KEGG   ORTHOLOGY: K12647
Entry
K12647                      KO                                     

Name
IFIH1, MDA5
Definition
interferon-induced helicase C domain-containing protein 1 [EC:3.6.4.13]
Pathway
ko04622  RIG-I-like receptor signaling pathway
ko05161  Hepatitis B
ko05162  Measles
ko05164  Influenza A
ko05168  Herpes simplex virus 1 infection
ko05171  Coronavirus disease - COVID-19
Disease
H00290  Aicardi-Goutieres syndrome
H00408  Type 1 diabetes mellitus
H01571  Singleton-Merten syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1
 09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1
   05171 Coronavirus disease - COVID-19
    K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1
   05164 Influenza A
    K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1
   05162 Measles
    K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1
   05168 Herpes simplex virus 1 infection
    K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors
    K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.4  Acting on acid anhydrides to facilitate cellular and subcellular movement
    3.6.4.13  RNA helicase
     K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1
Pattern recognition receptors [BR:ko04054]
 Cytoplasmic pattern recognition receptors
  RIG-I-like receptors
   K12647  IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1
Genes
HSA: 64135(IFIH1)
PTR: 459692(IFIH1)
PPS: 100981559(IFIH1)
GGO: 101142588(IFIH1)
PON: 100438807(IFIH1)
NLE: 100597651(IFIH1)
MCC: 702024(IFIH1)
MCF: 102135560(IFIH1)
CSAB: 103217190(IFIH1)
RRO: 104661275(IFIH1)
RBB: 108541427(IFIH1)
CJC: 100392317(IFIH1)
SBQ: 101040725(IFIH1)
MMU: 71586(Ifih1)
MCAL: 110289518(Ifih1)
MPAH: 110318467(Ifih1)
RNO: 499801(Ifih1)
MUN: 110548643(Ifih1)
CGE: 100767593(Ifih1)
NGI: 103744095(Ifih1)
HGL: 101721395(Ifih1)
CCAN: 109701161(Ifih1)
OCU: 100343560(IFIH1)
TUP: 102476561(IFIH1)
CFA: 488371(IFIH1)
VVP: 112916461(IFIH1)
AML: 100467176(IFIH1)
UMR: 103659509(IFIH1)
UAH: 113250835(IFIH1)
ORO: 101381886(IFIH1)
ELK: 111140996
FCA: 101099233(IFIH1)
PTG: 102970672(IFIH1)
PPAD: 109272005(IFIH1)
AJU: 106984839(IFIH1)
BTA: 535490(IFIH1)
BOM: 102266380(IFIH1)
BIU: 109567061(IFIH1)
BBUB: 102410252(IFIH1)
CHX: 102183188(IFIH1)
OAS: 101106234(IFIH1)
SSC: 100101927(IFIH1)
CFR: 102520863(IFIH1)
CDK: 105093686(IFIH1)
BACU: 103014106(IFIH1)
LVE: 103086848(IFIH1)
OOR: 101271323(IFIH1)
DLE: 111172800(IFIH1)
PCAD: 102994692(IFIH1)
ECB: 100061257(IFIH1)
EPZ: 103554416(IFIH1)
EAI: 106843229(IFIH1)
MYB: 102241185(IFIH1)
MYD: 102760067(IFIH1)
MNA: 107525248(IFIH1)
HAI: 109379834(IFIH1)
DRO: 112322284(IFIH1)
PALE: 102888688(IFIH1)
RAY: 107511736(IFIH1)
MJV: 108398082(IFIH1)
LAV: 100675913(IFIH1)
TMU: 101341398
MDO: 100022390(IFIH1)
SHR: 100915060(IFIH1)
PCW: 110220730(IFIH1)
OAA: 100082294(IFIH1)
GGA: 424185(IFIH1)
MGP: 100545639(IFIH1)
CJO: 107316932(IFIH1)
NMEL: 110399598(IFIH1)
APLA: 101800076(IFIH1)
ACYG: 106029824(IFIH1)
TGU: 100225529(IFIH1)
LSR: 110469640(IFIH1)
SCAN: 103814392(IFIH1)
GFR: 102040357(IFIH1)
FAB: 101809185(IFIH1)
PHI: 102107885(IFIH1)
PMAJ: 107207576(IFIH1)
CCAE: 111931733(IFIH1)
CCW: 104693924(IFIH1)
ETL: 114073731(IFIH1)
FPG: 101916011(IFIH1)
FCH: 102051096(IFIH1)
CLV: 102091175(IFIH1)
EGZ: 104128023(IFIH1)
NNI: 104009962(IFIH1)
ACUN: 113482120(IFIH1)
PADL: 103918138(IFIH1)
AAM: 106499314(IFIH1)
ASN: 102384738(IFIH1)
AMJ: 102560357(IFIH1)
PSS: 102443714(IFIH1)
CMY: 102943181(IFIH1)
CPIC: 101937263(IFIH1)
ACS: 100553529(ifih1)
PVT: 110089482(IFIH1)
PBI: 103050994(IFIH1)
PMUR: 107285523
TSR: 106539326(IFIH1)
PMUA: 114605687(IFIH1)
GJA: 107123061(IFIH1)
XLA: 108701345(ifih1.L) 108702266
XTR: 100488298(ifih1)
NPR: 108787198(IFIH1)
DRE: 565759(ifih1)
SANH: 107674760(ifih1)
IPU: 101154683(ifih1)
PHYP: 113526113(ifih1)
AMEX: 103026821(ifih1)
EEE: 113577523(ifih1)
TRU: 101076792(ifih1)
LCO: 104920059(ifih1)
NCC: 104955305(ifih1)
MZE: 101476548(ifih1)
ONL: 100703536(ifih1)
OLA: 101175445(ifih1)
XMA: 102237624(ifih1)
XCO: 114147627(ifih1)
PRET: 103461699(ifih1)
CVG: 107081995(ifih1)
NFU: 107390069(ifih1)
KMR: 108240713(ifih1)
ALIM: 106512943(ifih1)
AOCE: 111575744(ifih1)
CSEM: 103392158(ifih1)
POV: 109631067(ifih1)
LCF: 108901049(ifih1)
SDU: 111218444(ifih1)
SLAL: 111654519(ifih1)
HCQ: 109514801(ifih1)
BPEC: 110163921(ifih1)
MALB: 109957114(ifih1)
SASA: 106581804(ifih1)
OTW: 112225192
SALP: 111959481
ELS: 105022448(ifih1)
SFM: 108927949(ifih1)
PKI: 111849610(ifih1)
LCM: 102365428(IFIH1)
CMK: 103176369(ifih1)
PCAN: 112564109
ADF: 107355208
 » show all
Reference
  Authors
Kang DC, Gopalkrishnan RV, Wu Q, Jankowsky E, Pyle AM, Fisher PB
  Title
mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties.
  Journal
Proc Natl Acad Sci U S A 99:637-42 (2002)
DOI:10.1073/pnas.022637199
  Sequence
[hsa:64135]
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