KEGG   ORTHOLOGY: K15619
Entry
K15619                      KO                                     

Name
SPINT1
Definition
Kunitz-type protease inhibitor 1
Pathway
ko05202  Transcriptional misregulation in cancer
ko05215  Prostate cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K15619  SPINT1; Kunitz-type protease inhibitor 1
  09162 Cancer: specific types
   05215 Prostate cancer
    K15619  SPINT1; Kunitz-type protease inhibitor 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K15619  SPINT1; Kunitz-type protease inhibitor 1
Peptidases and inhibitors [BR:ko01002]
 Peptidase inhibitors
  Family I2: Kunitz - BPTI family
   K15619  SPINT1; Kunitz-type protease inhibitor 1
Other DBs
GO: 0004867
Genes
HSA: 6692(SPINT1)
PTR: 453342(SPINT1)
PPS: 100980002(SPINT1)
GGO: 101153457(SPINT1)
PON: 100436466(SPINT1)
NLE: 100585940(SPINT1)
MCC: 704578(SPINT1)
MCF: 102117924 102122045(SPINT1)
CSAB: 103245811(SPINT1)
RRO: 104682140(SPINT1)
RBB: 108523426(SPINT1)
CJC: 100412168(SPINT1)
SBQ: 101032978(SPINT1)
MMU: 20732(Spint1)
MCAL: 110289694(Spint1)
MPAH: 110318999(Spint1)
RNO: 311331(Spint1)
MUN: 110550615(Spint1)
CGE: 100761602(Spint1)
NGI: 103744920(Spint1)
HGL: 101720247(Spint1)
CCAN: 109694216(Spint1)
OCU: 100345098(SPINT1)
TUP: 102473206(SPINT1)
CFA: 487501(SPINT1)
VVP: 112919957(SPINT1)
AML: 100473505(SPINT1)
UMR: 103673545(SPINT1)
UAH: 113242021(SPINT1)
ORO: 101368336(SPINT1)
ELK: 111161450
FCA: 101085636(SPINT1)
PTG: 102961204(SPINT1)
PPAD: 109263140(SPINT1)
AJU: 106968572(SPINT1)
BTA: 534040(SPINT1)
BOM: 102265173(SPINT1)
BIU: 109564944(SPINT1)
BBUB: 102397807(SPINT1)
CHX: 102172450(SPINT1)
OAS: 101111287(SPINT1)
SSC: 100157387(SPINT1)
CFR: 102504207(SPINT1)
CDK: 105096869(SPINT1)
BACU: 103009906(SPINT1)
LVE: 103073315(SPINT1)
OOR: 101276699(SPINT1)
DLE: 111181728(SPINT1)
PCAD: 102991946(SPINT1)
ECB: 100071304(SPINT1)
EPZ: 103564740(SPINT1)
EAI: 106841370(SPINT1)
MYB: 102257664(SPINT1)
MYD: 102757690(SPINT1)
MNA: 107542962(SPINT1)
HAI: 109384036(SPINT1)
DRO: 112311875(SPINT1)
PALE: 102892287(SPINT1)
RAY: 107514475(SPINT1)
MJV: 108384314(SPINT1)
LAV: 100671409(SPINT1)
TMU: 101350726
MDO: 100032047(SPINT1)
SHR: 100933182(SPINT1)
PCW: 110223715(SPINT1)
OAA: 100089180(SPINT1)
GGA: 423206(SPINT1)
MGP: 100540482(SPINT1)
CJO: 107314832(SPINT1)
NMEL: 110401447(SPINT1)
APLA: 101804600(SPINT1)
ACYG: 106043273(SPINT1)
TGU: 100226787(SPINT1)
LSR: 110472090(SPINT1)
SCAN: 103826669(SPINT1)
GFR: 102045453(SPINT1)
FAB: 101820871(SPINT1)
PHI: 102102872(SPINT1)
PMAJ: 107206390(SPINT1)
CCAE: 111930201(SPINT1)
CCW: 104698319(SPINT1)
ETL: 114059297(SPINT1)
FPG: 101924714(SPINT1)
FCH: 102056380(SPINT1)
CLV: 102091675(SPINT1)
EGZ: 104134090(SPINT1)
NNI: 104020363(SPINT1)
ACUN: 113480557(SPINT1)
PADL: 103912823(SPINT1)
AAM: 106498361(SPINT1)
ASN: 102385030(SPINT1)
AMJ: 102574141(SPINT1)
PSS: 102452161(SPINT1)
CMY: 102932118(SPINT1)
CPIC: 101946553(SPINT1)
ACS: 100556267(spint1)
PVT: 110080117(SPINT1)
PBI: 103061939(SPINT1)
PMUR: 107291012(SPINT1)
TSR: 106545015(SPINT1)
PMUA: 114593957(SPINT1) 114603440
GJA: 107113928(SPINT1)
XTR: 100488118(spint1)
NPR: 108794335(SPINT1)
DRE: 406426(spint1a) 797346(spint1b)
IPU: 108257674 108269617(spint1)
PHYP: 113525046 113538656(spint1)
AMEX: 103024868 103032340(spint1)
EEE: 113571328(spint1) 113574350
TRU: 101073645 101079502(spint1)
LCO: 104924798(spint1) 104933381
NCC: 104953743(spint1)
MZE: 101464875 101473873(spint1)
ONL: 100695926 109194167(spint1)
XMA: 102223662 102231699(spint1)
XCO: 114134284(spint1) 114158159
PRET: 103457124 103458554(spint1)
CVG: 107094384(spint1) 107104114
NFU: 107377908 107392477(spint1)
KMR: 108237189(spint1) 108242575
ALIM: 106519872(spint1) 106528670
AOCE: 111577929(spint1) 111582617
CSEM: 103381353 103389490(spint1)
POV: 109628210(spint1) 109646404
LCF: 108892602(spint1)
SDU: 111225957(spint1) 111231748
SLAL: 111652481(spint1) 111656893
BPEC: 110155331(spint1) 110164255
MALB: 109968309(spint1) 109974449
SASA: 106571141(SPIT1) 106610865(SPIT1)
ELS: 105015646(spint1) 105021702
SFM: 108919608(spint1)
PKI: 111838886(spint1) 111861017
LCM: 102351733(SPINT1)
CMK: 103178451(spint1)
RTP: 109915790(spint1)
PTEP: 107449901
 » show all
Reference
PMID:9045658
  Authors
Shimomura T, Denda K, Kitamura A, Kawaguchi T, Kito M, Kondo J, Kagaya S, Qin L, Takata H, Miyazawa K, Kitamura N
  Title
Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor.
  Journal
J Biol Chem 272:6370-6 (1997)
DOI:10.1074/jbc.272.10.6370
  Sequence
[hsa:6692]
Reference
  Authors
Nagaike K, Kawaguchi M, Takeda N, Fukushima T, Sawaguchi A, Kohama K, Setoyama M, Kataoka H
  Title
Defect of hepatocyte growth factor activator inhibitor type 1/serine protease inhibitor, Kunitz type 1 (Hai-1/Spint1) leads to ichthyosis-like condition and abnormal hair development in mice.
  Journal
Am J Pathol 173:1464-75 (2008)
DOI:10.2353/ajpath.2008.071142
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