Entry |
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Name |
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Definition |
anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase [EC: 1.14.13.38 1.14.13.234]
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Pathway |
ko01057 | Biosynthesis of type II polyketide products |
ko01110 | Biosynthesis of secondary metabolites |
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Module |
M00780 | Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline |
M00823 | Chlortetracycline biosynthesis, pretetramide => chlortetracycline |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
01057 Biosynthesis of type II polyketide products
K14256 oxyS, cts8; anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase
00253 Tetracycline biosynthesis
K14256 oxyS, cts8; anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.38 anhydrotetracycline 6-monooxygenase
K14256 oxyS, cts8; anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase
1.14.13.234 5a,11a-dehydrotetracycline 5-monooxygenase
K14256 oxyS, cts8; anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase
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Other DBs |
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Genes |
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Reference |
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Authors |
Zhang W, Ames BD, Tsai SC, Tang Y |
Title |
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase. |
Journal |
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Sequence |
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Reference |
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Authors |
Peric-Concha N, Borovicka B, Long PF, Hranueli D, Waterman PG, Hunter IS |
Title |
Ablation of the otcC gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in Streptomyces rimosus results in novel polyketides with altered chain length. |
Journal |
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Reference |
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Authors |
Wang P, Bashiri G, Gao X, Sawaya MR, Tang Y |
Title |
Uncovering the enzymes that catalyze the final steps in oxytetracycline biosynthesis. |
Journal |
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LinkDB |
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