KEGG   ORTHOLOGY: K12405Help
Entry
K12405                      KO                                     

Name
HSD17B4
Definition
(3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2 [EC:1.1.1.- 4.2.1.107 4.2.1.119]
Pathway
ko00120  Primary bile acid biosynthesis
ko01040  Biosynthesis of unsaturated fatty acids
ko01100  Metabolic pathways
ko01212  Fatty acid metabolism
ko04146  Peroxisome
Module
M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
M00861  beta-Oxidation, peroxisome, VLCFA
M00862  beta-Oxidation, peroxisome, tri/dihydroxycholestanoyl-CoA => choloyl/chenodeoxycholoyl-CoA
Disease
H00407  Peroxisomal beta-oxidation enzyme deficiency
H02095  Perrault syndrome
H02098  D-bifunctional protein deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K12405  HSD17B4; (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2
   01040 Biosynthesis of unsaturated fatty acids
    K12405  HSD17B4; (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K12405  HSD17B4; (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-  
     K12405  HSD17B4; (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.107  3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase
     K12405  HSD17B4; (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2
    4.2.1.119  enoyl-CoA hydratase 2
     K12405  HSD17B4; (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2
BRITE hierarchy
Other DBs
RN: R04809 R04810 R04812 R04813 R07935 R07936 R07951 R07952 R09698
GO: 0033989
Genes
HSA: 3295(HSD17B4)
PTR: 462019(HSD17B4)
PPS: 100981028(HSD17B4)
GGO: 101129538(HSD17B4)
PON: 100448539(HSD17B4)
NLE: 100590035(HSD17B4)
MCC: 698369(HSD17B4)
MCF: 102123675(HSD17B4)
CSAB: 103244395(HSD17B4)
RRO: 104654581(HSD17B4)
RBB: 108517761 108529825(HSD17B4)
CJC: 100390100(HSD17B4)
SBQ: 101036776(HSD17B4)
MMU: 15488(Hsd17b4)
MCAL: 110284447(Hsd17b4)
MPAH: 110332881(Hsd17b4)
RNO: 79244(Hsd17b4)
CGE: 103161104(Hsd17b4)
NGI: 103745113(Hsd17b4)
HGL: 101713520(Hsd17b4)
OCU: 100346781(HSD17B4)
TUP: 102468828(HSD17B4)
CFA: 474630(HSD17B4)
VVP: 112932403(HSD17B4)
AML: 100471749(HSD17B4)
UMR: 103670554(HSD17B4)
UAH: 113261629(HSD17B4)
ORO: 101385731(HSD17B4)
FCA: 101091840(HSD17B4)
PTG: 102968873(HSD17B4)
AJU: 106975089(HSD17B4)
BTA: 493643(HSD17B4)
BOM: 102268517(HSD17B4)
BBUB: 102412917(HSD17B4)
PHD: 102329357(HSD17B4)
CHX: 102172142(HSD17B4)
OAS: 101114519(HSD17B4)
SSC: 397574(HSD17B4)
CFR: 102508317(HSD17B4)
CDK: 105104293(HSD17B4)
LVE: 103084787(HSD17B4)
OOR: 101282963(HSD17B4)
DLE: 111183342(HSD17B4)
ECB: 100034046(HSD17B4)
EPZ: 103548315(HSD17B4)
EAI: 106833039(HSD17B4)
MYB: 102240475(HSD17B4)
MYD: 102767159(HSD17B4)
MNA: 107530713(HSD17B4)
HAI: 109374101(HSD17B4)
RSS: 109455167(HSD17B4)
DRO: 112315031(HSD17B4)
PALE: 102887000(HSD17B4)
LAV: 100659299(HSD17B4)
TMU: 101356123
MDO: 100028098(HSD17B4)
SHR: 100932771(HSD17B4)
PCW: 110202743(HSD17B4)
OAA: 100081754(HSD17B4)
GGA: 395785(HSD17B4)
MGP: 100545396(HSD17B4)
CJO: 107306670(HSD17B4)
APLA: 101791118(HSD17B4)
ACYG: 106048362(HSD17B4)
TGU: 100218226(HSD17B4)
LSR: 110479177(HSD17B4)
SCAN: 103821465(HSD17B4)
GFR: 102036502(HSD17B4)
FAB: 101807233(HSD17B4)
PHI: 102109547(HSD17B4)
PMAJ: 107216347(HSD17B4)
CCAE: 111941198(HSD17B4)
CCW: 104690497(HSD17B4)
ETL: 114056305(HSD17B4)
FPG: 101917400(HSD17B4)
FCH: 102058406(HSD17B4)
CLV: 102095771(HSD17B4)
EGZ: 104122491(HSD17B4)
NNI: 104014571(HSD17B4)
ACUN: 113489653(HSD17B4)
ASN: 102371766(HSD17B4)
AMJ: 102571005(HSD17B4)
PSS: 102451304(HSD17B4)
CMY: 102933522(HSD17B4)
CPIC: 101945395(HSD17B4)
ACS: 100558484(hsd17b4)
PVT: 110077461(SCP2D1) 110084344(HSD17B4)
PBI: 103059748(SCP2D1) 103063870(HSD17B4)
PMUR: 107294349(HSD17B4)
GJA: 107106522(SCP2D1) 107116225(HSD17B4)
XLA: 444492(hsd17b4.L)
XTR: 613082(hsd17b4)
NPR: 108787696(HSD17B4)
DRE: 393105(hsd17b4)
SRX: 107713552(hsd17b4) 107713572
SANH: 107703629(hsd17b4)
SGH: 107571774(hsd17b4)
IPU: 108265438(hsd17b4)
PHYP: 113529268(hsd17b4)
AMEX: 103046836(hsd17b4)
EEE: 113571049(hsd17b4)
TRU: 101062498(hsd17b4)
LCO: 104920820(hsd17b4)
NCC: 104966339(hsd17b4)
MZE: 101482787(hsd17b4)
OLA: 101159921(hsd17b4)
XMA: 102223774(hsd17b4)
XCO: 114154573(hsd17b4)
PRET: 103470095(hsd17b4)
NFU: 107394149(hsd17b4)
KMR: 108233704(hsd17b4)
CSEM: 103397642(hsd17b4)
LCF: 108882142(hsd17b4)
SDU: 111230866(hsd17b4)
HCQ: 109526033(hsd17b4)
BPEC: 110167024(hsd17b4)
MALB: 109956607(hsd17b4)
SASA: 106585849(hsd17b4)
OTW: 112247069(hsd17b4)
SALP: 111974039(hsd17b4)
ELS: 105014609(hsd17b4)
SFM: 108938133(hsd17b4)
PKI: 111856620(hsd17b4)
LCM: 102356548(HSD17B4)
CMK: 103181119(hsd17b4)
CIN: 100187421
SPU: 581580(hsd17b4)
APLC: 110987677
DME: Dmel_CG3415(Mfe2)
DER: 6550509
DPE: 6599365
DSI: Dsimw501_GD29376(Dsim_GD29376)
DWI: 6648554
DAZ: 108619615
DNV: 108656784
DHE: 111598829
MDE: 101897498
AAG: 5568633
AME: 409986
BIM: 100745646
BTER: 100648641
SOC: 105192979
MPHA: 105839781
AEC: 105149946
ACEP: 105621202
HST: 105188161
DQU: 106744052
CFO: 105248091
LHU: 105679879
PGC: 109854791
OBO: 105280041
PCF: 106793023
NVI: 100123018
MDL: 103579980
TCA: 663655(17-beta-HD4)
DPA: 109536257
NVL: 108562871
BMOR: 101745499
PMAC: 106711197
PRAP: 110991438
HAW: 110370579
TNL: 113504311
PXY: 105391367
API: 100167575
DNX: 107163428
AGS: 114120233
CLEC: 106670504
ZNE: 110835121
TUT: 107364381
DPTE: 113789986
CEL: CELE_E04F6.3(maoc-1) CELE_M03A8.1(dhs-28)
CBR: CBG10899(Cbr-dhs-28) CBG13089(Cbr-maoc-1)
PCAN: 112553906
CRG: 105326295
MYI: 110453744
OBI: 106871734
EPA: 110252238
ADF: 107337999
PDAM: 113684402
SPIS: 111344377
AQU: 100640903
DDI: DDB_G0291247(mfeA)
DFA: DFA_02002(mfeA)
TGO: TGME49_234570(HAD2SCP2)
SMIN: v1.2.022875.t1(symbB.v1.2.022875.t1)
CARE: LT85_3600
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9089413
  Authors
Jiang LL, Miyazawa S, Souri M, Hashimoto T
  Title
Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein.
  Journal
J Biochem 121:364-9 (1997)
  Sequence
[hsa:3295]
Reference
  Authors
Koski KM, Haapalainen AM, Hiltunen JK, Glumoff T
  Title
Crystal structure of 2-enoyl-CoA hydratase 2 from human peroxisomal multifunctional enzyme type 2.
  Journal
J Mol Biol 345:1157-69 (2005)
DOI:10.1016/j.jmb.2004.11.009
  Sequence
[hsa:3295]
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