KEGG   ORTHOLOGY: K15320
Entry
K15320                      KO                                     

Name
ATX, chlB1, mdpB
Definition
6-methylsalicylic acid synthase [EC:2.3.1.165]
Pathway
ko01059  Biosynthesis of enediyne antibiotics
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00829  3,6-Dimethylsalicylyl-CoA biosynthesis, malonyl-CoA => 6-methylsalicylate => 3,6-dimethylsalicylyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K15320  ATX, chlB1, mdpB; 6-methylsalicylic acid synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15320  ATX, chlB1, mdpB; 6-methylsalicylic acid synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.165  6-methylsalicylic-acid synthase
     K15320  ATX, chlB1, mdpB; 6-methylsalicylic acid synthase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Iterative type I PKS
   Fungal partially reducing PKS (PR-PKS)
    K15320  ATX, chlB1, mdpB; 6-methylsalicylic acid synthase
Other DBs
RN: R07253
COG: COG0331 COG3321 COG1028
GO: 0050641
Genes
ELA: UCREL1_5691
PFY: PFICI_12928
GLZ: GLAREA_12216
ACT: ACLA_093660
AOR: AO090206000074
ANG: ANI_1_136174(An10g00140)
AFV: AFLA_114820
PCS: Pc16g00370 Pc22g08170
PDP: PDIP_42600
ABE: ARB_05854
TVE: TRV_06867
MMC: Mmcs_3472
MKM: Mkms_3535
MJL: Mjls_3485
MFJ: MFLOJ_23440(ppsA)
MVA: Mvan_3852
MGI: Mflv_2690
MPHL: MPHLCCUG_03492(ppsA_2)
MVQ: MYVA_3673
MTHN: 4412656_02813(ppsA_3)
MHAS: MHAS_01350(aziB)
MDU: MDUV_07090(ppsA)
MCHT: MCHIJ_31530(ppsA)
MAUU: NCTC10437_03653(ppsA_4)
MMOR: MMOR_27500(ppsA)
MJD: JDM601_1527(ppsD)
NAD: NCTC11293_04860(ppsA_4)
SALJ: SMD11_6411
SEN: SACE_5308(chlB1)
AOI: AORI_5397(ppsA)
AORI: SD37_05100
PSEH: XF36_29085
SESP: BN6_39100(pks6-1)
ACTI: UA75_18040
ACAD: UA74_17515
MCAB: HXZ27_04065(evdD3) HXZ27_20980
PSUU: Psuf_000690(ppsA)
AG: AAZ77673(chlB1) ABY66019(mdpB) BAA20102(atX) CAA39295
 » show all
Reference
PMID:9003280 (atX)
  Authors
Fujii I, Ono Y, Tada H, Gomi K, Ebizuka Y, Sankawa U
  Title
Cloning of the polyketide synthase gene atX from Aspergillus terreus and its identification as the 6-methylsalicylic acid synthase gene by heterologous expression.
  Journal
Mol Gen Genet 253:1-10 (1996)
DOI:10.1007/s004380050289
  Sequence
Reference
PMID:16677607 (chlB1)
  Authors
Shao L, Qu XD, Jia XY, Zhao QF, Tian ZH, Wang M, Tang GL, Liu W
  Title
Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase.
  Journal
Biochem Biophys Res Commun 345:133-9 (2006)
DOI:10.1016/j.bbrc.2006.04.069
  Sequence
Reference
PMID:2209605
  Authors
Beck J, Ripka S, Siegner A, Schiltz E, Schweizer E
  Title
The multifunctional 6-methylsalicylic acid synthase gene of Penicillium patulum. Its gene structure relative to that of other polyketide synthases.
  Journal
Eur J Biochem 192:487-98 (1990)
DOI:10.1111/j.1432-1033.1990.tb19252.x
  Sequence
Reference
PMID:17918933 (mdpB)
  Authors
Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B
  Title
Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.
  Journal
J Am Chem Soc 129:13082-94 (2007)
DOI:10.1021/ja073275o
  Sequence
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