KEGG   ORTHOLOGY: K15886Help
Entry
K15886                      KO                                     

Name
tcmN
Definition
multifunctional cyclase / dehydratase / O-methyltransferase [EC:2.3.1.235]
Pathway
ko01056  Biosynthesis of type II polyketide backbone
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
M00783  Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K15886  tcmN; multifunctional cyclase / dehydratase / O-methyltransferase
   01057 Biosynthesis of type II polyketide products
    K15886  tcmN; multifunctional cyclase / dehydratase / O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.235  tetracenomycin F2 synthase
     K15886  tcmN; multifunctional cyclase / dehydratase / O-methyltransferase
BRITE hierarchy
Other DBs
RN: R06701 R09269 R10960
Genes
SGU: SGLAU_26370(tcmN)
TaxonomyKoalaUniProt
Reference
PMID:1548230
  Authors
Summers RG, Wendt-Pienkowski E, Motamedi H, Hutchinson CR
  Title
Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase.
  Journal
J Bacteriol 174:1810-20 (1992)
DOI:10.1128/JB.174.6.1810-1820.1992
  Sequence
Reference
  Authors
Ames BD, Korman TP, Zhang W, Smith P, Vu T, Tang Y, Tsai SC
  Title
Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides.
  Journal
Proc Natl Acad Sci U S A 105:5349-54 (2008)
DOI:10.1073/pnas.0709223105
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