KEGG   ORTHOLOGY: K15184
Entry
K15184                      KO                                     

Name
AFF1
Definition
AF4/FMR2 family member 1
Pathway
ko05202  Transcriptional misregulation in cancer
Disease
H00001  B-cell acute lymphoblastic leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K15184  AFF1; AF4/FMR2 family member 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery
    K15184  AFF1; AF4/FMR2 family member 1
Transcription machinery [BR:ko03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Super elongation complex (SEC)
     K15184  AFF1; AF4/FMR2 family member 1
Genes
HSA: 4299(AFF1)
PTR: 461362(AFF1)
PPS: 100986387(AFF1)
GGO: 101129648(AFF1)
PON: 100460235(AFF1)
NLE: 100604892(AFF1)
MCC: 700733(AFF1)
MCF: 102127513(AFF1)
CSAB: 103235927(AFF1)
RRO: 104677962(AFF1)
RBB: 108520619(AFF1)
CJC: 100387576(AFF1)
SBQ: 101050392(AFF1)
MMU: 17355(Aff1)
MCAL: 110294174(Aff1)
MPAH: 110330552(Aff1)
RNO: 305152(Aff1)
MUN: 110561182(Aff1)
CGE: 100751914(Aff1)
NGI: 103748967(Aff1)
HGL: 101719249(Aff1)
CCAN: 109699383(Aff1)
OCU: 100352431(AFF1)
TUP: 102473626(AFF1)
CFA: 100683405(AFF1)
VVP: 112919671(AFF1)
AML: 100482315(AFF1)
UMR: 103676970(AFF1)
UAH: 113263175(AFF1)
ORO: 101385833(AFF1)
ELK: 111153808
FCA: 101099959(AFF1)
PTG: 102962294(AFF1)
PPAD: 109276267(AFF1)
AJU: 106970736(AFF1)
BTA: 781149(AFF1)
BOM: 102276209(AFF1)
BIU: 109560656(AFF1)
BBUB: 102399437(AFF1)
CHX: 102185996(AFF1)
OAS: 101111967(AFF1)
SSC: 100739621(AFF1)
CFR: 102513615(AFF1)
CDK: 105091585
BACU: 103004875(AFF1)
LVE: 103081984(AFF1)
OOR: 101269758(AFF1)
DLE: 111168096(AFF1)
PCAD: 102982098(AFF1)
ECB: 100062821(AFF1)
EPZ: 103561614(AFF1)
EAI: 106828861
MYB: 102260820(AFF1)
MYD: 102769006(AFF1)
MNA: 107537135(AFF1)
HAI: 109396335(AFF1)
DRO: 112317662(AFF1)
PALE: 102883711(AFF1)
RAY: 107518921(AFF1)
MJV: 108384255(AFF1)
LAV: 100675867(AFF1)
TMU: 101353116
MDO: 100017144(AFF1)
SHR: 100925988(AFF1)
PCW: 110209704(AFF1)
OAA: 100085607(AFF1)
GGA: 422590(AFF1)
MGP: 100540587(AFF1)
CJO: 107313389(AFF1)
NMEL: 110398550(AFF1)
APLA: 101793143(AFF1)
ACYG: 106041871(AFF1)
TGU: 100226441(AFF1)
LSR: 110480897(AFF1)
SCAN: 103826067(AFF1)
GFR: 102043450(AFF1)
FAB: 101808336(AFF1)
PHI: 102104833(AFF1)
PMAJ: 107203074(AFF1)
CCAE: 111928825(AFF1)
CCW: 104697229
ETL: 114059153(AFF1)
FPG: 101920038(AFF1)
FCH: 102056004(AFF1)
CLV: 102085365(AFF1)
EGZ: 104128550(AFF1)
NNI: 104019822(AFF1)
ACUN: 113479575
AAM: 106496661(AFF1)
ASN: 102376518(AFF1)
AMJ: 102560688(AFF1)
PSS: 102459614(AFF1)
CMY: 102936838(AFF1)
CPIC: 101934683(AFF1)
ACS: 100566940(aff1)
PVT: 110085321(AFF1)
PBI: 103048503(AFF1)
PMUR: 107293599(AFF1)
TSR: 106550739(AFF1)
PMUA: 114603985(AFF1)
GJA: 107113248(AFF1)
XLA: 108704103 108711465(aff1.L)
XTR: 100497189(aff1)
NPR: 108804453(AFF1)
IPU: 108279014
PHYP: 113535523
AMEX: 103045661(aff4)
EEE: 113586284
TRU: 101077779
LCO: 104926472
NCC: 104954544
MZE: 101464123
ONL: 100699586
OLA: 101169625
XMA: 102220674
XCO: 114149052
PRET: 103473488(aff1)
NFU: 107374724(aff1)
KMR: 108231075
ALIM: 106516227
AOCE: 111575643
CSEM: 103390398
POV: 109626481
LCF: 108874046
SDU: 111239873
SLAL: 111656821
HCQ: 109525171
MALB: 109972358
ELS: 105007529(aff1)
SFM: 108936227
PKI: 111852596
LCM: 102361211(AFF1)
CMK: 103180863(aff1)
RTP: 109918418
 » show all
Reference
  Authors
Lu H, Li Z, Xue Y, Schulze-Gahmen U, Johnson JR, Krogan NJ, Alber T, Zhou Q
  Title
AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation.
  Journal
Proc Natl Acad Sci U S A 111:E15-24 (2014)
DOI:10.1073/pnas.1318503111
  Sequence
[hsa:4299]
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