KEGG   ORTHOLOGY: K12966
Entry
K12966                      KO                                     

Name
AIM2
Definition
absent in melanoma 2
Pathway
ko04621  NOD-like receptor signaling pathway
ko04623  Cytosolic DNA-sensing pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K12966  AIM2; absent in melanoma 2
   04623 Cytosolic DNA-sensing pathway
    K12966  AIM2; absent in melanoma 2
Genes
HSA: 9447(AIM2)
PTR: 457425(AIM2)
PPS: 100976265(AIM2)
GGO: 101153886(AIM2)
PON: 100459446(AIM2)
NLE: 100579454(AIM2)
MCC: 719260(AIM2)
MCF: 102130525(AIM2)
CSAB: 103223764(AIM2)
RRO: 104657033(AIM2)
RBB: 108531891(AIM2)
CJC: 100396986(AIM2)
SBQ: 101049716
MMU: 383619(Aim2)
MCAL: 110304475
MPAH: 110314652 110322061(Aim2)
RNO: 304987(Aim2)
CGE: 100750381
NGI: 103740252(Aim2)
TUP: 102470019(AIM2)
BTA: 104971426(AIM2)
BOM: 102279174(AIM2)
BBUB: 102414912
CHX: 102184679(AIM2)
CDK: 105086559(AIM2)
ECB: 100057148(AIM2)
EPZ: 103553933
EAI: 106835730(AIM2)
MJV: 108394537(AIM2)
MDO: 103096087(IFI16)
SHR: 100921789(AIM2)
PCW: 110201877
ASN: 102385854
AMJ: 106737814(IFI16)
 » show all
Reference
  Authors
Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E, Fitzgerald KA
  Title
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
  Journal
Nature 458:514-8 (2009)
DOI:10.1038/nature07725
Reference
  Authors
Burckstummer T, Baumann C, Bluml S, Dixit E, Durnberger G, Jahn H, Planyavsky M, Bilban M, Colinge J, Bennett KL, Superti-Furga G
  Title
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.
  Journal
Nat Immunol 10:266-72 (2009)
DOI:10.1038/ni.1702
Reference
PMID:9242382
  Authors
DeYoung KL, Ray ME, Su YA, Anzick SL, Johnstone RW, Trapani JA, Meltzer PS, Trent JM
  Title
Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma.
  Journal
Oncogene 15:453-7 (1997)
DOI:10.1038/sj.onc.1201206
  Sequence
[hsa:9447]
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