KEGG   ORTHOLOGY: K14584
Entry
K14584                      KO                                     

Name
nahD
Definition
2-hydroxychromene-2-carboxylate isomerase [EC:5.99.1.4]
Pathway
ko00626  Naphthalene degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00534  Naphthalene degradation, naphthalene => salicylate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00626 Naphthalene degradation
    K14584  nahD; 2-hydroxychromene-2-carboxylate isomerase
Enzymes [BR:ko01000]
 5. Isomerases
  5.99  Other isomerases
   5.99.1  Sole sub-subclass for isomerases that do not belong in the other subclasses
    5.99.1.4  2-hydroxychromene-2-carboxylate isomerase
     K14584  nahD; 2-hydroxychromene-2-carboxylate isomerase
Other DBs
RN: R05137
GO: 0018845
Genes
PAEU: BN889_06506
PPI: ND062(nahD)
PSC: A458_06695
PSTU: UIB01_22655
PFK: PFAS1_28645
ATN: FM020_04060
ALT: ambt_17880
CYQ: Q91_2218(dsbA2)
CZA: CYCME_2536
CYY: CPC19_01710
BMK: DM80_1450(doxJ)
BFN: OI25_3056(nahD)
PUT: PT7_1103
PNA: Pnap_2478
PLA: Plav_3649
CID: P73_0352
NAR: Saro_3869
AG: AAA66358(nahD) AAD45416(nsaD)
 » show all
Reference
PMID:8002605
  Authors
Eaton RW
  Title
Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid.
  Journal
J Bacteriol 176:7757-62 (1994)
DOI:10.1128/JB.176.24.7757-7762.1994
  Sequence
Reference
  Authors
Peng RH, Xiong AS, Xue Y, Fu XY, Gao F, Zhao W, Tian YS, Yao QH
  Title
Microbial biodegradation of polyaromatic hydrocarbons.
  Journal
FEMS Microbiol Rev 32:927-55 (2008)
DOI:10.1111/j.1574-6976.2008.00127.x
LinkDB

KEGG   ENZYME: 5.99.1.4
Entry
EC 5.99.1.4                 Enzyme                                 

Name
2-hydroxychromene-2-carboxylate isomerase;
HCCA isomerase;
2HC2CA isomerase;
2-hydroxychromene-2-carboxylic acid isomerase
Class
Isomerases;
Other isomerases;
Sole sub-subclass for isomerases that do not belong in the other subclasses
Sysname
2-hydroxy-2H-chromene-2-carboxylate---(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate isomerase
Reaction(IUBMB)
2-hydroxy-2H-chromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate [RN:R05137]
Reaction(KEGG)
R05137
Substrate
2-hydroxy-2H-chromene-2-carboxylate [CPD:C06204]
Product
(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate [CPD:C06203]
Comment
This enzyme is involved in naphthalene degradation.
History
EC 5.99.1.4 created 2010
Pathway
ec00626  Naphthalene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14584  2-hydroxychromene-2-carboxylate isomerase
Genes
PAEU: BN889_06506
PPI: ND062(nahD)
PSC: A458_06695
PSTU: UIB01_22655
PFK: PFAS1_28645
ATN: FM020_04060
ALT: ambt_17880
CYQ: Q91_2218(dsbA2)
CZA: CYCME_2536
CYY: CPC19_01710
BMK: DM80_1450(doxJ)
BFN: OI25_3056(nahD)
PUT: PT7_1103
PNA: Pnap_2478
PLA: Plav_3649
CID: P73_0352
NAR: Saro_3869
 » show all
Reference
1  [PMID:9722670]
  Authors
Ohmoto T, Kinoshita T, Moriyoshi K, Sakai K, Hamada N, Ohe T
  Title
Purification and some properties of 2-hydroxychromene-2-carboxylate isomerase from naphthalenesulfonate-assimilating Pseudomonas sp. TA-2.
  Journal
J Biochem 124:591-7 (1998)
DOI:10.1093/oxfordjournals.jbchem.a022152
Reference
2  [PMID:16804169]
  Authors
Keck A, Conradt D, Mahler A, Stolz A, Mattes R, Klein J
  Title
Identification and functional analysis of the genes for naphthalenesulfonate catabolism by Sphingomonas xenophaga BN6.
  Journal
Microbiology 152:1929-40 (2006)
DOI:10.1099/mic.0.28783-0
  Sequence
Reference
3  [PMID:8002605]
  Authors
Eaton RW
  Title
Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid.
  Journal
J Bacteriol 176:7757-62 (1994)
DOI:10.1128/JB.176.24.7757-7762.1994
  Sequence
Reference
4  [PMID:17508726]
  Authors
Thompson LC, Ladner JE, Codreanu SG, Harp J, Gilliland GL, Armstrong RN
  Title
2-Hydroxychromene-2-carboxylic acid isomerase: a kappa class glutathione transferase from Pseudomonas putida.
  Journal
Biochemistry 46:6710-22 (2007)
DOI:10.1021/bi700356u
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.99.1.4
IUBMB Enzyme Nomenclature: 5.99.1.4
ExPASy - ENZYME nomenclature database: 5.99.1.4
UM-BBD (Biocatalysis/Biodegradation Database): 5.99.1.4
BRENDA, the Enzyme Database: 5.99.1.4
LinkDB

KEGG   REACTION: R05137
Entry
R05137                      Reaction                               

Name
2-hydroxy-2H-chromene-2-carboxylate---(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate isomerase
Definition
trans-o-Hydroxybenzylidenepyruvate <=> 2-Hydroxychromene-2-carboxylate
Equation
Reaction class
RC03084  C06203_C06204
Enzyme
Pathway
rn00626  Naphthalene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00534  Naphthalene degradation, naphthalene => salicylate
Orthology
K14584  2-hydroxychromene-2-carboxylate isomerase [EC:5.99.1.4]
Other DBs
RHEA: 27404
LinkDB

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