KEGG   ORTHOLOGY: K16194
Entry
K16194                      KO                                     

Name
EIF2AK1
Definition
eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1]
Pathway
ko04141  Protein processing in endoplasmic reticulum
ko05160  Hepatitis C
ko05162  Measles
ko05168  Herpes simplex virus 1 infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K16194  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1
 09160 Human Diseases
  09172 Infectious disease: viral
   05162 Measles
    K16194  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1
   05160 Hepatitis C
    K16194  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1
   05168 Herpes simplex virus 1 infection
    K16194  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K16194  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K16194  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  PEK family [OT]
   K16194  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1
Other DBs
GO: 0004694
Genes
HSA: 27102(EIF2AK1)
PTR: 463255(EIF2AK1)
PPS: 100973419(EIF2AK1)
GGO: 101137971(EIF2AK1)
PON: 100440695(EIF2AK1)
NLE: 100603184(EIF2AK1)
MCC: 703325(EIF2AK1)
MCF: 101865823(EIF2AK1)
CSAB: 103237668 103246806(EIF2AK1)
RRO: 104665816(EIF2AK1)
RBB: 108523984(EIF2AK1)
CJC: 100402296(EIF2AK1)
SBQ: 101041881(EIF2AK1)
MMU: 15467(Eif2ak1)
MCAL: 110294026(Eif2ak1)
MPAH: 110312763(Eif2ak1)
RNO: 27137(Eif2ak1)
MUN: 110557411(Eif2ak1)
CGE: 100764727(Eif2ak1)
NGI: 103726446(Eif2ak1)
HGL: 101711605(Eif2ak1)
CCAN: 109692916(Eif2ak1)
OCU: 100009522(EIF2AK1)
TUP: 102476193(EIF2AK1)
CFA: 100302056(EIF2AK1)
VVP: 112909999(EIF2AK1)
AML: 100477599(EIF2AK1)
UMR: 103670096(EIF2AK1)
UAH: 113267934(EIF2AK1)
ORO: 101380155(EIF2AK1)
ELK: 111145992
FCA: 101081103(EIF2AK1)
PTG: 102950763(EIF2AK1)
PPAD: 109251201(EIF2AK1)
AJU: 106982608(EIF2AK1)
BTA: 507689(EIF2AK1)
BOM: 102268458(EIF2AK1)
BIU: 109578406(EIF2AK1)
BBUB: 102395232(EIF2AK1)
CHX: 102175262(EIF2AK1)
OAS: 101116114(EIF2AK1)
SSC: 100514518(EIF2AK1)
CFR: 102510552(EIF2AK1)
CDK: 105099377(EIF2AK1)
BACU: 103006910(EIF2AK1)
LVE: 103073635(EIF2AK1)
OOR: 101272505(EIF2AK1)
DLE: 111181878(EIF2AK1)
PCAD: 102974312(EIF2AK1)
ECB: 100062309(EIF2AK1)
EPZ: 103555779(EIF2AK1)
EAI: 106840510(EIF2AK1)
MYB: 102257968(EIF2AK1)
MYD: 102758379(EIF2AK1)
MNA: 107533921(EIF2AK1)
HAI: 109380156(EIF2AK1)
DRO: 112319445(EIF2AK1)
PALE: 102880643(EIF2AK1)
RAY: 107515918(EIF2AK1)
MJV: 108404561(EIF2AK1)
TMU: 101355278
MDO: 100027204(EIF2AK1)
SHR: 100913926(EIF2AK1)
PCW: 110193461(EIF2AK1)
OAA: 100076291(EIF2AK1)
GGA: 395360(EIF2AK1)
MGP: 100542862(EIF2AK1)
CJO: 107320609(EIF2AK1)
NMEL: 110405844(EIF2AK1)
APLA: 101802809(EIF2AK1)
ACYG: 106033552(EIF2AK1)
TGU: 100223214(EIF2AK1)
LSR: 110475582(EIF2AK1)
SCAN: 103817878(EIF2AK1)
GFR: 102034943(EIF2AK1)
FAB: 101814759(EIF2AK1)
PHI: 102104095(EIF2AK1)
PMAJ: 107210977(EIF2AK1)
CCAE: 111922580(EIF2AK1)
CCW: 104685051(EIF2AK1)
ETL: 114054734(EIF2AK1)
FCH: 102050352(EIF2AK1)
CLV: 102094818(EIF2AK1)
EGZ: 104135817(EIF2AK1)
NNI: 104015198(EIF2AK1)
ACUN: 113485864(EIF2AK1)
PADL: 103913550(EIF2AK1)
AAM: 106491294(EIF2AK1)
ASN: 102388628(EIF2AK1)
AMJ: 102560081(EIF2AK1)
PSS: 102449404(EIF2AK1)
CMY: 102930275(EIF2AK1)
CPIC: 101951550(EIF2AK1)
ACS: 100564085(eif2ak1)
PVT: 110082194(EIF2AK1)
PBI: 103065155(EIF2AK1)
PMUR: 107291738(EIF2AK1)
PMUA: 114584353(EIF2AK1)
GJA: 107123050(EIF2AK1)
XLA: 100381177(eif2ak1.L)
XTR: 733794(eif2ak1)
NPR: 108795808(EIF2AK1)
DRE: 565338(eif2ak1)
SANH: 107669162 107699862(eif2ak1)
CCAR: 109053625
IPU: 108273656(eif2ak1)
PHYP: 113527498(eif2ak1)
AMEX: 103026818(eif2ak1)
EEE: 113579503(eif2ak1)
TRU: 101063998(eif2ak1)
LCO: 104918060(eif2ak1)
MZE: 101482844(eif2ak1)
ONL: 100708945(eif2ak1)
OLA: 101174538
XMA: 102234726(eif2ak1)
XCO: 114150766(eif2ak1)
PRET: 103482162(eif2ak1)
CVG: 107096447(eif2ak1)
NFU: 107388165(eif2ak1)
KMR: 108237180(eif2ak1)
ALIM: 106533510(eif2ak1)
AOCE: 111575372(eif2ak1)
CSEM: 103382342(eif2ak1)
POV: 109626975(eif2ak1)
LCF: 108880767(eif2ak1)
SDU: 111220222(eif2ak1)
SLAL: 111672019(eif2ak1)
HCQ: 109516152(eif2ak1)
BPEC: 110159706(eif2ak1)
MALB: 109969166(eif2ak1)
SASA: 100195543(e2ak1) 106589587
OTW: 112259470(eif2ak1)
ELS: 105031427(eif2ak1)
SFM: 108940154(eif2ak1)
LCM: 102347891(EIF2AK1)
CMK: 103178704(eif2ak1)
RTP: 109912931(eif2ak1)
CIN: 104266006
SPU: 100888225
APLC: 110984747
SKO: 102807945
AAG: 5567211
AALB: 109432321
AME: 552472
BIM: 100740642
BTER: 100645626
CCAL: 108628380
OBB: 114880956
MPHA: 105833322
AEC: 105148571
ACEP: 105624667
PBAR: 105422553
HST: 105183894
DQU: 106741688
CFO: 105259077
LHU: 105677933
PGC: 109854434
OBO: 105276756
PCF: 106785350
NVI: 100122970(Eif2ak1)
CSOL: 105368738
MDL: 103570088
TCA: 100142127
DPA: 109545452
ATD: 109598947
NVL: 108561437
BMOR: 693040
BMAN: 114241219
PMAC: 106712763
PRAP: 110991273
HAW: 110379682
TNL: 113501057
BTAB: 109033926
CLEC: 106666724
ZNE: 110836436
PVM: 113821880
TUT: 107365001
CSCU: 111618983
PTEP: 107439270
TSP: Tsp_13663
PCAN: 112577411
CRG: 105336011
MYI: 110443761
OBI: 106883935
EGL: EGR_04873
NVE: 5518541
EPA: 110236556
ADF: 107331600
AMIL: 114961438
PDAM: 113679487
SPIS: 111326079
DGT: 114532649
MNG: MNEG_2658
SPO: SPAC20G4.03c(hri1) SPAC222.07c(hri2)
SMIN: v1.2.015508.t1(symbB.v1.2.015508.t1)
SPAR: SPRG_11113
 » show all
Reference
  Authors
Omasa T, Chen YG, Mantalaris A, Tsai YC, Wu JH
  Title
Molecular cloning and sequencing of the human heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase from bone marrow culture.
  Journal
DNA Seq 13:133-7 (2002)
DOI:10.1080/10425170290023428
  Sequence
[hsa:27102]
Reference
PMID:7709427
  Authors
Chen JJ, London IM
  Title
Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase.
  Journal
Trends Biochem Sci 20:105-8 (1995)
DOI:10.1016/S0968-0004(00)88975-6
LinkDB

KEGG   ORTHOLOGY: K16195
Entry
K16195                      KO                                     

Name
EIF2AK2
Definition
eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
Pathway
ko04141  Protein processing in endoplasmic reticulum
ko04217  Necroptosis
ko05010  Alzheimer disease
ko05160  Hepatitis C
ko05162  Measles
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05203  Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
  09172 Infectious disease: viral
   05162 Measles
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05164 Influenza A
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05160 Hepatitis C
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05168 Herpes simplex virus 1 infection
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05169 Epstein-Barr virus infection
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05165 Human papillomavirus infection
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   01009 Protein phosphatases and associated proteins
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  PEK family [OT]
   K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Other DBs
GO: 0004694
Genes
HSA: 5610(EIF2AK2)
PTR: 459155(EIF2AK2)
PPS: 100982543(EIF2AK2)
GGO: 101133221(EIF2AK2)
PON: 100173054(EIF2AK2)
NLE: 100579484(EIF2AK2)
MCC: 708912(EIF2AK2)
MCF: 102124745(EIF2AK2)
CSAB: 103220482(EIF2AK2)
RRO: 104669977(EIF2AK2)
RBB: 108520352(EIF2AK2)
CJC: 100399251(EIF2AK2)
SBQ: 101053943(EIF2AK2)
MMU: 19106(Eif2ak2)
MCAL: 110312307(Eif2ak2)
MPAH: 110335815(Eif2ak2)
RNO: 54287(Eif2ak2)
MUN: 110564188
CGE: 100757909(Eif2ak2)
NGI: 103725269(Eif2ak2)
HGL: 101724844(Eif2ak2)
CCAN: 109688641(Eif2ak2)
OCU: 100009013(EIF2AK2)
TUP: 102469861(EIF2AK2)
CFA: 611397(EIF2AK2)
VVP: 112935312(EIF2AK2)
AML: 100469151(EIF2AK2)
UMR: 103671577(EIF2AK2)
UAH: 113241346(EIF2AK2)
ORO: 101373670(EIF2AK2)
ELK: 111158436
FCA: 101082744(EIF2AK2)
PTG: 102951575(EIF2AK2)
PPAD: 109265829(EIF2AK2)
AJU: 106978970(EIF2AK2)
BTA: 347700(EIF2AK2)
BOM: 102281444(EIF2AK2)
BIU: 109565977(EIF2AK2)
BBUB: 102391649(EIF2AK2)
CHX: 102171521(EIF2AK2)
OAS: 101121673(EIF2AK2)
SSC: 397588(EIF2AK2)
CFR: 102517994(EIF2AK2)
CDK: 105105818(EIF2AK2)
BACU: 103006520(EIF2AK2)
LVE: 103075964(EIF2AK2)
OOR: 101270256(EIF2AK2)
DLE: 111174878(EIF2AK2)
PCAD: 102977777(EIF2AK2)
ECB: 100147679(EIF2AK2)
EPZ: 103548399(EIF2AK2)
EAI: 106825858(EIF2AK2)
MYB: 102242739(EIF2AK2)
MNA: 107541819(EIF2AK2)
HAI: 109385455(EIF2AK2)
DRO: 112298045(EIF2AK2)
PALE: 102890643(EIF2AK2)
RAY: 107519635(EIF2AK2)
MJV: 108392233(EIF2AK2)
LAV: 100665908(EIF2AK2)
TMU: 101359071
MDO: 103106286(EIF2AK2)
SHR: 100931721(EIF2AK2)
PCW: 110212711(EIF2AK2)
OAA: 100077821(EIF2AK2)
GGA: 395147(EIF2AK2)
CJO: 107311230(EIF2AK2)
NMEL: 110397137(EIF2AK2)
APLA: 110353866
ACYG: 106029410(EIF2AK2)
TGU: 100223594(EIF2AK2)
LSR: 110469407(EIF2AK2)
SCAN: 103817583(EIF2AK2)
GFR: 102039637(EIF2AK2)
FAB: 101807308(EIF2AK2)
PHI: 102111278(EIF2AK2)
PMAJ: 107201738(EIF2AK2)
CCAE: 111926977(EIF2AK2)
CCW: 104684377(EIF2AK2)
ETL: 114065176(EIF2AK2)
FPG: 101910588(EIF2AK2)
FCH: 102051537(EIF2AK2)
CLV: 102085389(EIF2AK2)
EGZ: 104124114(EIF2AK2)
NNI: 104018710(EIF2AK2)
ACUN: 113478166(EIF2AK2)
PADL: 103922839(EIF2AK2)
AAM: 106485536(EIF2AK2)
ASN: 102379754(EIF2AK2)
AMJ: 102558195(EIF2AK2)
PSS: 102449543(EIF2AK2)
CMY: 102934103(EIF2AK2)
CPIC: 101940470(EIF2AK2)
ACS: 100561872(eif2ak2)
PVT: 110083920(EIF2AK2)
PBI: 103059200(EIF2AK2)
PMUR: 107287469(EIF2AK2)
PMUA: 114594483(EIF2AK2)
XTR: 100141483(pkr3) 779992(eif2ak2)
NPR: 108792731
DRE: 100001092(eif2ak2)
SANH: 107689757
SGH: 107562393
CCAR: 109064588
IPU: 108263213(eif2ak2)
PHYP: 113542164(eif2ak2)
AMEX: 107197130
EEE: 113579882(eif2ak2)
TRU: 100144316(eif2ak2)
LCO: 104918202
NCC: 104951309
XMA: 102232776
XCO: 114138280
PRET: 103477270
CVG: 107096530
NFU: 107375439
KMR: 108248129(eif2ak2)
ALIM: 106515883
AOCE: 111573721
CSEM: 103387634(eif2ak2)
POV: 109636756
LCF: 108885802(eif2ak2) 108885818
SDU: 111220787
SLAL: 111658980
HCQ: 109516199(eif2ak2)
BPEC: 110156836
MALB: 109959079
OTW: 112253229
SALP: 112073823
ELS: 105008364
SFM: 108927142
PKI: 111835715
LCM: 102365233(EIF2AK2)
CMK: 103187174(eif2ak2)
RTP: 109918246
 » show all
Reference
PMID:1695551
  Authors
Meurs E, Chong K, Galabru J, Thomas NS, Kerr IM, Williams BR, Hovanessian AG
  Title
Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon.
  Journal
Cell 62:379-90 (1990)
DOI:10.1016/0092-8674(90)90374-N
  Sequence
[hsa:5610]
LinkDB

KEGG   ORTHOLOGY: K08860
Entry
K08860                      KO                                     

Name
EIF2AK3
Definition
eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]
Pathway
ko04137  Mitophagy - animal
ko04140  Autophagy - animal
ko04141  Protein processing in endoplasmic reticulum
ko04210  Apoptosis
ko04214  Apoptosis - fly
ko04932  Non-alcoholic fatty liver disease
ko05010  Alzheimer disease
ko05012  Parkinson disease
ko05014  Amyotrophic lateral sclerosis
ko05020  Prion disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05160  Hepatitis C
ko05162  Measles
ko05168  Herpes simplex virus 1 infection
Disease
H00512  Permanent neonatal diabetes mellitus
H00766  Wolcott-Rallison syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
   04137 Mitophagy - animal
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
  09143 Cell growth and death
   04210 Apoptosis
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
   04214 Apoptosis - fly
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
   05012 Parkinson disease
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
   05014 Amyotrophic lateral sclerosis
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
   05020 Prion disease
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
   05022 Pathways of neurodegeneration - multiple diseases
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
  09172 Infectious disease: viral
   05162 Measles
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
   05160 Hepatitis C
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
   05168 Herpes simplex virus 1 infection
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  PEK family [OT]
   K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
Other DBs
GO: 0004694
Genes
HSA: 9451(EIF2AK3)
PTR: 459388(EIF2AK3)
PPS: 100981333(EIF2AK3)
GGO: 101147776(EIF2AK3)
PON: 100447385(EIF2AK3)
NLE: 100589743(EIF2AK3)
MCC: 699575(EIF2AK3)
MCF: 102117377(EIF2AK3)
CSAB: 103241350(EIF2AK3)
RRO: 104674177(EIF2AK3)
RBB: 108518882(EIF2AK3)
CJC: 100394186(EIF2AK3)
SBQ: 101031964(EIF2AK3)
MMU: 13666(Eif2ak3)
MCAL: 110296130(Eif2ak3)
RNO: 29702(Eif2ak3)
MUN: 110561216(Eif2ak3)
CGE: 100765343(Eif2ak3)
NGI: 103740131(Eif2ak3)
HGL: 101713561(Eif2ak3)
OCU: 100354847(EIF2AK3)
TUP: 102468736(EIF2AK3)
CFA: 475756(EIF2AK3)
VVP: 112916653(EIF2AK3)
AML: 100479743(EIF2AK3)
UMR: 103671855(EIF2AK3)
UAH: 113242804(EIF2AK3)
ORO: 101365565(EIF2AK3)
ELK: 111148064
FCA: 101095973(EIF2AK3)
PTG: 102963843(EIF2AK3)
AJU: 106978143(EIF2AK3)
BTA: 535820(EIF2AK3)
BIU: 109566145(EIF2AK3)
BBUB: 102406027(EIF2AK3)
CHX: 102185575(EIF2AK3)
OAS: 101110042(EIF2AK3)
SSC: 100513348(EIF2AK3)
CFR: 102523410(EIF2AK3)
CDK: 105104181(EIF2AK3)
BACU: 103020488(EIF2AK3)
LVE: 103068759(EIF2AK3)
OOR: 101282451(EIF2AK3)
DLE: 111187362(EIF2AK3)
PCAD: 102981822(EIF2AK3)
ECB: 100066488(EIF2AK3)
EPZ: 103549985(EIF2AK3)
EAI: 106838571(EIF2AK3)
MYB: 102256242(EIF2AK3)
MNA: 107528720(EIF2AK3)
HAI: 109394047(EIF2AK3)
DRO: 112297566(EIF2AK3)
PALE: 102894246(EIF2AK3)
RAY: 107512376(EIF2AK3)
MJV: 108410297(EIF2AK3)
LAV: 100671700(EIF2AK3)
TMU: 101342812
MDO: 100029557(EIF2AK3)
SHR: 100915385(EIF2AK3)
PCW: 110202783(EIF2AK3)
OAA: 100081193(EIF2AK3)
GGA: 422930(EIF2AK3)
CJO: 107313985(EIF2AK3)
NMEL: 110397823(EIF2AK3)
TGU: 100223479(EIF2AK3)
SCAN: 103823471(EIF2AK3)
GFR: 102039323(EIF2AK3)
PMAJ: 107203374(EIF2AK3)
EGZ: 104126987(EIF2AK3)
NNI: 104018561(EIF2AK3)
PADL: 103923526(EIF2AK3)
ACS: 100551680(eif2ak3)
PVT: 110086330(EIF2AK3)
PBI: 103053678(EIF2AK3)
PMUR: 107302385(EIF2AK3)
TSR: 106550345(EIF2AK3)
PMUA: 114581734(EIF2AK3)
XLA: 108697591 403386(eif2ak3.S)
XTR: 100190763(eif2ak3)
DRE: 559564(eif2ak3)
SANH: 107671339(eif2ak3)
CCAR: 109045292
TRU: 101068654(eif2ak3)
LCO: 104931193(eif2ak3)
NCC: 104951808(eif2ak3)
MZE: 101480980(eif2ak3)
ONL: 100691545(eif2ak3)
OLA: 101171373(eif2ak3)
XMA: 102220027(eif2ak3)
XCO: 114134784(eif2ak3)
PRET: 103458264(eif2ak3)
CVG: 107102124(eif2ak3)
NFU: 107373885(eif2ak3)
KMR: 108247269(eif2ak3)
ALIM: 106523590(eif2ak3)
AOCE: 111569316(eif2ak3)
CSEM: 103383108(eif2ak3)
POV: 109641514(eif2ak3)
LCF: 108889157(eif2ak3)
SDU: 111226127(eif2ak3)
SLAL: 111646809(eif2ak3)
HCQ: 109511559(eif2ak3)
BPEC: 110157424(eif2ak3)
MALB: 109962460(eif2ak3)
BFO: 118409008
DME: Dmel_CG2087(PEK)
DER: 6552401
DSE: 6613946
DSI: Dsimw501_GD19618(Dsim_GD19618)
DAN: 6500493
DSR: 110177163
DPE: 6591403
DMN: 108156119
DWI: 6649722
DAZ: 108620956
DNV: 108660208
DHE: 111598506
DVI: 6633051
AAG: 5563776
TCA: 658258
API: 100166491
CEL: CELE_F46C3.1(pek-1)
TSP: Tsp_11315
HMG: 101239642
ANI: AN7321.2
ANG: ANI_1_2152184(An04g08580)
ABE: ARB_03252
TVE: TRV_02482
PTE: PTT_19265
 » show all
Reference
  Authors
Schroder M, Kaufman RJ
  Title
Divergent roles of IRE1alpha and PERK in the unfolded protein response.
  Journal
Curr Mol Med 6:5-36 (2006)
DOI:10.2174/156652406775574569
Reference
  Authors
Baltzis D, Pluquet O, Papadakis AI, Kazemi S, Qu LK, Koromilas AE
  Title
The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53.
  Journal
J Biol Chem 282:31675-87 (2007)
DOI:10.1074/jbc.M704491200
Reference
  Authors
Shi Y, An J, Liang J, Hayes SE, Sandusky GE, Stramm LE, Yang NN
  Title
Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells.
  Journal
J Biol Chem 274:5723-30 (1999)
DOI:10.1074/jbc.274.9.5723
  Sequence
[hsa:9451]
LinkDB

KEGG   ORTHOLOGY: K16196
Entry
K16196                      KO                                     

Name
EIF2AK4
Definition
eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1]
Pathway
ko04138  Autophagy - yeast
ko04140  Autophagy - animal
ko04141  Protein processing in endoplasmic reticulum
ko05160  Hepatitis C
ko05162  Measles
ko05168  Herpes simplex virus 1 infection
Disease
H01621  Pulmonary arterial hypertension
H01866  Pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K16196  EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K16196  EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4
   04138 Autophagy - yeast
    K16196  EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4
 09160 Human Diseases
  09172 Infectious disease: viral
   05162 Measles
    K16196  EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4
   05160 Hepatitis C
    K16196  EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4
   05168 Herpes simplex virus 1 infection
    K16196  EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K16196  EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K16196  EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  PEK family [OT]
   K16196  EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4
Other DBs
GO: 0004694
Genes
HSA: 440275(EIF2AK4)
PTR: 453321(EIF2AK4)
PPS: 100985169(EIF2AK4)
GGO: 101139998(EIF2AK4)
PON: 100457992(EIF2AK4)
NLE: 100606228(EIF2AK4)
MCC: 100428309(EIF2AK4)
MCF: 102132060(EIF2AK4)
CSAB: 103245851(EIF2AK4)
RRO: 104659676(EIF2AK4)
RBB: 108526804(EIF2AK4)
CJC: 100392095(EIF2AK4)
SBQ: 101034876(EIF2AK4)
MMU: 27103(Eif2ak4)
MCAL: 110310480(Eif2ak4)
MPAH: 110317807(Eif2ak4)
RNO: 114859(Eif2ak4)
MUN: 110564590(Eif2ak4)
CGE: 100763206(Eif2ak4)
NGI: 103741495(Eif2ak4)
HGL: 101703546(Eif2ak4)
CCAN: 109677838(Eif2ak4)
OCU: 100358284(EIF2AK4)
TUP: 102495513(EIF2AK4)
CFA: 478257(EIF2AK4)
VVP: 112919935(EIF2AK4)
AML: 100475038(EIF2AK4)
UMR: 103673470(EIF2AK4)
UAH: 113242045(EIF2AK4)
ORO: 101374587(EIF2AK4)
ELK: 111161858
FCA: 101087928(EIF2AK4)
PTG: 102970603(EIF2AK4)
PPAD: 109263175(EIF2AK4)
AJU: 106968549(EIF2AK4)
BTA: 513829(EIF2AK4)
BOM: 102273847(EIF2AK4)
BIU: 109564329(EIF2AK4)
BBUB: 102414081(EIF2AK4)
CHX: 102175025(EIF2AK4)
OAS: 101107358(EIF2AK4)
SSC: 100621160(EIF2AK4)
CFR: 102508577(EIF2AK4)
CDK: 105096892(EIF2AK4)
BACU: 103018209(EIF2AK4)
LVE: 103079959(EIF2AK4)
OOR: 101288996(EIF2AK4)
DLE: 111181760(EIF2AK4)
PCAD: 102976822(EIF2AK4)
ECB: 100071494(EIF2AK4)
EPZ: 103561628(EIF2AK4)
EAI: 106835166(EIF2AK4)
MYB: 102252848(EIF2AK4)
MYD: 102761664(EIF2AK4)
MNA: 107542988(EIF2AK4)
HAI: 109383974(EIF2AK4)
DRO: 112311276(EIF2AK4)
PALE: 102897856(EIF2AK4)
RAY: 107514458(EIF2AK4)
MJV: 108401642(EIF2AK4)
LAV: 100668004(EIF2AK4)
MDO: 100031798(EIF2AK4)
SHR: 100927460(EIF2AK4)
PCW: 110202871(EIF2AK4)
OAA: 100088614(EIF2AK4)
GGA: 423285(EIF2AK4)
MGP: 100541758(EIF2AK4)
CJO: 107314918(EIF2AK4)
NMEL: 110402110(EIF2AK4)
APLA: 101793133(EIF2AK4)
ACYG: 106031689(EIF2AK4)
TGU: 100232582(EIF2AK4)
LSR: 110475261(EIF2AK4)
SCAN: 103826953(EIF2AK4)
GFR: 102032095(EIF2AK4)
FAB: 101814670(EIF2AK4)
PHI: 102104206(EIF2AK4)
PMAJ: 107205926(EIF2AK4)
CCAE: 111930308(EIF2AK4)
CCW: 104683994(EIF2AK4)
ETL: 114063737(EIF2AK4)
FPG: 101916120(EIF2AK4)
FCH: 102055208(EIF2AK4)
CLV: 102089107(EIF2AK4)
EGZ: 104122061(EIF2AK4)
NNI: 104020409(EIF2AK4)
ACUN: 113480323(EIF2AK4)
PADL: 103914372(EIF2AK4)
AAM: 106483021(EIF2AK4)
ASN: 102380802(EIF2AK4)
AMJ: 102573762(EIF2AK4)
PSS: 102458467(EIF2AK4)
CMY: 102930385(EIF2AK4)
CPIC: 101941322(EIF2AK4)
ACS: 100552145(eif2ak4)
PVT: 110080104(EIF2AK4)
PBI: 103061370(EIF2AK4)
PMUR: 107296475(EIF2AK4)
TSR: 106544753(EIF2AK4) 106552312
PMUA: 114593667(EIF2AK4)
GJA: 107119647(EIF2AK4)
XLA: 108699198
XTR: 100216307(eif2ak4)
NPR: 108796769(EIF2AK4)
DRE: 100149925(eif2ak4)
SRX: 107745362(eif2ak4)
SGH: 107598147(eif2ak4)
CCAR: 109047028
IPU: 108269995(eif2ak4)
PHYP: 113529646(eif2ak4)
AMEX: 103030079(eif2ak4)
EEE: 113571420(eif2ak4)
TRU: 101079424(eif2ak4)
LCO: 109141716(eif2ak4)
NCC: 104950587(eif2ak4)
MZE: 101476929(eif2ak4)
ONL: 100704164(eif2ak4)
OLA: 101172779(eif2ak4)
XMA: 102234794(eif2ak4)
XCO: 114134257(eif2ak4)
PRET: 103458531(eif2ak4)
CVG: 107084062(eif2ak4)
NFU: 107392455(eif2ak4)
KMR: 108233989(eif2ak4)
ALIM: 106520103(eif2ak4) 106534337
AOCE: 111562530(eif2ak4)
CSEM: 103387047(eif2ak4)
POV: 109628135(eif2ak4)
LCF: 108892512(eif2ak4)
SDU: 111225274(eif2ak4)
SLAL: 111673253(eif2ak4)
HCQ: 109515996(eif2ak4)
BPEC: 110155671(eif2ak4)
MALB: 109951637(eif2ak4)
SASA: 106586505(eif2ak4) 106610842
SALP: 111962960 111968770(eif2ak4)
ELS: 105015665(eif2ak4)
SFM: 108928299(eif2ak4)
PKI: 111838909(eif2ak4)
LCM: 102363377
BFO: 118420962
CIN: 100187226
SPU: 588023
APLC: 110980518
SKO: 102801472
DME: Dmel_CG1609(Gcn2)
DER: 6554743
DSE: 6612981
DSI: Dsimw501_GD21576(Dsim_GD21576)
DAN: 6500567
DSR: 110188087
DPE: 6598685
DMN: 108156379
DWI: 6649826
DAZ: 108608916
DNV: 108659599
DHE: 111597889
DVI: 6631055
MDE: 101888380
LCQ: 111676371
AAG: 5567177
AALB: 109397123
AME: 725088
BIM: 100748384
BTER: 100651725
CCAL: 108628228
OBB: 114874704
SOC: 105197320
MPHA: 105831880
AEC: 105146773
ACEP: 105617569
PBAR: 105428224
VEM: 105557638
HST: 105187416
DQU: 106752204
CFO: 105250501
LHU: 105676436
PGC: 109854435
OBO: 105279476
PCF: 106793825
NVI: 100114072
CSOL: 105366053
DPA: 109544183
ATD: 109597365
NVL: 108567811
BMOR: 101741238
BMAN: 114251487
PMAC: 106708562
HAW: 110375861
TNL: 113504773
API: 100162493
DNX: 107169118
AGS: 114127538
RMD: 113556590
BTAB: 109034460
CLEC: 106668925
ZNE: 110839198
FCD: 110842970
PVM: 113803775
TUT: 107368239
DPTE: 113794691
CSCU: 111620106
CEL: CELE_Y81G3A.3(gcn-2)
CBR: CBG02792
BMY: Bm1_30605
TSP: Tsp_09765
PCAN: 112570502
CRG: 105337869
MYI: 110447911
LAK: 106156059
SHX: MS3_06639
EGL: EGR_03914
NVE: 116620839
EPA: 110241067
ADF: 107336571
AMIL: 114954335
PDAM: 113686965
DGT: 114531605
ATH: AT3G59410(GCN2)
ALY: 9314339
CRB: 17885512
BRP: 103841785
BNA: 106368343
BOE: 106312474
RSZ: 108862466
THJ: 104803678
CPAP: 110821230
CIT: 102617770
TCC: 18602492
GRA: 105776161
GAB: 108489014
DZI: 111307752
GMX: 100797996
GSJ: 114379922
VRA: 106756291
VAR: 108340280
VUN: 114169169
CCAJ: 109815657
CAM: 101497225
ADU: 107476766
AIP: 107628988
FVE: 101294328
RCN: 112198276
PPER: 18792786
PMUM: 103322420
PAVI: 110756268
MDM: 103408203
PXB: 103953603
ZJU: 107434870
CSV: 101207000
CMO: 103488674
MCHA: 111018572
CMAX: 111497683
CMOS: 111460823
CPEP: 111778614
RCU: 8280409
JCU: 105628376
HBR: 110650860
MESC: 110626183
POP: 7469590
JRE: 108979906
VVI: 100249259
SLY: 101246209
SPEN: 107004566
SOT: 102605313
CANN: 107854404
NTA: 107761147(GCN2)
NSY: 104240540
NTO: 104105109
NAU: 109232139
INI: 109164117
SIND: 105179658
OEU: 111392082
HAN: 110930848
LSV: 111907811
CCAV: 112503069
DCR: 108195104
BVG: 104888797
SOE: 110797787
NNU: 104605188
OSA: 4336257
OBR: 102711525
BDI: 100838960
ATS: 109736948(LOC109736948)
SBI: 8073711
ZMA: 103646282
SITA: 101756420
PDA: 103708605
EGU: 105038626
MUS: 103978507
PEQ: 110031041
AOF: 109823752
ATR: 18441823
PPP: 112277870
MNG: MNEG_6157
APRO: F751_2353
SCE: YDR283C(GCN2)
KMX: KLMA_30413(GCN2)
NCS: NCAS_0F02520(NCAS0F02520)
NDI: NDAI_0C04000(NDAI0C04000)
TPF: TPHA_0D01770(TPHA0D01770)
TBL: TBLA_0C03180(TBLA0C03180)
TDL: TDEL_0E03300(TDEL0E03300)
KAF: KAFR_0E01490(KAFR0E01490)
SPAA: SPAPADRAFT_57569(GCN2)
CAL: CAALFM_C701330CA(GCN2)
SLB: AWJ20_4342(GCN2)
NCR: NCU01187(cpc-3)
NTE: NEUTE1DRAFT120007(NEUTE1DRAFT_120007)
MGR: MGG_08643
SSCK: SPSK_02923
MAW: MAC_03915
MAJ: MAA_01496
CMT: CCM_07739
MBE: MBM_08206
ANI: AN2246.2
ANG: ANI_1_114154(An17g00860)
ABE: ARB_07116
TVE: TRV_04902
PTE: PTT_16030
SPO: SPBC36B7.09(gcn2)
CNE: CNM01750
CNB: CNBM1630
ABP: AGABI1DRAFT109872(AGABI1DRAFT_109872)
ABV: AGABI2DRAFT122255(AGABI2DRAFT_122255)
WSE: WALSEDRAFT_68955(Gcn2)
MGL: MGL_2080
MRT: MRET_1612
DFA: DFA_03540(ifkB) DFA_03712(ifkC) DFA_05476
EHI: EHI_109700(128.t00022)
PCB: PCHAS_131160(PC001180.02.0)
TAN: TA14435
TPV: TP02_0664
BBO: BBOV_II006890(18.m06568) BBOV_IV006150(23.m06264)
CPV: cgd3_3230
SPAR: SPRG_11909
TCR: 508795.19
 » show all
Reference
  Authors
Berlanga JJ, Santoyo J, De Haro C
  Title
Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase.
  Journal
Eur J Biochem 265:754-62 (1999)
DOI:10.1046/j.1432-1327.1999.00780.x
  Sequence
[hsa:440275]
Reference
  Authors
Roobol A, Roobol J, Bastide A, Knight JR, Willis AE, Smales CM
  Title
p58IPK is an inhibitor of the eIF2alpha kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.
  Journal
Biochem J 465:213-25 (2015)
DOI:10.1042/BJ20140852
  Sequence
[hsa:440275]
LinkDB

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