KEGG   ORTHOLOGY: K15887
Entry
K15887            Tight     KO                                     

Name
ZFPS
Definition
(2Z,6Z)-farnesyl diphosphate synthase [EC:2.5.1.92]
Pathway
ko00900  Terpenoid backbone biosynthesis
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K15887  ZFPS; (2Z,6Z)-farnesyl diphosphate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.92  (2Z,6Z)-farnesyl diphosphate synthase
     K15887  ZFPS; (2Z,6Z)-farnesyl diphosphate synthase
Other DBs
RN: R09633
Genes
AG: ACJ38408(ZFPS)
Reference
  Authors
Sallaud C, Rontein D, Onillon S, Jabes F, Duffe P, Giacalone C, Thoraval S, Escoffier C, Herbette G, Leonhardt N, Causse M, Tissier A
  Title
A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites.
  Journal
Plant Cell 21:301-17 (2009)
DOI:10.1105/tpc.107.057885
  Sequence
LinkDB

KEGG   ENZYME: 2.5.1.92
Entry
EC 2.5.1.92                 Enzyme                                 

Name
(2Z,6Z)-farnesyl diphosphate synthase;
cis,cis-farnesyl diphosphate synthase;
Z,Z-FPP synthase;
zFPS;
Z,Z-farnesyl pyrophosphate synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
dimethylallyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 2 isopentenyl units)
Reaction(IUBMB)
dimethylallyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + (2Z,6Z)-farnesyl diphosphate [RN:R09633];
(1a) dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate [RN:R01659];
(1b) neryl diphosphate + isopentenyl diphosphate = diphosphate + (2Z,6Z)-farnesyl diphosphate [RN:R12638]
Reaction(KEGG)
Substrate
dimethylallyl diphosphate [CPD:C00235];
isopentenyl diphosphate [CPD:C00129];
neryl diphosphate [CPD:C02569]
Product
diphosphate [CPD:C00013];
(2Z,6Z)-farnesyl diphosphate [CPD:C19760];
neryl diphosphate [CPD:C02569]
Comment
This enzyme, originally characterized from wild tomato, specifically forms (2Z,6Z)-farnesyl diphosphate via neryl diphosphate and isopentenyl diphosphate. In wild tomato it is involved in the biosynthesis of several sesquiterpenes. See also EC 2.5.1.68 [(2Z,6E)-farnesyl diphosphate synthase] and EC 2.5.1.10 [(2E,6E)-farnesyl diphosphate synthase].
History
EC 2.5.1.92 created 2010, modified 2011
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K15887  (2Z,6Z)-farnesyl diphosphate synthase
Reference
1  [PMID:19155349]
  Authors
Sallaud C, Rontein D, Onillon S, Jabes F, Duffe P, Giacalone C, Thoraval S, Escoffier C, Herbette G, Leonhardt N, Causse M, Tissier A
  Title
A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites.
  Journal
Plant Cell 21:301-17 (2009)
DOI:10.1105/tpc.107.057885
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.92
IUBMB Enzyme Nomenclature: 2.5.1.92
ExPASy - ENZYME nomenclature database: 2.5.1.92
BRENDA, the Enzyme Database: 2.5.1.92
LinkDB

KEGG   REACTION: R09633
Entry
R09633                      Reaction                               

Name
dimethylallyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 2 isopentenyl units)
Definition
Dimethylallyl diphosphate + 2 Isopentenyl diphosphate <=> 2 Diphosphate + (2Z,6Z)-Farnesyl diphosphate
Equation
C00235 + 2 C00129 <=> 2 C00013 + C19760
Comment
two-step reaction (see R01659+R12638)
Reaction class
RC00279  C00129_C19760
Enzyme
Pathway
rn00900  Terpenoid backbone biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K15887  (2Z,6Z)-farnesyl diphosphate synthase [EC:2.5.1.92]
Other DBs
RHEA: 27813
LinkDB

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