KEGG   ORTHOLOGY: K15991
Entry
K15991            Tight     KO                                     

Name
tylHI, CYP105L1
Definition
20-oxo-5-O-mycaminosyltylactone 23-monooxygenase [EC:1.14.15.34]
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K15991  tylHI, CYP105L1; 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K15991  tylHI, CYP105L1; 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K15991  tylHI, CYP105L1; 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.34  20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
     K15991  tylHI, CYP105L1; 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, bacteria type
  CYP105 family
   K15991  tylHI, CYP105L1; 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
Other DBs
RN: R10656
COG: COG2124
Genes
STRE: GZL_03700
STRM: M444_29910
AG: AAD12167(tylHI)
Reference
  Authors
Fouces R, Mellado E, Diez B, Barredo JL
  Title
The tylosin biosynthetic cluster from Streptomyces fradiae: genetic organization of the left region.
  Journal
Microbiology 145 ( Pt 4):855-68 (1999)
DOI:10.1099/13500872-145-4-855
  Sequence
Reference
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (part B).
  Journal
Nat Prod Rep 18:231-81 (2001)
DOI:10.1039/B100191O
Reference
  Authors
Bate N, Cundliffe E
  Title
The mycinose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.
  Journal
J Ind Microbiol Biotechnol 23:118-122 (1999)
DOI:10.1038/sj.jim.2900707
  Sequence
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