KEGG   ORTHOLOGY: K15890
Entry
K15890                      KO                                     

Name
FOHSDR
Definition
NADP+-dependent farnesol dehydrogenase [EC:1.1.1.216]
Pathway
ko00900  Terpenoid backbone biosynthesis
ko00981  Insect hormone biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K15890  FOHSDR; NADP+-dependent farnesol dehydrogenase
   00981 Insect hormone biosynthesis
    K15890  FOHSDR; NADP+-dependent farnesol dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.216  farnesol dehydrogenase (NADP+)
     K15890  FOHSDR; NADP+-dependent farnesol dehydrogenase
Other DBs
RN: R03264
GO: 0047886
Genes
DME: Dmel_CG10962(CG10962) Dmel_CG1386(antdh) Dmel_CG3301(CG3301) Dmel_CG40485(CG40485) Dmel_CG40486(CG40486) Dmel_CG8757(CG8757) Dmel_CG9150(CG9150)
DER: 6543477 6545569 6549862 6549973 6549974 6551694 6553336
DSE: 6605603 6613582 6617640 6619743 6620024 6620089 6620090
DSI: Dsimw501_GD15999(Dsim_GD15999) Dsimw501_GD16091(Dsim_GD16091) Dsimw501_GD17575(Dsim_GD17575) Dsimw501_GD19991(Dsim_GD19991) Dsimw501_GD22600(Dsim_GD22600) Dsimw501_GD23342(Dsim_GD23342) Dsimw501_GD26908(Dsim_GD26908)
DYA: Dyak_GE15259 Dyak_GE15260 Dyak_GE17313 Dyak_GE17424 Dyak_GE18948 Dyak_GE20052 Dyak_GE25000
DAN: 6498214 6500045 6501882 6504823 6504824 6505023
DSR: 110176041 110180365 110180367 110182109 110182689 110187933 110188271 110190274
DPO: Dpse_GA12578 Dpse_GA17238 Dpse_GA21577 Dpse_GA22691 Dpse_GA23087 Dpse_GA23088 Dpse_GA25891
DPE: 6587226 6589226 6597291 6597788 6597841 6598208 6598768 6602913
DMN: 108150850 108151202 108154295 108157162 108157803 108162957 108165133 108165134
PBAR: 105433698
VEM: 105561928
LHU: 105673536
PMAC: 106709858
PRAP: 110991447
 » show all
Reference
  Authors
Mayoral JG, Nouzova M, Navare A, Noriega FG
  Title
NADP+-dependent farnesol dehydrogenase, a corpora allata enzyme involved in juvenile hormone synthesis.
  Journal
Proc Natl Acad Sci U S A 106:21091-6 (2009)
DOI:10.1073/pnas.0909938106
  Sequence
[aag:23687872]
LinkDB

KEGG   ENZYME: 1.1.1.216
Entry
EC 1.1.1.216                Enzyme                                 

Name
farnesol dehydrogenase (NADP+);
NADP+-farnesol dehydrogenase;
farnesol (nicotinamide adenine dinucleotide phosphate) dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2E,6E)-farnesol:NADP+ 1-oxidoreductase
Reaction(IUBMB)
(2E,6E)-farnesol + NADP+ = (2E,6E)-farnesal + NADPH + H+ [RN:R03264]
Reaction(KEGG)
R03264
Substrate
(2E,6E)-farnesol [CPD:C01126];
NADP+ [CPD:C00006]
Product
(2E,6E)-farnesal [CPD:C03461];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts, more slowly, on (2Z,6E)-farnesol, geraniol, citronerol and nerol.
History
EC 1.1.1.216 created 1989
Pathway
ec00900  Terpenoid backbone biosynthesis
ec00981  Insect hormone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K15890  NADP+-dependent farnesol dehydrogenase
Genes
DME: Dmel_CG10962(CG10962) Dmel_CG1386(antdh) Dmel_CG3301(CG3301) Dmel_CG40485(CG40485) Dmel_CG40486(CG40486) Dmel_CG8757(CG8757) Dmel_CG9150(CG9150)
DER: 6543477 6545569 6549862 6549973 6549974 6551694 6553336
DSE: 6605603 6613582 6617640 6619743 6620024 6620089 6620090
DSI: Dsimw501_GD15999(Dsim_GD15999) Dsimw501_GD16091(Dsim_GD16091) Dsimw501_GD17575(Dsim_GD17575) Dsimw501_GD19991(Dsim_GD19991) Dsimw501_GD22600(Dsim_GD22600) Dsimw501_GD23342(Dsim_GD23342) Dsimw501_GD26908(Dsim_GD26908)
DYA: Dyak_GE15259 Dyak_GE15260 Dyak_GE17313 Dyak_GE17424 Dyak_GE18948 Dyak_GE20052 Dyak_GE25000
DAN: 6498214 6500045 6501882 6504823 6504824 6505023
DSR: 110176041 110180365 110180367 110182109 110182689 110187933 110188271 110190274
DPO: Dpse_GA12578 Dpse_GA17238 Dpse_GA21577 Dpse_GA22691 Dpse_GA23087 Dpse_GA23088 Dpse_GA25891
DPE: 6587226 6589226 6597291 6597788 6597841 6598208 6598768 6602913
DMN: 108150850 108151202 108154295 108157162 108157803 108162957 108165133 108165134
PBAR: 105433698
VEM: 105561928
LHU: 105673536
PMAC: 106709858
PRAP: 110991447
 » show all
Reference
1
  Authors
Inoue, H., Tsuji, H. and Uritani, I.
  Title
Characterization and activity change of farnesol dehydrogenase in black rot fungus-infected sweet-potato.
  Journal
Agric Biol Chem 48:733-738 (1984)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.216
IUBMB Enzyme Nomenclature: 1.1.1.216
ExPASy - ENZYME nomenclature database: 1.1.1.216
BRENDA, the Enzyme Database: 1.1.1.216
CAS: 89089-75-8 90804-55-0
LinkDB

KEGG   REACTION: R03264
Entry
R03264                      Reaction                               

Name
2-trans,6-trans-farnesol:NADP+ 1-oxidoreductase
Definition
(2E,6E)-Farnesol + NADP+ <=> 2-trans,6-trans-Farnesal + NADPH + H+
Equation
Reaction class
RC00649  C01126_C03461
Enzyme
Pathway
rn00900  Terpenoid backbone biosynthesis
rn00981  Insect hormone biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K15890  NADP+-dependent farnesol dehydrogenase [EC:1.1.1.216]
Other DBs
RHEA: 14700
LinkDB

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