KEGG   ORTHOLOGY: K15420
Entry
K15420                      KO                                     

Name
EML4
Definition
echinoderm microtubule-associated protein-like 4
Pathway
ko05200  Pathways in cancer
ko05223  Non-small cell lung cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K15420  EML4; echinoderm microtubule-associated protein-like 4
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K15420  EML4; echinoderm microtubule-associated protein-like 4
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    K15420  EML4; echinoderm microtubule-associated protein-like 4
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K15420  EML4; echinoderm microtubule-associated protein-like 4
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    EMAP
     K15420  EML4; echinoderm microtubule-associated protein-like 4
Genes
HSA: 27436(EML4)
PTR: 459180(EML4)
PPS: 100968189(EML4)
GGO: 101144399(EML4)
PON: 100453034(EML4)
NLE: 100595819(EML4)
MCC: 715091(EML4)
MCF: 102117260(EML4)
CSAB: 103220407(EML4)
RRO: 104677542(EML4)
RBB: 108513214(EML4)
CJC: 100410033(EML4)
SBQ: 101039462(EML4)
MMU: 78798(Eml4)
MCAL: 110284386(Eml4)
MPAH: 110335391(Eml4)
RNO: 313861(Eml4)
MUN: 110555469(Eml4)
CGE: 100764725(Eml4)
NGI: 103736385(Eml4)
HGL: 101715651(Eml4)
CCAN: 109697438(Eml4)
OCU: 100352828(EML4)
TUP: 102468371(EML4)
CFA: 483048(EML4)
VVP: 112916607(EML4)
AML: 100475514(EML4)
UMR: 103671544(EML4)
UAH: 113241799(EML4)
ORO: 101370021(EML4)
ELK: 111158506
FCA: 101094586(EML4)
PTG: 102967307(EML4)
PPAD: 109265262(EML4)
AJU: 106970840(EML4)
BTA: 540187(EML4)
BOM: 102286590(EML4)
BIU: 109566017(EML4)
BBUB: 102403336(EML4)
CHX: 102187234(EML4)
OAS: 101115950(EML4)
SSC: 100515021(EML4)
CFR: 102507317(EML4)
CDK: 105103544(EML4)
BACU: 103018044(EML4)
LVE: 103073061(EML4)
OOR: 101282443(EML4)
DLE: 111174834(EML4)
PCAD: 102983752(EML4)
ECB: 100053784(EML4)
EPZ: 103557606(EML4)
EAI: 106848305(EML4)
MYB: 102256074(EML4)
MYD: 102765378(EML4)
MNA: 107539758(EML4)
HAI: 109385550(EML4)
DRO: 112297965(EML4)
PALE: 102879824(EML4)
RAY: 107509594(EML4)
MJV: 108397557(EML4)
LAV: 104846437(EML4)
TMU: 101355821
MDO: 100033382(EML4)
SHR: 100929628(EML4)
PCW: 110218476(EML4)
OAA: 100091982(EML4)
GGA: 771345(EML4)
MGP: 100541442(EML4)
CJO: 107311167(EML4)
NMEL: 110395521(EML4)
APLA: 101796290(EML4)
ACYG: 106031501(EML4)
TGU: 100219108(EML4)
LSR: 110479963(EML4)
SCAN: 103817014(EML4)
GFR: 102034770(EML4)
FAB: 101809113(EML4)
PHI: 102102750(EML4)
PMAJ: 107201852(EML4)
CCAE: 111926149(EML4)
CCW: 104685668(EML4)
ETL: 114065809(EML4)
FPG: 101918568(EML4)
FCH: 102047626(EML4)
CLV: 102088400(EML4)
EGZ: 104128728(EML4)
NNI: 104019722(EML4)
ACUN: 113477776(EML4)
PADL: 103922116(EML4)
AAM: 106490421(EML4)
ASN: 102368445(EML4)
AMJ: 102573028(EML4)
PSS: 102444410(EML4)
CMY: 102948338(EML4)
CPIC: 101945862(EML4)
ACS: 100563497(eml4)
PVT: 110084395(EML4)
PBI: 103050978(EML4)
PMUR: 107284972(EML4)
TSR: 106541016(EML4)
PMUA: 114594721(EML4)
GJA: 107114505(EML4)
XLA: 108716433(eml4.L) 735022(eml4.S)
XTR: 448764(eml4)
NPR: 108786116(EML4)
DRE: 100334728(eml4)
SRX: 107739484 107758131(eml4)
IPU: 108263481(eml4)
PHYP: 113540944(eml4)
AMEX: 103041533
EEE: 113572715(eml4)
TRU: 101074333(eml4)
LCO: 104934700(eml4)
MZE: 101483481(eml4)
ONL: 100706985(eml4)
OLA: 101175019(eml4)
XMA: 102216710(eml4)
XCO: 114137600(eml4)
PRET: 103477445
CVG: 107101396(eml4)
NFU: 107376417
KMR: 108247262(eml4)
ALIM: 106529813(eml4)
AOCE: 111586050(eml4)
CSEM: 103387130(eml4)
POV: 109644340(eml4)
LCF: 108874347(eml4)
SDU: 111223863(eml4)
SLAL: 111656068(eml4)
HCQ: 109510011(eml4)
BPEC: 110166511
MALB: 109972992(eml4)
SASA: 106576747 106605231(eml4)
OTW: 112253203(eml4) 112253520
SALP: 111977475 111978351(eml4)
ELS: 105030300(eml4)
SFM: 108932634 108942755(eml4)
LCM: 102367334(EML4)
CMK: 103177997(eml4)
RTP: 109936473(eml4)
 » show all
Reference
  Authors
Pollmann M, Parwaresch R, Adam-Klages S, Kruse ML, Buck F, Heidebrecht HJ
  Title
Human EML4, a novel member of the EMAP family, is essential for microtubule formation.
  Journal
Exp Cell Res 312:3241-51 (2006)
DOI:10.1016/j.yexcr.2006.06.035
  Sequence
[hsa:27436]
Reference
  Authors
Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara S, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y, Mano H
  Title
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer.
  Journal
Nature 448:561-6 (2007)
DOI:10.1038/nature05945
  Sequence
[hsa:27436]
Reference
  Authors
Heidebrecht HJ, Buck F, Pollmann M, Siebert R, Parwaresch R
  Title
Cloning and localization of C2orf2(ropp120), a previously unknown WD repeat protein.
  Journal
Genomics 68:348-50 (2000)
DOI:10.1006/geno.2000.6301
  Sequence
[hsa:27436]
LinkDB

KEGG   ORTHOLOGY: K05119
Entry
K05119                      KO                                     

Name
ALK, CD246
Definition
anaplastic lymphoma kinase [EC:2.7.10.1]
Pathway
ko05200  Pathways in cancer
ko05223  Non-small cell lung cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00014  Non-small cell lung cancer
H01601  Anaplastic large-cell lymphoma
H01892  Peripheral T cell lymphoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05119  ALK, CD246; anaplastic lymphoma kinase
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K05119  ALK, CD246; anaplastic lymphoma kinase
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    K05119  ALK, CD246; anaplastic lymphoma kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05119  ALK, CD246; anaplastic lymphoma kinase
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05119  ALK, CD246; anaplastic lymphoma kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05119  ALK, CD246; anaplastic lymphoma kinase
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  ALK family
   K05119  ALK, CD246; anaplastic lymphoma kinase
CD molecules [BR:ko04090]
 Proteins
  K05119  CD246, ALK; anaplastic lymphoma kinase (Ki-1)
Genes
HSA: 238(ALK)
PTR: 459127(ALK)
PPS: 100981152(ALK)
GGO: 101141580(ALK)
PON: 100458012(ALK)
NLE: 100593886(ALK)
MCC: 704823(ALK)
MCF: 102128455(ALK)
CSAB: 103220559(ALK)
RRO: 104663931(ALK)
RBB: 108532772(ALK)
CJC: 100399252(ALK)
SBQ: 101044905(ALK)
MMU: 11682(Alk)
MCAL: 110312131(Alk)
MPAH: 110335467(Alk)
RNO: 266802(Alk)
MUN: 110554521(Alk)
CGE: 100760366(Alk)
NGI: 103744649(Alk)
HGL: 101703312(Alk)
CCAN: 109679287(Alk)
OCU: 100347722(ALK)
TUP: 102492665(ALK)
CFA: 483021(ALK)
VVP: 112932997(ALK)
AML: 100473389(ALK)
UMR: 103671905(ALK)
UAH: 113268019(ALK)
ORO: 101373502(ALK)
ELK: 111139287
FCA: 101091689(ALK)
PTG: 102970257(ALK)
PPAD: 109266408(ALK)
AJU: 106967924(ALK)
BTA: 536642(ALK)
BOM: 106701242(ALK)
BIU: 109565582(ALK)
BBUB: 102394478(ALK)
CHX: 106502631(ALK)
OAS: 101114094(ALK)
SSC: 100518423(ALK)
CFR: 102504436(ALK)
CDK: 105098577(ALK)
BACU: 103020848(ALK)
LVE: 103082654(ALK)
OOR: 101281727(ALK)
DLE: 111174732(ALK)
PCAD: 102988118(ALK)
ECB: 100070891
EPZ: 103549200(ALK)
EAI: 106837084(ALK)
MYB: 102242645(ALK) 102263072
MYD: 102759675(ALK)
MNA: 107534860(ALK)
HAI: 109390951(ALK)
DRO: 112298036(ALK)
PALE: 102884662(ALK)
RAY: 107511136(ALK)
MJV: 108408692(ALK)
LAV: 100661350(ALK)
TMU: 101346489
MDO: 100031373(ALK)
SHR: 100931895(ALK)
PCW: 110206438(ALK)
OAA: 100078902(ALK)
GGA: 421297(ALK) 423216(LTK)
MGP: 100542012(LTK) 100543352(ALK)
CJO: 107310876(ALK) 107314725(LTK)
NMEL: 110396255(ALK) 110402026(LTK)
APLA: 101789875(LTK) 101797885(ALK)
ACYG: 106043115(LTK) 106043136(ALK)
TGU: 100221054(LTK) 100221929(ALK)
LSR: 110472103(LTK) 110472832(ALK)
SCAN: 103821381(ALK) 103826985(LTK)
GFR: 102034482(ALK) 102036797(LTK)
FAB: 101817862(LTK) 101819549(ALK)
PHI: 102108510(LTK) 102112738(ALK)
PMAJ: 107202471(ALK) 107205794(LTK)
CCAE: 111926304(ALK) 111930075(LTK)
CCW: 104685582(ALK) 104698444(LTK)
ETL: 114059427(LTK) 114060910(ALK)
FPG: 101923162(LTK) 101924804(ALK)
FCH: 102055199(LTK) 102059446(ALK)
CLV: 102096456 102097986(LTK)
EGZ: 104127545(LTK) 104134596(ALK)
NNI: 104018112(ALK) 104020450(LTK)
ACUN: 113478473(ALK) 113480533(LTK)
PADL: 103912815(LTK) 103925041(ALK)
AAM: 106490437(ALK) 106498243(LTK)
ASN: 102383997(ALK) 102386513(LTK)
AMJ: 102572248(LTK) 102573864(ALK)
PSS: 102449858(LTK) 102462403(ALK)
CMY: 102944568(ALK)
CPIC: 101947911(ALK) 101951471(LTK)
ACS: 100553426(alk) 100563969(ltk)
PVT: 110078686(ALK) 110079037(LTK)
PBI: 103054608 103060733(ALK)
PMUR: 107295457 107296234(ALK)
TSR: 106538234(ALK) 106547951 106548203(LTK)
PMUA: 114594117(LTK) 114594587(ALK)
GJA: 107113542(ALK) 107126012(LTK)
XTR: 100495071(alk) 100498306(ltk)
NPR: 108789911(LTK) 108796594(ALK)
DRE: 563509(alk) 564470(ltk)
IPU: 108270425 108270462(ltk)
PHYP: 113539006(ltk) 113545033(alk)
TRU: 101062160(ltk) 101068218(alk)
LCO: 104922171 104924780(alk)
NCC: 104960379
MZE: 101473442(alk) 101473463
ONL: 100690943 100710577(alk)
OLA: 101156784 105357017(alk)
XMA: 102218265(alk) 102223978
XCO: 114133996 114134142(alk)
PRET: 103458724(alk) 103458875
NFU: 107392283 107395952(alk)
KMR: 108237218 108241771(alk)
ALIM: 106518492(alk) 106521584(ltk)
CSEM: 103377486(ltk) 103383830(alk)
POV: 109627931(alk) 109628229
LCF: 108888127 108896151(alk)
SDU: 111225567 111226063(alk)
SLAL: 111644763 111656299(alk)
BPEC: 110155417
MALB: 109955116(ltk) 109972827
ELS: 105015742 105029147(alk)
SFM: 108919440 108940341(alk)
PKI: 111833981(alk) 111852371(ltk)
LCM: 102363060 102363661(ALK)
CMK: 103176144 103180837(alk)
RTP: 109937153
BFO: 118415382
APLC: 110975206
SKO: 100368524
DME: Dmel_CG8250(Alk)
DER: 6548537
DSE: 6609473
DSI: Dsimw501_GD25528(Dsim_GD25528)
DAN: 6496298
DSR: 110185803
DPE: 6601606
DWI: 6637928
DAZ: 108617073
DNV: 108653643
DHE: 111593842
DVI: 6625724
MDE: 101891328
LCQ: 111680623
AAG: 5579652
AALB: 109422212
AME: 408718
BIM: 100744065
BTER: 100646372
CCAL: 108625215
OBB: 114870959
SOC: 105197862
MPHA: 105828354
AEC: 105145518
ACEP: 105626376
PBAR: 105422090
VEM: 105567635
HST: 105191722
DQU: 106752358
CFO: 105251192
LHU: 105679911
PGC: 109854323
OBO: 105276946
PCF: 106791608
NVI: 100119087
CSOL: 105359312
MDL: 103571904
TCA: 657445
DPA: 109534510
ATD: 109607999
NVL: 108557067
BMOR: 101735728
BMAN: 114241134
PMAC: 106707912
PRAP: 110999387
TNL: 113505045
PXY: 105393450
API: 100169221
AGS: 114126210
RMD: 113559828
CLEC: 106665745
ZNE: 110837757
FCD: 110843553
TUT: 107365132
DPTE: 113791595
PTEP: 107456001
CEL: CELE_T10H9.2(scd-2)
CBR: CBG18982(Cbr-scd-2)
BMY: Bm1_52030
TSP: Tsp_02986
OBI: 106883653
 » show all
Reference
PMID:9174053
  Authors
Morris SW, Naeve C, Mathew P, James PL, Kirstein MN, Cui X, Witte DP
  Title
ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
  Journal
Oncogene 14:2175-88 (1997)
DOI:10.1038/sj.onc.1201062
  Sequence
[hsa:238]
Reference
  Authors
Palmer RH, Vernersson E, Grabbe C, Hallberg B
  Title
Anaplastic lymphoma kinase: signalling in development and disease.
  Journal
Biochem J 420:345-61 (2009)
DOI:10.1042/BJ20090387
LinkDB

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