KEGG   ORTHOLOGY: K15791
Entry
K15791                      KO                                     
Symbol
DHKTD1
Name
probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 [EC:1.2.4.2]
Pathway
map00310  Lysine degradation
map00380  Tryptophan metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
Disease
H00264  Charcot-Marie-Tooth disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K15791  DHKTD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1
   00380 Tryptophan metabolism
    K15791  DHKTD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K15791  DHKTD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.2  oxoglutarate dehydrogenase (succinyl-transferring)
     K15791  DHKTD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    K15791  DHKTD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1
Other DBs
RN: R01933 R01940
GO: 0004591
Genes
HSA: 55526(DHTKD1)
PTR: 736115(DHTKD1)
PPS: 100977202(DHTKD1)
GGO: 101146441(DHTKD1)
PON: 100173320(DHTKD1)
NLE: 100601330(DHTKD1)
MCC: 696445(DHTKD1)
MCF: 102119673(DHTKD1)
CSAB: 103238141(DHTKD1)
CATY: 105597390(DHTKD1)
PANU: 101020595(DHTKD1)
TGE: 112631903(DHTKD1)
RRO: 104664886(DHTKD1)
RBB: 108538522(DHTKD1)
TFN: 117082489(DHTKD1)
PTEH: 111550054(DHTKD1)
CJC: 100385948(DHTKD1)
SBQ: 101035476(DHTKD1)
CSYR: 103267160(DHTKD1)
MMUR: 105857730(DHTKD1)
OGA: 100959733(DHTKD1)
MMU: 209692(Dhtkd1)
MCAL: 110283664(Dhtkd1)
MPAH: 110333984(Dhtkd1)
RNO: 361272(Dhtkd1)
MCOC: 116082662(Dhtkd1)
MUN: 110560545(Dhtkd1)
CGE: 100753689(Dhtkd1)
PLEU: 114708434(Dhtkd1)
NGI: 103738703(Dhtkd1)
HGL: 101721202(Dhtkd1)
CPOC: 100725295(Dhtkd1)
CCAN: 109682443(Dhtkd1)
DORD: 105984544(Dhtkd1)
DSP: 122113216(Dhtkd1)
NCAR: 124962316
OCU: 100356735(DHTKD1)
OPI: 101517371(DHTKD1)
TUP: 102477878(DHTKD1)
CFA: 478008(DHTKD1)
VVP: 112933405(DHTKD1)
VLG: 121497342(DHTKD1)
AML: 100484376(DHTKD1)
UMR: 103676290(DHTKD1)
UAH: 113241065(DHTKD1)
UAR: 123789980(DHTKD1)
ELK: 111155533
LLV: 125107173
MPUF: 101680862(DHTKD1)
ORO: 101364717(DHTKD1)
EJU: 114217756(DHTKD1)
ZCA: 113922535(DHTKD1)
MLX: 118021587(DHTKD1)
FCA: 101086155(DHTKD1)
PYU: 121014819(DHTKD1)
PBG: 122473897(DHTKD1)
PTG: 102950462(DHTKD1)
PPAD: 109273731(DHTKD1)
AJU: 106971004(DHTKD1)
HHV: 120241093(DHTKD1)
BTA: 517113(DHTKD1)
BOM: 102284154(DHTKD1)
BIU: 109567875(DHTKD1)
BBUB: 102411718(DHTKD1)
CHX: 102173669(DHTKD1)
OAS: 101117008(DHTKD1)
ODA: 120869272(DHTKD1)
CCAD: 122448981(DHTKD1)
SSC: 102166829(DHTKD1)
CFR: 102505405(DHTKD1)
CBAI: 105067994(DHTKD1)
CDK: 105100312(DHTKD1)
VPC: 102527317(DHTKD1)
BACU: 103016269(DHTKD1)
LVE: 103088004(DHTKD1)
OOR: 101270888(DHTKD1)
DLE: 111178001(DHTKD1)
PCAD: 102985620(DHTKD1)
PSIU: 116749762(DHTKD1)
ECB: 100056844(DHTKD1)
EPZ: 103563359(DHTKD1)
EAI: 106836524(DHTKD1)
MYB: 102255818(DHTKD1)
MYD: 102774163(DHTKD1)
MMYO: 118677309(DHTKD1)
MLF: 102420365(DHTKD1)
MNA: 107530246(DHTKD1)
PKL: 118727229(DHTKD1)
HAI: 109390477(DHTKD1)
DRO: 112322617(DHTKD1)
SHON: 119000845(DHTKD1)
AJM: 119056684(DHTKD1)
PDIC: 114492871(DHTKD1)
PHAS: 123831150(DHTKD1)
MMF: 118642818(DHTKD1)
RFQ: 117019163(DHTKD1)
PALE: 102895062(DHTKD1)
PGIG: 120614597(DHTKD1)
PVP: 105291706(DHTKD1)
RAY: 107504853(DHTKD1)
MJV: 108395805(DHTKD1)
TOD: 119244684(DHTKD1)
SARA: 101556958(DHTKD1)
LAV: 100677553(DHTKD1)
TMU: 101351336
DNM: 101419725(DHTKD1)
MDO: 100013507(DHTKD1)
GAS: 123248719(DHTKD1)
SHR: 100931159(DHTKD1)
PCW: 110217338(DHTKD1)
OAA: 100085444(DHTKD1)
GGA: 426076(DHTKD1)
PCOC: 116240325(DHTKD1)
MGP: 100540782(DHTKD1)
CJO: 107317305(DHTKD1)
NMEL: 110392260(DHTKD1)
APLA: 101799410(DHTKD1)
ACYG: 106046213(DHTKD1)
AFUL: 116495957(DHTKD1)
TGU: 100227746(DHTKD1)
LSR: 110470969(DHTKD1)
SCAN: 103813742(DHTKD1)
PMOA: 120512518(DHTKD1)
OTC: 121340575(DHTKD1)
PRUF: 121362331(DHTKD1)
GFR: 102045028(DHTKD1)
FAB: 101819529(DHTKD1)
PHI: 102106815(DHTKD1)
PMAJ: 107204632(DHTKD1)
CCAE: 111923121(DHTKD1)
CCW: 104694504(DHTKD1)
ETL: 114066624(DHTKD1)
ZAB: 102070301(DHTKD1)
FPG: 101914531(DHTKD1)
FCH: 102046202(DHTKD1)
CLV: 102086057(DHTKD1)
EGZ: 104135760(DHTKD1)
NNI: 104014635(DHTKD1)
ACUN: 113491537(DHTKD1)
TALA: 104359434(DHTKD1)
PADL: 103915024(DHTKD1)
ACHC: 115341776(DHTKD1)
AAM: 106485083(DHTKD1)
AROW: 112978056(DHTKD1)
NPD: 112942383(DHTKD1)
DNE: 112994751(DHTKD1)
ASN: 102376609(DHTKD1)
AMJ: 102561159(DHTKD1)
CPOO: 109315807(DHTKD1)
GGN: 109292221(DHTKD1)
PSS: 102453971(DHTKD1)
CMY: 102945253(DHTKD1)
CPIC: 101940398(DHTKD1)
TST: 117874589(DHTKD1)
CABI: 116835454(DHTKD1)
MRV: 120395232(DHTKD1)
ACS: 100551958(dhtkd1)
PVT: 110081244(DHTKD1)
SUND: 121930960(DHTKD1)
PMUR: 107297191(DHTKD1) 107300248
TSR: 106550932(DHTKD1)
PGUT: 117668317(DHTKD1)
VKO: 123020101(DHTKD1)
PMUA: 114605061(DHTKD1)
ZVI: 118091023(DHTKD1)
GJA: 107111049(DHTKD1)
XLA: 403360(dhtkd1.L)
XTR: 100493977(dhtkd1)
NPR: 108784821(DHTKD1)
RTEM: 120931700(DHTKD1)
BBUF: 120983646(DHTKD1)
BGAR: 122925389(DHTKD1)
DRE: 494076(dhtkd1)
CCAR: 109053636(dhtkd1)
CAUA: 113043697(dhtkd1) 113066386
IPU: 108275231(dhtkd1)
PHYP: 113530129(dhtkd1)
SMEO: 124392776(dhtkd1)
TFD: 113653931(dhtkd1)
AMEX: 103041509(dhtkd1)
EEE: 113584502(dhtkd1)
TRU: 101070517(dhtkd1)
LCO: 104940683(dhtkd1)
NCC: 104940829
CGOB: 115010070(dhtkd1)
ELY: 117262481(dhtkd1)
PLEP: 121949834(dhtkd1)
SLUC: 116038313(dhtkd1)
ECRA: 117949413(dhtkd1)
PFLV: 114560607(dhtkd1)
GAT: 120809782(dhtkd1)
PPUG: 119196195(dhtkd1)
MSAM: 119893677(dhtkd1) 119893755
CUD: 121515538(dhtkd1)
MZE: 101480158(dhtkd1)
ONL: 100705674(dhtkd1)
OAU: 116332644(dhtkd1)
OLA: 101175318(dhtkd1)
OML: 112152326(dhtkd1)
XMA: 102229655(dhtkd1)
XCO: 114155128(dhtkd1)
XHE: 116735793(dhtkd1)
PRET: 103465849(dhtkd1)
PFOR: 103154904(dhtkd1)
PLAI: 106946083(dhtkd1)
PMEI: 106928901(dhtkd1)
GAF: 122835739(dhtkd1)
CVG: 107095058(dhtkd1)
CTUL: 119799135(dhtkd1)
GMU: 124881211(dhtkd1)
NFU: 107388455(dhtkd1)
KMR: 108230154(dhtkd1)
ALIM: 106523641(dhtkd1)
NWH: 119416487(dhtkd1)
AOCE: 111566787(dhtkd1)
CSEM: 103380546(dhtkd1)
POV: 109624521(dhtkd1)
SSEN: 122776246(dhtkd1)
HHIP: 117763866(dhtkd1)
LCF: 108888513(dhtkd1)
SDU: 111229832(dhtkd1)
SLAL: 111670862(dhtkd1)
XGL: 120793241(dhtkd1)
HCQ: 109522972(dhtkd1)
BPEC: 110169356(dhtkd1)
MALB: 109974702(dhtkd1)
ELS: 105021851(dhtkd1)
SFM: 108931528(dhtkd1)
PKI: 111842368(dhtkd1)
AANG: 118231643(dhtkd1)
LOC: 102690271(dhtkd1)
PSPA: 121318271
LCM: 102356663(DHTKD1)
CMK: 103187915(dhtkd1)
RTP: 109929690(dhtkd1)
BFO: 118411503
BBEL: 109472245
CIN: 100179490
SCLV: 120325963
SPU: 764393
APLC: 110979468
SKO: 102808810
DME: Dmel_CG1544(CG1544)
DER: 6554810
DSE: 6612954
DSI: Dsimw501_GD21563(Dsim_GD21563)
DAN: 6501192
DSR: 110187006
DPE: 6595098
DMN: 108154619
DWI: 6649550
DGR: 6569607
DAZ: 108621342
DNV: 108660392
DHE: 111597832
DVI: 6632830
CCAT: 101458616
BOD: 106617728
MDE: 101890127
SCAC: 106087844
LCQ: 111681550
ACOZ: 120949321
AARA: 120905523
AAG: 5566495
CPII: 120417032
CNS: 116345958
AME: 412569
ACER: 107993113
ALAB: 122711856
BIM: 100746454
BBIF: 117205190
BVK: 117230270
BVAN: 117161398
BTER: 100651648
BPYO: 122572120
CCAL: 108632091
OBB: 114880363
MGEN: 117223329
NMEA: 116433649
CGIG: 122401568
MPHA: 105837687
AEC: 105153258
ACEP: 105621467
PBAR: 105426032
VEM: 105564292
HST: 105187265
DQU: 106741705
CFO: 105254757
FEX: 115236893
LHU: 105671323
PGC: 109860826
OBO: 105285114
PCF: 106784155
PFUC: 122520379
VPS: 122635566
NVI: 100123741
CSOL: 105362936
MDL: 103574888
CGLO: 123262882
FAS: 105268389
DAM: 107039194
AGIF: 122857491
CCIN: 107274100
TCA: 656360(DHTKD1)
DPA: 109537220
SOY: 115881186
ATD: 109599346
CSET: 123308163
AGB: 108917308
LDC: 111505973
NVL: 108566386
APLN: 108738254
PPYR: 116174454
BMOR: 101740126
BMAN: 114252985
MSEX: 115440187
BANY: 112047992
PMAC: 106712864
PPOT: 106106300
PXU: 106122558
PRAP: 110995686
ZCE: 119836037
HAW: 110375316
OFU: 114358440
PXY: 105382046
CLEC: 106667210
NLU: 111045294
FOC: 113207532
ZNE: 110838858
CSEC: 111870112
FCD: 110859206
DMK: 116926291
PVM: 113818707
PJA: 122264808
PCHN: 125044782
HAME: 121863460
PCLA: 123762246
PTRU: 123514002
HAZT: 108671297
EAF: 111701102
DSV: 119457577
RSAN: 119375605
RMP: 119167088
VDE: 111246867
VJA: 111268015
TUT: 107364834
DPTE: 113789891
DFR: 124499321
CSCU: 111634585
PTEP: 107447474
SDM: 118202984
CEL: CELE_ZK836.2(ogdh-2)
CBR: CBG_23406
PCAN: 112570201
BGT: 106055934
HRF: 124132339
HRJ: 124287400
CRG: 105317940
MYI: 110455544
PMAX: 117324447
MMER: 123535921
OBI: 106874001
OSN: 115210904
NVE: 5514893
EPA: 110232683
ATEN: 116286237
AMIL: 114966664
PDAM: 113684930
SPIS: 111327291
DGT: 114520034
XEN: 124441974
HMG: 100204465
AQU: 100640196
TASA: A1Q1_04236
ABP: AGABI1DRAFT123391(AGABI1DRAFT_123391)
ABV: AGABI2DRAFT179884(AGABI2DRAFT_179884)
DDI: DDB_G0280353(odhA)
DFA: DFA_02482(odhA)
SPAR: SPRG_03427
 » show all
Reference
  Authors
Xu W, Zhu H, Gu M, Luo Q, Ding J, Yao Y, Chen F, Wang Z
  Title
DHTKD1 is essential for mitochondrial biogenesis and function maintenance.
  Journal
FEBS Lett 587:3587-92 (2013)
DOI:10.1016/j.febslet.2013.08.047
Reference
  Authors
Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O
  Title
Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
  Journal
DNA Res 7:273-81 (2000)
DOI:10.1093/dnares/7.4.271
Reference
  Authors
Nemeria NS, Gerfen G, Nareddy PR, Yang L, Zhang X, Szostak M, Jordan F
  Title
The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species.
  Journal
Free Radic Biol Med 115:136-145 (2018)
DOI:10.1016/j.freeradbiomed.2017.11.018
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