KEGG   ORTHOLOGY: K15967
Entry
K15967            Tight     KO                                     

Name
mtmW
Definition
ketoreductase
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00782  Mithramycin biosynthesis, 4-demethylpremithramycinone => mithramycin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15967  mtmW; ketoreductase
Other DBs
RN: R09354
Genes
AG: CAK50787(mtmW)
Reference
  Authors
Albertini V, Jain A, Vignati S, Napoli S, Rinaldi A, Kwee I, Nur-e-Alam M, Bergant J, Bertoni F, Carbone GM, Rohr J, Catapano CV
  Title
Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy.
  Journal
Nucleic Acids Res 34:1721-34 (2006)
DOI:10.1093/nar/gkl063
Reference
  Authors
Remsing LL, Gonzalez AM, Nur-e-Alam M, Fernandez-Lozano MJ, Brana AF, Rix U, Oliveira MA, Mendez C, Salas JA, Rohr J
  Title
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.
  Journal
J Am Chem Soc 125:5745-53 (2003)
DOI:10.1021/ja034162h
  Sequence
LinkDB

DBGET integrated database retrieval system