KEGG ORTHOLOGY: K16269

ORTHOLOGY: K16269

Entry

K16269 Tight KO

Name

todD, tcbB

Definition

cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase [EC:1.3.1.19 1.3.1.119]

Pathway

ko00361

Chlorocyclohexane and chlorobenzene degradation

ko00362

Benzoate degradation

ko00623

Toluene degradation

ko00624

Polycyclic aromatic hydrocarbon degradation

ko00643

Styrene degradation

ko01100

Metabolic pathways

ko01120

Microbial metabolism in diverse environments

ko01220

Degradation of aromatic compounds

Module

M00547

Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
   00361 Chlorocyclohexane and chlorobenzene degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
   00623 Toluene degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
   00643 Styrene degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
   00624 Polycyclic aromatic hydrocarbon degradation
    K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.19  cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
     K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase
    1.3.1.119  chlorobenzene dihydrodiol dehydrogenase
     K16269  todD, tcbB; cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase

Other DBs

RN:	R00812 R04088 R05354 R05397 R06832 R06857 R07703

COG:

COG1028

GO:	0018504 0018501

Genes

PPF:

Pput_2877

PPX:	T1E_4270(tobD)

PMON:

X969_10950

PMOT:

X970_10605

BPT:	Bpet3742(hcaB)

AG:	AAC43636(tcbB)

Reference

PMID:2670929

Authors

Zylstra GJ, Gibson DT

Title

Toluene degradation by Pseudomonas putida F1. Nucleotide sequence of the todC1C2BADE genes and their expression in Escherichia coli.

Journal

J Biol Chem 264:14940-6 (1989)

Sequence

[ppf:Pput_2877]

Reference

PMID:8626733

Authors

Werlen C, Kohler HP, van der Meer JR

Title

The broad substrate chlorobenzene dioxygenase and cis-chlorobenzene dihydrodiol dehydrogenase of Pseudomonas sp. strain P51 are linked evolutionarily to the enzymes for benzene and toluene degradation.

Journal

J Biol Chem 271:4009-16 (1996)
DOI:10.1074/jbc.271.8.4009

Sequence

[ag:AAC43636]

LinkDB

ENZYME: 1.3.1.19

Entry

EC 1.3.1.19 Enzyme

Name

cis-1,2-dihydrobenzene-1,2-diol dehydrogenase;
cis-benzene glycol dehydrogenase;
cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase

Reaction(IUBMB)

cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+ [RN:R00812]

Reaction(KEGG)

R00812;
(other) R04088 R05354 R07703

Substrate

cis-1,2-dihydrobenzene-1,2-diol [CPD:C04091];
NAD+ [CPD:C00003]

Product

catechol [CPD:C00090];
NADH [CPD:C00004];
H+ [CPD:C00080]

History

EC 1.3.1.19 created 1972

Pathway

ec00361

Chlorocyclohexane and chlorobenzene degradation

ec00362

Benzoate degradation

ec00623

Toluene degradation

ec00624

Polycyclic aromatic hydrocarbon degradation

ec00643

Styrene degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K16269

cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase

Genes

PPF:

Pput_2877

PPX:	T1E_4270(tobD)

PMON:

X969_10950

PMOT:

X970_10605

BPT:	Bpet3742(hcaB)

Reference

1 [PMID:4362337]

Authors

Axcell BC, Geary PJ.

Title

The metabolism of benzene by bacteria. Purification and some properties of the enzyme cis-1,2-dihydroxycyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase (cis-benzene glycol dehydrogenase).

Journal

Biochem J 136:927-34 (1973)
DOI:10.1042/bj1360927

Reference

2 [PMID:4298226]

Authors

Gibson DT, Koch JR, Kallio RE.

Title

Oxidative degradation of aromatic hydrocarbons by microorganisms. I. Enzymatic formation of catechol from benzene.

Journal

Biochemistry 7:2653-62 (1968)
DOI:10.1021/bi00847a031

Other DBs

ExplorEnz - The Enzyme Database: