KEGG   ORTHOLOGY: K16195
Entry
K16195                      KO                                     

Name
EIF2AK2
Definition
eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
Pathway
ko04141  Protein processing in endoplasmic reticulum
ko04217  Necroptosis
ko05010  Alzheimer disease
ko05160  Hepatitis C
ko05162  Measles
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05203  Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
  09172 Infectious disease: viral
   05162 Measles
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05164 Influenza A
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05160 Hepatitis C
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05168 Herpes simplex virus 1 infection
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05169 Epstein-Barr virus infection
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   05165 Human papillomavirus infection
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
   01009 Protein phosphatases and associated proteins
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  PEK family [OT]
   K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2
Other DBs
GO: 0004694
Genes
HSA: 5610(EIF2AK2)
PTR: 459155(EIF2AK2)
PPS: 100982543(EIF2AK2)
GGO: 101133221(EIF2AK2)
PON: 100173054(EIF2AK2)
NLE: 100579484(EIF2AK2)
MCC: 708912(EIF2AK2)
MCF: 102124745(EIF2AK2)
CSAB: 103220482(EIF2AK2)
RRO: 104669977(EIF2AK2)
RBB: 108520352(EIF2AK2)
CJC: 100399251(EIF2AK2)
SBQ: 101053943(EIF2AK2)
MMU: 19106(Eif2ak2)
MCAL: 110312307(Eif2ak2)
MPAH: 110335815(Eif2ak2)
RNO: 54287(Eif2ak2)
MUN: 110564188
CGE: 100757909
NGI: 103725269(Eif2ak2)
HGL: 101724844(Eif2ak2)
CCAN: 109688641(Eif2ak2)
OCU: 100009013(EIF2AK2)
TUP: 102469861(EIF2AK2)
CFA: 611397(EIF2AK2)
VVP: 112935312(EIF2AK2)
AML: 100469151(EIF2AK2)
UMR: 103671577(EIF2AK2)
UAH: 113241346(EIF2AK2)
ORO: 101373670(EIF2AK2)
ELK: 111158436
FCA: 101082744(EIF2AK2)
PTG: 102951575(EIF2AK2)
PPAD: 109265829(EIF2AK2)
AJU: 106978970(EIF2AK2)
BTA: 347700(EIF2AK2)
BOM: 102281444(EIF2AK2)
BIU: 109565977(EIF2AK2)
BBUB: 102391649(EIF2AK2)
CHX: 102171521(EIF2AK2)
OAS: 101121673(EIF2AK2)
SSC: 397588(EIF2AK2)
CFR: 102517994(EIF2AK2)
CDK: 105105818(EIF2AK2)
BACU: 103006520(EIF2AK2)
LVE: 103075964(EIF2AK2)
OOR: 101270256(EIF2AK2)
DLE: 111174878(EIF2AK2)
PCAD: 102977777(EIF2AK2)
ECB: 100147679(EIF2AK2)
EPZ: 103548399(EIF2AK2)
EAI: 106825858(EIF2AK2)
MYB: 102242739(EIF2AK2)
MNA: 107541819(EIF2AK2)
HAI: 109385455(EIF2AK2)
DRO: 112298045(EIF2AK2)
PALE: 102890643(EIF2AK2)
RAY: 107519635(EIF2AK2)
MJV: 108392233(EIF2AK2)
LAV: 100665908(EIF2AK2)
TMU: 101359071
MDO: 103106286(EIF2AK2)
SHR: 100931721(EIF2AK2)
PCW: 110212711(EIF2AK2)
OAA: 100077821(EIF2AK2)
GGA: 395147(EIF2AK2)
CJO: 107311230(EIF2AK2)
NMEL: 110397137(EIF2AK2)
APLA: 110353866
ACYG: 106029410(EIF2AK2)
TGU: 100223594(EIF2AK2)
LSR: 110469407(EIF2AK2)
SCAN: 103817583(EIF2AK2)
GFR: 102039637(EIF2AK2)
FAB: 101807308(EIF2AK2)
PHI: 102111278(EIF2AK2)
PMAJ: 107201738(EIF2AK2)
CCAE: 111926977(EIF2AK2)
CCW: 104684377(EIF2AK2)
ETL: 114065176(EIF2AK2)
FPG: 101910588(EIF2AK2)
FCH: 102051537(EIF2AK2)
CLV: 102085389(EIF2AK2)
EGZ: 104124114(EIF2AK2)
NNI: 104018710(EIF2AK2)
ACUN: 113478166(EIF2AK2)
PADL: 103922839(EIF2AK2)
AAM: 106485536(EIF2AK2)
ASN: 102379754(EIF2AK2)
AMJ: 102558195(EIF2AK2)
PSS: 102449543(EIF2AK2)
CMY: 102934103(EIF2AK2)
CPIC: 101940470(EIF2AK2)
ACS: 100561872(eif2ak2)
PVT: 110083920(EIF2AK2)
PBI: 103059200(EIF2AK2)
PMUR: 107287469(EIF2AK2)
PMUA: 114594483(EIF2AK2)
XTR: 100141483(pkr3) 779992(eif2ak2)
NPR: 108792731
DRE: 100001092(eif2ak2)
SANH: 107689757
SGH: 107562393
CCAR: 109064588
IPU: 108263213(eif2ak2)
PHYP: 113542164(eif2ak2)
AMEX: 107197130
EEE: 113579882(eif2ak2)
TRU: 100144316(eif2ak2)
LCO: 104918202
NCC: 104951309
XMA: 102232776
XCO: 114138280
PRET: 103477270
CVG: 107096530
NFU: 107375439
KMR: 108248129(eif2ak2)
ALIM: 106515883
AOCE: 111573721
CSEM: 103387634(eif2ak2)
POV: 109636756
LCF: 108885802(eif2ak2) 108885818
SDU: 111220787
SLAL: 111658980
HCQ: 109516199(eif2ak2)
BPEC: 110156836
MALB: 109959079
OTW: 112253229
SALP: 112073823
ELS: 105008364
SFM: 108927142
PKI: 111835715
LCM: 102365233(EIF2AK2)
CMK: 103187174(eif2ak2)
RTP: 109918246
 » show all
Reference
PMID:1695551
  Authors
Meurs E, Chong K, Galabru J, Thomas NS, Kerr IM, Williams BR, Hovanessian AG
  Title
Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon.
  Journal
Cell 62:379-90 (1990)
DOI:10.1016/0092-8674(90)90374-N
  Sequence
[hsa:5610]
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