KEGG   ORTHOLOGY: K12712
Entry
K12712                      KO                                     

Name
novP, cloP, couP
Definition
demethyldecarbamoylnovobiocin O-methyltransferase [EC:2.1.1.285]
Pathway
ko00401  Novobiocin biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00401 Novobiocin biosynthesis
    K12712  novP, cloP, couP; demethyldecarbamoylnovobiocin O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.285  demethyldecarbamoylnovobiocin O-methyltransferase
     K12712  novP, cloP, couP; demethyldecarbamoylnovobiocin O-methyltransferase
Other DBs
RN: R06767 R06771 R06774
Genes
NGV: CDO52_02225
AG: AAF67509(novP) AAG29794(couP) AAN65238(cloP)
Reference
  Authors
Steffensky M, Muhlenweg A, Wang ZX, Li SM, Heide L
  Title
Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.
  Journal
Antimicrob Agents Chemother 44:1214-22 (2000)
DOI:10.1128/AAC.44.5.1214-1222.2000
  Sequence
Reference
  Authors
Pojer F, Li SM, Heide L.
  Title
Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics.
  Journal
Microbiology 148:3901-11 (2002)
DOI:10.1099/00221287-148-12-3901
  Sequence
Reference
  Authors
Freel Meyers CL, Oberthur M, Heide L, Kahne D, Walsh CT
  Title
Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN.
  Journal
Biochemistry 43:15022-36 (2004)
DOI:10.1021/bi048457z
LinkDB

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