KEGG   ORTHOLOGY: K14613
Entry
K14613                      KO                                     

Name
SLC46A1
Definition
MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1
Pathway
ko01523  Antifolate resistance
ko04977  Vitamin digestion and absorption
ko04978  Mineral absorption
Disease
H01252  Hereditary folate malabsorption
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09154 Digestive system
   04977 Vitamin digestion and absorption
    K14613  SLC46A1; MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1
   04978 Mineral absorption
    K14613  SLC46A1; MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K14613  SLC46A1; MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K14613  SLC46A1; MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1
Transporters [BR:ko02000]
 Solute carrier family (SLC)
  SLC46: Folate transporter
   K14613  SLC46A1; MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1
 Major facilitator superfamily (MFS)
  Organic acid transporters
   Proton coupled folate transporter/heme carrier protein (PCFT/HCP) family
    K14613  SLC46A1; MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1
Other DBs
GO: 0008517 0015232
TC: 2.A.1.50.1 2.A.1.50.4
Genes
HSA: 113235(SLC46A1)
PTR: 454527(SLC46A1)
PPS: 100974524(SLC46A1)
GGO: 101124330(SLC46A1)
PON: 100440042(SLC46A1)
NLE: 100599656(SLC46A1)
MCC: 708727(SLC46A1)
MCF: 102128999(SLC46A1)
CSAB: 103242615(SLC46A1)
RRO: 104669366(SLC46A1)
RBB: 108539951(SLC46A1)
CJC: 100411886(SLC46A1)
SBQ: 101045373(SLC46A1)
MMU: 52466(Slc46a1)
MCAL: 110304950(Slc46a1)
MPAH: 110332272(Slc46a1)
RNO: 303333(Slc46a1)
MUN: 110550158(Slc46a1)
CGE: 100757832(Slc46a1)
NGI: 103724487(Slc46a1)
HGL: 101706680(Slc46a1)
CCAN: 109698359(Slc46a1)
OCU: 100009317(SLC46A1)
TUP: 102487532(SLC46A1)
CFA: 491166(SLC46A1)
VVP: 112933156(SLC46A1)
AML: 100468045(SLC46A1)
UMR: 103667230(SLC46A1)
UAH: 113269031(SLC46A1)
ORO: 101384984(SLC46A1)
ELK: 111151331
FCA: 101100096(SLC46A1)
PTG: 102952124(SLC46A1)
PPAD: 109251864(SLC46A1)
AJU: 106983255(SLC46A1)
BTA: 511097(SLC46A1)
BOM: 102275758(SLC46A1)
BIU: 109574229(SLC46A1)
BBUB: 102404458(SLC46A1)
CHX: 102191550(SLC46A1)
OAS: 101119738(SLC46A1)
SSC: 100628018(SLC46A1)
CFR: 102520521(SLC46A1)
CDK: 105088188(SLC46A1)
BACU: 103001026(SLC46A1)
LVE: 103077796(SLC46A1)
OOR: 101277661(SLC46A1)
DLE: 111185669(SLC46A1)
PCAD: 102986690(SLC46A1)
ECB: 100072047(SLC46A1)
EPZ: 103555942(SLC46A1)
EAI: 106844587(SLC46A1)
MYB: 102251643(SLC46A1)
MYD: 102762830(SLC46A1)
MNA: 107528773(SLC46A1)
HAI: 109385141(SLC46A1)
DRO: 112308870(SLC46A1)
PALE: 102893216(SLC46A1)
MJV: 108396944(SLC46A1)
LAV: 100654339(SLC46A1)
TMU: 101355552
MDO: 100024595(SLC46A1)
SHR: 100929844(SLC46A1)
PCW: 110192285(SLC46A1)
OAA: 100075532(SLC46A1)
GGA: 417569(SLC46A1)
MGP: 100543022(SLC46A1)
CJO: 107322471(SLC46A1)
NMEL: 110407579(SLC46A1)
APLA: 101800835(SLC46A1)
ACYG: 106049172(SLC46A1)
TGU: 100230017(SLC46A1)
LSR: 110482008(SLC46A1)
SCAN: 103820284(SLC46A1)
GFR: 102037163(SLC46A1)
FAB: 101822270(SLC46A1)
PHI: 102112748(SLC46A1)
PMAJ: 107212768(SLC46A1)
CCAE: 111937945(SLC46A1)
CCW: 104691199(SLC46A1)
ETL: 114060447(SLC46A1)
FPG: 101917306(SLC46A1)
FCH: 102060198(SLC46A1)
CLV: 102094714(SLC46A1)
EGZ: 104131842(SLC46A1)
NNI: 104012787(SLC46A1)
ACUN: 113487322(SLC46A1)
PADL: 103925576(SLC46A1)
AAM: 106484311(SLC46A1)
ASN: 102369417(SLC46A1)
AMJ: 102576403(SLC46A1)
PSS: 102452880(SLC46A1)
CMY: 102943040(SLC46A1)
CPIC: 101933711(SLC46A1)
ACS: 100564942(slc46a1)
PVT: 110084257(SLC46A1)
PBI: 103059612(SLC46A1)
PMUR: 107300069(SLC46A1)
TSR: 106548100(SLC46A1)
PMUA: 114585598(SLC46A1)
GJA: 107119418(SLC46A1)
XLA: 446819(slc46a1.L)
XTR: 100145771(slc46a1)
NPR: 108785845(SLC46A1)
DRE: 393255(slc46a1)
IPU: 108269442 108278182(slc46a1)
PHYP: 113538590 113539050(slc46a1)
EEE: 113589409(slc46a1)
LCO: 104922850(slc46a1)
NCC: 104966724(slc46a1)
MZE: 101480629(slc46a1)
ONL: 100698370(slc46a1)
OLA: 101170694(slc46a1)
XMA: 102230721(slc46a1)
XCO: 114133394(slc46a1)
PRET: 103474535(slc46a1)
CVG: 107095010(slc46a1)
NFU: 107380390(slc46a1) 107380625
KMR: 108246030(slc46a1)
ALIM: 106515486(slc46a1)
AOCE: 111585157(slc46a1)
CSEM: 103378088(slc46a1)
POV: 109630269(slc46a1)
LCF: 108890377(slc46a1)
SDU: 111224067(slc46a1)
SLAL: 111668114(slc46a1)
HCQ: 109525426(slc46a1)
BPEC: 110154124(slc46a1)
MALB: 109960243(slc46a1)
SASA: 106612857(slc46a1)
OTW: 112267018(slc46a1)
SALP: 111959404(slc46a1)
ELS: 105007880(slc46a1)
SFM: 108932381(slc46a1)
PKI: 111860957(slc46a1)
LCM: 102349580
CMK: 103180585(slc46a1)
RTP: 109921266(slc46a1)
DME: Dmel_CG30344(CG30344) Dmel_CG30345(CG30345)
DSI: Dsimw501_GD10098(Dsim_GD10098) Dsimw501_GD10638(Dsim_GD10638) Dsimw501_GD10640(Dsim_GD10640) Dsimw501_GD16622(Dsim_GD16622)
MDE: 101892378
AME: 727496
BIM: 100746633
BTER: 100648223
CCAL: 108623450
OBB: 114874809
SOC: 105204563
AEC: 105154461
ACEP: 105621066
VEM: 105557970
HST: 105187223
DQU: 106749067
CFO: 105257967
LHU: 105674642
PGC: 109853967
OBO: 105278107
PCF: 106791154
CSOL: 105360766
TCA: 664418
ATD: 109605725
NVL: 108568644
HAW: 110376377
TNL: 113495055
DNX: 107168348
CLEC: 106666493
FCD: 110861134
CBR: CBG04458
BMY: Bm1_12870
OBI: 106873029
SHX: MS3_02421
 » show all
Reference
  Authors
Qiu A, Jansen M, Sakaris A, Min SH, Chattopadhyay S, Tsai E, Sandoval C, Zhao R, Akabas MH, Goldman ID
  Title
Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption.
  Journal
Cell 127:917-28 (2006)
DOI:10.1016/j.cell.2006.09.041
  Sequence
[hsa:113235]
Reference
  Authors
Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y, Yuasa H
  Title
Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.
  Journal
J Pharmacol Exp Ther 322:469-76 (2007)
DOI:10.1124/jpet.107.122606
  Sequence
[hsa:113235]
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