2DRAFT224531(AGABI2DRAFT_224531)

MPR:	MPER_14522

MRR:	Moror_5621 Moror_7664

E1B28_011958

SCM:	SCHCO_02533733(SCHCODRAFT_02533733)

CPUT:

CONPUDRAFT_105397 CONPUDRAFT_119066 CONPUDRAFT_142331 CONPUDRAFT_163036

SLA:	SERLADRAFT_355191

WSE:	WALSEDRAFT_60732

WIC:	J056_000731

UMA:	UMAG_04015

PFP:	PFL1_00871

SGRA:

MGL:

MRT:

MSYM:

MLR:	MELLADRAFT_36857

RIE:	OCT59_004232

MBR:	MONBRDRAFT_13728

SRE:	PTSG_08562

EHI:	EHI_197070(92.t00023)

EDI:	EDI_121990

ACAN:

ACA1_369650

TGO:	TGME49_304480

TET:	TTHERM_01001550

PTM:	GSPATT00031296001

PTI:	PHATRDRAFT_17044(DET2)

FCY:	FRACYDRAFT_193359

TPS:	THAPSDRAFT_264431

PSOJ:

PHYSODRAFT_468531

EHX:	EMIHUDRAFT_433159

GTT:	GUITHDRAFT_86244

TBR:	Tb927.8.2480

TBG:	TbgDal_VIII1930

TCR:	504427.70 509331.70

LMA:	LMJF_17_1100

LIF:	LINJ_17_1200

LDO:	LDBPK_171200

LMI:	LMXM_17_1100

LMAT:

92515551(LSCM1_05591)

LBZ:	LBRM_17_1210

LPAN:

LPMP_171070

LOI:	92362800(LSCM4_06957)

LEIS:

94182107(GH5_06826)

LENR:

94173272(CUR178_06087)

LEIN:

94190956(JIQ42_07369)

PHET:

94291534(JKF63_05499)

NGR:	NAEGRDRAFT_70951

TVA:	TVAG_2v0232280 TVAG_2v0323150 TVAG_2v0342730 TVAG_2v0361710 TVAG_2v0562630

KAK:	Kalk_07490

HJA:	BST95_16395

AFUS:

EYZ66_13100

PAQM:

E0F26_07375

SINI:

GT972_15085

GPB:	HDN1F_37270

RBS:	RHODOSMS8_02182

PAUU:

E8A73_010030

MRM:	A7982_02520 A7982_12933

SAMY:

MUL:

MMI:

MMAE:

MLI:	MULP_02275

MPSE:

MPSD_26040

MYV:	G155_08770

MPAG:

C0J29_08580

MNM:	MNVM_29240

MSPG:

F6B93_00670

MFT:	XA26_17580

MFX:	MFAL_35050

MIJ:	MINS_15400

MALV:

MAUB:

MPHU:

MMUC:

MBOK:

MFG:	K6L26_24140

MSEN:

K3U95_07920

MKR:	MKOR_21160

MPAK:

MIU77_14390

MAB:

MAB_2819

MMV:	MYCMA_08060 MYCMA_11620

MABB:

MASS_1112 MASS_2760

MABL:

MMASJCM_2778

MCHE:

BB28_05475 BB28_14070

MIZ:	BAB75_15210

MSTE:

MSTE_01069 MSTE_02767

MSAO:

MYCSP_04805 MYCSP_12565

MSAL:

DSM43276_00972 DSM43276_02516

MJD:	JDM601_3147

MTER:

4434518_03133

MMIN:

MMIN_05900 MMIN_08290

MHIB:

MHIB_25630

MHER:

K3U94_16400 K3U94_17730

MVM:	MJO54_16480 MJO54_17815

CEI:	CEPID_12155

CKW:	CKALI_12040

NFA:

NFA_45190

NFR:	ERS450000_05412

NSL:	BOX37_21665

NSR:	NS506_05479

NOD:	FOH10_10905

NAD:	NCTC11293_05370

NTC:	KHQ06_20475

NHU:	H0264_19370

NYA:	LTV02_15210

NGP:	LTT66_20570

NSPU:

IFM12276_10870

NYU:	D7D52_23400

REQ:

REQ_08000

PDEF:

P9209_28360

LEIF:

HF024_09770

LSE:	F1C12_03535

LEIZ:

ACTN:

DACT:

TDE:

TPED:

TPK:	JO40_02460

TRM:	JO41_08055

TPHG:

FUT81_15525

TRZ:	GWP43_02315

TMED:

DWB79_05650

TRP:	ABH09_02290

STA:	STHERM_c16540

STQ:	Spith_1713

BTH:

BT_2068

BTHO:

Btheta7330_00976

BFR:

BF3752

BFS:	BF9343_3447

BFG:	BF638R_3566

BFB:	VU15_16805

BXY:

BXY_12340

BOA:	Bovatus_02113

BCEL:

BcellWH2_01542

BCAC:

CGC64_18210

BCAE:

A4V03_13475

BIS:	DXK01_022185

BUN:	Bun01g_37690

BEG:	INE88_00973

BSTE:

K6V31_07410

BFE:	K6V30_24730

BHUM:

JXR92_017165

BFC:	BacF7301_25355

BSAL:

K6V25_20715

BFIN:

BFINE_49090 BFINE_56890

BVU:

BVU_1964

BSA:	Bacsa_0228

BDO:	EL88_17455

BDH:	GV66_10105

PCOP:

I6J50_00590

PMER:

INE87_01664

PGOL:

K6V26_14130

PJO:	LK449_10745

PFAI:

NXY11_13535

MGOD:

E7746_12975

BVS:	BARVI_09125

COPR:

Cop2CBH44_15190

BUY:	D8S85_03720

BVIR:

I6J59_13230

BFH:	F1611_07765

AFD:

Alfi_2922

ASH:

AL1_03180

ALD:	GFH31_03765

AOK:	A3BBH6_25120

ACOU:

A5CBH24_21320

ADA:	A5CPEGH6_20250

AIT:	AI2BBH_18210

ASEN:

NQ519_14020

AIU:	NQ491_10500

COY:	HF329_12410

FLM:

MY04_0311

FLL:	EI427_03145

FYA:	KMW28_14730

FKA:	KM029_07525

LUY:	QZH61_00135

FTE:	Fluta_0261

CRM:	K6119_03435

SHYR:

LA303_11745

LOB:	NEF87_003396

PSYT:

DSAG12_01005

» show all

Reference

PMID:2339109

Authors

Andersson S, Russell DW

Title

Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases.

Journal

Proc Natl Acad Sci U S A 87:3640-4 (1990)
DOI:10.1073/pnas.87.10.3640

Sequence

[hsa:6715]

LinkDB

ORTHOLOGY: K12344

Entry

K12344                      KO

Symbol

SRD5A2

Name

3-oxo-5-alpha-steroid 4-dehydrogenase 2 [EC:1.3.1.22]

Pathway

map00140

Steroid hormone biosynthesis

map01100

Metabolic pathways

map05215

Prostate cancer

Module

M00976

C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone

Reaction

R02208

5alpha-pregnane-3,20-dione:NADP+ delta4-oxidoreductase

R02497

dihydrotestosterone:NADP+ delta4-oxidoreductase

R08954

5alpha-dihydrodeoxycorticosterone:NADP+ delta4-oxidoreductase

R10242

5alpha-androstane-3,17-dione:NADP+ delta4-oxidoreductase

Disease

H00608

46,XY disorder of sex development due to testosterone secretion defect

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K12344  SRD5A2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2
09160 Human Diseases
  09162 Cancer: specific types
   05215 Prostate cancer
    K12344  SRD5A2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.22  3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
     K12344  SRD5A2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Other DBs

GO:

0047751

Genes

HSA:	6716(SRD5A2)

PTR:	100614992(SRD5A2)

PPS:	100986960(SRD5A2)

GGO:	101138758(SRD5A2)

PON:	100454013(SRD5A2)

PPYG:

129030531(SRD5A2)

NLE:	100597634(SRD5A2)

HMH:	116480532(SRD5A2)

SSYN:

129467876(SRD5A2)

MCC:	705676(SRD5A2)

MCF:	102115639(SRD5A2)

MTHB:

126933895

MNI:	105479694(SRD5A2)

CSAB:

103220536(SRD5A2)

CATY:

105578406(SRD5A2)

PANU:

101025551(SRD5A2)

TGE:	112604924(SRD5A2)

MLEU:

105537625(SRD5A2)

RRO:	104669588(SRD5A2)

RBB:	108516633(SRD5A2)

TFN:	117063012(SRD5A2)

PTEH:

111546046(SRD5A2)

CANG:

105525038(SRD5A2)

CJC:	100415292(SRD5A2)

SBQ:	101043426(SRD5A2)

CIMI:

108284956(SRD5A2)

ANAN:

105733234(SRD5A2)

CSYR:

103254233(SRD5A2)

MMUR:

105884463(SRD5A2)

LCAT:

123636771(SRD5A2)

PCOQ:

105816878(SRD5A2)

OGA:	100965809(SRD5A2)

MMU:	94224(Srd5a2)

MCAL:

110284320(Srd5a2)

MPAH:

110336103(Srd5a2)

RNO:	64677(Srd5a2)

MCOC:

116080212(Srd5a2)

ANU:	117717102(Srd5a2)

MUN:	110539471(Srd5a2)

CGE:	100766917(Srd5a2)

MAUA:

101831309(Srd5a2)

PROB:

127220172(Srd5a2)

PLEU:

114696100(Srd5a2)

MORG:

121433000(Srd5a2)

MFOT:

126514211

AAMP:

119807309(Srd5a2)

NGI:	103748375(Srd5a2)

HGL:	101708836(Srd5a2)

CPOC:

100731664(Srd5a2)

CCAN:

109702049(Srd5a2)

DORD:

105983654(Srd5a2)

DSP:	122122519(Srd5a2)

PLOP:

125356918(Srd5a2)

NCAR:

124963170

MMMA:

107137134(Srd5a2)

OCU:

100343882

OPI:	101525741(SRD5A2)

TUP:	102478179(SRD5A2)

GVR:	103607361(SRD5A2)

CFA:	403715(SRD5A2)

CLUD:

112664568(SRD5A2)

VVP:	112932999(SRD5A2)

VLG:	121491663(SRD5A2)

NPO:	129511023(SRD5A2)

AML:

100466687

UMR:	103671605(SRD5A2)

UAH:	113240945(SRD5A2)

UAR:	123799861(SRD5A2)

ELK:

111154190

LLV:

125109219

MPUF:

101683373(SRD5A2)

MNP:	132022272(SRD5A2)

MLK:	131840564(SRD5A2)

NVS:	122915783(SRD5A2)

ORO:	101376466(SRD5A2)

EJU:	114219573(SRD5A2)

ZCA:	113938214(SRD5A2)

MLX:	118007743(SRD5A2)

NSU:	110587418(SRD5A2)

LWW:	102731648(SRD5A2)

FCA:	101086898(SRD5A2)

PYU:	121044312(SRD5A2)

PCOO:

112864274(SRD5A2)

PBG:	122497281(SRD5A2)

PVIV:

125162292(SRD5A2)

LRUF:

124503799

PTG:	102953790(SRD5A2)

PPAD:

109266286(SRD5A2)

PUC:

125937558

AJU:

113592483

HHV:	120244020(SRD5A2)

BTA:	527024(SRD5A2)

BOM:	102271230(SRD5A2)

BIU:	109565724(SRD5A2)

BBUB:

102399433(SRD5A2)

BBIS:

104980937(SRD5A2)

CHX:	102187232(SRD5A2)

OAS:	100820756(SRD5A2)

BTAX:

128056816(SRD5A2)

ODA:	120851646(SRD5A2)

CCAD:

122441534(SRD5A2)

MBEZ:

129539358(SRD5A2)

SSC:	397048(SRD5A2)

CFR:	102523831(SRD5A2)

CBAI:

105063794(SRD5A2)

CDK:	105095594(SRD5A2)

VPC:	102535532(SRD5A2)

BACU:

103005044

BMUS:

118894466 118905781(SRD5A2)

LVE:	103076251 103084942(SRD5A2)

OOR:	101284817(SRD5A2)

DLE:	111174761(SRD5A2)

PCAD:

102974072(SRD5A2)

PSIU:

116764622(SRD5A2)

NASI:

112401350(SRD5A2)

ECB:	100070655(SRD5A2)

EPZ:	103561662(SRD5A2)

EAI:	106847216(SRD5A2)

MYB:	102242056(SRD5A2)

MYD:	102773080(SRD5A2)

MMYO:

118669131(SRD5A2)

MLF:	102441748(SRD5A2)

MDT:	132213498(SRD5A2)

PKL:	118717139(SRD5A2)

EFUS:

103305485(SRD5A2)

MNA:	107541768(SRD5A2)

DRO:	112297688(SRD5A2)

SHON:

119001438(SRD5A2)

AJM:	119050365(SRD5A2)

PDIC:

114500997(SRD5A2)

PHAS:

123812041(SRD5A2)

MMF:	118631203(SRD5A2)

PPAM:

129064826(SRD5A2)

HAI:	109388788(SRD5A2)

RFQ:	117033123(SRD5A2)

PALE:

102884992(SRD5A2)

PGIG:

120621802(SRD5A2)

PVP:	105299142(SRD5A2)

RAY:	107505757(SRD5A2)

MJV:	108404077(SRD5A2)

TOD:	119258667(SRD5A2)

SARA:

101555141(SRD5A2)

SETR:

126023835(SRD5A2)

TMU:

101348818

ETF:	101660079(SRD5A2)

DNM:	101431169(SRD5A2)

MDO:	100031489(SRD5A2)

GAS:	123234969(SRD5A2)

SHR:	100934924(SRD5A2)

AFZ:

127548631

PCW:	110198195(SRD5A2)

TVP:	118841603(SRD5A2)

OAA:	100078235(SRD5A2)

GGA:	772291(SRD5A2)

PCOC:

116228837(SRD5A2)

MGP:	100546745(SRD5A2)

CJO:	107311306(SRD5A2)

TPAI:

128076072(SRD5A2)

LMUT:

125689663(SRD5A2)

NMEL:

110396297(SRD5A2)

APLA:

101799397(SRD5A2)

ACYG:

106049776(SRD5A2)

CATA:

118254293(SRD5A2)

AFUL:

116487990(SRD5A2)

TGU:	100225484(SRD5A2)

LSR:	110478672(SRD5A2)

SCAN:

103821781(SRD5A2)

PMOA:

120496855(SRD5A2)

OTC:	121335868(SRD5A2)

PRUF:

121358766(SRD5A2)

GFR:	102038097(SRD5A2)

FAB:	101808258(SRD5A2)

OMA:	130251713(SRD5A2)

PHI:	102108406(SRD5A2)

PMAJ:

107201346(SRD5A2)

CCAE:

111926994(SRD5A2)

CCW:	104684391(SRD5A2)

CBRC:

103621380(SRD5A2)

ETL:	114065340(SRD5A2)

ZAB:	102060646(SRD5A2)

ZLE:	135445773(SRD5A2)

ACHL:

103811537(SRD5A2)

SVG:	106861464(SRD5A2)

MMEA:

130588819(SRD5A2)

HRT:	120750784(SRD5A2)

SATI:

136358471(SRD5A2)

FPG:	101919492(SRD5A2)

FCH:	102046391(SRD5A2)

NNT:	104400542(SRD5A2)

SHAB:

115613952(SRD5A2)

ACUN:

113478727(SRD5A2)

TALA:

104360267(SRD5A2)

ACHC:

115350396(SRD5A2)

HALD:

104310652(SRD5A2)

HLE:	104840359(SRD5A2)

AGEN:

126051524

GCL:

127014788

CSTI:

104550160(SRD5A2)

LDI:	104345381(SRD5A2)

MNB:	103775870(SRD5A2)

DPUB:

104300625(SRD5A2)

AVIT:

104278499(SRD5A2)

BRHI:

104493686(SRD5A2)

EGZ:	104124808(SRD5A2)

NNI:	104012069(SRD5A2)

PCRI:

104029306(SRD5A2)

PCAO:

104040244

PADL:

103922830(SRD5A2)

AFOR:

103902709(SRD5A2)

FGA:	104077129(SRD5A2)

GSTE:

104258806(SRD5A2)

CLV:	102085278(SRD5A2)

MUI:	104539002(SRD5A2)

PGUU:

104461413(SRD5A2)

EHS:	104508582(SRD5A2)

CMAC:

104473620(SRD5A2)

CUCA:

104066527(SRD5A2)

TEO:	104375569(SRD5A2)

BREG:

104630614(SRD5A2)

OHA:	104329317(SRD5A2)

ACAR:

104529062(SRD5A2)

CPEA:

104394929(SRD5A2)

CVF:	104282341(SRD5A2)

RTD:	128907479(SRD5A2)

AAM:	106485465(SRD5A2)

AROW:

112973964(SRD5A2)

NPD:	112952940(SRD5A2)

TGT:	104579863(SRD5A2)

DNE:	112984640(SRD5A2)

SCAM:

104151662(SRD5A2)

ASN:	102380562(SRD5A2)

AMJ:	102573116(SRD5A2)

CPOO:

109319093(SRD5A2)

GGN:	109304231(SRD5A2)

PSS:	102451701(SRD5A2)

CMY:	102936118(SRD5A2)

CCAY:

125633826(SRD5A2)

DCC:	119853494(SRD5A2)

CPIC:

101939421(SRD5A2)

TST:	117874644(SRD5A2)

CABI:

116837012(SRD5A2)

MRV:	120402236(SRD5A2)

ACS:	100563846(srd5a2)

ASAO:

132761239(SRD5A2)

PVT:	110076132(SRD5A2)

SUND:

121922694(SRD5A2)

PBI:	103048475(SRD5A2)

PMUR:

107302483(SRD5A2)

CTIG:

120300695(SRD5A2)

TSR:	106537983(SRD5A2)

PGUT:

117671448(SRD5A2)

APRI:

131189222(SRD5A2)

PTEX:

113433022(SRD5A2)

VKO:	123032487(SRD5A2)

PMUA:

114594463(SRD5A2)

PRAF:

128410902(SRD5A2)

ZVI:	118081832(SRD5A2)

HCG:	128340234(SRD5A2)

GJA:	107108075(SRD5A2)

STOW:

125438858(SRD5A2)

EMC:	129335491(SRD5A2)

XLA:	108716702(srd5a2.L) 108717848(srd5a2.S)

XTR:	549867(srd5a2)

NPR:	108789853(SRD5A2)

RTEM:

120937590(SRD5A2)

BBUF:

120998608(SRD5A2)

BGAR:

122919298(SRD5A2)

MUO:	115465466(SRD5A2)

GSH:	117356345(SRD5A2)

DRE:	550388(srd5a2b) 550398(srd5a2a)

SRX:	107705374 107739895 107747406 107757027

SANH:

107654923 107675638 107683892 107684262

SGH:	107583229 107585529 107602938

CCAR:

109061892 109069511 109107327

CAUA:

113044127 113044741 113047413 113057512 113113161

CGIB:

127949024 127970773 128020888 128026786

PTET:

122351680(srd5a2a) 122356411(srd5a2b)

LROH:

127167953(srd5a2a) 127175378(srd5a2b)

OMC:	131527260(srd5a2a) 131552502(srd5a2b)

PPRM:

120463942(srd5a2b) 120489758(srd5a2a)

RKG:	130087333(srd5a2a) 130088216(srd5a2b)

MAMB:

125271908(srd5a2a) 125277637(srd5a2b)

CIDE:

127512105 127525582

CERY:

137020152(srd5a2b) 137032719(srd5a2a)

MASI:

127411864 127444060 127445399

TROS:

130553492(srd5a2a) 130559456(srd5a2b)

TDW:	130414353(srd5a2a) 130431960(srd5a2b)

MANU:

129415749(srd5a2b) 129444106(srd5a2a)

IPU:	108258997(srd5a2a)

IFU:	128602253(srd5a2a)

PHYP:

113537369(srd5a2)

SMEO:

124378422(srd5a2a)

TFD:	113663579(srd5a2a)

TVC:	132839683(srd5a2a)

TRN:	134328808(srd5a2a)

AMEX:

103036227(srd5a2a) 103043083(srd5a2b)

CMAO:

118798156(srd5a2a)

EEE:	113579627(srd5a2)

CHAR:

105909392(srd5a2a) 105911574

TRU:

101066856

TFS:	130527496(srd5a2a)

TNG:	GSTEN00030853G001

LCO:	104918211(srd5a2) 104939523

TBEN:

117484593(srd5a2a)

CGOB:

115006195 115020093(srd5a2)

EMAC:

134862796(srd5a2a)

ELY:	117248635(srd5a2b) 117255816(srd5a2a)

EFO:	125885534(srd5a2a) 125903872(srd5a2b)

PLEP:

121939878

SLUC:

116048133 116051343(srd5a2b)

ECRA:

117960842(srd5a2b)

ESP:	116705050(srd5a2)

PFLV:

114561859 114572596(srd5a2)

GAT:

120824638

PPUG:

119218569(srd5a2a)

AFB:	129092659(srd5a2b) 129114750

CLUM:

117735667 117744151(srd5a2b)

PSWI:

130191382(srd5a2a) 130206953(srd5a2b)

MSAM:

119899860(srd5a2a) 119917462(srd5a2b)

SCHU:

122874006 122883989(srd5a2b)

CUD:	121508787(srd5a2a) 121511471(srd5a2b)

ALAT:

119024109 119033351(srd5a2b)

ASTR:

137599631(srd5a2a) 137604252(srd5a2b)

MZE:	101476244 101484346

ONL:	100694036(srd5a2) 100711421

OAU:	116317821(srd5a2a) 116318612(srd5a2b)

OLA:	100125532 101156869

OML:	112143464 112161526(srd5a2b)

CSAI:

133445995(srd5a2a) 133463900(srd5a2b)

XMA:	102228249 102230435(srd5a2)

XCO:	114138402(srd5a2) 114144025

XHE:	116712842(srd5a2) 116720123

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122828959 122842957(srd5a2b)

PPRL:

129356393 129359823(srd5a2b)

CVG:	107096523(srd5a2) 107104491

CTUL:

119782874 119785475(srd5a2a)

GMU:	124858680(srd5a2b) 124868076

NFU:	107375448(srd5a2) 107394001

KMR:	108229061 108248141

ALIM:

106515891(srd5a2) 106533004

NWH:	119417692(srd5a2b) 119422747(srd5a2a)

AOCE:

111564580 111573725(srd5a2)

MCEP:

125004078(srd5a2a)

CSEM:

103383286

POV:

109648176

SSEN:

122770651

HHIP:

117764443 117764456 117775634(srd5a2b)

HSP:

118121131

PPLT:

128437481(srd5a2a)

SMAU:

118312175(srd5a2a)

LCF:	108882308 108885816(srd5a2b)

SDU:	111220716(srd5a2) 111237591

SLAL:

111658927(srd5a2) 111672886

XGL:	120796306(srd5a2b) 120800652(srd5a2a)

HCQ:	109516280(srd5a2)

SSCV:

125978990

SBIA:

133509562(srd5a2b)

PEE:	133410035(srd5a2b)

PTAO:

133485623(srd5a2b)

BPEC:

110153623 110157251(srd5a2)

MALB:

109971818(srd5a2)

BSPL:

114841974(srd5a2b) 114857800

SJO:	128372886(srd5a2b) 128378393

SASA:

100196185(s5a2) 106564819(S5A2)

STRU:

115155535 115178280 115208523

OTW:	112230405 112236516(srd5a2b) 112265604

OMY:	110486045 110492798 110493760

OGO:	124002466 124015479 124047514(srd5a2b)

ONE:	115103927 115143579

OKI:	109865644 109890015 116355388

OKE:	118365036 118380459(srd5a2b) 118389131

SALP:

111960592 111982243 112075001

SNH:	120027036 120032859

CCLU:

121572382 123483071

ELS:	105029457 105031435

SFM:	108927124 108933689

PKI:	111835705 111838099

AANG:

118217541(srd5a2b) 118219471(srd5a2a)

LOC:	102683139(srd5a2)

PSPA:

121317221

ARUT:

117402459(srd5a2a)

PSEX:

120516843

LCM:	102355026(SRD5A2)

CMK:	103181748(srd5a2a)

RTP:

109939020

CPLA:

122552653

HOC:	132819256 132819257

LERI:

129699474 129699475

PMRN:

116939457 116947671

LRJ:	133341486 133347096

BCOO:

119069246 119079665 119079666

GAE:

121374275

CRG:

105320402

CANU:

128178415

CVN:	111107628 111125200

OED:

125665974

HMG:

100197205

» show all

Reference

PMID:1944596

Authors

Andersson S, Berman DM, Jenkins EP, Russell DW

Title

Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism.

Journal

Nature 354:159-61 (1991)
DOI:10.1038/354159a0

Sequence

[hsa:6716]

Reference

PMID:21676395

Authors

Caglayan AO, Dundar M, Tanriverdi F, Baysal NA, Unluhizarci K, Ozkul Y, Borlu M, Batukan C, Kelestimur F

Title

Idiopathic hirsutism: local and peripheral expression of aromatase (CYP19A) and 5alpha-reductase genes (SRD5A1 and SRD5A2).

Journal

Fertil Steril 96:479-82 (2011)
DOI:10.1016/j.fertnstert.2011.05.040

LinkDB

ORTHOLOGY: K12345

Entry

K12345                      KO

Symbol

SRD5A3

Name

3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase [EC:1.3.1.22 1.3.1.94]

Pathway

map00140

Steroid hormone biosynthesis

map00510

N-Glycan biosynthesis

map01100

Metabolic pathways

Module

M00976

C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone

Reaction

R02208

5alpha-pregnane-3,20-dione:NADP+ delta4-oxidoreductase

R02497

dihydrotestosterone:NADP+ delta4-oxidoreductase

R08954

5alpha-dihydrodeoxycorticosterone:NADP+ delta4-oxidoreductase

R10242

5alpha-androstane-3,17-dione:NADP+ delta4-oxidoreductase

R12299

ditrans,polycis-dolichol:NADP+ 2,3-oxidoreductase

Disease

H00118

Congenital disorders of glycosylation type I

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K12345  SRD5A3; 3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    K12345  SRD5A3; 3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.22  3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
     K12345  SRD5A3; 3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase
    1.3.1.94  polyprenol reductase
     K12345  SRD5A3; 3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase

Other DBs

GO:	0047751 0102389

Genes

HSA:	79644(SRD5A3)

PTR:	471241(SRD5A3)

PPS:	100987485(SRD5A3)

GGO:	101127484(SRD5A3)

PON:	100461714(SRD5A3)

PPYG:

129034985(SRD5A3)

NLE:	100604898(SRD5A3)

HMH:	116476566(SRD5A3)

SSYN:

129491011(SRD5A3)

MCC:	696381(SRD5A3)

MCF:	102135568(SRD5A3)

MTHB:

126954746

MNI:	105463533(SRD5A3)

CSAB:

103235668(SRD5A3)

CATY:

105591982(SRD5A3)

PANU:

101018670(SRD5A3)

TGE:	112625457(SRD5A3)

MLEU:

105548473(SRD5A3)

RRO:	104662017(SRD5A3)

RBB:	108531594(SRD5A3)

TFN:	117085599(SRD5A3)

PTEH:

111526483(SRD5A3)

CANG:

105525911(SRD5A3)

CJC:	100409457(SRD5A3)

SBQ:	101035698(SRD5A3)

CIMI:

108312355(SRD5A3)

ANAN:

105709293(SRD5A3)

CSYR:

103249196(SRD5A3)

MMUR:

105867840(SRD5A3)

LCAT:

123624848(SRD5A3)

PCOQ:

105807667(SRD5A3)

OGA:	100962186(SRD5A3)

MMU:	57357(Srd5a3)

MCAL:

110294824(Srd5a3)

MPAH:

110330734(Srd5a3)

RNO:	305291(Srd5a3)

MCOC:

116071286(Srd5a3)

ANU:	117713183(Srd5a3)

MUN:	110556924(Srd5a3)

CGE:	100770660(Srd5a3)

MAUA:

101843963(Srd5a3)

PROB:

127232255(Srd5a3)

PLEU:

114683326(Srd5a3)

MORG:

121460946(Srd5a3)

MFOT:

126506599

AAMP:

119817624(Srd5a3)

NGI:	103734389(Srd5a3)

HGL:	101726767(Srd5a3)

CPOC:

100727041(Srd5a3)

CCAN:

109698967(Srd5a3)

DORD:

105980241(Srd5a3)

DSP:	122106914(Srd5a3)

PLOP:

125364717(Srd5a3)

NCAR:

124995103

MMMA:

107138961(Srd5a3)

OCU:

100346041

OPI:	101525367(SRD5A3)

TUP:	102493739(SRD5A3) 106736078

GVR:	103597798(SRD5A3)

CFA:	482155(SRD5A3)

CLUD:

112652140(SRD5A3)

VVP:	112923679(SRD5A3)

VLG:	121473600(SRD5A3)

NPO:	129520189(SRD5A3)

AML:	100463734(SRD5A3)

UMR:	103672741(SRD5A3)

UAH:	113262505(SRD5A3)

UAR:	123804043(SRD5A3)

ELK:

111149140

LLV:

125093733

MPUF:

101675597(SRD5A3)

MNP:	132006399(SRD5A3)

MLK:	131824002(SRD5A3)

NVS:	122889164(SRD5A3)

ORO:	101370876(SRD5A3)

EJU:	114206831(SRD5A3)

ZCA:	113925732(SRD5A3)

MLX:	118010518(SRD5A3)

NSU:	110590832(SRD5A3)

LWW:	102725779(SRD5A3)

FCA:	101090010(SRD5A3)

PYU:	121035507(SRD5A3)

PCOO:

112858346(SRD5A3)

PBG:	122478868(SRD5A3)

PVIV:

125164232(SRD5A3)

LRUF:

124520750

PTG:	102960215(SRD5A3)

PPAD:

109278937(SRD5A3)

PUC:

125922734

AJU:

113598703

HHV:	120243022(SRD5A3)

BTA:	535834(SRD5A3)

BOM:	102284607(SRD5A3)

BIU:	109560479(SRD5A3)

BBUB:

102412800(SRD5A3)

BBIS:

105002874(SRD5A3)

CHX:	102180581(SRD5A3)

OAS:	101106772(SRD5A3)

BTAX:

128049899(SRD5A3)

ODA:	120862131(SRD5A3)

CCAD:

122428312(SRD5A3)

MBEZ:

129561777(SRD5A3)

SSC:

100525350

CFR:	102523042(SRD5A3)

CBAI:

105077674(SRD5A3)

CDK:	105091542(SRD5A3)

VPC:	102537511(SRD5A3)

BACU:

103012155(SRD5A3)

BMUS:

118895670(SRD5A3)

LVE:	103087526(SRD5A3)

OOR:	101276021 101290031(SRD5A3)

DLE:	111169636(SRD5A3)

PCAD:

102987064(SRD5A3)

PSIU:

116749364 116754344(SRD5A3)

NASI:

112400794(SRD5A3)

ECB:	100059582(SRD5A3)

EPZ:	103554975(SRD5A3)

EAI:	106836922(SRD5A3)

MYB:	102257134(SRD5A3)

MYD:	102771502(SRD5A3)

MMYO:

118668902(SRD5A3)

MLF:	102442157(SRD5A3)

MDT:	132218962(SRD5A3)

PKL:	118706564(SRD5A3)

EFUS:

103285044(SRD5A3)

MNA:	107532791(SRD5A3)

DRO:	112316781(SRD5A3)

SHON:

118978619(SRD5A3)

AJM:	119044892(SRD5A3)

PHAS:

123815907(SRD5A3)

MMF:	118635260(SRD5A3)

PPAM:

129077730(SRD5A3)

HAI:	109381825(SRD5A3)

RFQ:	117022239(SRD5A3)

PALE:

102896891(SRD5A3)

PGIG:

120588089(SRD5A3)

PVP:	105293769(SRD5A3)

RAY:	107520901(SRD5A3)

MJV:	108400780(SRD5A3)

TOD:	119260781(SRD5A3)

SARA:

101539064(SRD5A3)

SETR:

126032285(SRD5A3)

LAV:	100671020(SRD5A3)

TMU:

101348372

ETF:	101664454(SRD5A3)

DNM:	101426407(SRD5A3)

MDO:	100017228(SRD5A3)

GAS:	123251476(SRD5A3)

SHR:	100928836(SRD5A3)

AFZ:

127542068

PCW:	110200149(SRD5A3)

TVP:	118854017(SRD5A3)

OAA:	100075423(SRD5A3)

GGA:	422750(SRD5A3)

PCOC:

116225919(SRD5A3)

MGP:	100541554(SRD5A3)

CJO:	107313729(SRD5A3)

TPAI:

128080385(SRD5A3)

LMUT:

125692454(SRD5A3)

NMEL:

110398188(SRD5A3)

APLA:

101796282(SRD5A3)

ACYG:

106030826(SRD5A3)

CATA:

118249701(SRD5A3)

AFUL:

116488841(SRD5A3)

TGU:	100224163(SRD5A3)

LSR:	110484867(SRD5A3)

SCAN:

103826189(SRD5A3)

PMOA:

120497508(SRD5A3)

OTC:	121335219(SRD5A3)

PRUF:

121348803(SRD5A3)

GFR:	102042544(SRD5A3)

FAB:	101812956(SRD5A3)

OMA:	130252540(SRD5A3)

PHI:	102113098(SRD5A3)

PMAJ:

107202960(SRD5A3)

CCAE:

111928443(SRD5A3)

CCW:	104690628(SRD5A3)

CBRC:

103622554(SRD5A3)

ETL:	114058307(SRD5A3)

ZAB:	102071936(SRD5A3)

ZLE:	135446534(SRD5A3)

ACHL:

103798413(SRD5A3)

SVG:	106851453(SRD5A3)

MMEA:

130573950(SRD5A3)

HRT:	120753061(SRD5A3)

SATI:

136360053(SRD5A3)

FPG:	101920408(SRD5A3)

FCH:	102059273(SRD5A3)

CCRI:

104154944(SRD5A3)

NNT:	104399303(SRD5A3)

SHAB:

115610950(SRD5A3)

ACUN:

113479224(SRD5A3)

TALA:

104360948(SRD5A3)

ACHC:

115347095(SRD5A3)

HALD:

104310495(SRD5A3)

HLE:	104836174(SRD5A3)

AGEN:

126051928

GCL:

127015700

CSTI:

104551479(SRD5A3)

LDI:	104341202(SRD5A3)

MNB:	103771301(SRD5A3)

DPUB:

104299167(SRD5A3)

AVIT:

104267397(SRD5A3)

BRHI:

104487960(SRD5A3)

EGZ:	104129459(SRD5A3)

NNI:	104020822(SRD5A3)

PCRI:

104026375(SRD5A3)

PADL:

103926347(SRD5A3)

AFOR:

103897439(SRD5A3)

FGA:	104069440(SRD5A3)

GSTE:

104251972(SRD5A3)

CLV:	102095131(SRD5A3)

MUI:	104538764(SRD5A3)

PGUU:

104460373(SRD5A3)

PLET:

104615121(SRD5A3)

EHS:	104502937(SRD5A3)

CMAC:

104474499(SRD5A3)

CUCA:

104067159(SRD5A3)

TEO:	104370738(SRD5A3)

OHA:	104334923(SRD5A3)

ACAR:

104517798(SRD5A3)

CPEA:

104393066(SRD5A3)

CVF:	104286438(SRD5A3)

RTD:	128910146(SRD5A3)

AAM:	106490085(SRD5A3)

AROW:

112975832(SRD5A3)

NPD:	112942655(SRD5A3)

TGT:	104565610(SRD5A3)

DNE:	112979429(TMEM165)

SCAM:

104138538(SRD5A3)

ASN:	102379264 102384757

AMJ:	102567202(SRD5A3)

CPOO:

109322191(SRD5A3)

GGN:	109303658(SRD5A3)

PSS:	102444263(SRD5A3)

CMY:	102936322(SRD5A3)

CCAY:

125635909(SRD5A3)

DCC:	119854684(SRD5A3)

CPIC:

101937467(SRD5A3)

TST:	117878354(SRD5A3)

CABI:

116826032(SRD5A3)

MRV:	120406924(SRD5A3)

ACS:	100551938(srd5a3) 103282902

ASAO:

132776654(SRD5A3)

PVT:	110078425(SRD5A3)

SUND:

121932100(SRD5A3)

PBI:	103063410(SRD5A3)

PMUR:

107292123(SRD5A3)

CTIG:

120316827(SRD5A3)

PGUT:

117662094(SRD5A3)

APRI:

131203383(SRD5A3)

PTEX:

113435832(SRD5A3)

NSS:	113417947(SRD5A3)

VKO:	123017059(SRD5A3)

PMUA:

114603835(SRD5A3)

PRAF:

128420790(SRD5A3)

ZVI:	118083326(SRD5A3)

HCG:	128327752(SRD5A3)

GJA:	107106033(SRD5A3)

STOW:

125439607 125439612(SRD5A3)

EMC:	129336718(SRD5A3)

XLA:	108698470(srd5a3.L) 379123(srd5a3.S)

XTR:	779994(srd5a3)

NPR:	108804033(SRD5A3)

RTEM:

120922855(SRD5A3)

BBUF:

120990206(SRD5A3)

BGAR:

122941791(SRD5A3)

MUO:	115461532(SRD5A3)

GSH:	117366889(SRD5A3)

DRE:	560717(srd5a3)

SRX:	107718431(srd5a3) 107755245

SANH:

107665336 107683999

SGH:	107573990(srd5a3) 107576144 107601910

CCAR:

109066982(srd5a3)

CAUA:

113062754 113120990(srd5a3)

CGIB:

127938786 127984218

PTET:

122342751(srd5a3)

LROH:

127183141(srd5a3)

OMC:	131527286(srd5a3)

PPRM:

120493381(srd5a3)

RKG:	130097540(srd5a3)

MAMB:

125277994(srd5a3)

CIDE:

127501869

CERY:

137018880(srd5a3)

MASI:

127410056

TROS:

130566100(srd5a3)

TDW:	130434542(srd5a3)

MANU:

129429141(srd5a3)

IPU:

108258126

IFU:	128601372(srd5a3)

PHYP:

113546831(srd5a3)

SMEO:

124377361(srd5a3)

TFD:	113653665(srd5a3)

TVC:	132843480(srd5a3)

TRN:	134320613(srd5a3)

AMEX:

103045498(srd5a3)

CMAO:

118815392(srd5a3)

EEE:	113586386(srd5a3)

CHAR:

105895061(srd5a3)

TRU:	105417901(srd5a3)

TFS:	130528421(srd5a3)

TNG:	GSTEN00032760G001

LCO:	104919092(srd5a3)

NCC:	104947078(srd5a3)

TBEN:

117496175(srd5a3)

CGOB:

115007066(srd5a3)

PGEO:

117445654(srd5a3)

GACU:

117555171(srd5a3)

EMAC:

134869283(srd5a3)

ELY:	117253571(srd5a3)

EFO:	125896382(srd5a3)

PLEP:

121941200(srd5a3) 121966138

SLUC:

116058786(srd5a3)

ECRA:

117950168(srd5a3)

ESP:	116695636(srd5a3)

PFLV:

114561858(srd5a3)

GAT:	120824159(srd5a3)

PPUG:

119217210(srd5a3)

AFB:	129094565(srd5a3)

CLUM:

117729245(srd5a3)

PSWI:

130193999(srd5a3)

MSAM:

119894691(srd5a3)

SCHU:

122877335(srd5a3)

CUD:	121512392(srd5a3)

ALAT:

119028120(srd5a3)

ASTR:

137599262(srd5a3)

MZE:	101473345(srd5a3)

ONL:	100691782(srd5a3)

OAU:	116331154(srd5a3)

OLA:	101156806(srd5a3)

OML:	112136777(srd5a3)

CSAI:

133457757(srd5a3)

XMA:	102237479(srd5a3)

XCO:	114150660(srd5a3)

XHE:	116725928(srd5a3)

PRET:

103463835(srd5a3)

PFOR:

103137113(srd5a3)

PLAI:

106963447(srd5a3)

PMEI:

106924151(srd5a3)

GAF:	122838027(srd5a3)

PPRL:

129375515(srd5a3)

CVG:	107091557(srd5a3)

CTUL:

119780609(srd5a3)

GMU:	124874145(srd5a3)

NFU:	107393391(srd5a3)

KMR:	108243377(srd5a3)

ALIM:

106537178(srd5a3)

NWH:	119407566(srd5a3)

AOCE:

111569622(srd5a3)

MCEP:

125009420(srd5a3)

CSEM:

103376703(srd5a3)

POV:	109625709(srd5a3)

SSEN:

122780962(srd5a3)

HHIP:

117759684(srd5a3)

HSP:	118120641(srd5a3)

PPLT:

128448110(srd5a3)

SMAU:

118318277(srd5a3)

LCF:

108879013

SDU:	111226375(srd5a3)

SLAL:

111644347(srd5a3)

XGL:	120790351(srd5a3)

HCQ:	109532109(srd5a3)

SSCV:

125967163

SBIA:

133503147(srd5a3)

PEE:	133406537(srd5a3)

PTAO:

133480900(srd5a3)

BPEC:

110154923(srd5a3)

MALB:

109962082(srd5a3)

BSPL:

114852942(srd5a3)

SJO:	128361821(srd5a3)

SASA:

106584121(srd5a3)

STRU:

115192382(srd5a3)

OTW:	112249150(srd5a3)

OMY:	110521674(srd5a3)

OGO:	124037860(srd5a3)

ONE:	115145132(srd5a3)

OKI:	109898028(srd5a3)

OKE:	118359031(srd5a3)

SALP:

111972319(srd5a3)

SNH:	120052585(srd5a3)

CCLU:

121539807(srd5a3)

ELS:	105011840(srd5a3)

PKI:	111850121(srd5a3)

AANG:

118225804(srd5a3)

LOC:	102697358(srd5a3)

PSPA:

121320069(srd5a3)

ARUT:

117421513(srd5a3)

PSEX:

120527451(srd5a3)

LCM:	102363132(SRD5A3)

CMK:	103178169(srd5a3)

RTP:	109934780(srd5a3)

CPLA:

122550125(srd5a3)

HOC:	132815397(srd5a3)

LERI:

129697437(srd5a3)

PMRN:

116942820(SRD5A3)

LRJ:	133342858(SRD5A3)

BFO:

BBEL:

CIN:

SCLV:

SPU:	115922155 579990

LPIC:

129260821

APLC:

110989371

ARUN:

117305508

DME:	Dmel_CG7840(CG7840)

DER:

6543492

DSE:

6611652

DSI:	Dsimw501_GD23520(Dsim_GD23520)

DYA:	Dyak_GE18750

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI17156

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:	101899650 101900443 131800346 131803438

SCAC:

106085989 106086001 106086027

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:	110674017 5575734

AALB:

109622565

ASUA:

134214068

CQU:	CpipJ_CPIJ008625

CPII:

120424174

CNS:

116348428

BCOO:

119071534

LLL:	129790901 129794435 129796202 129796420

AME:

ACER:

ALAB:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPAS:

FVI:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:	105207120 105208040

MPHA:

AEC:

ACEP:

VEM:

DQU:

CFO:

FEX:

LHU:

PGC:	109851972 109851983

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:	124947453 124947913 124947914

NVI:

100119448

CSOL:

105365575

TPRE:

106650373

LBD:	127281182 127281336

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	103312608 103312609

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_202637

BANY:

MJU:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

LSIN:

AAGE:

121728653 121728655 121728656

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

API:	100167163 103310029

DNX:	107161937 107171225

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM087110

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_200780

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:	119436748 119437645

RSAN:

RMP:

VDE:

VJA:

TUT:	107360225 107369870

DPTE:

113793835

DFR:

124490645

CSCU:

111620265 111627927

CVS:	136980345 136980375

PTEP:

ABRU:

UDV:

SDM:

LPOL:

CEL:	CELE_B0024.13(srdf-3)

CBR:

CBG_09584

CRQ:	GCK72_017534

NAI:	NECAME_03041

LOA:	LOAG_18143

HRO:	HELRODRAFT_188909 HELRODRAFT_66723

PVUL:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MMER:

RPHI:

132733554 132750458 132759076

DPOL:

127840096 127876108

MAEA:

128229049 128229304 128229874 128236525

OBI:

106867229

OSN:

115218440

LJP:	135473557 135477650

LAK:	106156499 106178503

OVI:	T265_11435

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

TAD:	TRIADDRAFT_53471

AQU:

105312044

ATH:	AT1G72590 AT2G16530

ALY:	9308832 9322122

CRB:

17891741

CSAT:

104747449 104766953 104792193

EUS:	EUTSA_v10000231mg EUTSA_v10022773mg

BRP:	103837771 103846037

BNA:	106360734 106409483 106433676 106439839 106443044 125577782

BOE:	106304466 106318133 106333812

RSZ:	108809075 108825107

THJ:

104807290

CPAP:

110808172

CIT:

102619924

CIC:	CICLE_v10028796mg

PVY:

116143770

MINC:

123228039

TCC:	18586049 18607676 18610799

GRA:	105766738 105778158 105787490

GHI:	107903719 107907818 107918655 107931746 107936328 107936539

GAB:	108463048 108464827 108482237

HSYR:

120216328

DZI:	111282724 111293122 111300810

EGR:	104453389 104456991

GMX:

100814660

GSJ:	114377345 114378552

PVU:	PHAVU_011G038300g

VRA:

106780535

VAR:	108324616 108339543

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:

LJA:

ADU:	107463066 107477024

AIP:	107613544 107624918 107628182

AHF:	112726933 112729143 112771455 112789130

LANG:

109325126

PCIN:

129307230

QSA:	O6P43_002050 O6P43_011531

FVE:	101307862 101308431

RCN:	112169559 112174812

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103445156 114824768

MSYL:

126584942 126624671

PXB:	103966945 103967954

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:	8284384 8286664

MEAN:

JCU:

HBR:

MESC:

POP:	7463988 7477843

PEU:	105134491 105141598

PALZ:

118050615 118058982

PNZ:	133680271 133698564

JRE:	108987005 109006543

CILL:

CAVE:

QSU:

QLO:

TWL:

VVI:	100243811 100265912

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107767964 107787404

NSY:

104249824

NTO:

104117912

NAU:

109210501

INI:	109154703 109154818

ITR:

SIND:

OEU:

EGT:

SSPL:

121775542 121775989 121790496

SMIL:

131001621

SHIS:

125201762

APAN:

127253337 127261950

HAN:	110911547 110923305

ECAD:

122579113 122581214

LSV:	111877104 111877105 111877106 111904331

CCAV:

112528787

DCR:

108203137

CSIN:

114303974 114304018 114319812

RVL:

131325142

AEW:	130779911 130780003 130784611

BVG:

104884739

SOE:

110792437

CQI:	110705196 110718859

ATRI:

MOF:

NNU:

MING:

TSS:	122660512 122662332

PSOM:

113288793 113289676

OSA:	4336740(OsJ_15866) 4343281(OsJ_24314)

OBR:

OGL:

BDI:

ATS:

TDC:	119356001 119365135

TAES:

123046245 123054115 123190006

TUA:

LPER:

LRD:

SBI:

ZMA:	100194237 100502028

MFLO:

136493509 136531176

SITA:

101786400

SVS:	117863313 117865725

PVIR:

PHAI:

PDA:

EGU:

MUS:

ZOF:	122041106 122045611

DCT:

110110583

PEQ:

110019516

AOF:	109827724 109848985

MSIN:

131228180

NCOL:

116261532

ATR:

18444657

SMO:	SELMODRAFT_24565 SELMODRAFT_66322

PPP:

112294840

CRE:	CHLRE_17g720950v5

VCN:	VOLCADRAFT_103030

CVR:	CHLNCDRAFT_135620

APRO:

F751_0034

OLU:	OSTLU_26674

OTA:	OT_ostta12g00150

BPG:	Bathy16g00230

MIS:	MICPUN_62047

MPP:	MICPUCDRAFT_40219

CME:	CYME_CMP066C

GSL:	Gasu_16010

SCE:	YIL049W(DFG10)

SEUB:

DI49_2730

SPAO:

SPAR_I01100

AGO:	AGOS_ADL073W

ERC:

Ecym_4334

KLA:	KLLA0_C08261g

KMX:	KLMA_70185(DFG10)

LTH:	KLTH0A04312g

VPO:	Kpol_1009p22

ZRO:	ZYRO0D16852g

CGR:	2890926(GVI51_L00473)

NCS:	NCAS_0A13460(NCAS0A13460)

NDI:	NDAI_0A02580(NDAI0A02580)

TPF:	TPHA_0K00940(TPHA0K00940)

TBL:	TBLA_0J01440(TBLA0J01440)

TGB:	HG536_0C04850

TDL:	TDEL_0H02090(TDEL0H02090)

KAF:	KAFR_0I01850(KAFR0I01850)

KNG:	KNAG_0D01650(KNAG0D01650)

ZMK:	HG535_0F03690

DHA:	DEHA2B09592g

PIC:	PICST_31592(DFG10)

PGU:	PGUG_02122

SPAA:

SPAPADRAFT_60183

LEL:	PVL30_003390(DFG10)

LBG:	92208836(LODBEIA_P36400)

CAL:	CAALFM_C208970CA(DFG10)

CTP:	CTRG_01961

COT:	CORT_0C02710

CDU:	CD36_23150(DFG10)

CTEN:

18248105(DFG10)

CLU:	CLUG_04172

CLUS:

A9F13_04g03520

CAUR:

CJI96_0004988

PPA:	PAS_chr1-4_0673

PKZ:	C5L36_0A07450

BBRX:

BRETT_003964

YLI:	2912457(YALI2_E00165g)

NCR:

NCU00387

NTE:	NEUTE1DRAFT82283(NEUTE1DRAFT_82283)

PAN:	PODANSg4842

PBEL:

QC761_702130(DFG10)

PPSD:

QC762_702130(DFG10)

PPSP:

QC763_702130(DFG10)

PPSA:

QC764_0112620(DFG10)

TTT:	THITE_2119503 THITE_2122302

MTM:	MYCTH_2079764

CTHR:

MGR:

PPEI:

PGRI:

SSCK:

FGR:	FGSG_07239

FPU:	FPSE_00195

FPOA:

FPOAC1_011014

FVN:	FVRRES_12034

FVR:	FVEG_05346

FOX:	FOXG_02178

NHE:	NECHADRAFT_104200

FFC:	NCS54_00589200

FKR:	NCS57_00626900

FMU:	J7337_002421

TRE:	TRIREDRAFT_2912

TRR:	M419DRAFT_127156

TATV:

25774923(TrAtP1_004650)

TASP:

36615605(TrAFT101_004084)

MAW:	19252966(J3458_007119)

MAJ:

MAA_05987

MBRN:

26238444(SRD5A3)

PCHM:

VFPPC_02706

CMT:

CCM_01790

AMUS:

LMH87_003550

PLJ:	28887811(PLICBS_003040)

PTKZ:

JDV02_000803(DFG10)

VAL:	VDBG_08774

VDA:	VDAG_06434

CFJ:	CFIO01_11465

CLUP:

CLUP02_03727

CHIG:

CH63R_02744

CDET:

87937494(CDEST_00991)

SAPO:

SAPIO_CDS5846

PFY:	PFICI_03778

SSL:	SS1G_06974

BFU:	BCIN_10g03390

MBE:

MBM_01200

PSCO:

LY89DRAFT_424051

GLZ:	GLAREA_05521

ANI:	ANIA_04071

AFM:	AFUA_1G05470

ACT:	ACLA_029190

NFI:	NFIA_019290

AOR:	AO090009000397

ANG:	An18g04290

AFV:	AFLA_010960

ALUC:

AKAW2_31167S

ACHE:

ACHE_11499S

APUU:

APUU_40276S

PCS:	N7525_000751

PDP:	PDIP_73410

POU:	POX_e06814

TMF:	EYB26_000925

TRG:	TRUGW13939_03718

CIM:	CIMG_03924

CPW:	CPC735_004260

ABE:

ARB_05619

TVE:

TRV_07203

PBL:	PAAG_08631

BGH:	BDBG_04981

PNO:	SNOG_11892

PTE:

PTT_08450

PTRR:

6344471(PtrM4_005980)

BZE:	COCCADRAFT_3232

BSC:	COCSADRAFT_40094

BOR:	COCMIDRAFT_84729

AALT:

CC77DRAFT_1029182

ARAB:

EKO05_0003469

ZTR:	MYCGRDRAFT_40170

PFJ:	MYCFIDRAFT_28109

FFU:	CLAFUR5_01652

CBET:

CB0940_00678

BCOM:

BAUCODRAFT_118870

TML:	GSTUM_00003395001

SPO:	2541583(dfg10)

SOM:	SOMG_03647(dfg10)

RIE:	OCT59_005755

SRE:	PTSG_08028

DPP:	DICPUDRAFT_83663

DFA:

DFA_07066

ACAN:

ACA1_096750

PFA:	PF3D7_1455900

PFH:	PFHG_00677

PREI:

PRSY57_1455200

PGAB:

PGSY75_1455900

PLAG:

39744496(PADL01_1455900)

PYO:	PY17X_1323400

PCB:	PCHAS_1322900

PBE:	PBANKA_1319600

PVV:	PVVCY_1302110

PKN:	PKNH_1225900

PVX:	PVX_117670

PCY:	PCYB_125920

PMAL:

PMUG01_12061000

PREL:

PRELSG_1225000

PCOT:

PCOAH_00045560

TOT:	TOT_040000692

BMIC:

BMR1_03g02520

CPV:

cgd5_1340

CHO:	Chro.50250

TGO:	TGME49_272180

PIF:	PITG_09474

PSOJ:

PHYSODRAFT_335266

SPAR:

SPRG_09830

GTT:	GUITHDRAFT_163089

» show all

Reference

PMID:20637498

Authors

Cantagrel V, Lefeber DJ, Ng BG, Guan Z, Silhavy JL, Bielas SL, Lehle L, Hombauer H, Adamowicz M, Swiezewska E, De Brouwer AP, Blumel P, Sykut-Cegielska J, Houliston S, Swistun D, Ali BR, Dobyns WB, Babovic-Vuksanovic D, van Bokhoven H, Wevers RA, Raetz CR, Freeze HH, Morava E, Al-Gazali L, Gleeson JG

Title

SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder.

Journal

Cell 142:203-17 (2010)
DOI:10.1016/j.cell.2010.06.001

Sequence

[hsa:79644] [mmu:57357] [sce:YIL049W]

LinkDB

DBGET integrated database retrieval system