KEGG   ORTHOLOGY: K14583
Entry
K14583                      KO                                     

Name
nahC
Definition
1,2-dihydroxynaphthalene dioxygenase [EC:1.13.11.56]
Pathway
ko00626  Naphthalene degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00534  Naphthalene degradation, naphthalene => salicylate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00626 Naphthalene degradation
    K14583  nahC; 1,2-dihydroxynaphthalene dioxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.56  1,2-dihydroxynaphthalene dioxygenase
     K14583  nahC; 1,2-dihydroxynaphthalene dioxygenase
Other DBs
RN: R04117
GO: 0018554
Genes
PPI: ND059(nahC)
PSC: A458_06705
PSTU: UIB01_22645
PBM: CL52_14630
PFK: PFAS1_28630
RMN: TK49_07970
BMK: DM80_1447(doxG)
PARB: CJU94_38640
PNA: Pnap_2481
AG: AAA91577(nahC) AAB06725(nsaC)
Reference
  Authors
Peng RH, Xiong AS, Xue Y, Fu XY, Gao F, Zhao W, Tian YS, Yao QH
  Title
Microbial biodegradation of polyaromatic hydrocarbons.
  Journal
FEMS Microbiol Rev 32:927-55 (2008)
DOI:10.1111/j.1574-6976.2008.00127.x
Reference
PMID:2670937
  Authors
Harayama S, Rekik M
  Title
Bacterial aromatic ring-cleavage enzymes are classified into two different gene families.
  Journal
J Biol Chem 264:15328-33 (1989)
  Sequence
LinkDB

KEGG   ENZYME: 1.13.11.56
Entry
EC 1.13.11.56               Enzyme                                 

Name
1,2-dihydroxynaphthalene dioxygenase;
1,2-DHN dioxygenase;
DHNDO;
1,2-dihydroxynaphthalene oxygenase;
1,2-dihydroxynaphthalene:oxygen oxidoreductase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
naphthalene-1,2-diol:oxygen oxidoreductase
Reaction(IUBMB)
naphthalene-1,2-diol + O2 = 2-hydroxy-2H-chromene-2-carboxylate [RN:R04117]
Reaction(KEGG)
R04117
Substrate
naphthalene-1,2-diol [CPD:C03012];
O2 [CPD:C00007]
Product
2-hydroxy-2H-chromene-2-carboxylate [CPD:C06204]
Comment
This enzyme is involved in naphthalene degradation. Requires Fe2+.
History
EC 1.13.11.56 created 2010, modified 2010
Pathway
ec00626  Naphthalene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14583  1,2-dihydroxynaphthalene dioxygenase
Genes
PPI: ND059(nahC)
PSC: A458_06705
PSTU: UIB01_22645
PBM: CL52_14630
PFK: PFAS1_28630
RMN: TK49_07970
BMK: DM80_1447(doxG)
PARB: CJU94_38640
PNA: Pnap_2481
Reference
1  [PMID:2050635]
  Authors
Kuhm AE, Stolz A, Ngai KL, Knackmuss HJ
  Title
Purification and characterization of a 1,2-dihydroxynaphthalene dioxygenase from  a bacterium that degrades naphthalenesulfonic acids.
  Journal
J Bacteriol 173:3795-802 (1991)
DOI:10.1128/JB.173.12.3795-3802.1991
  Sequence
Reference
2  [PMID:16804169]
  Authors
Keck A, Conradt D, Mahler A, Stolz A, Mattes R, Klein J
  Title
Identification and functional analysis of the genes for naphthalenesulfonate catabolism by Sphingomonas xenophaga BN6.
  Journal
Microbiology 152:1929-40 (2006)
DOI:10.1099/mic.0.28783-0
  Sequence
Reference
3  [PMID:7204331]
  Authors
Patel TR, Barnsley EA
  Title
Naphthalene metabolism by pseudomonads: purification and properties of 1,2-dihydroxynaphthalene oxygenase.
  Journal
J Bacteriol 143:668-73 (1980)
DOI:10.1128/JB.143.2.668-673.1980
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.56
IUBMB Enzyme Nomenclature: 1.13.11.56
ExPASy - ENZYME nomenclature database: 1.13.11.56
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.56
BRENDA, the Enzyme Database: 1.13.11.56
LinkDB

KEGG   REACTION: R04117
Entry
R04117                      Reaction                               

Name
naphthalene-1,2-diol:oxygen oxidoreductase
Definition
Naphthalene-1,2-diol + Oxygen <=> 2-Hydroxychromene-2-carboxylate
Equation
Comment
multi-step reaction
Reaction class
RC01081  C03012_C06204
Enzyme
Pathway
rn00626  Naphthalene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00534  Naphthalene degradation, naphthalene => salicylate
Orthology
K14583  1,2-dihydroxynaphthalene dioxygenase [EC:1.13.11.56]
Other DBs
RHEA: 27313
LinkDB

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