KEGG ORTHOLOGY: K13098

ORTHOLOGY: K13098

Entry

K13098                      KO

Symbol

TLS, FUS

Name

RNA-binding protein FUS

Pathway

map03015

mRNA surveillance pathway

map03040

Spliceosome

map05014

Amyotrophic lateral sclerosis

map05022

Pathways of neurodegeneration - multiple diseases

map05202

Transcriptional misregulation in cancer

Disease

H00058

Amyotrophic lateral sclerosis (ALS)

H01577

Essential tremor

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09121 Transcription
   03040 Spliceosome
    K13098  TLS, FUS; RNA-binding protein FUS
  09122 Translation
   03015 mRNA surveillance pathway
    K13098  TLS, FUS; RNA-binding protein FUS
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K13098  TLS, FUS; RNA-binding protein FUS
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K13098  TLS, FUS; RNA-binding protein FUS
   05022 Pathways of neurodegeneration - multiple diseases
    K13098  TLS, FUS; RNA-binding protein FUS
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03041 Spliceosome
    K13098  TLS, FUS; RNA-binding protein FUS
Spliceosome [BR:ko03041]
Complex A
  Other components
   Complex A specific factors
    K13098  TLS, FUS; RNA-binding protein FUS

Genes

HSA:

2521(FUS)

PTR:	104002580(FUS)

PPS:	100990768(FUS)

GGO:	101129147(FUS)

PON:	100438926(FUS)

PPYG:

129015788(FUS)

NLE:	100594007(FUS)

HMH:	116471191(FUS)

SSYN:

129492588(FUS)

MCC:	713433(FUS)

MCF:	101925561(FUS)

MTHB:

126944202

MNI:	105482959(FUS)

CSAB:

103231346(FUS)

CATY:

105599559(FUS)

PANU:

100999207(FUS)

TGE:	112613693(FUS)

MLEU:

105541469(FUS)

RRO:	104661574(FUS)

RBB:	108528462(FUS)

TFN:	117087694(FUS)

PTEH:

111525624(FUS)

CANG:

105505707(FUS)

CJC:	100395517(FUS)

SBQ:	101037596(FUS) 101046669

CIMI:

108293912(FUS)

ANAN:

105729277(FUS) 110569273

CSYR:

103264395(FUS)

MMUR:

105871040(FUS)

LCAT:

123632692(FUS)

PCOQ:

105823163(FUS)

OGA:	100966489(FUS)

MMU:	233908(Fus)

MCAL:

110298234(Fus)

MPAH:

110320507(Fus)

RNO:	317385(Fus) 501526(Fusl1)

MCOC:

116103046(Fus)

ANU:	117706860(Fus)

MUN:	110564540(Fus)

CGE:	100756868(Fus)

MAUA:

101844333(Fus)

PROB:

127228412(Fus)

PLEU:

114704401(Fus)

MORG:

121457773(Fus)

MFOT:

126515932

AAMP:

119812907 119823612 119824833(Fus)

NGI:	103726321(Fus)

HGL:	101716667(Fus)

CPOC:

100734300(Fus)

CCAN:

109682708(Fus)

DORD:

105982131(Fus)

DSP:	122096207(Fus)

PLOP:

125340640(Fus)

NCAR:

124970068

MMMA:

107146978(Fus)

OCU:

100352362

OPI:	101521802(FUS)

TUP:	102485712(FUS)

GVR:	103610076(FUS)

CFA:	100856381(FUS)

CLUD:

112640138(FUS)

VVP:	112929268(FUS)

VLG:	121487657(FUS) 121489323

NPO:	129499971 129519945(FUS)

AML:	100475993(FUS)

UMR:	103657887(FUS)

UAH:	113267720(FUS)

UAR:	123784679(FUS)

ELK:

111162225

LLV:

125090619

MPUF:

101673938(FUS)

MNP:	132026682(FUS)

MLK:	131819639(FUS)

NVS:	122896101(FUS)

ORO:	101381149(FUS)

EJU:	114214370(FUS)

ZCA:	113932716(FUS) 113934143

MLX:	117999562(FUS)

NSU:	110589756(FUS)

LWW:	102727166(FUS)

FCA:	101088901(FUS)

PYU:	121022232(FUS)

PCOO:

112856824(FUS)

PBG:	122471415(FUS)

PVIV:

125154177(FUS)

LRUF:

124517772

PTG:	102965237(FUS)

PPAD:

109259028(FUS)

PUC:

125928118

AJU:

106979119

HHV:	120242218(FUS)

BTA:	280796(FUS)

BOM:	102271294(FUS)

BIU:	109578507(FUS)

BBUB:

102397686(FUS)

BBIS:

104986685(FUS)

CHX:	102171834(FUS)

OAS:	101104799(FUS)

BTAX:

128061851(FUS) 128066972

ODA:	120877695(FUS)

CCAD:

122433100(FUS)

MBEZ:

129536979 129545562(FUS)

SSC:	100522185(FUS)

CFR:	102513734(FUS)

CBAI:

105082775(FUS)

CDK:	105106644(FUS)

VPC:	102531841(FUS)

BACU:

103003978(FUS) 103015565

BMUS:

118880332 118881196(FUS)

LVE:	103074584(FUS)

OOR:	101286694(FUS)

DLE:	111182109(FUS)

PCAD:

102986151(FUS)

PSIU:

116740161(FUS)

NASI:

112399306(FUS)

ECB:	100063286(FUS)

EPZ:	103547247(FUS) 103549245

EAI:	106831882(FUS) 106838884

MYB:	102240997(FUS)

MYD:	102754952(FUS)

MMYO:

118656085(FUS)

MLF:	102438593(FUS)

MDT:	132213372 132232704(FUS)

PKL:	118704936(FUS)

EFUS:

103296231(FUS)

MNA:	107540822(FUS)

DRO:	112304771(FUS)

AJM:	119035620 119051384(FUS)

PDIC:

114491559(FUS) 114496464

PHAS:

123825569(FUS)

MMF:	118641859(FUS)

PPAM:

129073218 129078007(FUS)

HAI:	109374204(FUS)

RFQ:	117019637(FUS)

PALE:

102888091(FUS)

PGIG:

120620053(FUS)

PVP:	105304505(FUS)

RAY:	107503992(FUS)

MJV:	108400694(FUS)

TOD:	119241704(FUS)

SARA:

101546135(FUS)

SETR:

126030886(FUS)

LAV:	100664019(FUS)

TMU:

101357666

DNM:	101412934(FUS)

MDO:	100013799(FUS)

GAS:	123233462(FUS)

SHR:	100915308(FUS)

AFZ:

127562697

PCW:	110223099(FUS)

TVP:	118831287 118833679(FUS)

OAA:	100087740(FUS)

GGA:	414144(FUS)

PCOC:

116239937(FUS)

LMUT:

125687757

NMEL:

110391737(FUS)

ACYG:

106029462(FUS)

OTC:

121343092

PHI:	102106592(FUS)

ZLE:	135460553(FUS)

FPG:	106112254(FUS)

SHAB:

115603317(FUS)

ACHC:

115338555(FUS)

HLE:	104835810(FUS)

GCL:

127027937

CUCA:

128850075(FUS)

AAM:

106486934

AROW:

112965812(FUS)

ASN:	102385490(FUS)

AMJ:	102558245(FUS)

PSS:	102461749(FUS)

CMY:	102933986(FUS)

CCAY:

125638259(FUS)

DCC:	119856520(FUS)

CPIC:

101945727(FUS)

TST:	117876259(FUS)

CABI:

116827471(FUS)

MRV:	120403156(FUS)

ACS:	100556650(fus)

ASAO:

132777746(FUS)

PVT:	110086399(FUS)

SUND:

121933319(FUS)

PBI:	103051127(FUS)

PMUR:

107294321(FUS) 107296285

CTIG:

120302220(FUS)

TSR:

106538129

PGUT:

117666823(FUS)

APRI:

131197354(FUS)

PTEX:

113449979(FUS)

NSS:	113422513(FUS)

VKO:	123032166(FUS)

PMUA:

114582856 114590173

PRAF:

128399699(FUS)

ZVI:	118094298(FUS)

HCG:	128330057(FUS)

GJA:	107120003(FUS)

STOW:

125438266 125444547(FUS)

EMC:	129340529(FUS)

XLA:	380075(fus.S) 444722

XTR:	100038234(fus)

NPR:	108800963(FUS)

RTEM:

120942997(FUS)

BBUF:

121009016(FUS)

MUO:	115473739(FUS)

GSH:	117360533(FUS)

DRE:	394058(fus) 558760(taf15)

SRX:	107728230 107729526 107737761

SANH:

107658502 107689689 107703040 107703972

SGH:	107551305 107554122 107582996(fus) 107598573

CAUA:

113047181 113058198 113115406

CGIB:

127953805 127973104 128028708

PTET:

122341746(fus) 122359075(taf15)

LROH:

127163519(fus) 127176874(taf15)

OMC:	131520580(taf15) 131537939(fus)

PPRM:

120465209(taf15) 120489595(fus)

RKG:	130088465(fus) 130104366(taf15)

MAMB:

125248486(taf15) 125277573(fus)

CIDE:

127495349 127508016

CERY:

137004892(taf15) 137017625(fus)

MASI:

127422277 127429499 127450456 127451804

TROS:

130561010(fus) 130565320(taf15)

TDW:	130426846(fus) 130429105(taf15)

MANU:

129436030(fus) 129437520(taf15)

IPU:	108280371 108280676

IFU:	128604183(fus) 128623922(taf15)

PHYP:

113528617(fus) 113543154

SMEO:

124403041(taf15)

TFD:	113653208(taf15)

TVC:	132849128(taf15)

TRN:	134336282(fus)

AMEX:

103040960(fus) 111194496(taf15)

CMAO:

118796993(taf15) 118800516(fus)

EEE:	113580836(fus) 113590282

CHAR:

105905021(taf15)

TRU:	101075112(fus)

TFS:	130514820(fus) 130534838(taf15)

TNG:	GSTEN00006655G001

LCO:	104924159 109142515(fus)

NCC:

104940865

TBEN:

117470296(taf15)

CGOB:

115012481(fus) 115017696

PGEO:

117457199(taf15)

GACU:

117557381(taf15)

EMAC:

134878524(fus) 134880002(taf15)

ELY:	117259618(taf15) 117268564(fus)

EFO:	125879601(fus) 125888623(taf15)

PLEP:

121943298(taf15) 121957034(fus)

SLUC:

116045567(taf15) 116063760(fus) 116063767

ECRA:

117938000(taf15) 117958187(fus)

ESP:	116675470 116702748(fus)

PFLV:

114552526 114569496(fus)

GAT:	120827693(fus) 120830407(taf15)

PPUG:

119210347(taf15) 119220514(fus)

AFB:	129094192(taf15) 129098485(fus)

CLUM:

117734709(fus) 117741080(taf15)

PSWI:

130211376(taf15)

MSAM:

119882993(taf15) 119895231(fus)

SCHU:

122869042(fus) 122878585(taf15)

CUD:	121503563(fus) 121520142(taf15)

ALAT:

119013156(taf15) 119013550(fus)

MZE:	101474870(fus) 101480127

ONL:	100697861(fus) 100703628

OAU:	116313822(taf15) 116314281(fus)

OLA:

101173726

OML:	112149479(taf15)

CSAI:

133422602(fus) 133441665(taf15)

XMA:	102220690(fus)

XCO:

114161555

XHE:	116737343(fus)

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122832934(taf15)

PPRL:

129358736(taf15)

CVG:

107103138

CTUL:

119771784(taf15)

GMU:	124884406(taf15)

NFU:	107380477(taf15) 107396385(fus)

KMR:	108240491(taf15)

ALIM:

106524381

NWH:	119410508(taf15)

AOCE:

111579601(fus) 111585121

MCEP:

124998257(fus) 125013428(taf15)

POV:	109634518 109643360(fus)

SSEN:

122773397(taf15) 122785313(fus)

HHIP:

117765983(fus) 117765986 117772904(taf15)

HSP:	118105922(taf15) 118123955(fus)

PPLT:

128439626(taf15) 128457991(fus)

SMAU:

118289110(fus) 118299385(taf15)

LCF:	108878172 108894793(taf15)

SDU:	111224056 111230204(fus)

SLAL:

111651163(fus) 111655313

XGL:	120792120(taf15) 120806629(fus)

HCQ:

109525460

SSCV:

125971844

SBIA:

133505348(taf15)

PEE:	133405326(taf15)

PTAO:

133481846(taf15)

BPEC:

110174344

MALB:

109952712(fus) 109970563

BSPL:

114859835(fus) 114868728(taf15)

SJO:	128360955(taf15) 128379353(fus)

SASA:

106580678 106600706(fus) 106612447

STRU:

115162908 115170788(fus) 115205863

OTW:	112251726 112265044 112266700

OMY:	110503518(taf15) 110507354 110539084(fus)

OGO:	123993125 124000771(fus) 124005010

ONE:	115109995(fus) 115137149 115141467

OKI:	109893094(fus) 109905361 109908844

OKE:	118384261(fus) 118386672

SALP:

111960620 111982008(fus) 111982634

SNH:	120018437 120028344 120032921(fus)

CCLU:

121550325 121561315(taf15) 121567326 123491218

ELS:	105011361 105030395

SFM:	108941662(fus)

PKI:	111836826(fus)

AANG:

118210265 118216738(fus) 118235886

LOC:	102696885(fus)

PSPA:

121305225 121306854

ARUT:

117398135(fus)

LCM:	102359170(FUS)

PMRN:

BFO:

CIN:

SCLV:

SPU:	105436972 580739

APLC:

110982217

SKO:

100378778

DME:	Dmel_CG3606(caz)

DER:

DSE:

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:	6637750 6648996

DGR:

6565458

DMO:	Dmoj_GI11213

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108374812 108382905

AOQ:

129238965

TDA:	119667615 119682339

MDE:	101898630 131802616

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:	110674160 5566429

AALB:

109402413 109405455 115253590 115260811

ASUA:

134226670

CQU:	CpipJ_CPIJ006342

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105670389(caz)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

TCA:

DPA:	109539567 125504653

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_203043

BANY:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

LSIN:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PGW:

LGLY:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:	128994089 128994101

PHU:	Phum_PHUM175000

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_238350

PVM:	113803030 113818823

PJA:

PCHN:

PCLA:

MNZ:

HAZT:

EAF:	111710581 111715121

VDE:

VJA:

TUT:

CSCU:

PTEP:

ABRU:

NAI:	NECAME_12824

HRO:	HELRODRAFT_186994

PCAN:

112561246

MYI:	110457833 110458751

MAEA:

128231257

OBI:

106872884

LAK:	106150805 106181033

SMM:	Smp_000240.1

SHX:	MS3_00005787

OVI:	T265_14223

NVE:

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

AQU:

ATH:	AT5G58470(TAF15b)

ALY:

9302343

CRB:

17877142

CSAT:

104726419 104735613 104761946

BRP:	103845274 103851637 103856687

BNA:	106376291 106387469 106388117 106420496 106435835 111213276

BOE:	106318098 106322778 106329134

RSZ:	108827721 108844428 108844947 130494460

THJ:

CPAP:

CIT:

PVY:

MINC:

TCC:

GRA:	105768605 105789028 105789029

GHI:	107906289 107927097 107927098 107963856 107963857

GAB:	108483440 108483519

HSYR:

120113493 120114523 120131352 120179175 120194309 120196251 120206273

DZI:	111284815 111301489 111303494

EGR:

104432617

GMX:	100778472 100782124 100813547 100819953

GSJ:	114374593 114384713 114395481 114396870

PVU:	PHAVU_006G072900g PHAVU_008G257600g

VRA:	106752498 106752587

VAR:	108338707 108343209

VUN:	114187555 114195227

VUM:	124839164 124846974

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:	131662131 131662136

ADU:	107458307 107474590

AIP:	107607023 107646645

AHF:	112702763 112719951 112767226 112792815

LANG:

109339152 109357243 109360820

PCIN:

129303296 129317919

QSA:	O6P43_014091 O6P43_020396

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103412797 103418745

MSYL:

126589537 126615314

PXB:	103945404 103958964

ZJU:

107411555

MNT:	21384171 21411591

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:

HBR:	110670982 110671902

MESC:

110606479 110609201

POP:	18095136 18102067

PEU:	105110189 105125922

PALZ:

118027549 118055575

PNZ:	133679817 133702666

JRE:

CILL:

CAVE:

QSU:

QLO:

TWL:	119991234 120002251

VVI:

VRI:

SLY:

SPEN:

SOT:	102588476 102596777

SSTN:

125872036

SDUL:

129898843 129899389

CANN:

107873586 107875449

LBB:	132605783 132606432

NTA:	107775077 107780234 107807996 107832244

NSY:	104232906 104237606

NTO:	104093081 104121313

NAU:	109208102 109214491 109222445

INI:

109182817

ITR:

116025207

SIND:

105163938

OEU:	111369731 111407814

EGT:

SSPL:

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:	130762056 130774101

BVG:

104900228

SOE:

110800084

CQI:	110684173 110688526

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119267159 119275003

TAES:

123060329 123068849 123077359

TUA:

LPER:

LRD:

SBI:

ZMA:	103634842 103649720

MFLO:

136449563 136457703 136461720

SITA:

SVS:

PVIR:

PHAI:

PDA:	103720206 103722407

EGU:	105033649 105045885 105057147

MUS:	103971079 103971890

ZOF:	122026975 122029434 122031750 122034328

DCT:

AOF:

MSIN:

NCOL:

ATR:

SMO:	SELMODRAFT_405186

PPP:	112289997 112294861

MNG:

MNEG_4302

OTA:	OT_ostta10g03400

BPG:	Bathy11g03710

MIS:	MICPUN_101327

MPP:	MICPUCDRAFT_50552 MICPUCDRAFT_60878

ACAN:

ACA1_096950

SPAR:

SPRG_03848

» show all

Reference

PMID:15826835

Authors

Perez-Mancera PA, Sanchez-Garcia I

Title

Understanding mesenchymal cancer: the liposarcoma-associated FUS-DDIT3 fusion gene as a model.

Journal

Semin Cancer Biol 15:206-14 (2005)
DOI:10.1016/j.semcancer.2005.01.006

Reference

PMID:8510758

Authors

Crozat A, Aman P, Mandahl N, Ron D

Title

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.

Journal

Nature 363:640-4 (1993)
DOI:10.1038/363640a0

Sequence

[hsa:2521]

LinkDB

DBGET integrated database retrieval system