KEGG   ORTHOLOGY: K14215
Entry
K14215                      KO                                     

Name
E2.5.1.86
Definition
trans,polycis-decaprenyl diphosphate synthase [EC:2.5.1.86]
Pathway
ko00900  Terpenoid backbone biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K14215  E2.5.1.86; trans,polycis-decaprenyl diphosphate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.86  trans,polycis-decaprenyl diphosphate synthase
     K14215  E2.5.1.86; trans,polycis-decaprenyl diphosphate synthase
Other DBs
RN: R09244
COG: COG0020
Genes
MTU: Rv2361c(uppS)
MTV: RVBD_2361c
MTC: MT2430(uppS-2)
MRA: MRA_2385
MTF: TBFG_12387
MTB: TBMG_01614
MTK: TBSG_01623
MTZ: TBXG_001599
MTG: MRGA327_14530
MTI: MRGA423_14675
MTUR: CFBS_2500
MTD: UDA_2361c
MTUC: J113_16365
MTUE: J114_12645
MTUH: I917_16605
MTUL: TBHG_02300
MTUT: HKBT1_2491
MTUU: HKBT2_2494
MBB: BCG_2375c
MBT: JTY_2369
MBM: BCGMEX_2364c(uppS)
MBX: BCGT_2185
MAF: MAF_23750
MMIC: RN08_2617
MLE: ML0634
MLB: MLBr00634
MPA: MAP_2141c
MAO: MAP4_1681
MAVI: RC58_08405
MAVU: RE97_08405
MAV: MAV_2034(uppS)
MIT: OCO_20180
MIA: OCU_20280
MID: MIP_02839
MYO: OEM_18010
MIR: OCQ_18850
MLP: MLM_2658
MUL: MUL_3614
MMC: Mmcs_3449
MKM: Mkms_3512
MJL: Mjls_3460
MMI: MMAR_3671
MMM: W7S_09455
MLI: MULP_03919(uppS)
MHAD: B586_09310
MSHG: MSG_03355(uppS)
MFJ: MFLOJ_53690(uppS)
MXE: MYXE_19080(uppS)
MNV: MNVI_00550(uppS)
MSM: MSMEG_4490(uppS)
MSG: MSMEI_4379(uppS)
MVA: Mvan_3822
MGI: Mflv_2714
MPHL: MPHLCCUG_03461(uppS_1)
MVQ: MYVA_3646
MTHN: 4412656_02789(uppS)
MHAS: MHAS_01373(uppS_1)
MDU: MDUV_07360(uppS)
MCHT: MCHIJ_31760(uppS_2)
MDR: MDOR_25540(uppS_1)
MAUU: NCTC10437_03626(uppS_2)
MAB: MAB_1676
MABB: MASS_1769
MCHE: BB28_09115
MSTE: MSTE_01676
MSAL: DSM43276_01538(uppS_2)
MTER: 4434518_01468(uppS_2)
MMIN: MMIN_31680(uppS)
MHIB: MHIB_10160(uppS)
MKR: MKOR_04020(uppS_1)
SAMB: SAM23877_0125(uppS) SAM23877_7548(uppS)
SMAL: SMALA_6898
ACTI: UA75_19165
ACAD: UA74_18675
 » show all
Reference
  Authors
Kaur D, Brennan PJ, Crick DC
  Title
Decaprenyl diphosphate synthesis in Mycobacterium tuberculosis.
  Journal
J Bacteriol 186:7564-70 (2004)
DOI:10.1128/JB.186.22.7564-7570.2004
  Sequence
[mtu:Rv2361c]
LinkDB

KEGG   ENZYME: 2.5.1.86
Entry
EC 2.5.1.86                 Enzyme                                 

Name
trans,polycis-decaprenyl diphosphate synthase;
Rv2361c;
(2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
(2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesylcistransferase (adding 7 isopentenyl units)
Reaction(IUBMB)
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + trans,octacis-decaprenyl diphosphate [RN:R09244]
Reaction(KEGG)
R09244
Substrate
(2Z,6E)-farnesyl diphosphate [CPD:C16826];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
trans,octacis-decaprenyl diphosphate [CPD:C18321]
Comment
The enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan [2].
History
EC 2.5.1.86 created 2010
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K14215  trans,polycis-decaprenyl diphosphate synthase
Genes
MTU: Rv2361c(uppS)
MTV: RVBD_2361c
MTC: MT2430(uppS-2)
MRA: MRA_2385
MTF: TBFG_12387
MTB: TBMG_01614
MTK: TBSG_01623
MTZ: TBXG_001599
MTG: MRGA327_14530
MTI: MRGA423_14675
MTUR: CFBS_2500
MTD: UDA_2361c
MTUC: J113_16365
MTUE: J114_12645
MTUH: I917_16605
MTUL: TBHG_02300
MTUT: HKBT1_2491
MTUU: HKBT2_2494
MBB: BCG_2375c
MBT: JTY_2369
MBM: BCGMEX_2364c(uppS)
MBX: BCGT_2185
MAF: MAF_23750
MMIC: RN08_2617
MLE: ML0634
MLB: MLBr00634
MPA: MAP_2141c
MAO: MAP4_1681
MAVI: RC58_08405
MAVU: RE97_08405
MAV: MAV_2034(uppS)
MIT: OCO_20180
MIA: OCU_20280
MID: MIP_02839
MYO: OEM_18010
MIR: OCQ_18850
MLP: MLM_2658
MUL: MUL_3614
MMC: Mmcs_3449
MKM: Mkms_3512
MJL: Mjls_3460
MMI: MMAR_3671
MMM: W7S_09455
MLI: MULP_03919(uppS)
MHAD: B586_09310
MSHG: MSG_03355(uppS)
MFJ: MFLOJ_53690(uppS)
MXE: MYXE_19080(uppS)
MNV: MNVI_00550(uppS)
MSM: MSMEG_4490(uppS)
MSG: MSMEI_4379(uppS)
MVA: Mvan_3822
MGI: Mflv_2714
MPHL: MPHLCCUG_03461(uppS_1)
MVQ: MYVA_3646
MTHN: 4412656_02789(uppS)
MHAS: MHAS_01373(uppS_1)
MDU: MDUV_07360(uppS)
MCHT: MCHIJ_31760(uppS_2)
MDR: MDOR_25540(uppS_1)
MAUU: NCTC10437_03626(uppS_2)
MAB: MAB_1676
MABB: MASS_1769
MCHE: BB28_09115
MSTE: MSTE_01676
MSAL: DSM43276_01538(uppS_2)
MTER: 4434518_01468(uppS_2)
MMIN: MMIN_31680(uppS)
MHIB: MHIB_10160(uppS)
MKR: MKOR_04020(uppS_1)
SAMB: SAM23877_0125(uppS) SAM23877_7548(uppS)
SMAL: SMALA_6898
ACTI: UA75_19165
ACAD: UA74_18675
 » show all
Reference
1  [PMID:15516568]
  Authors
Kaur D, Brennan PJ, Crick DC
  Title
Decaprenyl diphosphate synthesis in Mycobacterium tuberculosis.
  Journal
J Bacteriol 186:7564-70 (2004)
DOI:10.1128/JB.186.22.7564-7570.2004
  Sequence
[mtu:Rv2361c]
Reference
2  [PMID:18597781]
  Authors
Wang W, Dong C, McNeil M, Kaur D, Mahapatra S, Crick DC, Naismith JH
  Title
The structural basis of chain length control in Rv1086.
  Journal
J Mol Biol 381:129-40 (2008)
DOI:10.1016/j.jmb.2008.05.060
  Sequence
[mtu:Rv2361c]
Reference
3  [PMID:11004176]
  Authors
Crick DC, Schulbach MC, Zink EE, Macchia M, Barontini S, Besra GS, Brennan PJ
  Title
Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis.
  Journal
J Bacteriol 182:5771-8 (2000)
DOI:10.1128/JB.182.20.5771-5778.2000
  Sequence
[mtu:Rv2361c] [msm:MSMEG_4490]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.86
IUBMB Enzyme Nomenclature: 2.5.1.86
ExPASy - ENZYME nomenclature database: 2.5.1.86
BRENDA, the Enzyme Database: 2.5.1.86
LinkDB

KEGG   REACTION: R09244
Entry
R09244                      Reaction                               

Name
(2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesylcistransferase (adding 7 isopentenyl units)
Definition
2-cis,6-trans-Farnesyl diphosphate + 7 Isopentenyl diphosphate <=> trans,octacis-Decaprenyl diphosphate + 7 Diphosphate
Equation
C16826 + 7 C00129 <=> C18321 + 7 C00013
Comment
7-step reaction
Enzyme
Pathway
rn00900  Terpenoid backbone biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K14215  trans,polycis-decaprenyl diphosphate synthase [EC:2.5.1.86]
Other DBs
RHEA: 47099
LinkDB

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