KEGG ORTHOLOGY: K15791

ORTHOLOGY: K15791

Entry

K15791                      KO

Symbol

DHKTD1

Name

2-oxoadipate dehydrogenase E1 component [EC:1.2.4.-]

Pathway

map00310

Lysine degradation

map00380

Tryptophan metabolism

map00785

Lipoic acid metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01210

2-Oxocarboxylic acid metabolism

Module

M00032

Lysine degradation, lysine => saccharopine => acetoacetyl-CoA

Disease

H00264

Charcot-Marie-Tooth disease

H02644

Alpha-aminoadipic and alpha-ketoadipic aciduria

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K15791  DHKTD1; 2-oxoadipate dehydrogenase E1 component
   00380 Tryptophan metabolism
    K15791  DHKTD1; 2-oxoadipate dehydrogenase E1 component
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    K15791  DHKTD1; 2-oxoadipate dehydrogenase E1 component
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K15791  DHKTD1; 2-oxoadipate dehydrogenase E1 component
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.-
     K15791  DHKTD1; 2-oxoadipate dehydrogenase E1 component
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    K15791  DHKTD1; 2-oxoadipate dehydrogenase E1 component

Other DBs

RN:	R01933 R01940 R13166 R13167

Genes

HSA:	55526(DHTKD1)

PTR:	736115(DHTKD1)

PPS:	100977202(DHTKD1)

GGO:	101146441(DHTKD1)

PON:	100173320(DHTKD1)

NLE:	100601330(DHTKD1)

HMH:	116473730(DHTKD1)

MCC:	696445(DHTKD1)

MCF:	102119673(DHTKD1)

MTHB:

126962360

MNI:	105490650(DHTKD1)

CSAB:

103238141(DHTKD1)

CATY:

105597390(DHTKD1)

PANU:

101020595(DHTKD1)

TGE:	112631903(DHTKD1)

MLEU:

105535700(DHTKD1)

RRO:	104664886(DHTKD1)

RBB:	108538522(DHTKD1)

TFN:	117082489(DHTKD1)

PTEH:

111550054(DHTKD1)

CANG:

105506180(DHTKD1)

CJC:	100385948(DHTKD1)

SBQ:	101035476(DHTKD1)

CIMI:

108305278(DHTKD1)

CSYR:

103267160(DHTKD1)

MMUR:

105857730(DHTKD1)

LCAT:

123626697(DHTKD1)

PCOQ:

105808524(DHTKD1)

OGA:	100959733(DHTKD1)

MMU:	209692(Dhtkd1)

MCAL:

110283664(Dhtkd1)

MPAH:

110333984(Dhtkd1)

RNO:	361272(Dhtkd1)

MCOC:

116082662(Dhtkd1)

ANU:	117713635(Dhtkd1)

MUN:	110560545(Dhtkd1)

CGE:	100753689(Dhtkd1)

MAUA:

101828306(Dhtkd1)

PROB:

127229842(Dhtkd1)

PLEU:

114708434(Dhtkd1)

MORG:

121432649(Dhtkd1)

MFOT:

126506779

AAMP:

119816151(Dhtkd1)

NGI:	103738703(Dhtkd1)

HGL:	101721202(Dhtkd1)

CPOC:

100725295(Dhtkd1)

CCAN:

109682443(Dhtkd1)

DORD:

105984544(Dhtkd1)

DSP:	122113216(Dhtkd1)

PLOP:

125366826(Dhtkd1)

NCAR:

124962316

OCU:

100356735

OPI:	101517371(DHTKD1)

TUP:	102477878(DHTKD1)

GVR:	103590731(DHTKD1)

CFA:	478008(DHTKD1)

CLUD:

112658905(DHTKD1)

VVP:	112933405(DHTKD1)

VLG:	121497342(DHTKD1)

NPO:	129514025(DHTKD1)

AML:	100484376(DHTKD1)

UMR:	103676290(DHTKD1)

UAH:	113241065(DHTKD1)

UAR:	123789980(DHTKD1)

ELK:

111155533

LLV:

125107173

MPUF:

101680862(DHTKD1)

NVS:	122891349(DHTKD1)

ORO:	101364717(DHTKD1)

EJU:	114217756(DHTKD1)

ZCA:	113922535(DHTKD1)

MLX:	118021587(DHTKD1)

NSU:	110586473(DHTKD1)

LWW:

102732460

FCA:	101086155(DHTKD1)

PYU:	121014819(DHTKD1)

PCOO:

112867990(DHTKD1)

PBG:	122473897(DHTKD1)

LRUF:

124501743

PTG:	102950462(DHTKD1)

PPAD:

109273731(DHTKD1)

PUC:

125919977

AJU:

106971004

HHV:	120241093(DHTKD1)

BTA:	517113(DHTKD1)

BOM:	102284154(DHTKD1)

BIU:	109567875(DHTKD1)

BBUB:

102411718(DHTKD1)

BBIS:

104998765(DHTKD1)

CHX:	102173669(DHTKD1)

OAS:	101117008(DHTKD1)

BTAX:

128058625(DHTKD1)

ODA:	120869272(DHTKD1)

CCAD:

122448981(DHTKD1)

MBEZ:

129557058(DHTKD1)

SSC:	102166829(DHTKD1)

CFR:	102505405(DHTKD1)

CBAI:

105067994(DHTKD1)

CDK:	105100312(DHTKD1)

VPC:	102527317(DHTKD1)

BACU:

103016269(DHTKD1)

LVE:	103088004(DHTKD1)

OOR:	101270888(DHTKD1)

DLE:	111178001(DHTKD1)

PCAD:

102985620(DHTKD1)

PSIU:

116749762(DHTKD1)

NASI:

112392454(DHTKD1)

ECB:	100056844(DHTKD1)

EPZ:	103563359(DHTKD1)

EAI:	106836524(DHTKD1)

MYB:	102255818(DHTKD1)

MYD:	102774163(DHTKD1)

MMYO:

118677309(DHTKD1)

MLF:	102420365(DHTKD1)

MNA:	107530246(DHTKD1)

PKL:	118727229(DHTKD1)

EFUS:

103294022(DHTKD1)

HAI:	109390477(DHTKD1)

DRO:	112322617(DHTKD1)

SHON:

119000845(DHTKD1)

AJM:	119056684(DHTKD1)

PDIC:

114492871(DHTKD1)

PHAS:

123831150(DHTKD1)

MMF:	118642818(DHTKD1)

RFQ:	117019163(DHTKD1)

PALE:

102895062(DHTKD1)

PGIG:

120614597(DHTKD1)

PVP:	105291706(DHTKD1)

RAY:	107504853(DHTKD1)

MJV:	108395805(DHTKD1)

TOD:	119244684(DHTKD1)

SARA:

101556958(DHTKD1)

LAV:	100677553(DHTKD1)

TMU:

101351336

ETF:	101656724(DHTKD1)

DNM:	101419725(DHTKD1)

MDO:	100013507(DHTKD1)

GAS:	123248719(DHTKD1)

SHR:	100931159(DHTKD1)

AFZ:

127539055

PCW:	110217338(DHTKD1)

OAA:	100085444(DHTKD1)

GGA:	426076(DHTKD1)

PCOC:

116240325(DHTKD1)

MGP:	100540782(DHTKD1)

CJO:	107317305(DHTKD1)

TPAI:

128079725(DHTKD1)

LMUT:

125701211(DHTKD1)

NMEL:

110392260(DHTKD1)

APLA:

101799410(DHTKD1)

ACYG:

106046213(DHTKD1)

CATA:

118249490(DHTKD1)

AFUL:

116495957(DHTKD1)

TGU:	100227746(DHTKD1)

LSR:	110470969(DHTKD1)

SCAN:

103813742(DHTKD1)

PMOA:

120512518(DHTKD1)

OTC:	121340575(DHTKD1)

PRUF:

121362331(DHTKD1)

GFR:	102045028(DHTKD1)

FAB:	101819529(DHTKD1)

OMA:	130264338(DHTKD1)

PHI:	102106815(DHTKD1)

PMAJ:

107204632(DHTKD1)

CCAE:

111923121(DHTKD1)

CCW:	104694504(DHTKD1)

CBRC:

103619833(DHTKD1)

ETL:	114066624(DHTKD1)

ZAB:	102070301(DHTKD1)

ACHL:

103802633(DHTKD1)

SVG:	106857169(DHTKD1)

MMEA:

130585392(DHTKD1)

FPG:	101914531(DHTKD1)

FCH:	102046202(DHTKD1)

CLV:	102086057(DHTKD1)

EGZ:	104135760(DHTKD1)

NNI:	104014635(DHTKD1)

PLET:

104621912(DHTKD1)

PCRI:

104034005(DHTKD1)

PCAO:

104044214(DHTKD1)

ACUN:

113491537(DHTKD1)

TALA:

104359434(DHTKD1)

PADL:

103915024(DHTKD1)

AFOR:

103904154(DHTKD1)

ACHC:

115341776(DHTKD1)

HALD:

104325563(DHTKD1)

HLE:	104840284(DHTKD1)

AGEN:

126044574

GCL:

127017884

CCRI:

104167150(DHTKD1)

CSTI:

104549268(DHTKD1)

EHS:	104503355(DHTKD1)

CMAC:

104478924(DHTKD1)

MUI:	104533890(DHTKD1)

BREG:

104629106(DHTKD1)

FGA:	104079747(DHTKD1)

GSTE:

104251226(DHTKD1)

LDI:	104340428(DHTKD1)

MNB:	103778515(DHTKD1)

OHA:	104337655(DHTKD1)

NNT:	104399629(DHTKD1)

SHAB:

115605678(DHTKD1)

DPUB:

104300026(DHTKD1)

PGUU:

104458330(DHTKD1)

ACAR:

104517498(DHTKD1)

CPEA:

104391942(DHTKD1)

AVIT:

104267826(DHTKD1)

CVF:	104284652(DHTKD1)

CUCA:

104066476(DHTKD1)

TEO:	104377868(DHTKD1)

BRHI:

104489135(DHTKD1)

AAM:	106485083(DHTKD1)

AROW:

112978056(DHTKD1)

NPD:	112942383(DHTKD1)

TGT:	104569299(DHTKD1)

DNE:	112994751(DHTKD1)

SCAM:

104149422(DHTKD1)

ASN:	102376609(DHTKD1)

AMJ:	102561159(DHTKD1)

CPOO:

109315807(DHTKD1)

GGN:	109292221(DHTKD1)

PSS:	102453971(DHTKD1)

CMY:	102945253(DHTKD1)

CCAY:

125630524(DHTKD1)

DCC:	119847757(DHTKD1)

CPIC:

101940398(DHTKD1)

TST:	117874589(DHTKD1)

CABI:

116835454(DHTKD1)

MRV:	120395232(DHTKD1)

ACS:	100551958(dhtkd1)

PVT:	110081244(DHTKD1)

SUND:

121930960(DHTKD1)

PBI:	103051773 103066009

PMUR:

107297191(DHTKD1) 107300248

CTIG:

120314440(DHTKD1)

TSR:	106550932(DHTKD1)

PGUT:

117668317(DHTKD1)

APRI:

131202203(DHTKD1)

PTEX:

113436373(DHTKD1)

NSS:	113412187(DHTKD1)

VKO:	123020101(DHTKD1)

PMUA:

114605061(DHTKD1)

PRAF:

128421854(DHTKD1)

ZVI:	118091023(DHTKD1)

HCG:	128326498(DHTKD1)

GJA:	107111049(DHTKD1)

STOW:

125435027(DHTKD1)

EMC:	129335546(DHTKD1)

XLA:	403360(dhtkd1.L)

XTR:	100493977(dhtkd1)

NPR:	108784821(DHTKD1)

RTEM:

120931700(DHTKD1)

BBUF:

120983646(DHTKD1)

BGAR:

122925389(DHTKD1)

MUO:	115478619(DHTKD1)

GSH:	117366798(DHTKD1)

DRE:	494076(dhtkd1)

SRX:	107720787(dhtkd1) 107740898 107750732

SANH:

107670224 107673284

SGH:	107559980 107569696

CCAR:

109053636(dhtkd1)

CAUA:

113043697(dhtkd1) 113066386

CGIB:

127946691 128014587

PTET:

122331000(dhtkd1)

LROH:

127156383(dhtkd1)

OMC:	131534060(dhtkd1)

PPRM:

120475341(dhtkd1)

MAMB:

125246798(dhtkd1)

CIDE:

127507467

MASI:

127436111

TROS:

130551686(dhtkd1)

IPU:

108275231

PHYP:

113530129(dhtkd1)

SMEO:

124392776(dhtkd1)

TFD:	113653931(dhtkd1)

AMEX:

103041509(dhtkd1)

CMAO:

118811883(dhtkd1)

EEE:	113584502(dhtkd1)

CHAR:

105913424(dhtkd1)

TRU:	101070517(dhtkd1)

TFS:	130536567(dhtkd1)

TNG:	GSTEN00029738G001

LCO:	104940683(dhtkd1)

NCC:

104940829

CGOB:

115010070(dhtkd1)

ELY:	117262481(dhtkd1)

EFO:	125887743(dhtkd1)

PLEP:

121949834(dhtkd1)

SLUC:

116038313(dhtkd1)

ECRA:

117949413(dhtkd1)

ESP:	116694289(dhtkd1)

PFLV:

114560607(dhtkd1)

GAT:	120809782(dhtkd1)

PPUG:

119196195(dhtkd1)

AFB:	129107801(dhtkd1)

CLUM:

117732179(dhtkd1)

MSAM:

119893677(dhtkd1) 119893755

SCHU:

122874246(dhtkd1)

CUD:	121515538(dhtkd1)

ALAT:

119024840(dhtkd1)

MZE:	101480158(dhtkd1)

ONL:	100705674(dhtkd1)

OAU:	116332644(dhtkd1)

OLA:	101175318(dhtkd1)

OML:	112152326(dhtkd1)

XMA:	102229655(dhtkd1)

XCO:	114155128(dhtkd1)

XHE:	116735793(dhtkd1)

PRET:

103465849(dhtkd1)

PFOR:

103154904(dhtkd1)

PLAI:

106946083(dhtkd1)

PMEI:

106928901(dhtkd1)

GAF:	122835739(dhtkd1)

CVG:	107095058(dhtkd1)

CTUL:

119799135(dhtkd1)

GMU:	124881211(dhtkd1)

NFU:	107388455(dhtkd1)

KMR:	108230154(dhtkd1)

ALIM:

106523641(dhtkd1)

NWH:	119416487(dhtkd1)

AOCE:

111566787(dhtkd1)

MCEP:

125015132(dhtkd1)

CSEM:

103380546(dhtkd1)

POV:	109624521(dhtkd1)

SSEN:

122776246(dhtkd1)

HHIP:

117763866(dhtkd1)

HSP:	118109529(dhtkd1)

LCF:

108888513

SDU:	111229832(dhtkd1)

SLAL:

111670862(dhtkd1)

XGL:	120793241(dhtkd1)

HCQ:	109522972(dhtkd1)

SSCV:

125970261

BPEC:

110169356(dhtkd1)

MALB:

109974702(dhtkd1)

BSPL:

114857377(dhtkd1)

SASA:

106561658 106573060

STRU:

115152393 115197645

OTW:	112218920 112253499

OMY:	110500303 110524999

OGO:	124004706 124032433

ONE:	115109716 115133925

OKI:	109867047 109889674

SALP:

111952755 111962791

SNH:	120054182 120066485

CCLU:

121531607 121577079

ELS:	105021851(dhtkd1)

SFM:	108931528(dhtkd1)

PKI:	111842368(dhtkd1)

AANG:

118231643(dhtkd1)

LOC:	102690271(dhtkd1)

PSPA:

121318271

ARUT:

117415044 117419461

PSEX:

120534055(dhtkd1)

LCM:	102356663(DHTKD1)

CMK:	103187915(dhtkd1)

RTP:	109929690(dhtkd1)

CPLA:

122561860(dhtkd1)

LERI:

129707957(dhtkd1)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG1544(CG1544)

DER:

6554810

DSE:

6612954

DSI:	Dsimw501_GD21563(Dsim_GD21563)

DYA:	Dyak_GE10922

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI22321

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

RZE:

TDA:	119682611 119683263

MDE:

SCAC:

LCQ:

LSQ:

HIS:

AGA:	AgaP_AGAP000551

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ017085

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:	105199284 105208178

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

NVI:

CSOL:

TPRE:

106655398 106656887 106660311

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

TCA:	656360(DHTKD1)

DPA:

SOY:

AGRG:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:	111415918 111419702

BMOR:

101740126

BMAN:

114252985

MSEX:

115440187

DPL:	KGM_210696

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

HAW:

HZE:

TNL:	113496596 113507165

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

CLEC:

NLU:

HVI:	124371401 124373448

PHU:	Phum_PHUM315960

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

IEL:

FCD:

DPX:	DAPPUDRAFT_311540

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:	126985020 126992875

HAZT:

EAF:

LSM:

PPOI:

ISC:	IscW_ISCW021407

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_ZK836.2(ogdh-2)

CBR:

CBG_23406

CRQ:	GCK72_018219

NAI:	NECAME_12214

HRO:	HELRODRAFT_106795

LGI:	LOTGIDRAFT_215641

PCAN:

112570201

BGT:

106055934

GAE:	121372730 121392756

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

DPOL:

OBI:

OSN:

LAK:	106169636 106176283 106178702

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_19360

AQU:

100640196

TMS:	TREMEDRAFT_39360

TASA:

A1Q1_04236

TVS:	TRAVEDRAFT_50847

DSQ:	DICSQDRAFT_182608

PCO:	PHACADRAFT_152038

SHS:	STEHIDRAFT_119946

HIR:	HETIRDRAFT_157309

PSQ:	PUNSTDRAFT_52703

ADL:	AURDEDRAFT_82563

FME:	FOMMEDRAFT_142811

GTR:	GLOTRDRAFT_82042

RSX:	RhiXN_00266

CCI:	CC1G_03565

ABP:	AGABI1DRAFT123391(AGABI1DRAFT_123391)

ABV:	AGABI2DRAFT179884(AGABI2DRAFT_179884)

PCUB:

JR316_0008654

MRR:	Moror_10402

E1B28_005474

SCM:	SCHCO_02639805(SCHCODRAFT_02639805)

CPUT:

CONPUDRAFT_107933

SLA:	SERLADRAFT_433954

PTRC:

PtA15_14A160

DDI:	DDB_G0280353(odhA)

DPP:	DICPUDRAFT_150923

DFA:	DFA_02482(odhA)

ACAN:

ACA1_283230

TET:	TTHERM_00954380

PTM:	GSPATT00004489001

PIF:	PITG_00553 PITG_21517

PSOJ:

PHYSODRAFT_561452

SPAR:

SPRG_03427

NGR:	NAEGRDRAFT_80828

» show all

Reference

PMID:24076469

Authors

Xu W, Zhu H, Gu M, Luo Q, Ding J, Yao Y, Chen F, Wang Z

Title

DHTKD1 is essential for mitochondrial biogenesis and function maintenance.

Journal

FEBS Lett 587:3587-92 (2013)
DOI:10.1016/j.febslet.2013.08.047

Reference

PMID:10997877

Authors

Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O

Title

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

Journal

DNA Res 7:273-81 (2000)
DOI:10.1093/dnares/7.4.271

Reference

PMID:29191460

Authors

Nemeria NS, Gerfen G, Nareddy PR, Yang L, Zhang X, Szostak M, Jordan F

Title

The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species.

Journal

Free Radic Biol Med 115:136-145 (2018)
DOI:10.1016/j.freeradbiomed.2017.11.018

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