KEGG   ORTHOLOGY: K16004
Entry
K16004            Tight     KO                                     

Name
desVII
Definition
narbonolide/10-deoxymethynolide desosaminyltransferase [EC:2.4.1.277]
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00776  Pikromycin/methymycin biosynthesis, methylmalonyl-CoA + malonyl-CoA => narbonolide/10-deoxymethynolide => pikromycin/methymycin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16004  desVII; narbonolide/10-deoxymethynolide desosaminyltransferase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K16004  desVII; narbonolide/10-deoxymethynolide desosaminyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.277  10-deoxymethynolide desosaminyltransferase
     K16004  desVII; narbonolide/10-deoxymethynolide desosaminyltransferase
Other DBs
RN: R06460 R06461
COG: COG1819
CAZy: GT1
Genes
AG: AAC68677(desVII)
Reference
PMID:9770448
  Authors
Xue Y, Zhao L, Liu HW, Sherman DH
  Title
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.
  Journal
Proc Natl Acad Sci U S A 95:12111-6 (1998)
DOI:10.1073/pnas.95.21.12111
  Sequence
Reference
  Authors
Borisova SA, Liu HW
  Title
Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway.
  Journal
Biochemistry 49:8071-84 (2010)
DOI:10.1021/bi1007657
  Sequence
LinkDB

KEGG   ORTHOLOGY: K16005
Entry
K16005            Tight     KO                                     

Name
desVIII
Definition
narbonolide/10-deoxymethynolide desosaminyltransferase auxiliary protein
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00776  Pikromycin/methymycin biosynthesis, methylmalonyl-CoA + malonyl-CoA => narbonolide/10-deoxymethynolide => pikromycin/methymycin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16005  desVIII; narbonolide/10-deoxymethynolide desosaminyltransferase auxiliary protein
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K16005  desVIII; narbonolide/10-deoxymethynolide desosaminyltransferase auxiliary protein
Other DBs
RN: R06460 R06461
Genes
AG: AAC68676(desVIII)
Reference
  Authors
Borisova SA, Liu HW
  Title
Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway.
  Journal
Biochemistry 49:8071-84 (2010)
DOI:10.1021/bi1007657
  Sequence
Reference
  Authors
Hong JS, Park SJ, Parajuli N, Park SR, Koh HS, Jung WS, Choi CY, Yoon YJ
  Title
Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementation.
  Journal
Gene 386:123-30 (2007)
DOI:10.1016/j.gene.2006.08.021
  Sequence
LinkDB

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