KEGG   ORTHOLOGY: K16007
Entry
K16007            Tight     KO                                     

Name
oleA
Definition
8,8a-deoxyoleandolide synthase
Pathway
ko00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ko01052  Type I polyketide structures
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00775  Oleandomycin biosynthesis, malonyl-CoA + methylmalonyl-CoA => 8,8a-deoxyoleandolide => oleandomycin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16007  oleA; 8,8a-deoxyoleandolide synthase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K16007  oleA; 8,8a-deoxyoleandolide synthase
Other DBs
RN: R06453
Genes
AG: AAA19695(oleAIII) AAF82408(oleAI) AAF82409(oleAII)
Reference
  Authors
Shah S, Xue Q, Tang L, Carney JR, Betlach M, McDaniel R
  Title
Cloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin.
  Journal
J Antibiot (Tokyo) 53:502-8 (2000)
DOI:10.7164/antibiotics.53.502
  Sequence
Reference
PMID:8107683
  Authors
Swan DG, Rodriguez AM, Vilches C, Mendez C, Salas JA
  Title
Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence.
  Journal
Mol Gen Genet 242:358-62 (1994)
DOI:10.1007/BF00280426
  Sequence
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