KEGG   ORTHOLOGY: K14338
Entry
K14338                      KO                                     

Name
cypD_E, CYP102A, CYP505
Definition
cytochrome P450 / NADPH-cytochrome P450 reductase [EC:1.14.14.1 1.6.2.4]
Pathway
ko00071  Fatty acid degradation
ko00380  Tryptophan metabolism
ko00627  Aminobenzoate degradation
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K14338  cypD_E, CYP102A, CYP505; cytochrome P450 / NADPH-cytochrome P450 reductase
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K14338  cypD_E, CYP102A, CYP505; cytochrome P450 / NADPH-cytochrome P450 reductase
  09111 Xenobiotics biodegradation and metabolism
   00627 Aminobenzoate degradation
    K14338  cypD_E, CYP102A, CYP505; cytochrome P450 / NADPH-cytochrome P450 reductase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K14338  cypD_E, CYP102A, CYP505; cytochrome P450 / NADPH-cytochrome P450 reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.6  Acting on NADH or NADPH
   1.6.2  With a heme protein as acceptor
    1.6.2.4  NADPH---hemoprotein reductase
     K14338  cypD_E, CYP102A, CYP505; cytochrome P450 / NADPH-cytochrome P450 reductase
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K14338  cypD_E, CYP102A, CYP505; cytochrome P450 / NADPH-cytochrome P450 reductase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, fungi type
  CYP505 family
   K14338  cypD_E, CYP102A, CYP505; cytochrome P450 / NADPH-cytochrome P450 reductase
 Cytochrome P450, bacteria type
  CYP102 family
   K14338  cypD_E, CYP102A, CYP505; cytochrome P450 / NADPH-cytochrome P450 reductase
Other DBs
RN: R03629 R04121 R05259
COG: COG2124 COG0369
GO: 0070330 0003958
Genes
QSU: 111990039 112011098
NCR: NCU05185
NTE: NEUTE1DRAFT145879(NEUTE1DRAFT_145879)
SMP: SMAC_07143
PAN: PODANSg1328 PODANSg2208 PODANSg3804 PODANSg5780
TTT: THITE_2144773
MTM: MYCTH_101224
MGR: MGG_01925 MGG_05401 MGG_07953 MGG_10879
TMN: UCRPA7_3289
SSCK: SPSK_05863 SPSK_08392
CMT: CCM_02979
MBE: MBM_08168
ANI: AN6835.2
ANG: ANI_1_2654014(An01g06820) ANI_1_396144(An16g02820) ANI_1_622054(An06g02530)
ABE: ARB_05231
TVE: TRV_02270
ZTR: MYCGRDRAFT_100796(CYP-40) MYCGRDRAFT_70343(CYP-50)
HIR: HETIRDRAFT_124013(cpr1)
PCT: PC1_0268
RPI: Rpic_4258
REH: H16_B1009(h16_B1009)
CNC: CNE_2c09660(cypE)
RME: Rmet_3467
BCEO: I35_5939
BCED: DM42_5902
BCON: NL30_31780
BPSL: WS57_03680
BJA: blr2882
BRS: S23_51340
BRAD: BF49_1812
RPB: RPB_3645
RPD: RPD_1820
VGO: GJW-30_1_03917(cypE)
ELI: ELI_00100
BSU: BSU07250(yetO) BSU27160(cypB)
BSH: BSU6051_07250(yetO) BSU6051_27160(cypB)
BSUT: BSUB_00799(yetO) BSUB_02898(cypB)
BSUL: BSUA_00799(yetO) BSUA_02898(cypB)
BSS: BSUW23_03690(cypD) BSUW23_13125(cypB)
BSQ: B657_07250(cypD) B657_27160(cypB)
BSX: C663_0751(cypD) C663_2550(cypE)
BLI: BL02398(cypE)
BLD: BLi02848(yrhJ)
BLH: BaLi_c29470(cypB)
BAQ: BACAU_0708(yetO) BACAU_2438(yrhJ)
BYA: BANAU_0661(yetO) BANAU_2583(yrhJ)
BAML: BAM5036_0659(cypD) BAM5036_2365(cypB)
BAMA: RBAU_0722(cypD) RBAU_2563(cypB)
BAMN: BASU_0699(cypD) BASU_2369(cypB)
BAMB: BAPNAU_0670(YetO) BAPNAU_1137(yrhJ)
BAMY: V529_06850(yetO) V529_27090(yrhJ)
BAO: BAMF_0695(yetO) BAMF_2522(cypB)
BAZ: BAMTA208_03280(yetO) BAMTA208_13325(cypB)
BQL: LL3_00745(yetO) LL3_02800(yrhJ)
BXH: BAXH7_00690(yetO) BAXH7_02724(yrhJ)
BQY: MUS_0726(yetO) MUS_2901(yrhJ)
BAN: BA_3221(cypD)
BAR: GBAA_3221(cypD)
BAT: BAS2993
BAH: BAMEG_1392(cypD)
BAI: BAA_3269(cypD)
BANT: A16_32460
BANR: A16R_32890
BANS: BAPAT_3089
BANV: DJ46_1971(cyp102A1)
BCE: BC3211
BCA: BCE_3239(cypD)
BCR: BCAH187_A3250(cypD)
BCB: BCB4264_A3231(cypD)
BCU: BCAH820_3229(cypD)
BCG: BCG9842_B2016(cypD)
BCQ: BCQ_3034(cypD)
BCX: BCA_3251(cypD)
BNC: BCN_3047
BCF: bcf_15685
BCER: BCK_18985
BTL: BALH_2868
BTB: BMB171_C2898(cypD)
BTT: HD73_2783
BTHI: BTK_13800
BTC: CT43_CH3164(cypD)
BTM: MC28_2359
BTG: BTB_c32980(cypD)
BTI: BTG_03315
BTW: BF38_4372(cyp102A1)
BWW: bwei_1841(cypD)
BMYC: DJ92_5480(cyp102A1)
BTRO: FJR70_03215(cypD)
BPU: BPUM_1680
BPUM: BW16_09260
BPUS: UP12_08650
BMQ: BMQ_3237
BMD: BMD_3248
BMH: BMWSH_1945(cypD)
BMEG: BG04_163(cYP102a1)
BACW: QR42_08590
BACL: BS34A_08250(yetO) BS34A_29630(cypB)
BEO: BEH_16435
BGY: BGLY_3163
PPO: PPM_3514(M1_3883)
PPOL: X809_33460
PPQ: PPSQR21_035110(cysJ)
PPOY: RE92_19680
PMS: KNP414_03453(cypD)
PMW: B2K_06870
PSWU: SY83_13600
ASOC: CB4_02158(cypE)
MCHE: BB28_22565
MSTE: MSTE_04573
MMIN: MMIN_05950
MHIB: MHIB_23090
SMA: SAVERM_575(cyp2)
SCB: SCAB_5931
SCT: SCAT_4838(CYP102A)
SHY: SHJG_8055
SDV: BN159_1745(cypD)
SALU: DC74_6871
SALL: SAZ_35695
STRE: GZL_01897
SLD: T261_1104
STRM: M444_30060
SLE: sle_05650(sle_05650)
SALJ: SMD11_0205(cypD_E)
SRO: Sros_6421
SEN: SACE_4205(cypD)
PDX: Psed_5892
PSEE: FRP1_10540
KAL: KALB_657
HAU: Haur_2522
DGO: DGo_PB0521(cypD)
SACI: Sinac_6636
PBOR: BSF38_00176(cypB)
SGN: SGRA_1002
 » show all
Reference
PMID:9141694
  Authors
Yamamoto H, Uchiyama S, Nugroho FA, Sekiguchi J
  Title
A 23.4 kb segment at the 69 degrees-70 degrees region of the Bacillus subtilis genome.
  Journal
Microbiology 143 ( Pt 4):1317-20 (1997)
DOI:10.1099/00221287-143-4-1317
  Sequence
[bsu:BSU07250]
Reference
  Authors
Gustafsson MC, Roitel O, Marshall KR, Noble MA, Chapman SK, Pessegueiro A, Fulco AJ, Cheesman MR, von Wachenfeldt C, Munro AW
  Title
Expression, purification, and characterization of Bacillus subtilis cytochromes P450 CYP102A2 and CYP102A3: flavocytochrome homologues of P450 BM3 from Bacillus megaterium.
  Journal
Biochemistry 43:5474-87 (2004)
DOI:10.1021/bi035904m
Reference
  Authors
Kitazume T, Tanaka A, Takaya N, Nakamura A, Matsuyama S, Suzuki T, Shoun H
  Title
Kinetic analysis of hydroxylation of saturated fatty acids by recombinant P450foxy produced by an Escherichia coli expression system.
  Journal
Eur J Biochem 269:2075-82 (2002)
DOI:10.1046/j.1432-1033.2002.02855.x
  Sequence
LinkDB

KEGG   ENZYME: 1.14.14.1
Entry
EC 1.14.14.1                Enzyme                                 

Name
unspecific monooxygenase;
microsomal monooxygenase;
xenobiotic monooxygenase;
aryl-4-monooxygenase;
aryl hydrocarbon hydroxylase;
microsomal P-450;
flavoprotein-linked monooxygenase;
flavoprotein monooxygenase;
substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
substrate,NADPH---hemoprotein reductase:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
Reaction(IUBMB)
RH + [reduced NADPH---hemoprotein reductase] + O2 = ROH + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R04122]
Reaction(KEGG)
Substrate
RH [CPD:C01371];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
ROH [CPD:C01335];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A group of P-450 heme-thiolate proteins, acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups. Together with EC 1.6.2.4, NADPH---hemoprotein reductase, it forms a system in which two reducing equivalents are supplied by NADPH. Some of the reactions attributed to EC 1.14.15.3, alkane 1-monooxygenase, belong here.
History
EC 1.14.14.1 created 1961 as EC 1.99.1.1, transferred 1965 to EC 1.14.1.1, transferred 1972 to EC 1.14.14.1 (EC 1.14.14.2 created 1972, incorporated 1976, EC 1.14.99.8 created 1972, incorporated 1984), modified 2015
Pathway
ec00071  Fatty acid degradation
ec00140  Steroid hormone biosynthesis
ec00232  Caffeine metabolism
ec00380  Tryptophan metabolism
ec00590  Arachidonic acid metabolism
ec00591  Linoleic acid metabolism
ec00627  Aminobenzoate degradation
ec00830  Retinol metabolism
ec00980  Metabolism of xenobiotics by cytochrome P450
ec00982  Drug metabolism - cytochrome P450
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K00490  cytochrome P450 family 4 subfamily F
K07408  cytochrome P450 family 1 subfamily A polypeptide 1
K07409  cytochrome P450 family 1 subfamily A polypeptide 2
K07410  cytochrome P450 family 1 subfamily B polypeptide 1
K07411  cytochrome P450 family 2 subfamily A
K07412  cytochrome P450 family 2 subfamily B
K07413  cytochrome P450 family 2 subfamily C
K07414  cytochrome P450 family 2 subfamily D
K07416  cytochrome P450 family 2 subfamily F
K07418  cytochrome P450 family 2 subfamily J
K07420  cytochrome P450 family 2 subfamily S polypeptide 1
K07424  cytochrome P450 family 3 subfamily A
K07426  cytochrome P450 family 4 subfamily B polypeptide 1
K07428  cytochrome P450 family 4 subfamily X
K07429  cytochrome P450 family 4 subfamily Z
K14338  cytochrome P450 / NADPH-cytochrome P450 reductase
K17684  cytochrome P450 family 2 subfamily A polypeptide 7
K17685  cytochrome P450 family 2 subfamily A polypeptide 13
K17690  cytochrome P450 family 3 subfamily A polypeptide 5
K17691  cytochrome P450 family 3 subfamily A polypeptide 7
K17692  cytochrome P450 family 3 subfamily A polypeptide 43
K17712  cytochrome P450 family 2 subfamily D polypeptide 6
K17718  cytochrome P450 family 2 subfamily C polypeptide 8
K17720  cytochrome P450 family 2 subfamily C polypeptide 18
K17728  cytochrome P450 family 4 subfamily F polypeptide 8
K17729  cytochrome P450 family 4 subfamily F polypeptide 11
K17730  cytochrome P450 family 4 subfamily F polypeptide 12
Genes
HSA: 100861540(CYP3A7-CYP3A51P) 107987478 107987479(CYP2D6) 11283(CYP4F8) 1543(CYP1A1) 1544(CYP1A2) 1545(CYP1B1) 1549(CYP2A7) 1551(CYP3A7) 1553(CYP2A13) 1558(CYP2C8) 1562(CYP2C18) 1564(CYP2D7) 1565(CYP2D6) 1572(CYP2F1) 1573(CYP2J2) 1577(CYP3A5) 1580(CYP4B1) 199974(CYP4Z1) 260293(CYP4X1) 29785(CYP2S1) 57834(CYP4F11) 64816(CYP3A43) 66002(CYP4F12)
PTR: 100614519 100616514(CYP4F11) 101058187 107966456 112206755 450909(CYP2C8) 453744(CYP1A1) 456557(CYP4B1) 456833(CYP4X1) 456834 456896(CYP2J2) 459163(CYP1B1) 468754(CYP4F12) 470228(CYP2D6) 472456(CYP3A43) 735881(CYP1A2) 737263(CYP3A7) 737374(CYP3A5) 738883 739649(CYP2S1) 748442(CYP4F8)
PPS: 100967379 100967578 100969491 100970184 100972566 100974522 100975837 100975985 100976184 100976333 100978561 100979109 100979695 100982833 100983164 100984148 100988273(CYP2D6) 100989599 100994607 100995728 103785103 103785155
GGO: 101126416 101127173 101127384 101127998 101129522 101130358 101134278 101139245 101141065 101142890 101147001 101147010 101147362 101148349 101151604 101152395 101152766 101153230 109025371 115931944 115936030
PON: 100172192(CYP1B1) 100172368(CYP1A2) 100173089(CYP4F12) 100174280(CYP4F11) 100434899 100435763 100436403 100437391 100441499 100442601 100444727 100446370 100447634 100447840 100449185 100452833 100453198 100455064 100456680 100457153 100458527 100458875 100459240
NLE: 100579248 100580051 100580500 100580825 100582281 100583040 100585507 100586622 100589053 100591599 100592711 100593273 100593769 100602226 100606221 100606376 105737754 115830387 115830830
MCC: 100144394(CYP3A7) 100424240(CYP2C76) 100424795 100424965 114674219 678683(CYP2C8) 678686(CYP2C75) 678690(CYP2A23) 678691(CYP2D6) 678692(CYP3A5) 678694(CYP1A1) 678696(CYP2F1) 693631 701855(CYP2C18) 702239 702954(CYP2A26) 705884 709290 709535 709770(CYP3A43) 710385(CYP1B1) 718335(CYP4F8) 718379(CYP4F12) 719353 722086
MCF: 102114994(CYP2C76) 102117212(CYP2C20) 102119662(CYP2J2) 102121341(CYP2A26) 102123758(CYP2A23) 102123985 102125382 102125467 102125667 102129994(CYP1A1) 102130053 102130662(CYP1A2) 102131739(CYP4F12) 102135027(CYP4F11) 102140079(CYP2D44) 102143092(CYP2D17) 102143277 102143360(CYP3A43) 102145015(CYP) 102145601(CYP2C18) 102146134(CYP3A5) 102146810 107126471
CSAB: 103216300(CYP2C18) 103216303(CYP2C8) 103220462(CYP1B1) 103223410 103223412 103224719(CYP2J2) 103224873(CYP4X1) 103224875(CYP4Z1) 103224876(CYP4B1) 103234078 103234083 103234090 103234718 103234724 103235509 103235510 103235511 103245329(CYP1A2) 103245331(CYP1A1) 103246765(CYP3A43) 103246770(CYP3A5) 103246772(CYP3A7)
RRO: 104661011 104661013 104662102 104662104 104664669 104664684 104665592 104668045 104670080 104670158 104672095 104672151 104672152 104673586 104676091 104676095 104676097 104676180 104676181 104680972
CJC: 100385343(CYP2D19) 100389345(CYP2C18) 100390915(CYP2C8) 100391987(CYP2C76) 100392712(CYP1A2) 100393083(CYP1A1) 100395270(CYP1B1) 100397287(CYP2J2) 100398692 100399054(CYP2A6) 100404344(CYP3A4) 100404952(CYP3A5) 100405792(CYP3A90) 100406326(CYP2S1) 100411508(CYP4F12) 100411868(CYP4F11) 100413208(CYP4B1) 100413928(CYP4X1) 100415600(CYP2D8) 100415609(CYP4Z1)
MMU: 100041375(Cyp3a41b) 100066(Cyp2j11) 106648(Cyp4f15) 107141(Cyp2c50) 13076(Cyp1a1) 13077(Cyp1a2) 13078(Cyp1b1) 13085(Cyp2a12) 13086(Cyp2a4) 13087(Cyp2a5) 13088(Cyp2b10) 13089(Cyp2b13) 13090(Cyp2b19) 13094(Cyp2b9) 13095(Cyp2c29) 13096(Cyp2c37) 13097(Cyp2c38) 13098(Cyp2c39) 13099(Cyp2c40) 13101(Cyp2d10) 13105(Cyp2d9) 13107(Cyp2f2) 13109(Cyp2j5) 13110(Cyp2j6) 13112(Cyp3a11) 13113(Cyp3a13) 13114(Cyp3a16) 13120(Cyp4b1) 208285(Cyp4f17) 223706(Cyp2d34) 226105(Cyp2c70) 226143(Cyp2c23) 230459(Cyp2j13) 242546(Cyp2j12) 243881(Cyp2b23) 320997(Cyp4f39) 337924(Cyp3a44) 380997(Cyp2d12) 404195(Cyp2c54) 433247(Cyp2c68) 53973(Cyp3a41a) 545123(Cyp2d11) 56388(Cyp3a25) 56448(Cyp2d22) 631304(Cyp4f40) 665095(Cyp2j8) 677156(Cyp4f37) 69888(Cyp2c66) 70101(Cyp4f16) 71754(Cyp2d40) 72082(Cyp2c55) 72303(Cyp2c65) 74134(Cyp2s1) 74519(Cyp2j9) 76279(Cyp2d26) 81906(Cyp4x1)
RNO: 100910127 100910877 100912642 103691072(CYP2B15) 103691092 108348266 170509(Cyp3a62) 171352(Cyp3a9) 171518(Cyp2c22) 171521(Cyp2c13) 171522(Cyp2d4) 24296(Cyp1a1) 24297(Cyp1a2) 24299(Cyp2a3) 24300(Cyp2b1) 24303(Cyp2d3) 24307(Cyp4b1) 246767(Cyp4x1) 24894(Cyp2a1) 24895(Cyp2a2) 25011(Cyp2c12) 25053(Cyp2d2) 252931(Cyp3a18) 25426(Cyp1b1) 25642(Cyp3a23/3a1) 266682(Cyp3a2) 266684(Cyp2d1) 286904(Cyp4f4) 286905(Cyp4f5) 286953(Cyp2b3) 286963(Cyp2d5) 292728(Cyp2b21) 29277(Cyp2c11) 29295(Cyp2b12) 29298(Cyp2c7) 293989(Cyp2c6v1) 299566(Cyp4f39) 308445(Cyp2s1) 313373(Cyp2j10) 313375(Cyp2j3) 361523(Cyp2b2) 499353(Cyp2c24) 500801(Cyp4f17) 502969(Cyp2j16) 503122(Cyp4f40) 54246(Cyp2f4) 65210(Cyp2j4) 685222(Cyp2b15) 83790(Cyp2c23)
OCU: 100008805(CYP4B1) 100301544(CYP2J1) 100316858(CYP2D24) 100327257(CYP2B4) 100328549(CYP2C5) 100328596(CYP2A11) 100328598(CYP2A10) 100328613(CYP1A1) 100328924(CYP2C2) 100328933(CYP2C) 100328935(CYP2C30) 100328936(CYP2C14) 100328937(CYP1A2) 100328938(CYP2C16) 100328947(CYP2B5) 100328948 100328954(CYP3A6) 100338914 100345193 100346743(CYP2C1) 100349436(CYP2C4) 100353317 100353460 100353574 100353821 100358590 103351405
CFA: 100686778(CYP1A1) 100688697 415120(CYP2D15) 415122(CYP2C18) 415127(CYP3A26) 415129(CYP3A12) 474177(CYP2B6) 482505(CYP4X1) 483038(CYP1B1) 484491(CYP2S1) 484493(CYP2A7) 484494(CYP2A13) 489851 494010(CYP1A2) 608452(CYP4B1) 610195(CYP2J2) 612477
BTA: 100847677 282211(CYP2D14) 282214(CYP3A5) 282870(CYP1A1) 503552(CYP1A2) 504769(CYP2B6) 507988(CYP3A4) 511470(CYP1B1) 511498 511936 514971(CYP2S1) 517246(CYP3A24) 526682(CYP3A5) 530571 530929 535243(CYP2C18) 540149(CYP4B1) 540707 615697 616593(CYP2C87) 785540 785824(MGC127055)
SSC: 100126281(CYP3A46) 100144468(CYP3A22) 100152910(CYP1A2) 100523190 100523909 100524750(CYP2J34) 100524940 100525112 100621407 100625479 100627093 100739741 102165015 106510546 110261221 397687(CYP2D25) 403103(CYP1A1) 403104(CYP2B22) 403106(CYP2C32) 403107(CYP2C33) 403108(CYP2C34) 403110(CYP2C36) 403111(CYP2C42) 403149(CYP2A19) 403215(CYP2C49) 403324(CYP3A29)
GGA: 100858007(RP11-400G3.5) 100859277(CYP4F22) 101750603(CYP2J21) 396051(CYP1A2) 396052(CYP1A1) 414832(CYP3A5) 414833(CYP2C45) 416477(CYP3A4) 417981(CYP2D6) 421466(CYP1B1) 424618(CYP4B7) 424676(CYP2J23) 424677(CYP2J22) 771974(CYP4A22)
XLA: 100036770(cyp2a6.L) 100036771(cyp4b1.2.L) 100036772(cyp4b1.L) 100036775(cyp1a1.L) 100036876(LOC100488227.L) 100037189(cyp3a4) 100337623(cyp1a1.S) 108698626 108699286 108714294 108714295 108714516 108715021 108715777 108715778 108716653(cyp1b1.L) 108717803(cyp1b1.S) 108718493 373549(LOC100487918.L) 379297(cyp2c8.1.S) 379479(cyp2d6-b) 398964 444392 444542(cyp2c8.2.L) 446878(cyp2d6.S) 495363(cyp3a5.L)
XTR: 100037911(cyp1a1) 100145080(cyp4b1) 100145323 100487054 100487846 100487918 100488078 100488227 100488386 100490477(cyp1b1) 100494106 100494419(cyp3a4.2) 100495359 100495518 101731511 116406634 448236(cyp2c8.2) 496407(cyp2a6.9) 496408(cyp2a6.8) 548436(cyp2d6) 548503(cyp3a4.3) 548774(cyp4f2) 550102(cyp4b1.2)
DRE: 100034366(cyp2p8) 100034406(cyp2p7) 100150054(cyp1b1) 140634(cyp1a) 387527(cyp4t8) 553969(cyp3a65) 797309(cyp2j20)
IPU: 100313516(cyp1b) 108258748(CYP3A125) 108258760(cyp3a27) 108258762(CYP3A128) 108258764(CYP3A127) 108264711(cyp1a1) 108269368
OLA: 100125806(cyp1a) 100302452(cyp2p3) 101155406(cyp3a) 101159216 101165838
DMN: 117188691
AME: 727290
HST: 105187605
PGC: 109858307
OBO: 105280474
NVI: 100121599(Cyp303a1)
CSOL: 105360113
MDL: 103580958
TCA: 658783(CYP305A1)
DPA: 109543005
ATD: 109595197
BMOR: 101743283(CYP303A1)
BMAN: 114246377
PMAC: 106717103
PRAP: 111003399
API: 100162206
DNX: 107166593
AGS: 114124824
BTAB: 109029996
OBI: 106870255
EPA: 110232159
CSV: 101207867
CPEP: 111792333
NCR: NCU05185
NTE: NEUTE1DRAFT145879(NEUTE1DRAFT_145879)
MBE: MBM_08168
ANI: AN6835.2
ANG: ANI_1_2654014(An01g06820) ANI_1_396144(An16g02820) ANI_1_622054(An06g02530)
ABE: ARB_05231
TVE: TRV_02270
ZTR: MYCGRDRAFT_100796(CYP-40) MYCGRDRAFT_70343(CYP-50)
ABP: AGABI1DRAFT122003(AGABI1DRAFT_122003) AGABI1DRAFT93343(AGABI1DRAFT_93343)
ABV: AGABI2DRAFT188118(AGABI2DRAFT_188118)
DFA: DFA_07281(CYP513C1) DFA_10184
PCT: PC1_0268
RPI: Rpic_4258
REH: H16_B1009(h16_B1009)
CNC: CNE_2c09660(cypE)
RME: Rmet_3467
BCEO: I35_5939
BCED: DM42_5902
BCON: NL30_31780
BPSL: WS57_03680
BJA: blr2882
BRS: S23_51340
BRAD: BF49_1812
RPB: RPB_3645
RPD: RPD_1820
VGO: GJW-30_1_03917(cypE)
ELI: ELI_00100
BSU: BSU07250(yetO) BSU27160(cypB)
BSH: BSU6051_07250(yetO) BSU6051_27160(cypB)
BSUT: BSUB_00799(yetO) BSUB_02898(cypB)
BSUL: BSUA_00799(yetO) BSUA_02898(cypB)
BSS: BSUW23_03690(cypD) BSUW23_13125(cypB)
BSQ: B657_07250(cypD) B657_27160(cypB)
BSX: C663_0751(cypD) C663_2550(cypE)
BLI: BL02398(cypE)
BLD: BLi02848(yrhJ)
BLH: BaLi_c29470(cypB)
BAQ: BACAU_0708(yetO) BACAU_2438(yrhJ)
BYA: BANAU_0661(yetO) BANAU_2583(yrhJ)
BAML: BAM5036_0659(cypD) BAM5036_2365(cypB)
BAMA: RBAU_0722(cypD) RBAU_2563(cypB)
BAMN: BASU_0699(cypD) BASU_2369(cypB)
BAMB: BAPNAU_0670(YetO) BAPNAU_1137(yrhJ)
BAMY: V529_06850(yetO) V529_27090(yrhJ)
BAO: BAMF_0695(yetO) BAMF_2522(cypB)
BAZ: BAMTA208_03280(yetO) BAMTA208_13325(cypB)
BQL: LL3_00745(yetO) LL3_02800(yrhJ)
BXH: BAXH7_00690(yetO) BAXH7_02724(yrhJ)
BQY: MUS_0726(yetO) MUS_2901(yrhJ)
BAN: BA_3221(cypD)
BAR: GBAA_3221(cypD)
BAT: BAS2993
BAH: BAMEG_1392(cypD)
BAI: BAA_3269(cypD)
BANT: A16_32460
BANR: A16R_32890
BANS: BAPAT_3089
BANV: DJ46_1971(cyp102A1)
BCE: BC3211
BCA: BCE_3239(cypD)
BCR: BCAH187_A3250(cypD)
BCB: BCB4264_A3231(cypD)
BCU: BCAH820_3229(cypD)
BCG: BCG9842_B2016(cypD)
BCQ: BCQ_3034(cypD)
BCX: BCA_3251(cypD)
BNC: BCN_3047
BCF: bcf_15685
BCER: BCK_18985
BTL: BALH_2868
BTB: BMB171_C2898(cypD)
BTT: HD73_2783
BTHI: BTK_13800
BTC: CT43_CH3164(cypD)
BTM: MC28_2359
BTG: BTB_c32980(cypD)
BTI: BTG_03315
BTW: BF38_4372(cyp102A1)
BWW: bwei_1841(cypD)
BMYC: DJ92_5480(cyp102A1)
BTRO: FJR70_03215(cypD)
BPU: BPUM_1680
BPUM: BW16_09260
BPUS: UP12_08650
BMQ: BMQ_3237
BMD: BMD_3248
BMH: BMWSH_1945(cypD)
BMEG: BG04_163(cYP102a1)
BACW: QR42_08590
BACL: BS34A_08250(yetO) BS34A_29630(cypB)
BEO: BEH_16435
BGY: BGLY_3163
PPO: PPM_3514(M1_3883)
PPOL: X809_33460
PPQ: PPSQR21_035110(cysJ)
PPOY: RE92_19680
PMS: KNP414_03453(cypD)
PMW: B2K_06870
PSWU: SY83_13600
ASOC: CB4_02158(cypE)
MCHE: BB28_22565
MSTE: MSTE_04573
MMIN: MMIN_05950
MHIB: MHIB_23090
SMA: SAVERM_575(cyp2)
SCB: SCAB_5931
SCT: SCAT_4838(CYP102A)
SHY: SHJG_8055
SDV: BN159_1745(cypD)
SALU: DC74_6871
SALL: SAZ_35695
STRE: GZL_01897
SLD: T261_1104
STRM: M444_30060
SLE: sle_05650(sle_05650)
SALJ: SMD11_0205(cypD_E)
SRO: Sros_6421
SEN: SACE_4205(cypD)
PDX: Psed_5892
PSEE: FRP1_10540
KAL: KALB_657
HAU: Haur_2522
DGO: DGo_PB0521(cypD)
SACI: Sinac_6636
PBOR: BSF38_00176(cypB)
SGN: SGRA_1002
 » show all
Reference
1  [PMID:13426111]
  Authors
BOOTH J, BOYLAND E.
  Title
The biochemistry of aromatic amines.  III.  Enzymic hydroxylation by rat-liver microsomes.
  Journal
Biochem J 66:73-8 (1957)
DOI:10.1042/bj0660073
Reference
2  [PMID:5132997]
  Authors
Fujita T, Mannering GJ.
  Title
Differences in soluble P-450 hemoproteins from livers of rats treated with phenobarbital and 3-methylcholanthrene.
  Journal
Chem Biol Interact 3:264-5 (1971)
DOI:10.1016/0009-2797(71)90053-6
Reference
3  [PMID:187601]
  Authors
Haugen DA, Coon MJ.
  Title
Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450.
  Journal
J Biol Chem 251:7929-39 (1976)
Reference
4  [PMID:3415241]
  Authors
Imaoka S, Inoue K, Funae Y.
  Title
Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography.
  Journal
Arch Biochem Biophys 265:159-70 (1988)
DOI:10.1016/0003-9861(88)90381-5
Reference
5  [PMID:434823]
  Authors
Johnson EF, Zounes MC, Muller-Eberhard U.
  Title
Characterization of three forms of rabbit microsomal cytochrome P-450 by peptide mapping utilizing limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.
  Journal
Arch Biochem Biophys 192:282-9 (1979)
DOI:10.1016/0003-9861(79)90093-6
Reference
6  [PMID:489601]
  Authors
Kupfer D, Miranda GK, Navarro J, Piccolo DE, Theoharides AD.
  Title
Effect of inducers and inhibitors of monooxygenase on the hydroxylation of prostaglandins in the guinea pig. Evidence for several monooxygenases catalyzing omega- and omega-1-hydroxylation.
  Journal
J Biol Chem 254:10405-14 (1979)
Reference
7  [PMID:7298645]
  Authors
Lang MA, Gielen JE, Nebert DW.
  Title
Genetic evidence for many unique liver microsomal P-450-mediated monooxygenase activities in heterogeneic stock mice.
  Journal
J Biol Chem 256:12068-75 (1981)
Reference
8  [PMID:7298644]
  Authors
Lang MA, Nebert DW.
  Title
Structural gene products of the Ah locus. Evidence for many unique P-450-mediated monooxygenase activities reconstituted from 3-methylcholanthrene-treated C57BL/6N mouse liver microsomes.
  Journal
J Biol Chem 256:12058-67 (1981)
Reference
9  [PMID:2916844]
  Authors
Leo MA, Lasker JM, Raucy JL, Kim CI, Black M, Lieber CS.
  Title
Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8.
  Journal
Arch Biochem Biophys 269:305-12 (1989)
DOI:10.1016/0003-9861(89)90112-4
Reference
10 [PMID:4401153]
  Authors
Lu AY, Kuntzman R, West S, Jacobson M, Conney AH.
  Title
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations.
  Journal
J Biol Chem 247:1727-34 (1972)
Reference
11 [PMID:13314626]
  Authors
MITOMA C, POSNER HS, REITZ HC, UDENFRIEND S.
  Title
Enzymatic hydroxylation of aromatic compounds.
  Journal
Arch Biochem Biophys 61:431-41 (1956)
DOI:10.1016/0003-9861(56)90366-6
Reference
12
  Authors
Mitoma, C. and Udenfriend, S.
  Title
Aryl-4-hydroxylase.
  Journal
Methods Enzymol 5:816-819 (1962)
Reference
13 [PMID:7295706]
  Authors
Napoli JL, Okita RT, Masters BS, Horst RL.
  Title
Identification of 25,26-dihydroxyvitamin D3 as a rat renal 25-hydroxyvitamin D3 metabolite.
  Journal
Biochemistry 20:5865-71 (1981)
DOI:10.1021/bi00523a033
Reference
14 [PMID:4387094]
  Authors
Nebert DW, Gelboin HV.
  Title
Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme.
  Journal
J Biol Chem 243:6242-9 (1968)
Reference
15 [PMID:3264134]
  Authors
Suhara K, Ohashi K, Takahashi K, Katagiri M.
  Title
Aromatase and nonaromatizing 10-demethylase activity of adrenal cortex mitochondrial P-450(11)beta.
  Journal
Arch Biochem Biophys 267:31-7 (1988)
DOI:10.1016/0003-9861(88)90004-5
Reference
16 [PMID:7462235]
  Authors
Theoharides AD, Kupfer D.
  Title
Evidence for different hepatic microsomal monooxygenases catalyzing omega- and (omega-1)-hydroxylations of prostaglandins E1 and E2. Effects of inducers of monooxygenase on the kinetic constants of prostaglandin hydroxylation.
  Journal
J Biol Chem 256:2168-75 (1981)
Reference
17 [PMID:825720]
  Authors
Thomas PE, Lu AY, Ryan D, West SB, Kawalek J, Levin W.
  Title
Immunochemical evidence for six forms of rat liver cytochrome P450 obtained using antibodies against purified rat liver cytochromes P450 and P448.
  Journal
Mol Pharmacol 12:746-58 (1976)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.1
IUBMB Enzyme Nomenclature: 1.14.14.1
ExPASy - ENZYME nomenclature database: 1.14.14.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.14.1
BRENDA, the Enzyme Database: 1.14.14.1
CAS: 9038-14-6
LinkDB

KEGG   REACTION: R04121
Entry
R04121                      Reaction                               

Name
fatty acid,reduced-flaboprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
Definition
[Reduced NADPH---hemoprotein reductase] + Fatty acid + Oxygen <=> alpha-Hydroxy fatty acid + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
Enzyme
Pathway
rn00071  Fatty acid degradation
Orthology
K14338  cytochrome P450 / NADPH-cytochrome P450 reductase [EC:1.14.14.1 1.6.2.4]
LinkDB

DBGET integrated database retrieval system