KEGG   ORTHOLOGY: K15015
Entry
K15015                      KO                                     

Name
SLC32A, VGAT
Definition
solute carrier family 32 (vesicular inhibitory amino acid transporter)
Pathway
ko04721  Synaptic vesicle cycle
ko04723  Retrograde endocannabinoid signaling
ko04727  GABAergic synapse
ko05032  Morphine addiction
ko05033  Nicotine addiction
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    K15015  SLC32A, VGAT; solute carrier family 32 (vesicular inhibitory amino acid transporter)
   04723 Retrograde endocannabinoid signaling
    K15015  SLC32A, VGAT; solute carrier family 32 (vesicular inhibitory amino acid transporter)
   04721 Synaptic vesicle cycle
    K15015  SLC32A, VGAT; solute carrier family 32 (vesicular inhibitory amino acid transporter)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    K15015  SLC32A, VGAT; solute carrier family 32 (vesicular inhibitory amino acid transporter)
   05033 Nicotine addiction
    K15015  SLC32A, VGAT; solute carrier family 32 (vesicular inhibitory amino acid transporter)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K15015  SLC32A, VGAT; solute carrier family 32 (vesicular inhibitory amino acid transporter)
Transporters [BR:ko02000]
 Solute carrier family (SLC)
  SLC32: Vesicular inhibitory amino acid transporter
   K15015  SLC32A, VGAT; solute carrier family 32 (vesicular inhibitory amino acid transporter)
Other DBs
GO: 0005276 0005302 0015186 0015188
TC: 2.A.18.5
Genes
HSA: 140679(SLC32A1)
PTR: 469940(SLC32A1)
PPS: 100990783(SLC32A1)
GGO: 101128362(SLC32A1)
PON: 100448409(SLC32A1)
NLE: 100590105(SLC32A1)
MCC: 698315(SLC32A1)
MCF: 102130972(SLC32A1)
CSAB: 103246166(SLC32A1)
RRO: 104655831(SLC32A1)
RBB: 108519810(SLC32A1)
CJC: 100391438(SLC32A1)
SBQ: 101031715(SLC32A1)
MMU: 22348(Slc32a1)
MCAL: 110289801(Slc32a1)
MPAH: 110318258(Slc32a1)
RNO: 83612(Slc32a1)
MUN: 110565877(Slc32a1)
CGE: 100760747(Slc32a1)
NGI: 103747235(Slc32a1)
HGL: 101725145(Slc32a1)
CCAN: 109699856(Slc32a1)
OCU: 100350638(SLC32A1)
TUP: 102501347(SLC32A1)
CFA: 485870(SLC32A1)
VVP: 112928131(SLC32A1)
AML: 100472086(SLC32A1)
UMR: 103669896(SLC32A1)
UAH: 113258598(SLC32A1)
ORO: 101368793(SLC32A1)
ELK: 111141928
FCA: 101096880(SLC32A1)
PTG: 102950064(SLC32A1)
PPAD: 109272452(SLC32A1)
AJU: 106974481(SLC32A1)
BTA: 100301361(SLC32A1)
BOM: 102280205(SLC32A1)
BBUB: 112578712(SLC32A1)
CHX: 102180509(SLC32A1)
OAS: 101105268(SLC32A1)
SSC: 100517013(SLC32A1)
CFR: 102523431(SLC32A1)
CDK: 105085015(SLC32A1)
BACU: 103019095(SLC32A1)
LVE: 103090618(SLC32A1)
OOR: 101279144(SLC32A1)
DLE: 111184183(SLC32A1)
PCAD: 102995853(SLC32A1)
ECB: 100146532(SLC32A1)
EPZ: 103549241(SLC32A1)
EAI: 106835078(SLC32A1)
MYB: 102244823(SLC32A1)
MYD: 102754201(SLC32A1)
MNA: 107542119(SLC32A1)
HAI: 109372140(SLC32A1)
DRO: 112304182(SLC32A1)
PALE: 102894523(SLC32A1)
RAY: 107512578(SLC32A1)
MJV: 108402449(SLC32A1)
LAV: 100653936(SLC32A1)
TMU: 101361059
MDO: 100029278(SLC32A1)
SHR: 100925130(SLC32A1)
PCW: 110211282(SLC32A1)
OAA: 100081840(SLC32A1)
GGA: 100857259 419167(SLC32A1)
MGP: 100545776 104914001(SLC32A1)
CJO: 107311710 107322883(SLC32A1)
NMEL: 110396374 110408262(SLC32A1)
APLA: 101790712(SLC32A1) 101791143
ACYG: 106032488 106043463(SLC32A1)
TGU: 100223745 100223958(SLC32A1)
LSR: 110473168(SLC32A1) 110479693
SCAN: 103818602(SLC32A1) 103821950
GFR: 102033546(SLC32A1) 102040427
FAB: 101806607 101813445(SLC32A1)
PHI: 102100710 102102262(SLC32A1)
PMAJ: 107201343 107213051(SLC32A1)
CCAE: 111927275 111938444(SLC32A1)
CCW: 104687772(SLC32A1) 104693986
ETL: 114055915 114060944(SLC32A1)
FPG: 101911572(SLC32A1)
FCH: 102050868(SLC32A1) 102059268
CLV: 102097640(SLC32A1)
EGZ: 104131157 104132208(SLC32A1)
NNI: 104008904 104013078(SLC32A1)
ACUN: 113477854 113487575(SLC32A1)
PADL: 103912433(SLC32A1) 103918369
AAM: 106491402(SLC32A1) 106497885
ASN: 102380843(SLC32A1) 102383721
AMJ: 102569011 102576603(SLC32A1)
PSS: 102448237(SLC32A1) 102450548
CMY: 102936709(SLC32A1) 102943195
CPIC: 101939180(SLC32A1) 101952873
ACS: 100552943 100553313(slc32a1)
PVT: 110077566 110081601(SLC32A1)
PBI: 103048080(SLC32A1) 103061287
PMUR: 107287707 107291056(SLC32A1)
TSR: 106542571 106549504(SLC32A1)
PMUA: 114599540(SLC32A1)
GJA: 107113852(SLC32A1) 107115140
XLA: 379652(slc32a1.S)
XTR: 448348(slc32a1)
NPR: 108791970(SLC32A1)
DRE: 100002902(si:dkey-126h10.1) 798575(slc32a1)
SANH: 107653135 107682900(slc32a1)
SGH: 107558157(slc32a1) 107564828
CCAR: 109063084
IPU: 108265235(slc32a1) 108272428
PHYP: 113533240 113545820(slc32a1)
AMEX: 103031061(slc32a1) 103045701
PRET: 103457356 103464388(slc32a1) 103468036
CSEM: 103381241 103384503(slc32a1) 103386684
SFM: 108928377(slc32a1) 108928481
PKI: 111835220(slc32a1) 111836137
LCM: 102353815 102364258(SLC32A1)
CMK: 103172063(slc32a1) 103182331
RTP: 109929160(slc32a1)
DME: Dmel_CG8394(VGAT)
DER: 6549212
DSE: 6609104
DSI: Dsimw501_GD15231(Dsim_GD15231)
DAN: 6495745
DSR: 110179282
DPE: 6592247
DWI: 6640331
DAZ: 108616179
DNV: 108653018
DHE: 111599640
DVI: 6626463
MDE: 101896347
LCQ: 111689653
AME: 409089
SOC: 105207723
MPHA: 105833550
AEC: 105144374
ACEP: 105622966
PBAR: 105434070
VEM: 105570457
HST: 105183698
DQU: 106750932
CFO: 105257896
LHU: 105673198
PGC: 109851616
OBO: 105274854
PCF: 106787334
CSOL: 105368649
FCD: 110844345
CEL: CELE_T20G5.6(unc-47) CELE_Y32F6A.4(Y32F6A.4)
CBR: CBG05208 CBG09610 CBG09800(Cbr-unc-47)
TSP: Tsp_04599
LJA: Lj0g3v0174619.1(Lj0g3v0174619.1) Lj0g3v0233549.1(Lj0g3v0233549.1) Lj1g3v2965850.1(Lj1g3v2965850.1) Lj1g3v2965870.1(Lj1g3v2965870.1) Lj1g3v3443960.1(Lj1g3v3443960.1)
DOSA: Os01t0597400-00(Os01g0597400) Os01t0597600-01(Os01g0597600) Os02t0101000-01(Os02g0101000) Os02t0788800-01(Os02g0788800) Os04t0201800-00(Os04g0201800) Os04t0460200-00(Os04g0460200) Os04t0460300-01(Os04g0460300) Os06t0228500-01(Os06g0228500) Os12t0574000-01(Os12g0574000)
ATS: 109732898(LOC109732898) 109733537(LOC109733537) 109734949(LOC109734949) 109734959(LOC109734959) 109739016(LOC109739016) 109739018(LOC109739018) 109746994(LOC109746994) 109753893(LOC109753893) 109753896(LOC109753896) 109753899(LOC109753899) 109758050(LOC109758050) 109767681(LOC109767681) 109779016(LOC109779016)
CRE: CHLREDRAFT_196429(AOT3)
APRO: F751_4126
SCE: YJR001W(AVT1)
ERC: Ecym_8272
KMX: KLMA_20681(AVT1)
NCS: NCAS_0D02870(NCAS0D02870)
NDI: NDAI_0I02030(NDAI0I02030)
TPF: TPHA_0N00770(TPHA0N00770)
TBL: TBLA_0D03110(TBLA0D03110)
TDL: TDEL_0E04090(TDEL0E04090)
KAF: KAFR_0J01200(KAFR0J01200)
CAL: CAALFM_C206330CA(AVT1) CAALFM_C700230WA(CaO19.7100)
CDU: CD36_20720(ScAVT1) CD36_70440
SLB: AWJ20_3776(AVT1)
NCR: NCU06231
NTE: NEUTE1DRAFT81376(NEUTE1DRAFT_81376)
MGR: MGG_08827
SSCK: SPSK_02239
MAJ: MAA_00601
CMT: CCM_05844
BFU: BCIN_03g07440(Bcavt1)
ANI: AN8854.2
ANG: ANI_1_512154(An17g02220)
PNO: SNOG_09432(SNOG_09431)
PTE: PTT_16420
MRR: Moror_118
ABP: AGABI1DRAFT51156(AGABI1DRAFT_51156)
ABV: AGABI2DRAFT114231(AGABI2DRAFT_114231)
MGL: MGL_3604
MRT: MRET_0561
SMIN: v1.2.004152.t1(symbB.v1.2.004152.t1) v1.2.009437.t1(symbB.v1.2.009437.t1) v1.2.009971.t1(symbB.v1.2.009971.t1) v1.2.012882.t1(symbB.v1.2.012882.t1) v1.2.018933.t1(symbB.v1.2.018933.t1) v1.2.029126.t1(symbB.v1.2.029126.t1)
AAF: AURANDRAFT_62192(AOT9)
 » show all
Reference
  Authors
Gasnier B
  Title
The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids.
  Journal
Pflugers Arch 447:756-9 (2004)
DOI:10.1007/s00424-003-1091-2
  Sequence
[hsa:140679]
LinkDB

KEGG   ORTHOLOGY: K08155
Entry
K08155                      KO                                     

Name
SLC18A1_2, VMAT
Definition
MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
Pathway
ko04721  Synaptic vesicle cycle
ko04726  Serotonergic synapse
ko04728  Dopaminergic synapse
ko05012  Parkinson disease
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05034  Alcoholism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
   04726 Serotonergic synapse
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
   04721 Synaptic vesicle cycle
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
  09165 Substance dependence
   05030 Cocaine addiction
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
   05031 Amphetamine addiction
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
   05034 Alcoholism
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
Transporters [BR:ko02000]
 Solute carrier family (SLC)
  SLC18: Vesicular amine transporter
   K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
 Major facilitator superfamily (MFS)
  Drug transporters
   Drug:H+ antiporter-1 (12 spanner) (DHA1) family
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
Other DBs
GO: 0008504
TC: 2.A.1.2.11 2.A.1.2.12 2.A.1.2.29
Genes
HSA: 6570(SLC18A1) 6571(SLC18A2)
PTR: 464032(SLC18A1) 466213(SLC18A2)
PPS: 100967958(SLC18A2) 100986598(SLC18A1)
GGO: 101124622(SLC18A1) 101132348(SLC18A2)
PON: 100444121(SLC18A1) 100447972(SLC18A2)
NLE: 100586312(SLC18A2) 100592997(SLC18A1)
MCC: 701133(SLC18A2) 705489(SLC18A1)
MCF: 102119311(SLC18A2) 102131054(SLC18A1)
CSAB: 103215416(SLC18A1) 103216582(SLC18A2)
RRO: 104672557(SLC18A1) 104682306(SLC18A2)
RBB: 108529152(SLC18A2) 108532608(SLC18A1)
CJC: 100395730(SLC18A2) 100405909(SLC18A1)
SBQ: 101044005(SLC18A2) 101050367(SLC18A1)
MMU: 110877(Slc18a1) 214084(Slc18a2)
MCAL: 110285258(Slc18a2) 110300754(Slc18a1)
MPAH: 110333946(Slc18a2) 110336763(Slc18a1)
RNO: 25549(Slc18a2) 25693(Slc18a1)
MUN: 110552258(Slc18a2) 110557633(Slc18a1)
CGE: 100755842(Slc18a1) 100774860(Slc18a2)
NGI: 103729298(Slc18a2) 103747655(Slc18a1)
HGL: 101703356(Slc18a1) 101725597(Slc18a2)
CCAN: 109700669(Slc18a2)
OCU: 100340936(SLC18A1) 100351780(SLC18A2)
TUP: 102492742(SLC18A1) 102494965(SLC18A2)
CFA: 486138(SLC18A1) 486908(SLC18A2)
VVP: 112916463(SLC18A2) 112925441(SLC18A1)
AML: 100463950(SLC18A1) 100473870(SLC18A2)
UMR: 103657567(SLC18A2) 103676704(SLC18A1)
UAH: 113251976(SLC18A2) 113270073(SLC18A1)
ORO: 101379977(SLC18A1) 101381057(SLC18A2)
FCA: 101086507(SLC18A2) 101094843(SLC18A1)
PTG: 102970532(SLC18A2) 102970567(SLC18A1)
PPAD: 109272958(SLC18A2) 109277413(SLC18A1)
AJU: 106971854(SLC18A1) 106974109(SLC18A2)
BTA: 282471(SLC18A2) 617708(SLC18A1)
BOM: 102271632(SLC18A2) 102274678
BIU: 109562706(SLC18A1) 109579167(SLC18A2)
BBUB: 102408717(SLC18A2) 102409259(SLC18A1)
CHX: 102187453(SLC18A2) 102190515(SLC18A1)
OAS: 101104796(SLC18A2) 101121491(SLC18A1)
SSC: 100154435(SLC18A1) 100154950(SLC18A2)
CFR: 102523059(SLC18A1) 102523925(SLC18A2)
CDK: 105095097(SLC18A2) 105102901(SLC18A1)
BACU: 103000979(SLC18A2) 103003968(SLC18A1)
LVE: 103075046(SLC18A2) 103084206(SLC18A1)
OOR: 101279274(SLC18A2) 101285599(SLC18A1)
DLE: 111168991(SLC18A1) 111172270(SLC18A2)
PCAD: 102978728(SLC18A1) 102994134(SLC18A2)
ECB: 100055485(SLC18A1) 100058805(SLC18A2)
EPZ: 103554413(SLC18A2) 103561143(SLC18A1)
EAI: 106831222(SLC18A1) 106836377(SLC18A2)
MYB: 102246774(SLC18A1)
MYD: 102757123(SLC18A1) 102764776(SLC18A2)
MNA: 107535441(SLC18A1) 107536429(SLC18A2)
HAI: 109382401(SLC18A1) 109383017(SLC18A2)
DRO: 112300293(SLC18A2) 112305205(SLC18A1)
PALE: 102892885(SLC18A1) 102896474(SLC18A2)
RAY: 107503755(SLC18A1) 107509743(SLC18A2)
MJV: 108383434(SLC18A2) 108384238(SLC18A1)
LAV: 100667118(SLC18A1) 100668348(SLC18A2)
MDO: 100020699(SLC18A2) 100033069(SLC18A1)
SHR: 100916325(SLC18A2) 100933876(SLC18A1)
PCW: 110196419(SLC18A1) 110209553(SLC18A2)
OAA: 100073866(SLC18A1) 100081376(SLC18A2)
GGA: 423921(SLC18A2) 431330(SLC18A1)
CJO: 107316210(SLC18A2) 107323772(SLC18A1)
NMEL: 110387020(SLC18A1) 110400070(SLC18A2)
APLA: 101802757(SLC18A2) 101805341(SLC18A1)
ACYG: 106044367(SLC18A1) 106045203(SLC18A2)
TGU: 100228266(SLC18A2)
LSR: 110478521(SLC18A2)
SCAN: 103813802(SLC18A2) 103824520
GFR: 102034248(SLC18A2)
FAB: 101814308(SLC18A1) 101816900(SLC18A2)
PHI: 102100715(SLC18A2) 102113147(SLC18A1)
PMAJ: 107206905(SLC18A2) 107213830(SLC18A1)
CCAE: 111931348(SLC18A2) 111938761(SLC18A1)
CCW: 104694889(SLC18A1) 104694947(SLC18A2)
ETL: 114064382(SLC18A1) 114069973(SLC18A2)
FPG: 101917215(SLC18A1) 101917491(SLC18A2)
FCH: 102049236(SLC18A1) 102059762(SLC18A2)
CLV: 102096441(SLC18A2) 102097425(SLC18A1)
EGZ: 104127841(SLC18A1) 104128609(SLC18A2)
NNI: 104016044(SLC18A1) 104022351(SLC18A2)
ACUN: 113481785(SLC18A2) 113488101(SLC18A1)
PADL: 103912381(SLC18A1) 103918556(SLC18A2)
AAM: 106489486(SLC18A2) 106498832(SLC18A1)
ASN: 102368779(SLC18A2) 102377559(SLC18A1)
AMJ: 102565966(SLC18A2) 102575216(SLC18A1)
PSS: 102458866(SLC18A2) 102464018(SLC18A1)
CMY: 102933350(SLC18A1) 102940972(SLC18A2)
CPIC: 101931537(SLC18A1) 101932022(SLC18A2)
ACS: 100555086(slc18a1) 100555672(slc18a2)
PVT: 110071993(SLC18A2) 110089340
PBI: 103057330(SLC18A2) 103062718(SLC18A1)
PMUR: 107286798(SLC18A2) 107297451(SLC18A1)
TSR: 106556071(SLC18A1)
PMUA: 114585851(SLC18A1) 114597448(SLC18A2)
GJA: 107110450(SLC18A2) 107115370(SLC18A1)
NPR: 108795038(SLC18A1)
DRE: 553304(slc18a2) 571483(slc18a1)
IPU: 108265875(slc18a1) 108270156(slc18a2)
PHYP: 113544961(slc18a2) 113546107(slc18a1)
AMEX: 103028146(slc18a1) 103032219
EEE: 113586455(slc18a2) 113590243(slc18a1)
TRU: 101066290(slc18a1) 101069336(slc18a2)
LCO: 104929391(slc18a2)
NCC: 104957734(slc18a2)
MZE: 101478189(slc18a1) 101481739(slc18a2)
ONL: 100699691(slc18a2) 100703472(slc18a1)
OLA: 101158793(slc18a2) 101172172(slc18a1)
XMA: 102230760(slc18a1) 102236350(slc18a2)
XCO: 114137716(slc18a2) 114144799(slc18a1)
PRET: 103470757(slc18a1) 103476537(slc18a2)
CVG: 107095083(slc18a2) 107097909
NFU: 107375486(slc18a2) 107386158
KMR: 108239127(slc18a2) 108241525
ALIM: 106513871(slc18a2) 106527823
AOCE: 111579962 111586787(slc18a2)
CSEM: 103376790 103387791(slc18a2) 103398054(slc18a1)
POV: 109631469(slc18a2)
LCF: 108875429(slc18a1) 108884808(slc18a2)
SDU: 111236433(slc18a2) 111236962(slc18a1)
SLAL: 111646053(slc18a1) 111672959(slc18a2)
HCQ: 109523233(slc18a2)
BPEC: 110171919(slc18a2) 110173987
MALB: 109957424(slc18a1) 109960073(slc18a2)
SASA: 106576939 106587027 106606532(slc18a2)
ELS: 105014047(slc18a1) 105023227(slc18a2)
SFM: 108940370(slc18a1) 108942709(slc18a2)
PKI: 111839782(slc18a2) 111857492(slc18a1)
LCM: 102351318(SLC18A2)
CMK: 103185206(slc18a2)
SKO: 100367975
DME: Dmel_CG10251(prt) Dmel_CG33528(Vmat)
DSI: Dsimw501_GD18364(Dsim_GD18364) Dsimw501_GD25754(Dsim_GD25754)
HAW: 110380111
CEL: CELE_W01C8.6(cat-1)
CBR: CBG14734(Cbr-cat-1)
BMY: Bm1_40865
TSP: Tsp_06252
SHX: MS3_00673
EGL: EGR_02979
ADF: 107337828
AMIL: 114962503
PDAM: 113686527
SPIS: 111324422
BMYC: DJ92_4764
BFD: NCTC4823_00502(tetA_1)
PPO: PPM_1213(M1_1438)
CGV: CGLAU_03610(tetA1)
PAUS: NCTC13651_02180(tetA_2)
RCI: RRC10
 » show all
Reference
  Authors
Eiden LE, Schafer MK, Weihe E, Schutz B
  Title
The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine.
  Journal
Pflugers Arch 447:636-40 (2004)
DOI:10.1007/s00424-003-1100-5
Reference
  Authors
Gasnier B
  Title
The loading of neurotransmitters into synaptic vesicles.
  Journal
Biochimie 82:327-37 (2000)
DOI:10.1016/S0300-9084(00)00221-2
Reference
PMID:8643547
  Authors
Erickson JD, Schafer MK, Bonner TI, Eiden LE, Weihe E
  Title
Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.
  Journal
Proc Natl Acad Sci U S A 93:5166-71 (1996)
DOI:10.1073/pnas.93.10.5166
  Sequence
[hsa:6570]
LinkDB

KEGG   ORTHOLOGY: K14636
Entry
K14636                      KO                                     

Name
SLC18A3, VACHT
Definition
MFS transporter, DHA1 family, solute carrier family 18 (vesicular acetylcholine transporter), member 3
Pathway
ko04721  Synaptic vesicle cycle
ko04725  Cholinergic synapse
Disease
H00770  Congenital myasthenic syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09156 Nervous system
   04725 Cholinergic synapse
    K14636  SLC18A3, VACHT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular acetylcholine transporter), member 3
   04721 Synaptic vesicle cycle
    K14636  SLC18A3, VACHT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular acetylcholine transporter), member 3
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K14636  SLC18A3, VACHT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular acetylcholine transporter), member 3
Transporters [BR:ko02000]
 Solute carrier family (SLC)
  SLC18: Vesicular amine transporter
   K14636  SLC18A3, VACHT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular acetylcholine transporter), member 3
 Major facilitator superfamily (MFS)
  Drug transporters
   Drug:H+ antiporter-1 (12 spanner) (DHA1) family
    K14636  SLC18A3, VACHT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular acetylcholine transporter), member 3
Other DBs
GO: 0005277
TC: 2.A.1.2.28
Genes
HSA: 6572(SLC18A3)
PTR: 466071(SLC18A3)
PPS: 100977293(SLC18A3)
GGO: 101129932(SLC18A3)
PON: 100443171(SLC18A3)
NLE: 100585211(SLC18A3)
MCC: 710053(SLC18A3)
MCF: 102147099(SLC18A3)
CSAB: 103215828(SLC18A3)
RRO: 104677711(SLC18A3)
RBB: 108525235 108537795(SLC18A3)
CJC: 100385857(SLC18A3)
SBQ: 101043767(SLC18A3)
MMU: 20508(Slc18a3)
MCAL: 110309906(Slc18a3)
MPAH: 110325358(Slc18a3)
RNO: 60422(Slc18a3)
MUN: 110561616(Slc18a3) 110561620
CGE: 100770013(Slc18a3)
NGI: 103735014(Slc18a3)
HGL: 101711570(Slc18a3)
CCAN: 109683981(Slc18a3)
OCU: 100346044(SLC18A3)
TUP: 102491448(SLC18A3)
CFA: 486774(SLC18A3)
VVP: 112917461(SLC18A3)
AML: 100473979(SLC18A3)
UMR: 103668060(SLC18A3)
UAH: 113243063(SLC18A3)
ORO: 101377232(SLC18A3)
ELK: 111145430
FCA: 101096265(SLC18A3)
PTG: 102972167(SLC18A3)
PPAD: 109264565(SLC18A3)
AJU: 106989677(SLC18A3)
BTA: 785833(SLC18A3)
BOM: 102279860(SLC18A3)
BIU: 109553705(SLC18A3)
BBUB: 102405514(SLC18A3)
CHX: 102191210(SLC18A3)
OAS: 105605099(SLC18A3)
SSC: 100157804(SLC18A3)
CFR: 102516553(SLC18A3)
CDK: 105093439(SLC18A3)
BACU: 103017928(SLC18A3)
LVE: 103089984(SLC18A3)
OOR: 101289142(SLC18A3)
DLE: 111169912(SLC18A3)
PCAD: 102997035(SLC18A3)
ECB: 102151059(SLC18A3)
EPZ: 103552169(SLC18A3)
EAI: 106824263(SLC18A3)
MYD: 102773600(SLC18A3)
MNA: 107527935(SLC18A3)
HAI: 109389482(SLC18A3)
DRO: 112305409(SLC18A3)
PALE: 102879180(SLC18A3)
RAY: 107508903(SLC18A3)
MJV: 108390138(SLC18A3)
LAV: 100673370(SLC18A3)
TMU: 101341783
MDO: 103092068(SLC18A3)
SHR: 100920172(SLC18A3)
PCW: 110215513(SLC18A3)
OAA: 100091000(SLC18A3)
GGA: 404302(SLC18A3)
MGP: 100544659(SLC18A3)
CJO: 107315574(SLC18A3)
NMEL: 110399555(SLC18A3)
APLA: 101802572(SLC18A3)
ACYG: 106032275(SLC18A3)
TGU: 100226071(SLC18A3)
LSR: 110473540(SLC18A3)
SCAN: 103814217(SLC18A3)
GFR: 102039803(SLC18A3)
FAB: 101810942(SLC18A3)
PHI: 102110958(SLC18A3)
PMAJ: 107206608(SLC18A3)
CCAE: 111942132(SLC18A3)
ETL: 114063573(SLC18A3)
FPG: 101922714(SLC18A3)
FCH: 102047773(SLC18A3)
CLV: 102097921(SLC18A3)
NNI: 104013528(SLC18A3)
PADL: 103925857(SLC18A3)
AAM: 106499849(SLC18A3)
ASN: 102376961(SLC18A3)
AMJ: 102568633(SLC18A3)
PSS: 102449556(SLC18A3)
CMY: 102936071
CPIC: 101946676(SLC18A3)
ACS: 100558687(slc18a3)
PVT: 110080704(SLC18A3)
PBI: 103065278(SLC18A3)
PMUR: 107302240(SLC18A3)
TSR: 106557078(SLC18A3)
PMUA: 114589945 114597119(SLC18A3)
GJA: 107115809(SLC18A3)
XLA: 108696294(slc18a3.L) 108703383(slc18a3.S)
XTR: 780320(slc18a3)
NPR: 108788614(SLC18A3)
DRE: 394082(slc18a3b) 559347(slc18a3a)
AMEX: 103043590 103044616(slc18a3)
EEE: 113581951(slc18a3) 113588412
TRU: 101077087(slc18a3) 105416362
KMR: 108245715(slc18a3a) 108247108(slc18a3b)
ELS: 105009931(slc18a3)
SFM: 108939584(slc18a3)
PKI: 111859566(slc18a3)
LCM: 102365037(SLC18A3)
CMK: 103181720(slc18a3)
RTP: 109926269(slc18a3)
BFO: 118412582
CIN: 445809(vachtp)
SPU: 115917906
APLC: 110984350
SKO: 100369395
DME: Dmel_CG32848(VAChT)
DER: 26526782
DSE: 116801669
DSI: Dsimw501_GD28645(Dsim_GD28645)
DAN: 26513882
DSR: 110186254
DPE: 113566344
DMN: 108157196
DWI: 26529871
DAZ: 108620891
DNV: 108659622
DHE: 111602662
DVI: 6634978
MDE: 101889588
LCQ: 111681467
AAG: 5573369
AALB: 109430731
AME: 725064
BIM: 100747830
BTER: 110120229
CCAL: 108625583
SOC: 105197490
MPHA: 105831894
ACEP: 105623294
VEM: 105569891
HST: 105190826
DQU: 106741915
CFO: 109610054
LHU: 105672718
PGC: 109859135
OBO: 109610998
PCF: 106786481
NVI: 116415675
CSOL: 105368215
MDL: 103580848
TCA: 664399
DPA: 109542854
NVL: 108560935
BMOR: 101742935
BMAN: 114240980
PMAC: 106709856
PRAP: 111000843
HAW: 110378253
PXY: 105387855
DNX: 107162879
AGS: 114122676
BTAB: 109040045
CLEC: 106664035
ZNE: 110832663
FCD: 110862614
TUT: 107366465
DPTE: 113797165
PTEP: 107445054
CEL: CELE_unc-17(unc-17)
CBR: CBG08307
BMY: Bm1_31305
TSP: Tsp_03272
PCAN: 112573918
CRG: 105321957
MYI: 110446985
OBI: 106867713
SHX: MS3_09985
CNB: CNBE2470
TASA: A1Q1_05998
 » show all
Reference
  Authors
Eiden LE, Schafer MK, Weihe E, Schutz B
  Title
The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine.
  Journal
Pflugers Arch 447:636-40 (2004)
DOI:10.1007/s00424-003-1100-5
  Sequence
[hsa:6572]
LinkDB

KEGG   ORTHOLOGY: K12302
Entry
K12302                      KO                                     

Name
SLC17A6_7_8
Definition
MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6/7/8
Pathway
ko04721  Synaptic vesicle cycle
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko05033  Nicotine addiction
Disease
H00604  Deafness, autosomal dominant
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    K12302  SLC17A6_7_8; MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6/7/8
   04723 Retrograde endocannabinoid signaling
    K12302  SLC17A6_7_8; MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6/7/8
   04721 Synaptic vesicle cycle
    K12302  SLC17A6_7_8; MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6/7/8
 09160 Human Diseases
  09165 Substance dependence
   05033 Nicotine addiction
    K12302  SLC17A6_7_8; MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6/7/8
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K12302  SLC17A6_7_8; MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6/7/8
Transporters [BR:ko02000]
 Solute carrier family (SLC)
  SLC17: Vesicular glutamate transporter
   K12302  SLC17A6_7_8; MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6/7/8
 Major facilitator superfamily (MFS)
  Organic acid transporters
   Anion:cation symporter (ACS) family
    K12302  SLC17A6_7_8; MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6/7/8
Other DBs
TC: 2.A.1.14
Genes
HSA: 246213(SLC17A8) 57030(SLC17A7) 57084(SLC17A6)
PTR: 100610704(SLC17A6) 452161(SLC17A8) 456204(SLC17A7)
PPS: 100972690(SLC17A7) 100993099(SLC17A6) 100993589(SLC17A8)
GGO: 101125140(SLC17A6) 101139692(SLC17A7) 101142214(SLC17A8)
PON: 100433325(SLC17A8) 100434103(SLC17A7) 100460788(SLC17A6)
NLE: 100586734(SLC17A8) 100587650(SLC17A6) 100599485(SLC17A7)
MCC: 100425977(SLC17A6) 574349(SLC17A7) 695508(SLC17A8)
MCF: 101867437(SLC17A7) 102143247(SLC17A8) 102143809(SLC17A6)
CSAB: 103235034(SLC17A7) 103238798(SLC17A6) 103238934(SLC17A8)
RRO: 104667075(SLC17A6) 104667191(SLC17A7) 104678322(SLC17A8)
RBB: 108519104(SLC17A6) 108535839(SLC17A7) 108538923(SLC17A8)
CJC: 100406370(SLC17A8) 100410190(SLC17A7) 100412993(SLC17A6)
SBQ: 101029577(SLC17A8) 101031504(SLC17A6) 101053804(SLC17A7)
MMU: 140919(Slc17a6) 216227(Slc17a8) 72961(Slc17a7)
MCAL: 110297910(Slc17a7) 110297939(Slc17a6) 110303590(Slc17a8)
MPAH: 110322538(Slc17a6) 110324671(Slc17a7) 110326645(Slc17a8)
RNO: 116638(Slc17a7) 266767(Slc17a8) 84487(Slc17a6)
MUN: 110546834 110546835 110553662(Slc17a8) 110561295(Slc17a6)
CGE: 100756172(Slc17a7) 100763319(Slc17a8) 100773912(Slc17a6)
NGI: 103734672 103743660(Slc17a7) 103748153(Slc17a6) 103748498(Slc17a8)
HGL: 101697739(Slc17a6) 101701355(Slc17a7) 101716472(Slc17a8)
CCAN: 109680100(Slc17a8) 109683847(Slc17a7) 109699785(Slc17a6)
OCU: 100338809(SLC17A8) 100339044(SLC17A7) 100349381(SLC17A6)
TUP: 102480900(SLC17A8) 102489837(SLC17A7) 102496224(SLC17A6)
CFA: 100316859(SLC17A6) 476415(SLC17A7) 482623(SLC17A8)
VVP: 112930695(SLC17A8) 112931290(SLC17A7) 112934720(SLC17A6)
AML: 100470140(SLC17A8) 100473621(SLC17A7) 100482818(SLC17A6)
UMR: 103657253(SLC17A7) 103659384(SLC17A6) 103676511(SLC17A8)
UAH: 113243303(SLC17A7) 113256102(SLC17A8) 113264907(SLC17A6)
ORO: 101363056(SLC17A6) 101378355(SLC17A8) 101382839(SLC17A7)
FCA: 100216332(SLC17A7) 101096579(SLC17A8) 101098576(SLC17A6)
PTG: 102955175(SLC17A7) 102955225(SLC17A6) 102967613(SLC17A8)
PPAD: 109253064(SLC17A7) 109265395(SLC17A8) 109271257(SLC17A6)
AJU: 106973740(SLC17A8) 106978437(SLC17A6) 106988673(SLC17A7)
BTA: 100125225(SLC17A6) 518849(SLC17A7) 529659(SLC17A8)
BOM: 102274062(SLC17A8) 102274267(SLC17A6) 102275739(SLC17A7)
BIU: 109554210(SLC17A6) 109559427(SLC17A8) 109572101(SLC17A7)
BBUB: 102390711(SLC17A8) 102403879(SLC17A7) 102411760(SLC17A6)
CHX: 102169042(SLC17A7) 102169078(SLC17A8) 102185064(SLC17A6)
OAS: 101104980(SLC17A8) 101111653(SLC17A7) 101112431(SLC17A6)
SSC: 100514772(SLC17A7) 100519886(SLC17A6) 100526221(SLC17A8)
CFR: 102508498(SLC17A8) 102514706(SLC17A6) 102518698(SLC17A7)
CDK: 105095350(SLC17A6) 105097448(SLC17A8) 105100210(SLC17A7)
BACU: 103001035(SLC17A8) 103002238(SLC17A7) 103011040(SLC17A6)
LVE: 103070744(SLC17A6) 103079899(SLC17A8) 103090329(SLC17A7)
OOR: 101276929(SLC17A8) 101278204(SLC17A6) 101280222(SLC17A7)
DLE: 111179833(SLC17A6) 111180625(SLC17A7) 111187899(SLC17A8)
PCAD: 102981216(SLC17A7) 102990352(SLC17A6) 102996059(SLC17A8)
ECB: 100052766(SLC17A8) 100057463(SLC17A6) 100146907(SLC17A7)
EPZ: 103548555(SLC17A8) 103553289(SLC17A7) 103563460(SLC17A6)
EAI: 106827290(SLC17A8) 106831326(SLC17A6) 106838291(SLC17A7)
MYB: 102240489(SLC17A7) 102240999(SLC17A8) 102251226(SLC17A6)
MYD: 102757917(SLC17A8) 102759051(SLC17A6) 102772594(SLC17A7)
MNA: 107528546(SLC17A6) 107531888(SLC17A7) 107545115(SLC17A8)
HAI: 109377016(SLC17A6) 109382331(SLC17A8) 109391121(SLC17A7)
DRO: 112303440(SLC17A6) 112310067(SLC17A7) 112321804(SLC17A8)
PALE: 102882016(SLC17A7) 102892329(SLC17A6) 102896537(SLC17A8)
RAY: 107497930(SLC17A8) 107498877(SLC17A7) 107507389(SLC17A6)
MJV: 108386762(SLC17A6) 108400281(SLC17A7) 108402176(SLC17A8)
LAV: 100657804(SLC17A7) 100662164(SLC17A8) 100669857(SLC17A6)
MDO: 100019451(SLC17A8) 100618682(SLC17A6)
SHR: 100913698(SLC17A8) 100928483(SLC17A6) 100930519(SLC17A7)
PCW: 110205607(SLC17A8) 110218994(SLC17A6) 110220164(SLC17A7)
OAA: 100073458(SLC17A8) 100680547(SLC17A6) 114814644(SLC17A7)
GGA: 422971(SLC17A6) 427877(SLC17A8)
MGP: 100549005(SLC17A6) 100550525(SLC17A8)
CJO: 107307478 107312035(SLC17A8) 107314301(SLC17A6)
NMEL: 110401144(SLC17A6) 110405457(SLC17A8)
APLA: 101790743(SLC17A6) 101801276(SLC17A8)
ACYG: 106033886(SLC17A6) 106036907(SLC17A8)
TGU: 100217699(SLC17A8) 100220715 101233392(SLC17A6)
LSR: 110469624(SLC17A6) 110481419(SLC17A7) 110483084(SLC17A8)
SCAN: 103813380(SLC17A8) 103823614(SLC17A6) 103825389
GFR: 102039648(SLC17A8) 102043979(SLC17A6)
FAB: 101817140(SLC17A6) 101818959(SLC17A8)
PHI: 102103847(SLC17A8) 102105101(SLC17A7) 102109376(SLC17A6)
PMAJ: 107199050(SLC17A7) 107204242(SLC17A8) 107206164(SLC17A6)
CCAE: 111930675(SLC17A6) 111931119(SLC17A8) 111943544
CCW: 104696418(SLC17A8) 104697684(SLC17A6)
ETL: 114058430(SLC17A8) 114066959(SLC17A6)
FPG: 101912066(SLC17A8) 101913043(SLC17A6)
FCH: 102046163(SLC17A8) 102054249(SLC17A6)
CLV: 102090096(SLC17A8) 102093241(SLC17A6)
EGZ: 104132314(SLC17A8) 104135656(SLC17A6)
NNI: 104009417(SLC17A6) 104011664(SLC17A8)
ACUN: 113481240(SLC17A6) 113491095(SLC17A8)
PADL: 103914656(SLC17A8) 103925761(SLC17A6)
AAM: 106488473(SLC17A8) 106498155(SLC17A6)
ASN: 102372812(SLC17A8) 102384583(SLC17A6) 102385717(SLC17A7)
AMJ: 102559658(SLC17A6) 102566487(SLC17A7) 102571822(SLC17A8)
PSS: 102447404(SLC17A7) 102453003(SLC17A8) 102462708(SLC17A6)
CMY: 102930595(SLC17A8) 102944551(SLC17A6) 102947352
CPIC: 101932824(SLC17A8) 101937650(SLC17A6) 101949900(SLC17A7)
ACS: 100555413(slc17a8) 100560537(slc17a7) 100564428(slc17a6)
PVT: 110078586(SLC17A7) 110084197(SLC17A8) 110085411(SLC17A6)
PBI: 103055684(SLC17A7) 103063128 103068174(SLC17A6)
PMUR: 107282459(SLC17A7) 107289404(SLC17A8) 107294094(SLC17A6) 107296476
TSR: 106538691(SLC17A7) 106552493(SLC17A6) 106555955(SLC17A8)
PMUA: 114582342(SLC17A7) 114597072(SLC17A6) 114605498(SLC17A8)
GJA: 107110443(SLC17A6) 107116607(SLC17A7) 107121819(SLC17A8)
XLA: 108711007 108713213 108713448 108715292 398748(slc17a7.L) 432152(slc17a8.L)
XTR: 100489470(slc17a8) 101730310(slc17a6) 780064(slc17a7)
NPR: 108787162(SLC17A8) 108792274(SLC17A6) 108797019
DRE: 100149756(slc17a6b) 100331980(slc17a7b) 494492(slc17a6a) 563467(slc17a8) 795293(slc17a7a)
IPU: 108259138 108260804 108261301(slc17a7) 108263983(slc17a8) 108274505(slc17a6)
KMR: 108228822(slc17a6b) 108230014(slc17a6a) 108237059 108239927(slc17a8) 108242916(slc17a7a)
PKI: 111836498(slc17a6) 111836807(slc17a7) 111842429
LCM: 102353796(SLC17A7) 102356463(SLC17A8) 102365380(SLC17A6)
CMK: 103173615 103174995(slc17a6) 103179921(slc17a8)
RTP: 109935159(slc17a6)
CIN: 100169904(vglut)
SPU: 581383
APLC: 110975478
SKO: 100377394
DME: Dmel_CG9887(VGlut)
DER: 6541698
DSE: 6613096
DSI: Dsimw501_GD23154(Dsim_GD23154)
DAN: 6498316
DSR: 110184946
DPE: 6596478
DMN: 108164163
DWI: 6641602
DNV: 108649929
DVI: 6627356
LCQ: 111683149
AAG: 5572657
AALB: 109401721
CCAL: 108629912
OBB: 114877522
MPHA: 105830989
AEC: 105152563
ACEP: 105625530
PBAR: 105429696
VEM: 105561907
HST: 105183414
DQU: 106749001
CFO: 105251400
LHU: 105673316
PGC: 109861573
OBO: 105275117
NVL: 108565466
BMOR: 101744894
BMAN: 114244793
PRAP: 110996019
BTAB: 109035056
CLEC: 106663939
ZNE: 110829873
FCD: 110850721
PVM: 113829008
DPTE: 113793560
CEL: CELE_K10G9.1(vglu-2) CELE_T07A5.3(vglu-3) CELE_ZK512.6(eat-4)
CBR: CBG06792(Cbr-eat-4) CBG24614
OBI: 106873512
SPIS: 111335386
HMG: 100202735
 » show all
Reference
  Authors
Takamori S, Malherbe P, Broger C, Jahn R
  Title
Molecular cloning and functional characterization of human vesicular glutamate transporter 3.
  Journal
EMBO Rep 3:798-803 (2002)
DOI:10.1093/embo-reports/kvf159
  Sequence
[hsa:246213]
Reference
  Authors
Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J
  Title
Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter.
  Journal
J Neurochem 74:2622-5 (2000)
DOI:10.1046/j.1471-4159.2000.0742622.x
  Sequence
[hsa:57030 57084]
Reference
  Authors
Takamori S
  Title
VGLUTs: 'exciting' times for glutamatergic research?
  Journal
Neurosci Res 55:343-51 (2006)
DOI:10.1016/j.neures.2006.04.016
Reference
  Authors
Santos MS, Li H, Voglmaier SM
  Title
Synaptic vesicle protein trafficking at the glutamate synapse.
  Journal
Neuroscience 158:189-203 (2009)
DOI:10.1016/j.neuroscience.2008.03.029
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