KEGG   ORTHOLOGY: K16172
Entry
K16172                      KO                                     

Name
IRS1
Definition
insulin receptor substrate 1
Pathway
map04022  cGMP-PKG signaling pathway
map04068  FoxO signaling pathway
map04140  Autophagy - animal
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04212  Longevity regulating pathway - worm
map04213  Longevity regulating pathway - multiple species
map04722  Neurotrophin signaling pathway
map04910  Insulin signaling pathway
map04920  Adipocytokine signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04930  Type II diabetes mellitus
map04931  Insulin resistance
map04932  Non-alcoholic fatty liver disease
map04935  Growth hormone synthesis, secretion and action
map04960  Aldosterone-regulated sodium reabsorption
map05010  Alzheimer disease
map05206  MicroRNAs in cancer
map05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04022 cGMP-PKG signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04151 PI3K-Akt signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04152 AMPK signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04150 mTOR signaling pathway
    K16172  IRS1; insulin receptor substrate 1
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K16172  IRS1; insulin receptor substrate 1
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04923 Regulation of lipolysis in adipocytes
    K16172  IRS1; insulin receptor substrate 1
   04920 Adipocytokine signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04935 Growth hormone synthesis, secretion and action
    K16172  IRS1; insulin receptor substrate 1
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K16172  IRS1; insulin receptor substrate 1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K16172  IRS1; insulin receptor substrate 1
  09149 Aging
   04211 Longevity regulating pathway
    K16172  IRS1; insulin receptor substrate 1
   04212 Longevity regulating pathway - worm
    K16172  IRS1; insulin receptor substrate 1
   04213 Longevity regulating pathway - multiple species
    K16172  IRS1; insulin receptor substrate 1
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K16172  IRS1; insulin receptor substrate 1
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K16172  IRS1; insulin receptor substrate 1
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K16172  IRS1; insulin receptor substrate 1
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K16172  IRS1; insulin receptor substrate 1
   04932 Non-alcoholic fatty liver disease
    K16172  IRS1; insulin receptor substrate 1
   04931 Insulin resistance
    K16172  IRS1; insulin receptor substrate 1
Genes
HSA: 3667(IRS1)
PTR: 459985(IRS1)
PPS: 100971596(IRS1)
GGO: 101132740(IRS1)
PON: 100442255(IRS1)
NLE: 100607873(IRS1)
MCC: 707870(IRS1)
MCF: 102117978(IRS1)
CSAB: 103217981(IRS1)
CATY: 105586974(IRS1)
PANU: 100999369(IRS1)
RRO: 104656078(IRS1)
RBB: 108538753(IRS1)
TFN: 117094439(IRS1)
PTEH: 111527547(IRS1)
CJC: 100387742(IRS1)
SBQ: 101035868(IRS1)
MMUR: 105862871(IRS1)
MMU: 16367(Irs1)
MCAL: 110292727(Irs1)
MPAH: 110321270(Irs1)
RNO: 25467(Irs1)
MCOC: 116088647(Irs1)
MUN: 110547502(Irs1)
CGE: 100755710(Irs1)
PLEU: 114696438(Irs1)
NGI: 103727788(Irs1)
HGL: 101708189(Irs1)
CCAN: 109696750(Irs1)
OCU: 100339981(IRS1)
TUP: 102496620(IRS1)
CFA: 486148(IRS1)
VVP: 112925532(IRS1)
VLG: 121496830(IRS1)
AML: 100477645(IRS1)
UMR: 103662712(IRS1)
UAH: 113250390(IRS1)
ORO: 101367978(IRS1)
ELK: 111143995
MPUF: 101684695(IRS1)
EJU: 114210848(IRS1)
MLX: 118011983(IRS1)
FCA: 101087257(IRS1)
PTG: 102965599(IRS1)
PPAD: 109264970(IRS1)
AJU: 106972296(IRS1)
HHV: 120249142(IRS1)
BTA: 538598(IRS1)
BOM: 102284664(IRS1)
BIU: 109571355(IRS1)
BBUB: 102416637(IRS1)
CHX: 102184858(IRS1)
OAS: 101102293(IRS1)
ODA: 120854447(IRS1)
SSC: 100512686(IRS1)
CFR: 102512682(IRS1)
CDK: 105088301(IRS1)
BACU: 103011761(IRS1)
LVE: 103074278(IRS1)
OOR: 101271463(IRS1)
DLE: 111171885(IRS1)
PCAD: 102992290(IRS1)
ECB: 100061987(IRS1)
EPZ: 103547143(IRS1)
EAI: 106827854(IRS1)
MYB: 102247525(IRS1)
MYD: 102752666(IRS1)
MMYO: 118661524(IRS1)
MNA: 107525521(IRS1)
HAI: 109396328(IRS1)
DRO: 112307950(IRS1)
SHON: 118975374(IRS1)
AJM: 119044737(IRS1)
MMF: 118625363(IRS1)
PALE: 102891583(IRS1)
RAY: 107497246(IRS1)
MJV: 108397189(IRS1)
TOD: 119256266(IRS1)
LAV: 100664968(IRS1)
TMU: 101356151
MDO: 100021838(IRS1)
SHR: 100918116(IRS1)
PCW: 110200253(IRS1)
OAA: 103170729(IRS1)
GGA: 107051846
PCOC: 116230914(IRS1)
MGP: 100539255(IRS1)
CJO: 107318049(IRS1)
NMEL: 110397421(IRS1)
APLA: 101796950(IRS1)
ACYG: 106036186(IRS1)
TGU: 105759506(IRS1)
LSR: 110483660(IRS1)
SCAN: 103815658(IRS1)
PMOA: 120508576(IRS1)
GFR: 102044407(IRS1)
FAB: 101810426(IRS1)
PHI: 102101540(IRS1)
PMAJ: 107208936(IRS1)
CCAE: 111933626(IRS1)
CCW: 109145556(IRS1)
ETL: 114068746(IRS1)
FPG: 101922249(IRS1)
FCH: 102052001(IRS1)
CLV: 102083619(IRS1)
EGZ: 104127063(IRS1)
NNI: 104016496(IRS1)
ACUN: 113483461(IRS1)
PADL: 103917904(IRS1)
AAM: 106485843(IRS1)
ASN: 102372136(IRS1)
AMJ: 102574179(IRS1)
CPOO: 109308621(IRS1)
GGN: 109288184(IRS1)
PSS: 102455771 102463626(IRS1)
CMY: 102945843(IRS1) 119565054
CPIC: 101931522(IRS1)
TST: 117882685(IRS1)
CABI: 116829822(IRS1)
ACS: 100565100(irs1) 103282162
PVT: 110078456(IRS1) 110082325
PBI: 103048511 103055013(IRS1)
PMUR: 107286667(IRS1)
TSR: 106542051(IRS1) 106556223
PGUT: 117658926 117678362(IRS1)
PMUA: 114582338 114597807(IRS1)
ZVI: 118093487(IRS1) 118095226
GJA: 107116003(IRS1)
XLA: 108711802(irs2.L) 108718134 399299(irs1.L)
XTR: 100495320(irs1) 394823(irs2)
NPR: 108796838(IRS1) 108800291
DRE: 559281(irs1)
IPU: 108260367 108267519(Irs1) 108278298(irs1)
AMEX: 103025632(irs1) 103042975
EEE: 113588983(irs1) 113591002
LCO: 104923989
ELY: 117246218(si:ch73-335l21.1) 117263376(si:ch211-284e13.4)
PLEP: 121939025(si:ch73-335l21.1) 121952980(si:ch211-284e13.4)
SLUC: 116048982(si:ch73-335l21.1) 116064954(si:ch211-284e13.4)
ECRA: 117955928(si:ch211-284e13.4) 117962219(si:ch73-335l21.1)
GAT: 120822124(si:ch73-335l21.1) 120822445(si:ch211-284e13.4)
MSAM: 119896161(si:ch211-284e13.4) 119911745(si:ch73-335l21.1)
CUD: 121504510(si:ch73-335l21.1) 121519283(si:ch211-284e13.4)
OAU: 116330213(si:ch211-284e13.4) 116330728(si:ch73-335l21.1)
OML: 112142839(si:ch211-284e13.4) 112155960(si:ch73-335l21.1)
XMA: 102224423
XCO: 114157029
PRET: 103480483
CVG: 107087768
CTUL: 119779217(si:ch211-284e13.4) 119783405(si:ch73-335l21.1)
KMR: 108241811(si:ch73-335l21.1) 108245231(si:ch211-284e13.4)
ALIM: 106529184
AOCE: 111571694
LCF: 108897056
SDU: 111233019
SLAL: 111665735
XGL: 120797377(si:ch73-335l21.1) 120802170(si:ch211-284e13.4)
MALB: 109966482
OMY: 110490060(irs1) 110500592 110531720(si:ch73-335l21.1) 110533721(si:ch211-284e13.4) 110537392
ELS: 105020633
LOC: 102684310 102696987(irs1)
LCM: 102366510(IRS1) 102367331
CMK: 103180489(irs1)
BFO: 118404526
CIN: 100185541
SCLV: 120328915
SPU: 100890677
APLC: 110985759
SKO: 102809894
DME: Dmel_CG5686(chico)
DER: 6542588
DSE: 6611937
DSI: Dsimw501_GD22290(Dsim_GD22290)
DSR: 110183373
DPE: 6589676
DMN: 108162201
DWI: 6652608
DAZ: 108610418
DNV: 115563042
DHE: 111603951
AAG: 5569675
AALB: 109411294
CPII: 120414058
AME: 408438
ACER: 107999616
BIM: 100742603
BTER: 100644779
CCAL: 108623285
OBB: 114878683
MGEN: 117221395
NMEA: 116428644
CGIG: 122403420
SOC: 105202010
MPHA: 105833897
ACEP: 105627057
PBAR: 105427691
VEM: 105562552
HST: 105180459
DQU: 106741422
CFO: 105251794
FEX: 115242179
LHU: 105679317
PGC: 109861371
OBO: 105280708
PCF: 106792141
NVI: 100119908
CSOL: 105368177
MDL: 103578429
TCA: 103313904
ATD: 109598230
NVL: 108558535
APLN: 108734879
PPYR: 116178891
OTU: 111426727
BMAN: 114247063
MSEX: 115441776
BANY: 112053097
PMAC: 106718294
PXU: 106126509
PRAP: 110993911
ZCE: 119840245
HAW: 110376740
TNL: 113497656
API: 100569479
DNX: 107161961
AGS: 114131651
RMD: 113547937
BTAB: 109033713
CLEC: 106667510
NLU: 111053511
ZNE: 110835233
CSEC: 111867485
FCD: 110847979
EAF: 111716183
DSV: 119461122
VDE: 111246385
VJA: 111270069
TUT: 107366694
DPTE: 113791832
CSCU: 111622797
CEL: CELE_C54D1.3(ist-1)
CBR: CBG10979(Cbr-ist-1)
BMY: BM_BM2926(Bma-ist-1)
TSP: Tsp_03690
PCAN: 112561836
GAE: 121377759
CRG: 105342662
MYI: 110464153
OBI: 106875365
NVE: 5517532
ATEN: 116300822
ADF: 107342456
AMIL: 114960550
HMG: 101240709
 » show all
Reference
  Authors
Sisci D, Morelli C, Cascio S, Lanzino M, Garofalo C, Reiss K, Garcia M, Russo A, Ando S, Surmacz E
  Title
The estrogen receptor alpha:insulin receptor substrate 1 complex in breast cancer: structure-function relationships.
  Journal
Ann Oncol 18 Suppl 6:vi81-5 (2007)
DOI:10.1093/annonc/mdm232
Reference
PMID:8513971
  Authors
Araki E, Sun XJ, Haag BL 3rd, Chuang LM, Zhang Y, Yang-Feng TL, White MF, Kahn CR
  Title
Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization.
  Journal
Diabetes 42:1041-54 (1993)
DOI:10.2337/diab.42.7.1041
  Sequence
[hsa:3667]
Reference
PMID:1380456
  Authors
Backer JM, Myers MG Jr, Shoelson SE, Chin DJ, Sun XJ, Miralpeix M, Hu P, Margolis B, Skolnik EY, Schlessinger J, et al.
  Title
Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation.
  Journal
EMBO J 11:3469-79 (1992)
DOI:10.1002/j.1460-2075.1992.tb05426.x
  Sequence
[rno:25467]
LinkDB

KEGG   ORTHOLOGY: K07187
Entry
K07187                      KO                                     

Name
IRS2
Definition
insulin receptor substrate 2
Pathway
map04022  cGMP-PKG signaling pathway
map04068  FoxO signaling pathway
map04140  Autophagy - animal
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04910  Insulin signaling pathway
map04920  Adipocytokine signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04930  Type II diabetes mellitus
map04931  Insulin resistance
map04932  Non-alcoholic fatty liver disease
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
map05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K07187  IRS2; insulin receptor substrate 2
   04022 cGMP-PKG signaling pathway
    K07187  IRS2; insulin receptor substrate 2
   04152 AMPK signaling pathway
    K07187  IRS2; insulin receptor substrate 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K07187  IRS2; insulin receptor substrate 2
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07187  IRS2; insulin receptor substrate 2
   04923 Regulation of lipolysis in adipocytes
    K07187  IRS2; insulin receptor substrate 2
   04920 Adipocytokine signaling pathway
    K07187  IRS2; insulin receptor substrate 2
   04935 Growth hormone synthesis, secretion and action
    K07187  IRS2; insulin receptor substrate 2
  09149 Aging
   04211 Longevity regulating pathway
    K07187  IRS2; insulin receptor substrate 2
   04213 Longevity regulating pathway - multiple species
    K07187  IRS2; insulin receptor substrate 2
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K07187  IRS2; insulin receptor substrate 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K07187  IRS2; insulin receptor substrate 2
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K07187  IRS2; insulin receptor substrate 2
   04932 Non-alcoholic fatty liver disease
    K07187  IRS2; insulin receptor substrate 2
   04931 Insulin resistance
    K07187  IRS2; insulin receptor substrate 2
Genes
HSA: 8660(IRS2)
PTR: 452657(IRS2)
PPS: 100982406(IRS2)
GGO: 101127585(IRS2)
PON: 100452233(IRS2)
NLE: 100583956(IRS2)
MCC: 698536(IRS2)
MCF: 102122241(IRS2)
CSAB: 103214788(IRS2)
CATY: 105584904(IRS2)
PANU: 101011176(IRS2)
RRO: 104679253(IRS2)
RBB: 108527055(IRS2)
TFN: 117063516(IRS2)
PTEH: 111546313(IRS2)
CJC: 100404822(IRS2)
SBQ: 101038649(IRS2)
MMUR: 105864251(IRS2)
MMU: 384783(Irs2)
MCAL: 110300614(Irs2)
MPAH: 110336729(Irs2)
RNO: 29376(Irs2)
MCOC: 116068902(Irs2)
MUN: 110548880(Irs2)
CGE: 100771848(Irs2)
PLEU: 114695106(Irs2)
NGI: 103751690(Irs2)
HGL: 101719081(Irs2)
CCAN: 109700963(Irs2)
CFA: 485548(IRS2)
VVP: 112927496(IRS2)
VLG: 121476873(IRS2)
AML: 100477685(IRS2)
UAH: 113251536(IRS2)
ORO: 101381397(IRS2)
ELK: 111147115
MPUF: 101689279(IRS2)
EJU: 114196636(IRS2)
FCA: 101095791(IRS2)
PPAD: 109264073(IRS2)
AJU: 113601123(IRS2)
HHV: 120228369(IRS2)
BTA: 100300012(IRS2)
BIU: 109567100(IRS2)
BBUB: 102405314(IRS2)
CHX: 108637286(IRS2)
OAS: 106991367(IRS2)
ODA: 120883252(IRS2)
SSC: 110255858(IRS2)
CFR: 116668634(IRS2)
CDK: 116157131(IRS2)
BACU: 103005810(IRS2)
LVE: 103088704(IRS2)
OOR: 101276950(IRS2)
DLE: 111176387(IRS2)
PCAD: 112064787(IRS2)
ECB: 100146249(IRS2)
EAI: 106838201(IRS2)
MYB: 102249810(IRS2)
MYD: 102753060(IRS2)
MMYO: 118651692(IRS2)
MNA: 107530378(IRS2)
HAI: 109383948(IRS2)
DRO: 112321408(IRS2)
SHON: 118981568(IRS2)
AJM: 119042698(IRS2)
MMF: 118622304(IRS2)
PALE: 102898575(IRS2)
RAY: 107511114(IRS2)
MJV: 108403230
TOD: 119259653(IRS2)
LAV: 100676904(IRS2)
TMU: 101345051
MDO: 100023831(IRS2) 100025395(IRS4)
SHR: 100924829(IRS2) 100931354(IRS4)
PCW: 110194742(IRS4) 110196696(IRS2)
OAA: 114805830(IRS2)
GGA: 101749060(IRS2) 422347(IRS4)
PCOC: 116229775(IRS4) 116242784(IRS2)
MGP: 100540702(IRS4) 100548754(IRS2)
CJO: 107307936(IRS2) 107312783(IRS4)
NMEL: 110391172 110403269(IRS4) 110407441(IRS2)
APLA: 101801905(IRS4) 101804723(IRS2)
ACYG: 106038523(IRS4)
TGU: 100220894(IRS2) 100223674(IRS4)
LSR: 110478760(IRS2) 110480059(IRS4)
SCAN: 103812665(IRS2) 103816520(IRS4)
PMOA: 120504647(IRS2) 120506231(IRS4)
GFR: 102041556(IRS4) 102044059(IRS2)
FAB: 101807499(IRS4) 101814066(IRS2)
PHI: 102103569(IRS4) 102111858(IRS2)
PMAJ: 107203717(IRS4) 107208306(IRS2)
CCAE: 111928696(IRS4) 111945898
CCW: 104686328(IRS2) 104694453(IRS4)
ETL: 114059692(IRS4) 114073373(IRS2)
FPG: 101918515(IRS4) 101924402(IRS2)
FCH: 102046894(IRS2) 102052095(IRS4)
CLV: 102089452(IRS2) 102090441
EGZ: 104133285(IRS4)
NNI: 104012562(IRS2) 104023330(IRS4)
ACUN: 113478507(IRS2) 113479916(IRS4)
PADL: 103920154(IRS4)
ASN: 102374791(IRS2) 102382907(IRS4)
AMJ: 102558545(IRS4) 102565350(IRS2)
CPOO: 109306322(IRS2) 109313719(IRS4)
GGN: 109300745(IRS4) 109303148(IRS2)
PSS: 102457842(IRS4)
CMY: 102934421(IRS2) 102943497(IRS4)
CPIC: 101945214(IRS2) 101951320(IRS4)
TST: 117870803(IRS2) 117882623(IRS4)
CABI: 116815629(IRS2) 116829393(IRS4)
ACS: 100555020(irs4) 103279765(irs2)
PVT: 110074287(IRS4) 110090941(IRS2)
PBI: 103051591(IRS2) 103052062
PMUR: 107296125(IRS2) 107298766
TSR: 106548513(IRS4) 106552209(IRS2)
PGUT: 117671161(IRS2) 117675956(IRS4)
PMUA: 114588807(IRS4) 114593451(IRS2)
ZVI: 118082626(IRS2) 118084286(IRS4)
GJA: 107114014(IRS4) 107120743
XLA: 108708462 108709741 399388(irs4.S) 495836(irs4.L)
XTR: 100196925(irs4) 100498409
NPR: 108787450(IRS2) 108788816
DRE: 100329897(irs4a) 393285(irs2a) 572001(irs2b) 794462
SLUC: 116044568(irs2a) 116046847(irs2b) 116053173
LOC: 102682802(irs2) 102693755(irs4)
ARUT: 117407256(irs2b) 117412261
LCM: 102364884(IRS2) 102366705(IRS4)
CMK: 103178654(irs2) 103179604
RTP: 109919326 109921559(irs2)
AGB: 108904873
RSAN: 119396415
RMP: 119174621
PMAX: 117316183
LAK: 106181472
 » show all
Reference
  Authors
Giovannone B, Scaldaferri ML, Federici M, Porzio O, Lauro D, Fusco A, Sbraccia P, Borboni P, Lauro R, Sesti G
  Title
Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential.
  Journal
Diabetes Metab Res Rev 16:434-41 (2000)
DOI:10.1002/1520-7560(2000)9999:9999<::AID-DMRR159>3.0.CO;2-8
Reference
  Authors
Hashimoto S, Kubota N, Sato H, Sasaki M, Takamoto I, Kubota T, Nakaya K, Noda M, Ueki K, Kadowaki T
  Title
Insulin receptor substrate-2 (Irs2) in endothelial cells plays a crucial role in insulin secretion.
  Journal
Diabetes 64:876-86 (2015)
DOI:10.2337/db14-0432
  Sequence
[mmu:384783]
Reference
  Authors
Vassen L, Wegrzyn W, Klein-Hitpass L
  Title
Human insulin receptor substrate-2 (IRS-2) is a primary progesterone response gene.
  Journal
Mol Endocrinol 13:485-94 (1999)
DOI:10.1210/mend.13.3.0256
  Sequence
[hsa:8660]
LinkDB

KEGG   ORTHOLOGY: K17445
Entry
K17445                      KO                                     

Name
IRS3
Definition
insulin receptor substrate 3
Pathway
map04022  cGMP-PKG signaling pathway
map04068  FoxO signaling pathway
map04140  Autophagy - animal
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04910  Insulin signaling pathway
map04920  Adipocytokine signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04930  Type II diabetes mellitus
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K17445  IRS3; insulin receptor substrate 3
   04022 cGMP-PKG signaling pathway
    K17445  IRS3; insulin receptor substrate 3
   04152 AMPK signaling pathway
    K17445  IRS3; insulin receptor substrate 3
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K17445  IRS3; insulin receptor substrate 3
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K17445  IRS3; insulin receptor substrate 3
   04923 Regulation of lipolysis in adipocytes
    K17445  IRS3; insulin receptor substrate 3
   04920 Adipocytokine signaling pathway
    K17445  IRS3; insulin receptor substrate 3
   04935 Growth hormone synthesis, secretion and action
    K17445  IRS3; insulin receptor substrate 3
  09149 Aging
   04211 Longevity regulating pathway
    K17445  IRS3; insulin receptor substrate 3
   04213 Longevity regulating pathway - multiple species
    K17445  IRS3; insulin receptor substrate 3
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K17445  IRS3; insulin receptor substrate 3
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K17445  IRS3; insulin receptor substrate 3
Genes
PANU: 101021880
MMUR: 105868385
MMU: 16369(Irs3)
MCAL: 110293997
RNO: 84021(Irs3)
MCOC: 116068604
MUN: 110556773
CGE: 100751390
PLEU: 114686777
NGI: 103733517
CCAN: 109698062
OCU: 100339305
TUP: 106735628
AML: 100467269
UMR: 103670034
UAH: 113267858
ORO: 101378833
ELK: 111146232
MPUF: 101671264
EJU: 114214389
MLX: 117999416
FCA: 101100432
PTG: 102952104
PPAD: 109251297
AJU: 106987435
HHV: 120223687
BTA: 107131843
BIU: 109578427
BBUB: 102404040
OAS: 101121655
ODA: 120879389
SSC: 100515824
CFR: 116657470
CDK: 105105271
BACU: 103005013
OOR: 101279800
DLE: 111181964
PCAD: 102982336
ECB: 100069009
EPZ: 103555632
EAI: 106839324
HAI: 109374927
MJV: 108409367
TOD: 119242334
LAV: 100660353
TMU: 101362072
MDO: 103100498
OAA: 114808089
 » show all
Reference
PMID:9348224
  Authors
Sciacchitano S, Taylor SI
  Title
Cloning, tissue expression, and chromosomal localization of the mouse IRS-3 gene.
  Journal
Endocrinology 138:4931-40 (1997)
DOI:10.1210/endo.138.11.5518
  Sequence
[mmu:16369]
Reference
  Authors
Kabuta T, Hakuno F, Asano T, Takahashi S
  Title
Insulin receptor substrate-3 functions as transcriptional activator in the nucleus.
  Journal
J Biol Chem 277:6846-51 (2002)
DOI:10.1074/jbc.M107058200
  Sequence
[rno:84021]
LinkDB

KEGG   ORTHOLOGY: K17446
Entry
K17446                      KO                                     

Name
IRS4
Definition
insulin receptor substrate 4
Pathway
map04022  cGMP-PKG signaling pathway
map04068  FoxO signaling pathway
map04140  Autophagy - animal
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04910  Insulin signaling pathway
map04920  Adipocytokine signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04930  Type II diabetes mellitus
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
Disease
H00250  Congenital nongoitrous hypothyroidism (CHNG)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K17446  IRS4; insulin receptor substrate 4
   04022 cGMP-PKG signaling pathway
    K17446  IRS4; insulin receptor substrate 4
   04152 AMPK signaling pathway
    K17446  IRS4; insulin receptor substrate 4
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K17446  IRS4; insulin receptor substrate 4
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K17446  IRS4; insulin receptor substrate 4
   04923 Regulation of lipolysis in adipocytes
    K17446  IRS4; insulin receptor substrate 4
   04920 Adipocytokine signaling pathway
    K17446  IRS4; insulin receptor substrate 4
   04935 Growth hormone synthesis, secretion and action
    K17446  IRS4; insulin receptor substrate 4
  09149 Aging
   04211 Longevity regulating pathway
    K17446  IRS4; insulin receptor substrate 4
   04213 Longevity regulating pathway - multiple species
    K17446  IRS4; insulin receptor substrate 4
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K17446  IRS4; insulin receptor substrate 4
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K17446  IRS4; insulin receptor substrate 4
Genes
HSA: 8471(IRS4)
PTR: 473846(IRS4)
PPS: 100991292(IRS4)
GGO: 109024862(IRS4)
PON: 100458662(IRS4)
NLE: 100588594(IRS4)
MCC: 703846(IRS4)
MCF: 102128819(IRS4)
CSAB: 103232472(IRS4)
CATY: 105598463(IRS4)
PANU: 101027041(IRS4)
RRO: 104676250(IRS4)
RBB: 108541574(IRS4)
TFN: 117077563(IRS4)
PTEH: 111536706(IRS4)
CJC: 100410200(IRS4)
SBQ: 101035392(IRS4)
MMUR: 105863379(IRS4)
MMU: 16370(Irs4)
MCAL: 110287491(Irs4)
MPAH: 110313986(Irs4)
RNO: 315350(Irs4)
MCOC: 116089083(Irs4)
MUN: 110540163(Irs4)
CGE: 100773159
PLEU: 114698331(Irs4)
NGI: 103750027(Irs4)
HGL: 101719321(Irs4)
CCAN: 109675517(Irs4)
OCU: 103351932(IRS4)
TUP: 102489416(IRS4)
CFA: 492059(IRS4)
VVP: 112932035(IRS4)
VLG: 121483169(IRS4)
AML: 105240373(IRS4)
UMR: 103679770(IRS4)
UAH: 113241174(IRS4)
ORO: 101371781(IRS4)
ELK: 111161266
MPUF: 101680131(IRS4)
EJU: 114198362(IRS4)
MLX: 118010742(IRS4)
FCA: 101093251(IRS4)
PTG: 102952189(IRS4)
PPAD: 109253661(IRS4)
AJU: 106973150(IRS4)
HHV: 120232651(IRS4)
BTA: 514607(IRS4)
BOM: 102273597(IRS4)
BIU: 109555543(IRS4)
BBUB: 102400715(IRS4)
CHX: 102179643(IRS4)
OAS: 101112456(IRS4)
ODA: 120881381(IRS4)
SSC: 100622674(IRS4)
CFR: 102521714(IRS4)
CDK: 105099556(IRS4)
BACU: 102998877(IRS4)
LVE: 103068740(IRS4)
OOR: 101290244(IRS4)
DLE: 111165800(IRS4)
PCAD: 102989579(IRS4)
ECB: 100059954(IRS4)
EPZ: 103545515(IRS4)
EAI: 106839711(IRS4)
MYB: 102242347(IRS4)
MYD: 102753243(IRS4)
MMYO: 118654640(IRS4)
MNA: 107526265(IRS4)
HAI: 109393345(IRS4)
DRO: 112296869(IRS4)
SHON: 118984183(IRS4)
AJM: 119065177(IRS4)
MMF: 118636678(IRS4)
PALE: 102895007(IRS4)
RAY: 107506967(IRS4)
MJV: 108406099(IRS4)
TOD: 119245973(IRS4)
LAV: 100667324(IRS4)
TMU: 101350401
 » show all
Reference
PMID:9261155
  Authors
Lavan BE, Fantin VR, Chang ET, Lane WS, Keller SR, Lienhard GE
  Title
A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family.
  Journal
J Biol Chem 272:21403-7 (1997)
DOI:10.1074/jbc.272.34.21403
  Sequence
[hsa:8471]
Reference
  Authors
Schreyer S, Ledwig D, Rakatzi I, Kloting I, Eckel J
  Title
Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor.
  Journal
Endocrinology 144:1211-8 (2003)
DOI:10.1210/en.2002-220723
  Sequence
[hsa:8471]
LinkDB

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