KEGG   ORTHOLOGY: K15988
Entry
K15988            Tight     KO                                     

Name
tylG1
Definition
tylactone synthase 1
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K15988  tylG1; tylactone synthase 1
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K15988  tylG1; tylactone synthase 1
Other DBs
RN: R06448
Genes
AG: AAB66504(tylG1)
Reference
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (part B).
  Journal
Nat Prod Rep 18:231-81 (2001)
DOI:10.1039/B100191O
Reference
  Authors
Butler AR, Bate N, Cundliffe E
  Title
Impact of thioesterase activity on tylosin biosynthesis in Streptomyces fradiae.
  Journal
Chem Biol 6:287-92 (1999)
DOI:10.1016/S1074-5521(99)80074-X
  Sequence
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