KEGG ORTHOLOGY: K15184

ORTHOLOGY: K15184

Entry

K15184                      KO

Symbol

AFF1

Name

AF4/FMR2 family member 1

Pathway

map05202

Transcriptional misregulation in cancer

Disease

H00001

B-cell acute lymphoblastic leukemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K15184  AFF1; AF4/FMR2 family member 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery
    K15184  AFF1; AF4/FMR2 family member 1
Transcription machinery [BR:ko03021]
Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Super elongation complex (SEC)
     K15184  AFF1; AF4/FMR2 family member 1

Genes

HSA:	4299(AFF1)

PTR:	461362(AFF1)

PPS:	100986387(AFF1)

GGO:	101129648(AFF1)

PON:	100460235(AFF1)

NLE:	100604892(AFF1)

HMH:	116462312(AFF1)

MCC:	700733(AFF1)

MCF:	102127513(AFF1)

MTHB:

126954677

MNI:	105479662(AFF1)

CSAB:

103235927(AFF1)

CATY:

105576768(AFF1)

PANU:

101009853(AFF1)

TGE:	112624496(AFF1)

MLEU:

105547240(AFF1)

RRO:	104677962(AFF1)

RBB:	108520619(AFF1)

TFN:	117085347(AFF1)

PTEH:

111530870(AFF1)

CANG:

105518708(AFF1)

CJC:	100387576(AFF1)

SBQ:	101050392(AFF1)

CIMI:

108315645(AFF1)

CSYR:

103257134

MMUR:

105858338

LCAT:

123627299(AFF1)

PCOQ:

105812702(AFF1)

OGA:	100961632(AFF1)

MMU:	17355(Aff1)

MCAL:

110294174(Aff1)

MPAH:

110330552(Aff1)

RNO:	305152(Aff1)

MCOC:

116067990(Aff1)

ANU:	117699943(Aff1)

MUN:	110561182(Aff1)

CGE:	100751914(Aff1)

MAUA:

101842801(Aff1)

PROB:

127232162(Aff1)

PLEU:

114691781(Aff1)

MORG:

121440931(Aff1) 121464524

MFOT:

126496186 126499987 126509753

AAMP:

119809482 119810323(Aff1)

NGI:	103748967(Aff1)

HGL:	101719249(Aff1)

CPOC:

100716638(Aff1)

CCAN:

109699383(Aff1)

DORD:

105995931(Aff1)

DSP:	122097795(Aff1)

PLOP:

125364832(Aff1)

NCAR:

124994368

MMMA:

107153609(Aff1)

OCU:

100352431

OPI:	101524970(AFF1)

TUP:	102473626(AFF1)

GVR:	103600828(AFF1)

CFA:	100683405(AFF1)

CLUD:

112645833(AFF1)

VVP:	112919671(AFF1)

VLG:	121493244(AFF1)

NPO:	129501795(AFF1)

AML:	100482315(AFF1)

UMR:	103676970(AFF1)

UAH:	113263175(AFF1)

UAR:	123788194(AFF1)

ELK:

111153808

LLV:

125093144

MPUF:

101679180(AFF1)

MNP:	132001165(AFF1)

MLK:	131830923(AFF1)

NVS:	122889442(AFF1)

ORO:	101385833(AFF1)

EJU:	114203028 114203032

ZCA:	113925539(AFF1)

MLX:	118010358(AFF1)

NSU:	110591394(AFF1)

LWW:	102729471(AFF1)

FCA:	101099959(AFF1)

PYU:	121032933(AFF1)

PCOO:

112858768(AFF1)

PBG:	122478685(AFF1)

PVIV:

125164313(AFF1)

LRUF:

124520808

PTG:	102962294(AFF1)

PPAD:

109276267(AFF1)

PUC:

125922899

AJU:

106970736

HHV:	120244175(AFF1)

BTA:	781149(AFF1)

BOM:	102276209(AFF1)

BIU:	109560656(AFF1)

BBUB:

102399437(AFF1)

BBIS:

104984144(AFF1)

CHX:	102185996(AFF1)

OAS:	101111967(AFF1)

BTAX:

128049414(AFF1)

ODA:	120861544(AFF1)

CCAD:

122428279(AFF1)

MBEZ:

129561595(AFF1)

SSC:	100739621(AFF1)

CFR:	102513615(AFF1)

CBAI:

105077739(AFF1)

CDK:

105091585

VPC:	102539381(AFF1)

BACU:

103004875(AFF1)

BMUS:

118895476(AFF1)

LVE:	103081984(AFF1)

OOR:	101269758(AFF1)

DLE:	111168096(AFF1)

PCAD:

102982098(AFF1)

PSIU:

116753900(AFF1)

NASI:

112412505(AFF1)

ECB:	100062821(AFF1)

EPZ:	103561614(AFF1)

EAI:	106828861(AFF1)

MYB:	102260820(AFF1)

MYD:	102769006(AFF1)

MMYO:

118671169(AFF1)

MLF:	102439608(AFF1)

PKL:	118727003(AFF1)

EFUS:

103287985(AFF1)

MNA:	107537135(AFF1)

DRO:	112317662(AFF1)

SHON:

118976177(AFF1)

AJM:	119039610(AFF1)

PDIC:

114493197(AFF1)

PHAS:

123806677(AFF1)

MMF:	118629140(AFF1)

PPAM:

129085373(AFF1)

HAI:	109396335(AFF1)

RFQ:	117022189(AFF1)

PALE:

102883711(AFF1)

PGIG:

120588292(AFF1)

PVP:	105289580(AFF1)

RAY:	107518921(AFF1)

MJV:	108384255(AFF1)

TOD:	119260173(AFF1)

SARA:

101547607(AFF1)

LAV:	100675867(AFF1)

TMU:

101353116

ETF:	101646985(AFF1)

DNM:

101411392

MDO:	100017144(AFF1)

GAS:	123252221(AFF1)

SHR:	100925988(AFF1)

AFZ:

127541162

PCW:	110209704(AFF1)

OAA:	100085607(AFF1)

GGA:	422590(AFF1)

PCOC:

116231095(AFF1)

MGP:	100540587(AFF1)

CJO:	107313389(AFF1)

TPAI:

128080632(AFF1)

LMUT:

125692649(AFF1)

NMEL:

110398550(AFF1)

APLA:

101793143(AFF1)

ACYG:

106041871(AFF1)

CATA:

118248364(AFF1)

AFUL:

116488724(AFF1)

TGU:	100226441(AFF1)

LSR:	110480897(AFF1)

SCAN:

103826067(AFF1)

PMOA:

120502711(AFF1)

OTC:	121339811(AFF1)

PRUF:

121365216(AFF1)

GFR:	102043450(AFF1)

FAB:	101808336(AFF1)

OMA:	130252197(AFF1)

PHI:	102104833(AFF1)

PMAJ:

107203074(AFF1)

CCAE:

111928825(AFF1)

CCW:	104697229(AFF1)

CBRC:

103622410(AFF1)

ETL:	114059153(AFF1)

ZAB:	102070706 113459109(AFF1)

ACHL:

103806219(AFF1)

SVG:	106855697(AFF1)

MMEA:

130581508(AFF1)

HRT:	120752613(AFF1)

FPG:	101920038(AFF1)

FCH:	102056004(AFF1)

CLV:	102085365(AFF1)

EGZ:	104128550(AFF1)

NNI:	104019822(AFF1)

PCRI:

104028284(AFF1)

PLET:

104627095(AFF1)

EHS:	104512894(AFF1)

PCAO:

104049639(AFF1)

ACUN:

113479575

TALA:

104365360(AFF1)

AFOR:

103899711(AFF1)

ACHC:

115346121(AFF1)

HALD:

104315486(AFF1)

HLE:	104829903(AFF1)

AGEN:

126044884

GCL:

127015435

CCRI:

104159566(AFF1)

CSTI:

104563224(AFF1)

CMAC:

104481132(AFF1)

BREG:

104632977(AFF1)

FGA:	104077494(AFF1)

GSTE:

104261830(AFF1)

LDI:	104352927(AFF1)

MNB:	103780012(AFF1)

OHA:	104331783(AFF1)

NNT:	104401895(AFF1)

SHAB:

115610870(AFF1)

ACAR:

104530923(AFF1)

CPEA:

104385376(AFF1)

AVIT:

104271102(AFF1)

RTD:	128910550(AFF1)

CUCA:

104058079(AFF1)

TEO:	104374380(AFF1)

AAM:	106496661(AFF1)

AROW:

112967354(AFF1)

NPD:	112948940(AFF1)

TGT:	104580950(AFF1)

DNE:	112984714(AFF1)

SCAM:

104145153(AFF1)

ASN:	102376518(AFF1)

AMJ:	102560688(AFF1)

CPOO:

109322025(AFF1)

GGN:	109303769(AFF1)

PSS:	102459614(AFF1)

CMY:	102936838(AFF1)

CCAY:

125635877(AFF1)

DCC:	119854392(AFF1)

CPIC:

101934683(AFF1)

TST:	117877576(AFF1)

CABI:

116836552(AFF1)

MRV:	120406275(AFF1)

ACS:	100566940(aff1)

ASAO:

132777022(AFF1)

PVT:	110085321(AFF1)

SUND:

121931999(AFF1)

PBI:	103048503(AFF1)

PMUR:

107293599(AFF1)

CTIG:

120316043(AFF1)

TSR:	106550739(AFF1)

PGUT:

117678931(AFF1)

APRI:

131203540(AFF1)

PTEX:

113434850(AFF1)

NSS:	113425687(AFF1)

VKO:	123022512(AFF1)

PMUA:

114603985(AFF1)

PRAF:

128421394(AFF1)

ZVI:	118083448(AFF1)

HCG:	128326942(AFF1)

GJA:	107113248(AFF1)

STOW:

125439639

EMC:	129336471(AFF1)

XLA:	108711465(aff1.L)

XTR:	100497189(aff1)

NPR:	108804453(AFF1)

RTEM:

120915870(AFF1)

BBUF:

120989709(AFF1)

BGAR:

122944971(AFF1)

MUO:	115461065(AFF1)

GSH:	117368980(AFF1)

IPU:	108279014(aff1)

IFU:	128621983(aff1)

PHYP:

113535523

SMEO:

124398442(aff1)

TFD:	113650413(aff1)

TVC:	132859684(aff1)

AMEX:

103045661(aff4)

CMAO:

118820718

EEE:

113586284

TRU:

101077779

TFS:	130517768(aff1)

TNG:	GSTEN00014441G001

LCO:

104926472

NCC:

104954544

TBEN:

117476307(aff1)

CGOB:

115016535

PGEO:

117455947

GACU:

117551265(aff1)

EMAC:

134868406(aff1)

ELY:	117269809(aff1)

EFO:	125905495(aff1)

PLEP:

121959555(aff1)

SLUC:

116062826(aff1)

ECRA:

117959108(aff1)

ESP:

116704212

PFLV:

114570922

GAT:	120831817(aff1)

PPUG:

119226238(aff1)

AFB:	129102363(aff1)

CLUM:

117740285(aff1)

PSWI:

130205096

MSAM:

119914383

SCHU:

122865811(aff1)

CUD:	121525036(aff1)

ALAT:

119029996(aff1)

MZE:

101464123

ONL:

100699586

OAU:	116331727(aff1)

OLA:

101169625

OML:	112163005(aff1)

XMA:

102220674

XCO:

114149052

XHE:

116724258

PRET:

103473488(aff1)

PFOR:

103142781

PLAI:

106959059

PMEI:

106917992(aff1)

GAF:	122846855(aff1)

PPRL:

129374208(aff1)

CVG:	107085831(aff1)

CTUL:

119776534(aff1)

GMU:	124872745(aff1)

NFU:	107374724(aff1)

KMR:	108231075(aff1)

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

POV:

SSEN:

122758058(aff1)

HHIP:

117771832(aff1)

HSP:	118125552(aff1)

SMAU:

118284569(aff1)

LCF:

108874046

SDU:

111239873

SLAL:

111656821

XGL:	120806082(aff1)

HCQ:

SBIA:

PEE:

PTAO:

MALB:

BSPL:

114867429(aff1)

SJO:	128380360(aff1)

SASA:

106560682 106568507

STRU:

115149491(aff1) 115159074

OTW:	112219622 112259488

OMY:	110523980 110536914

OGO:	123999414 124047659

ONE:	115106032 115127956

OKI:	109877937 109893611

OKE:	118387814 118391635

SALP:

111961219 111980068

SNH:	120025650 120044852

CCLU:

121573394 121582740

ELS:	105007529(aff1)

SFM:

108936227

PKI:

111852596

AANG:

118212831(aff1)

LOC:	102693993(aff1)

PSPA:

121301515 121316180

ARUT:

117400839 117409413

LCM:	102361211(AFF1)

CMK:

103180863

CPLA:

122552813

HOC:

132816400

LERI:

129699821(aff1)

HAZT:

108680616

VJA:

111271343

» show all

Reference

PMID:24367103

Authors

Lu H, Li Z, Xue Y, Schulze-Gahmen U, Johnson JR, Krogan NJ, Alber T, Zhou Q

Title

AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation.

Journal

Proc Natl Acad Sci U S A 111:E15-24 (2014)
DOI:10.1073/pnas.1318503111

Sequence

[hsa:4299]

LinkDB

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