KEGG   ORTHOLOGY: K12361
Entry
K12361                      KO                                     

Name
RASGRP2
Definition
RAS guanyl-releasing protein 2
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04062  Chemokine signaling pathway
ko04611  Platelet activation
ko05200  Pathways in cancer
Disease
H01235  Bleeding disorder platelet-type
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K12361  RASGRP2; RAS guanyl-releasing protein 2
   04014 Ras signaling pathway
    K12361  RASGRP2; RAS guanyl-releasing protein 2
   04015 Rap1 signaling pathway
    K12361  RASGRP2; RAS guanyl-releasing protein 2
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K12361  RASGRP2; RAS guanyl-releasing protein 2
   04062 Chemokine signaling pathway
    K12361  RASGRP2; RAS guanyl-releasing protein 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K12361  RASGRP2; RAS guanyl-releasing protein 2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K12361  RASGRP2; RAS guanyl-releasing protein 2
Domain-containing proteins not elsewhere classified [BR:ko04990]
 EF-hand domain-containing proteins
  Other EF-hand domain-containing proteins
   K12361  RASGRP2; RAS guanyl-releasing protein 2
Other DBs
GO: 0005088
Genes
HSA: 10235(RASGRP2)
PTR: 451298(RASGRP2)
PPS: 100993077(RASGRP2)
GGO: 101125864(RASGRP2)
PON: 100447844(RASGRP2)
NLE: 100603817(RASGRP2)
MCC: 722044(RASGRP2)
MCF: 102139509(RASGRP2)
CSAB: 103233086(RASGRP2)
RRO: 104673274(RASGRP2)
RBB: 108542853(RASGRP2)
CJC: 100896269(RASGRP2)
SBQ: 101053574(RASGRP2)
MMU: 19395(Rasgrp2)
MCAL: 110285321(Rasgrp2)
MPAH: 110318723(Rasgrp2)
RNO: 361714(Rasgrp2)
MUN: 110549343(Rasgrp2)
CGE: 100757059(Rasgrp2)
NGI: 103738782(Rasgrp2)
HGL: 101714183(Rasgrp2)
CCAN: 109687177(Rasgrp2)
OCU: 100328903(RASGRP2)
TUP: 102468592(RASGRP2)
CFA: 612101(RASGRP2)
VVP: 112924301(RASGRP2)
AML: 105236463(RASGRP2)
UMR: 103679557(RASGRP2)
UAH: 113244161(RASGRP2)
ORO: 101369676(RASGRP2)
ELK: 111149468
FCA: 101094450(RASGRP2)
PTG: 102958860(RASGRP2)
PPAD: 109246682(RASGRP2)
AJU: 106981708(RASGRP2)
BTA: 512056(RASGRP2)
BOM: 102264750(RASGRP2)
BBUB: 102391415(RASGRP2)
CHX: 102168515(RASGRP2)
OAS: 101104023(RASGRP2)
SSC: 100626093(RASGRP2)
CFR: 102515600(RASGRP2)
CDK: 105101557(RASGRP2)
BACU: 103000066(RASGRP2)
LVE: 103078201(RASGRP2)
OOR: 101278371(RASGRP2)
DLE: 111183796(RASGRP2)
PCAD: 102990537
ECB: 102150244(RASGRP2)
EPZ: 103565063(RASGRP2)
EAI: 106833617(RASGRP2)
MYB: 102242639(RASGRP2)
MYD: 102766192(RASGRP2)
MNA: 107542784(RASGRP2)
HAI: 109384326(RASGRP2)
DRO: 112317389(RASGRP2)
PALE: 102896690(RASGRP2)
RAY: 107517268(RASGRP2)
MJV: 108396371(RASGRP2)
LAV: 100661291(RASGRP2)
TMU: 101347941
SHR: 100916150(RASGRP2)
PCW: 110195541(RASGRP2)
OAA: 100090421(RASGRP2)
PHI: 106628736(RASGRP2)
ASN: 102372838(RASGRP2)
AMJ: 102566493(RASGRP2)
PSS: 102445100(RASGRP2)
CMY: 102937915(RASGRP2)
CPIC: 101946976(RASGRP2)
ACS: 103282338
PVT: 110083762(RASGRP2)
PBI: 103054829
PMUR: 107289925(RASGRP2)
PMUA: 114586605(RASGRP2)
GJA: 107121068(RASGRP2)
XLA: 379250(rasgrp2.L) 447008(rasgrp2.S)
XTR: 101733706(rasgrp2)
NPR: 108800280(RASGRP2)
DRE: 557063(rasgrp2) 797658
EEE: 113585260(rasgrp2)
TRU: 101074408(rasgrp2)
LCO: 104924060(rasgrp2)
NCC: 104942268
MZE: 101465816(rasgrp2)
ONL: 100692458(rasgrp2)
OLA: 101160849(rasgrp2)
XMA: 102220152(rasgrp2)
XCO: 114157439(rasgrp2)
PRET: 103480179(rasgrp2)
CVG: 107100159(rasgrp2)
NFU: 107384786(rasgrp2)
KMR: 108239371(rasgrp2)
ALIM: 106528460(rasgrp2)
AOCE: 111562544(rasgrp2)
CSEM: 103391165(rasgrp2)
POV: 109637668(rasgrp2)
LCF: 108882034(rasgrp2)
SDU: 111226917(rasgrp2)
SLAL: 111654226(rasgrp2)
HCQ: 109511891(rasgrp2)
BPEC: 110168337(rasgrp2)
MALB: 109969412(rasgrp2)
SASA: 100194852(grp2) 106577535(rasgrp2) 106608563
ELS: 105010908 105020724(rasgrp2)
SFM: 108934392(rasgrp2)
LCM: 102348970(RASGRP2)
RTP: 109925825(rasgrp2)
 » show all
Reference
  Authors
Clyde-Smith J, Silins G, Gartside M, Grimmond S, Etheridge M, Apolloni A, Hayward N, Hancock JF
  Title
Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor.
  Journal
J Biol Chem 275:32260-7 (2000)
DOI:10.1074/jbc.M006087200
  Sequence
[hsa:10235]
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