KEGG   ORTHOLOGY: K15972
Entry
K15972                      KO                                     

Name
tcmG, elmG
Definition
tetracenomycin A2 monooxygenase-dioxygenase [EC:1.14.13.200]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00783  Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15972  tcmG, elmG; tetracenomycin A2 monooxygenase-dioxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.200  tetracenomycin A2 monooxygenase-dioxygenase
     K15972  tcmG, elmG; tetracenomycin A2 monooxygenase-dioxygenase
Other DBs
RN: R06704 R10954
COG: COG0654
Genes
SGU: SGLAU_26335(tcmG)
SLD: T261_0037
SRO: Sros_4156
AMD: AMED_5441
AMN: RAM_27735
AMM: AMES_5376
AMZ: B737_5376
AG: CAP12596(elmG)
Reference
PMID:8509339
  Authors
Decker H, Motamedi H, Hutchinson CR
  Title
Nucleotide sequences and heterologous expression of tcmG and tcmP, biosynthetic genes for tetracenomycin C in Streptomyces glaucescens.
  Journal
J Bacteriol 175:3876-86 (1993)
DOI:10.1128/JB.175.12.3876-3886.1993
  Sequence
Reference
  Authors
Rafanan ER Jr, Hutchinson CR, Shen B
  Title
Triple hydroxylation of tetracenomycin A2 to tetracenomycin C involving two molecules of O(2) and one molecule of H(2)O.
  Journal
Org Lett 2:3225-7 (2000)
DOI:10.1021/ol0002267
Reference
  Authors
Rafanan ER Jr, Le L, Zhao L, Decker H, Shen B
  Title
Cloning, sequencing, and heterologous expression of the elmGHIJ genes involved in the biosynthesis of the polyketide antibiotic elloramycin from Streptomyces olivaceus Tu2353.
  Journal
J Nat Prod 64:444-9 (2001)
DOI:10.1021/np010007+
  Sequence
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