KEGG   ORTHOLOGY: K14630
Entry
K14630                      KO                                     

Name
actVA5
Definition
two-component flavin-dependent monooxygenase [EC:1.14.14.-]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00779  Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14630  actVA5; two-component flavin-dependent monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14630  actVA5; two-component flavin-dependent monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.-  
     K14630  actVA5; two-component flavin-dependent monooxygenase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K14630  actVA5; two-component flavin-dependent monooxygenase
Other DBs
RN: R09313 R09314
Genes
SCO: SCO5080(actVA5)
SDV: BN159_2499
SLV: SLIV_12985
SVT: SVTN_18835
SGD: ELQ87_08030
SCYA: EJ357_29930
TFU: Tfu_1234
FRA: Francci3_4102
FRI: FraEuI1c_1309
AMS: AMIS_50490
CAI: Caci_6489
 » show all
Reference
  Authors
Valton J, Filisetti L, Fontecave M, Niviere V
  Title
A two-component flavin-dependent monooxygenase involved in actinorhodin biosynthesis in Streptomyces coelicolor.
  Journal
J Biol Chem 279:44362-9 (2004)
DOI:10.1074/jbc.M407722200
Reference
  Authors
Valton J, Fontecave M, Douki T, Kendrew SG, Niviere V
  Title
An aromatic hydroxylation reaction catalyzed by a two-component FMN-dependent Monooxygenase. The ActVA-ActVB system from Streptomyces coelicolor.
  Journal
J Biol Chem 281:27-35 (2006)
DOI:10.1074/jbc.M506146200
Reference
  Authors
Ellis HR
  Title
The FMN-dependent two-component monooxygenase systems.
  Journal
Arch Biochem Biophys 497:1-12 (2010)
DOI:10.1016/j.abb.2010.02.007
LinkDB

KEGG   ORTHOLOGY: K14631
Entry
K14631                      KO                                     

Name
actVB
Definition
flavin reductase ActVB [EC:1.5.1.-]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00779  Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14631  actVB; flavin reductase ActVB
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.-  
     K14631  actVB; flavin reductase ActVB
Other DBs
RN: R05705
Genes
BUE: BRPE67_CCDS03520
BUO: BRPE64_CCDS02020
CID: P73_0185
PABY: Ga0080574_TMP226
NOV: TQ38_005245
CVA: CVAR_0219
NNO: NONO_c51280
NOZ: DMB37_03455
NAD: NCTC11293_02475(hsaB_3)
ROP: ROP_46610
SCO: SCO5092(actVB)
SHY: SHJG_7334
SLV: SLIV_12925(actVB)
SRW: TUE45_01562(snaC)
SLE: sle_03080(sle_03080)
STRD: NI25_26845
SALF: SMD44_00656(actVB)
SALJ: SMD11_0681(actVB) SMD11_1393(actVB)
SLX: SLAV_40520(snaC2)
SFK: KY5_7707c
NDK: I601_2566(snaC)
SAQ: Sare_0591
ASE: ACPL_2178(ntaB) ACPL_6076
CAI: Caci_6495
TBI: Tbis_2517
RXY: Rxyl_1781
 » show all
Reference
  Authors
Valton J, Filisetti L, Fontecave M, Niviere V
  Title
A two-component flavin-dependent monooxygenase involved in actinorhodin biosynthesis in Streptomyces coelicolor.
  Journal
J Biol Chem 279:44362-9 (2004)
DOI:10.1074/jbc.M407722200
Reference
  Authors
Valton J, Fontecave M, Douki T, Kendrew SG, Niviere V
  Title
An aromatic hydroxylation reaction catalyzed by a two-component FMN-dependent Monooxygenase. The ActVA-ActVB system from Streptomyces coelicolor.
  Journal
J Biol Chem 281:27-35 (2006)
DOI:10.1074/jbc.M506146200
Reference
  Authors
Ellis HR
  Title
The FMN-dependent two-component monooxygenase systems.
  Journal
Arch Biochem Biophys 497:1-12 (2010)
DOI:10.1016/j.abb.2010.02.007
Reference
  Authors
Filisetti L, Fontecave M, Niviere V
  Title
Mechanism and substrate specificity of the flavin reductase ActVB from Streptomyces coelicolor.
  Journal
J Biol Chem 278:296-303 (2003)
DOI:10.1074/jbc.M209689200
LinkDB

KEGG   ORTHOLOGY: K14632
Entry
K14632                      KO                                     

Name
actVA6
Definition
C-6 monooxygenase
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00779  Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14632  actVA6; C-6 monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14632  actVA6; C-6 monooxygenase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K14632  actVA6; C-6 monooxygenase
Other DBs
RN: R06696
Genes
DUG: HH213_27030
RTM: G4H71_15880
SCO: SCO5081(actVA6)
SLV: SLIV_12980
SCYA: EJ357_29935
SRO: Sros_4752
AOI: AORI_4199
AJA: AJAP_17915
AORI: SD37_21520
CAI: Caci_6490
Reference
PMID:9209048
  Authors
Kendrew SG, Hopwood DA, Marsh EN
  Title
Identification of a monooxygenase from Streptomyces coelicolor A3(2) involved in biosynthesis of actinorhodin: purification and characterization of the recombinant enzyme.
  Journal
J Bacteriol 179:4305-10 (1997)
DOI:10.1128/JB.179.13.4305-4310.1997
Reference
  Authors
Sciara G, Kendrew SG, Miele AE, Marsh NG, Federici L, Malatesta F, Schimperna G, Savino C, Vallone B
  Title
The structure of ActVA-Orf6, a novel type of monooxygenase involved in actinorhodin biosynthesis.
  Journal
EMBO J 22:205-15 (2003)
DOI:10.1093/emboj/cdg031
LinkDB

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