KEGG   ORTHOLOGY: K15309
Entry
K15309                      KO                                     

Name
CRTC1, TORC1
Definition
CREB-regulated transcription coactivator 1
Pathway
ko05166  Human T-cell leukemia virus 1 infection
Disease
H01508  Salivary gland cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K15309  CRTC1, TORC1; CREB-regulated transcription coactivator 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K15309  CRTC1, TORC1; CREB-regulated transcription coactivator 1
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Coactivators
    K15309  CRTC1, TORC1; CREB-regulated transcription coactivator 1
Genes
HSA: 23373(CRTC1)
PTR: 735806(CRTC1)
PPS: 100968822(CRTC1)
GGO: 101151673(CRTC1)
PON: 100446802(CRTC1)
NLE: 100581987(CRTC1)
MCC: 720274(CRTC1)
MCF: 102125583(CRTC1)
CSAB: 103234193(CRTC1)
RRO: 104680676(CRTC1)
RBB: 108515626(CRTC1)
CJC: 100385682(CRTC1)
SBQ: 101036511(CRTC1) 101038725
MMU: 382056(Crtc1)
MCAL: 110300532(Crtc1)
MPAH: 110336689(Crtc1)
RNO: 684527(Crtc1)
MUN: 110549173(Crtc1)
CGE: 100766676(Crtc1)
NGI: 103726938(Crtc1)
HGL: 101702435(Crtc1)
CCAN: 109694650(Crtc1)
OCU: 103347054(CRTC1)
TUP: 102500132(CRTC1)
CFA: 100684638(CRTC1)
VVP: 112913076(CRTC1)
AML: 100479645(CRTC1)
UMR: 103675152(CRTC1)
UAH: 113256729(CRTC1)
ORO: 101379339(CRTC1)
ELK: 111144042
FCA: 101095803(CRTC1)
PTG: 102971521(CRTC1)
PPAD: 109247640(CRTC1)
AJU: 106969138(CRTC1)
BTA: 510465(CRTC1)
BOM: 102270306(CRTC1)
BIU: 109561394(CRTC1)
BBUB: 102402466(CRTC1)
CHX: 106502271(CRTC1)
OAS: 101108130(CRTC1)
SSC: 100523662(CRTC1)
CFR: 102511971(CRTC1)
CDK: 105101911(CRTC1)
BACU: 103004025(CRTC1)
LVE: 103090501(CRTC1)
OOR: 101274445(CRTC1)
DLE: 111166782(CRTC1)
PCAD: 102993436(CRTC1)
ECB: 100071052(CRTC1)
EPZ: 103565072(CRTC1)
EAI: 106846479(CRTC1)
MYB: 102250141(CRTC1)
MYD: 102770653(CRTC1)
MNA: 107535339(CRTC1)
HAI: 109382398(CRTC1)
DRO: 112305214(CRTC1)
PALE: 102885130(CRTC1)
RAY: 107503720(CRTC1)
MJV: 108406008(CRTC1)
LAV: 100667887(CRTC1)
TMU: 101348456
MDO: 100012734(CRTC1)
SHR: 100934324(CRTC1)
PCW: 110223413(CRTC1)
OAA: 100078229(CRTC1)
GGA: 771015(CRTC1)
MGP: 100548464(CRTC1)
CJO: 107325351(CRTC1)
NMEL: 110388913(CRTC1)
APLA: 101805161(CRTC1)
ACYG: 106047958(CRTC1)
TGU: 100227217(CRTC1)
LSR: 110482832(CRTC1)
SCAN: 103824544(CRTC1)
GFR: 102035257(CRTC1)
FAB: 101810146(CRTC1)
PHI: 102107013(CRTC1)
PMAJ: 107215385(CRTC1)
CCAE: 111940340(CRTC1)
CCW: 104697386(CRTC1)
ETL: 114070020(CRTC1)
FPG: 101924162(CRTC1)
FCH: 102058681(CRTC1)
CLV: 102096009(CRTC1)
EGZ: 104129781(CRTC1)
NNI: 104013691(CRTC1)
ACUN: 113489301(CRTC1)
PADL: 103923283(CRTC1)
AAM: 106496804(CRTC1)
ASN: 102384868(CRTC1)
AMJ: 102576855(CRTC1)
PSS: 102450279(CRTC1)
CMY: 102939031(CRTC1)
CPIC: 101938127(CRTC1)
PVT: 110072669(CRTC1)
PBI: 103067163(CRTC1)
PMUR: 107282870(CRTC1)
TSR: 106539498
PMUA: 114588670(CRTC1)
GJA: 107125776(CRTC1)
XLA: 108706909(crtc1.S) 108713350(crtc1.L) 734879
XTR: 100036611(crtc1)
NPR: 108796351(CRTC1)
DRE: 101886240(crtc1b) 768293(crtc1a)
IPU: 108271387(crtc1)
PHYP: 113536719(crtc1)
AMEX: 103042200(crtc1)
EEE: 113581912(crtc1)
TRU: 101063023 101071758(crtc1)
LCO: 104920414(crtc1) 104921003
NCC: 104959362(crtc1) 104959378
MZE: 101470904(crtc1) 101481701
ONL: 100694462 100705339(crtc1)
OLA: 101160545(crtc1)
XMA: 102216691 102222237(crtc1)
XCO: 114147172 114151491(crtc1)
CVG: 107095129 107099659(crtc1)
NFU: 107392797(crtc1)
KMR: 108234364(crtc1) 108244849
ALIM: 106535321(crtc1)
AOCE: 111566861 111576554(crtc1)
CSEM: 103395649(crtc1) 103395874
POV: 109636684(crtc1) 109637946
LCF: 108881183(crtc1) 108883669
SDU: 111229073 111240391(crtc1)
SLAL: 111670003(crtc1) 111671111
HCQ: 109519076(crtc1)
BPEC: 110167998(crtc1) 110174802
MALB: 109966888(crtc1) 109969312
ELS: 105024335 105029284(crtc1)
SFM: 108930604(crtc1)
PKI: 111860220(crtc1)
LCM: 102365940(CRTC1)
CMK: 103182100(crtc1)
RTP: 109922343
BFO: 118410400
CIN: 100176783
SPU: 578358
APLC: 110987068
SKO: 100378719
AAG: 110680907
AME: 408676
BIM: 100747412
BTER: 100652098
CCAL: 108624508
OBB: 114882328
SOC: 105195108
MPHA: 105828790
AEC: 105144143
ACEP: 105617651
PBAR: 105427548
VEM: 105560315
HST: 105185932
DQU: 106745578
CFO: 105248586
LHU: 105675855
PGC: 109857703
OBO: 105285045
PCF: 106787322
NVI: 100116193
CSOL: 105366402
MDL: 103576227
TCA: 657895
DPA: 109545699
ATD: 109602815
NVL: 108564413
BMAN: 114244002
PMAC: 106716501
PRAP: 110991527
HAW: 110382017
TNL: 113495410
PXY: 105396383
API: 100568914
DNX: 107173687
AGS: 114119817
RMD: 113549501
BTAB: 109033324
CLEC: 106671874
ZNE: 110826785
FCD: 110849783
TUT: 107366220
CSCU: 111634314
PTEP: 107448198
PCAN: 112554006
CRG: 105334573
MYI: 110460164
OBI: 106881030
LAK: 106162653
NVE: 5503296
ADF: 107358340
AMIL: 114947029
PDAM: 113668405
SPIS: 111324849
DGT: 114533894
HMG: 101240388
 » show all
Reference
  Authors
Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M
  Title
TORCs: transducers of regulated CREB activity.
  Journal
Mol Cell 12:413-23 (2003)
DOI:10.1016/j.molcel.2003.08.013
Reference
  Authors
Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA
  Title
Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.
  Journal
Proc Natl Acad Sci U S A 100:12147-52 (2003)
DOI:10.1073/pnas.1932773100
  Sequence
[hsa:23373]
LinkDB

KEGG   ORTHOLOGY: K16333
Entry
K16333                      KO                                     

Name
CRTC2, TORC2
Definition
CREB-regulated transcription coactivator 2
Pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04922  Glucagon signaling pathway
ko04931  Insulin resistance
ko05166  Human T-cell leukemia virus 1 infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K16333  CRTC2, TORC2; CREB-regulated transcription coactivator 2
   04152 AMPK signaling pathway
    K16333  CRTC2, TORC2; CREB-regulated transcription coactivator 2
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    K16333  CRTC2, TORC2; CREB-regulated transcription coactivator 2
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K16333  CRTC2, TORC2; CREB-regulated transcription coactivator 2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K16333  CRTC2, TORC2; CREB-regulated transcription coactivator 2
Genes
HSA: 200186(CRTC2)
PTR: 738694(CRTC2)
PPS: 100976458(CRTC2)
GGO: 101149666(CRTC2)
PON: 100438416(CRTC2)
NLE: 100597840(CRTC2)
MCC: 715908(CRTC2)
MCF: 102137277(CRTC2)
CSAB: 103223939(CRTC2)
RRO: 104663514(CRTC2)
RBB: 108518844(CRTC2)
CJC: 103789006(CRTC2)
SBQ: 101040859(CRTC2)
MMU: 74343(Crtc2)
MCAL: 110291453(Crtc2)
MPAH: 110320038(Crtc2)
RNO: 310615(Crtc2)
MUN: 110554243(Crtc2)
CGE: 100751848(Crtc2)
NGI: 103751715(Crtc2)
HGL: 101709168(Crtc2)
CCAN: 109688050(Crtc2)
OCU: 100358960(CRTC2)
TUP: 102481058(CRTC2)
CFA: 612305(CRTC2)
VVP: 112918870(CRTC2)
AML: 100472270(CRTC2)
UMR: 103668413(CRTC2)
UAH: 113245327(CRTC2)
ORO: 101383200(CRTC2)
ELK: 111138927
FCA: 101101104(CRTC2)
PTG: 102953123(CRTC2)
PPAD: 109256187
BTA: 540959(CRTC2)
BOM: 102280934(CRTC2)
BIU: 109554474(CRTC2)
BBUB: 102397007(CRTC2)
CHX: 102180907(CRTC2)
OAS: 101102117(CRTC2)
SSC: 100519835(CRTC2)
CFR: 102515899(CRTC2)
CDK: 105089365(CRTC2)
BACU: 103004880(CRTC2)
LVE: 103086651(CRTC2)
OOR: 101287600(CRTC2)
DLE: 111167180(CRTC2)
PCAD: 112061832(CRTC2)
ECB: 100056571(CRTC2)
EPZ: 103555397(CRTC2)
EAI: 106846251(CRTC2)
MYB: 102257000(CRTC2)
MYD: 102770919(CRTC2)
MNA: 107543902(CRTC2)
HAI: 109373525(CRTC2)
DRO: 112316349(CRTC2)
PALE: 102879203(CRTC2)
RAY: 107509408(CRTC2)
MJV: 108408207(CRTC2)
LAV: 100673108(CRTC2)
TMU: 101344998
MDO: 100019951(CRTC2)
SHR: 100922824(CRTC2)
PCW: 110211993(CRTC2)
OAA: 114808055(CRTC2)
CJO: 107324475(CRTC2)
TGU: 100221000(CRTC2)
LSR: 110476855(CRTC2)
SCAN: 108964479
FAB: 101816291(CRTC2)
PHI: 102110933(CRTC2)
PMAJ: 107214640(CRTC2)
FPG: 101923752(CRTC2)
FCH: 102050437(CRTC2)
CLV: 110364232(CRTC2)
EGZ: 104123012(CRTC2)
NNI: 104018282(CRTC2)
AAM: 106484278(CRTC2)
ASN: 102372662(CRTC2)
AMJ: 102571416(CRTC2)
CMY: 102939459(CRTC2)
CPIC: 101942224(CRTC2)
PVT: 110088491(CRTC2)
PBI: 103055527(CRTC2)
PMUR: 107285215(CRTC2)
TSR: 106552862
PMUA: 114586231
GJA: 107110880(CRTC2)
XTR: 101733698(crtc2)
DRE: 108179660
SRX: 107745155
CCAR: 109073074
IPU: 108256981 108267545(crtc2)
TRU: 101063579(crtc2)
MZE: 101479703(crtc2)
ONL: 100694646(crtc2)
OLA: 101166701
XMA: 102220988(crtc2)
XCO: 114141694(crtc2)
PRET: 103477480(crtc2)
CVG: 107095534(crtc2)
NFU: 107378893
KMR: 108229424
AOCE: 111568265
CSEM: 103388972(crtc2)
POV: 109646180
LCF: 108884694
SDU: 111234090
HCQ: 109512134(crtc2)
BPEC: 110157907
MALB: 109970057
ELS: 105012688(crtc2) 105019155
SFM: 108941900
PKI: 111838365(crtc2) 111848277
LCM: 102352254(CRTC2)
RTP: 109926463
 » show all
Reference
  Authors
Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M
  Title
TORCs: transducers of regulated CREB activity.
  Journal
Mol Cell 12:413-23 (2003)
DOI:10.1016/j.molcel.2003.08.013
Reference
  Authors
Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA
  Title
Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.
  Journal
Proc Natl Acad Sci U S A 100:12147-52 (2003)
DOI:10.1073/pnas.1932773100
  Sequence
[hsa:200186]
LinkDB

KEGG   ORTHOLOGY: K16334
Entry
K16334                      KO                                     

Name
CRTC3, TORC3
Definition
CREB-regulated transcription coactivator 3
Pathway
ko05166  Human T-cell leukemia virus 1 infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K16334  CRTC3, TORC3; CREB-regulated transcription coactivator 3
Genes
HSA: 64784(CRTC3)
PTR: 453648(CRTC3)
PPS: 100985037(CRTC3)
GGO: 101133514(CRTC3)
PON: 100450653(CRTC3)
NLE: 100591649(CRTC3)
MCC: 709458(CRTC3)
MCF: 102126031(CRTC3)
CSAB: 103231190(CRTC3)
RRO: 104679276(CRTC3)
RBB: 108517220(CRTC3)
CJC: 100398349(CRTC3)
SBQ: 101048796(CRTC3)
MMU: 70461(Crtc3)
MCAL: 110299051(Crtc3)
MPAH: 110330056(Crtc3)
RNO: 365297(Crtc3)
CGE: 100751622(Crtc3)
NGI: 103749879(Crtc3)
HGL: 101719615(Crtc3)
CCAN: 109696762(Crtc3)
OCU: 100338531(CRTC3)
TUP: 102487015(CRTC3)
CFA: 488747(CRTC3)
VVP: 112922908(CRTC3)
AML: 100479341(CRTC3)
UMR: 103660203(CRTC3)
UAH: 113263723(CRTC3)
ORO: 101385678(CRTC3)
ELK: 111152573
FCA: 101088084(CRTC3)
PTG: 102957650(CRTC3)
PPAD: 109273297(CRTC3)
AJU: 106965943(CRTC3)
BTA: 540109(CRTC3)
BOM: 102283526(CRTC3)
BIU: 109575455(CRTC3)
BBUB: 102396979(CRTC3)
CHX: 102172203(CRTC3)
OAS: 101104349(CRTC3)
SSC: 100621206(CRTC3)
CFR: 102523372(CRTC3)
CDK: 105094700(CRTC3)
BACU: 103014069(CRTC3)
LVE: 103077437(CRTC3)
OOR: 101273725(CRTC3)
DLE: 111169684(CRTC3)
PCAD: 102977337(CRTC3)
ECB: 100068775(CRTC3)
EPZ: 103546216(CRTC3)
EAI: 106832053(CRTC3)
MYB: 102238823(CRTC3)
MYD: 102765896(CRTC3)
MNA: 107540383(CRTC3)
HAI: 109381500(CRTC3)
DRO: 112306135(CRTC3)
PALE: 102884635(CRTC3)
RAY: 107514137(CRTC3)
MJV: 108385795(CRTC3)
LAV: 100660495(CRTC3)
TMU: 101353789
MDO: 100013995(CRTC3)
SHR: 100932728(CRTC3)
PCW: 110213999(CRTC3)
OAA: 103167239(CRTC3)
XLA: 108712880(crtc3.S)
XTR: 496857(crtc3)
NPR: 108795259(CRTC3)
DRE: 570024(crtc3)
IPU: 108259259(crtc3)
PHYP: 113540922(crtc3)
AMEX: 103042762
EEE: 113579689(crtc3)
TRU: 101061280(crtc3)
LCO: 104935422(crtc3)
MZE: 101469041(crtc3)
ONL: 100710887(crtc3)
OLA: 101166367
XMA: 102219154(crtc3)
XCO: 114142739(crtc3)
PRET: 103462974
CVG: 107091086(crtc3)
NFU: 107382016(crtc3)
KMR: 108247122(crtc3)
ALIM: 106526742(crtc3)
AOCE: 111578517
CSEM: 103398469(crtc3)
POV: 109642608
LCF: 108894244(crtc3)
SDU: 111223944(crtc3)
SLAL: 111656637
HCQ: 109514309(crtc3)
BPEC: 110168841
MALB: 109954521(crtc3)
SALP: 112078324
ELS: 105014905(crtc3)
SFM: 108941110(crtc3)
PKI: 111844999(crtc3)
LCM: 102354566(CRTC3)
CMK: 103188597(crtc3)
 » show all
Reference
  Authors
Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA
  Title
Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.
  Journal
Proc Natl Acad Sci U S A 100:12147-52 (2003)
DOI:10.1073/pnas.1932773100
  Sequence
[hsa:64784]
LinkDB

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