KEGG   ORTHOLOGY: K16342
Entry
K16342                      KO                                     

Name
PLA2G4, CPLA2
Definition
cytosolic phospholipase A2 [EC:3.1.1.4]
Pathway
map00564  Glycerophospholipid metabolism
map00565  Ether lipid metabolism
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00592  alpha-Linolenic acid metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04072  Phospholipase D signaling pathway
map04217  Necroptosis
map04270  Vascular smooth muscle contraction
map04370  VEGF signaling pathway
map04611  Platelet activation
map04664  Fc epsilon RI signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map04724  Glutamatergic synapse
map04726  Serotonergic synapse
map04730  Long-term depression
map04750  Inflammatory mediator regulation of TRP channels
map04912  GnRH signaling pathway
map04913  Ovarian steroidogenesis
map04921  Oxytocin signaling pathway
map05231  Choline metabolism in cancer
Disease
H02504  Gastrointestinal ulceration, recurrent, with dysfunctional platelets
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00564 Glycerophospholipid metabolism
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   00565 Ether lipid metabolism
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   00590 Arachidonic acid metabolism
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   00591 Linoleic acid metabolism
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   00592 alpha-Linolenic acid metabolism
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04014 Ras signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04370 VEGF signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04072 Phospholipase D signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04664 Fc epsilon RI signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04666 Fc gamma R-mediated phagocytosis
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
  09152 Endocrine system
   04912 GnRH signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04913 Ovarian steroidogenesis
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04921 Oxytocin signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
  09156 Nervous system
   04724 Glutamatergic synapse
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04726 Serotonergic synapse
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04730 Long-term depression
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.4  phospholipase A2
     K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
Other DBs
RN: R01315 R01317 R02053 R07064 R07379 R07387 R07859
GO: 0004623
Genes
HSA: 100137049(PLA2G4B) 123745(PLA2G4E) 255189(PLA2G4F) 283748(PLA2G4D) 5321(PLA2G4A) 8605(PLA2G4C) 8681(JMJD7-PLA2G4B)
PTR: 100610135(PLA2G4D) 453356(PLA2G4F) 467664(PLA2G4E) 468935(PLA2G4C) 469617(PLA2G4A) 747584
PPS: 100978248(PLA2G4C) 100984773(PLA2G4A) 100986585(PLA2G4F) 100986912(PLA2G4D) 100987249(PLA2G4E)
GGO: 101126764(PLA2G4C) 101137812(PLA2G4E) 101138793(PLA2G4F) 101147399(PLA2G4A) 109025233(PLA2G4D)
PON: 100173125(PLA2G4A) 100434495(PLA2G4C) 100447631(PLA2G4B) 100448616(PLA2G4F) 100454614(PLA2G4E) 100454977(PLA2G4D)
NLE: 100587969(PLA2G4C) 100591421(PLA2G4A) 100591987 100593220(PLA2G4E) 100593575(PLA2G4D) 100593907(PLA2G4F)
MCC: 100424593(PLA2G4E) 100533113(PLA2G4B) 707592(PLA2G4D) 707690(PLA2G4F) 716635(PLA2G4A) 718510
MCF: 102142596(PLA2G4C) 102143026(PLA2G4B) 102143695(PLA2G4A) 102143812(PLA2G4E) 102144463(PLA2G4D) 102146081(PLA2G4F)
CSAB: 103230418(PLA2G4A) 103235528(PLA2G4C) 103245774(PLA2G4F) 103245776(PLA2G4D) 103245777(PLA2G4E) 103246100(PLA2G4B)
CATY: 105574211(PLA2G4B) 105574213(PLA2G4E) 105574214(PLA2G4F) 105574265(PLA2G4D) 105579889(PLA2G4A) 105595443(PLA2G4C)
PANU: 101000142 101002468(PLA2G4E) 101002819(PLA2G4D) 101004198(PLA2G4C) 101007440(PLA2G4F) 101026142(PLA2G4A)
RRO: 104664371(PLA2G4A) 104665267(PLA2G4F) 104666910(PLA2G4B) 104666913(PLA2G4E) 104666914(PLA2G4D) 104673480(PLA2G4C) 115897634
RBB: 108517617(PLA2G4F) 108523179(PLA2G4A) 108540165(PLA2G4C) 108544325(PLA2G4D) 108544332(PLA2G4E) 108544335(PLA2G4B)
TFN: 117070813(PLA2G4F) 117070841(PLA2G4B) 117070845(PLA2G4E) 117071115 117071121(PLA2G4D) 117074917(PLA2G4A) 117091486(PLA2G4C)
PTEH: 111520161(PLA2G4C) 111531132(PLA2G4E) 111531141(PLA2G4B) 111531158(PLA2G4D) 111534477 111536920(PLA2G4A) 113224231
CJC: 100391709(PLA2G4F) 100400789(PLA2G4D) 100401154(PLA2G4E) 100402439(PLA2G4A)
SBQ: 101036859(PLA2G4F) 101037291(PLA2G4D) 101037621(PLA2G4E) 101038256(PLA2G4B) 101054434(PLA2G4A)
MMUR: 105855508(PLA2G4A) 105872489(PLA2G4B) 105872491(PLA2G4E) 105872495(PLA2G4F) 105872576(PLA2G4D)
MMU: 18783(Pla2g4a) 211429(Pla2g4b) 232889(Pla2g4c) 271844(Pla2g4f) 329502(Pla2g4e) 78390(Pla2g4d)
MCAL: 110284581(Pla2g4b) 110289370(Pla2g4f) 110289583(Pla2g4d) 110290316(Pla2g4e) 110294088(Pla2g4a) 110298861(Pla2g4c)
MPAH: 110317835(Pla2g4b) 110318542(Pla2g4f) 110318953(Pla2g4d) 110319432(Pla2g4e) 110321382(Pla2g4a) 110336949(Pla2g4c)
RNO: 24653(Pla2g4a) 296091(Pla2g4e) 311341(Pla2g4b) 691810(Pla2g4c) 691905(Pla2g4d) 691907(Pla2g4f)
MCOC: 116090743(Pla2g4b) 116090754(Pla2g4e) 116090758(Pla2g4f) 116090760(Pla2g4d) 116100272(Pla2g4c) 116100719(Pla2g4a)
MUN: 110553491(Pla2g4a) 110554755(Pla2g4b) 110554759(Pla2g4e) 110554765(Pla2g4d) 110554773(Pla2g4f)
CGE: 100750927(Pla2g4a) 100754559(Pla2g4c) 100770605(Pla2g4f) 100770894(Pla2g4e) 100771756(Pla2g4b) 103158591(Pla2g4d)
PLEU: 114681114(Pla2g4e) 114681118(Pla2g4b) 114681139(Pla2g4d) 114681142(Pla2g4f) 114696773(Pla2g4a) 114703899(Pla2g4c)
NGI: 103726649(Pla2g4a) 103732429(Pla2g4c) 103744942(Pla2g4b) 103744945(Pla2g4e) 103744946(Pla2g4d) 103744947(Pla2g4f)
HGL: 101703792(Pla2g4b) 101704061(Pla2g4a) 101705849(Pla2g4e) 101706202(Pla2g4f) 101713091(Pla2g4c) 101717491(Pla2g4d)
CCAN: 109678488(Pla2g4d) 109682660(Pla2g4f) 109685136(Pla2g4a) 109693126(Pla2g4e) 109697572 109697577 109697580 109697581
OCU: 100008748(PLA2G4A) 100340517(PLA2G4F) 100340775(PLA2G4D) 100341033(PLA2G4E) 100341237(PLA2G4C) 100533118(PLA2G4B)
TUP: 102470223(PLA2G4E) 102470647(PLA2G4F) 102471767(PLA2G4D) 102472618(JMJD7) 102473333(PLA2G4C) 102477396(PLA2G4A)
CFA: 480048(PLA2G4A) 487512(PLA2G4B) 487514(PLA2G4E) 487515(PLA2G4F) 608811(PLA2G4D)
VVP: 112919809(PLA2G4D) 112919810(PLA2G4F) 112919975(PLA2G4B) 112919979(PLA2G4E) 112921831(PLA2G4A)
VLG: 121473357(PLA2G4A) 121477473(PLA2G4F) 121484241 121485280(PLA2G4D) 121485788(PLA2G4E)
AML: 100469987(PLA2G4F) 100470240(PLA2G4D) 100470490(PLA2G4E) 100470998 100482619(PLA2G4A)
UMR: 103668635(PLA2G4A) 103673432(PLA2G4E) 103673531(PLA2G4F) 103673532(PLA2G4D) 103673534(PLA2G4B)
UAH: 113241915(PLA2G4F) 113241916(PLA2G4D) 113241996(PLA2G4E) 113262763(PLA2G4A)
ORO: 101362322(PLA2G4B) 101374803(PLA2G4A) 101377203(PLA2G4F) 101377493(PLA2G4D) 101386671(PLA2G4E)
MPUF: 101671103(PLA2G4E) 101672795(PLA2G4D) 101673065(PLA2G4F) 101688390(PLA2G4A) 101694107
EJU: 114201653(PLA2G4E) 114201670(PLA2G4D) 114201676(PLA2G4F) 114201677(PLA2G4B) 114222866(PLA2G4A)
MLX: 118003270(PLA2G4E) 118003295(PLA2G4F) 118003418 118003546(PLA2G4D) 118014408(PLA2G4A)
FCA: 101082033(PLA2G4A) 101082574(PLA2G4F) 101082828(PLA2G4E) 101082829(PLA2G4D) 101083342
PTG: 102948969(PLA2G4A) 102959018(PLA2G4B) 102959667(PLA2G4E) 102959937(PLA2G4F) 102964036(PLA2G4D)
PPAD: 109253583(PLA2G4A) 109263108(PLA2G4F) 109263110(PLA2G4D) 109263111(PLA2G4E)
AJU: 106968512(PLA2G4E) 106968514 106968562(PLA2G4F) 106968584(PLA2G4D) 106977949(PLA2G4A)
HHV: 120232221(PLA2G4B) 120232262(PLA2G4E) 120232263(PLA2G4D) 120232300(PLA2G4F) 120248736(PLA2G4A)
BTA: 505485(PLA2G4B) 522866(PLA2G4F) 525072(PLA2G4A) 526364(PLA2G4E) 531209(PLA2G4D)
BOM: 102271639(PLA2G4A) 102282019(PLA2G4B) 102282579(PLA2G4E) 102282862(PLA2G4D) 102283142(PLA2G4F)
BIU: 109564977(PLA2G4B) 109564980(PLA2G4E) 109564981(PLA2G4D) 109564982(PLA2G4F) 109570696(PLA2G4A)
BBUB: 102389740(PLA2G4A) 102397348(PLA2G4F) 102397889(PLA2G4D) 102398203(PLA2G4E) 102398843
CHX: 102175216(JMJD7) 102178930(PLA2G4A) 102187595(PLA2G4E) 102187867(PLA2G4D) 102188141(PLA2G4F)
OAS: 101111472(PLA2G4A) 101115372(PLA2G4B) 101115878(PLA2G4E) 101116150(PLA2G4D) 101116403(PLA2G4F)
ODA: 120853166(PLA2G4F) 120853167(PLA2G4E) 120853172(PLA2G4B) 120853656(PLA2G4D) 120880448(PLA2G4A)
SSC: 100152927(PLA2G4B) 100513834(PLA2G4F) 100514811(PLA2G4E) 100520687(PLA2G4A) 102162529(PLA2G4D)
CFR: 102507142(PLA2G4D) 102509341(PLA2G4A) 102516599 102517096(PLA2G4E) 102517351(PLA2G4F)
CDK: 105096850 105099290(PLA2G4A) 105101745(PLA2G4E) 105101759(PLA2G4F) 105101760(PLA2G4D)
BACU: 102999275(PLA2G4B) 103008898(PLA2G4F) 103009192(PLA2G4D) 103012091 103012675
LVE: 103083510(PLA2G4D) 103083784(PLA2G4E) 103089071(PLA2G4A) 103090681(PLA2G4F) 103090934(PLA2G4B)
OOR: 101269805(PLA2G4F) 101270052(PLA2G4E) 101270539 101270543(PLA2G4A) 101286206(PLA2G4D)
DLE: 111181572(PLA2G4D) 111181701(PLA2G4F) 111181702(PLA2G4E) 111181704(PLA2G4B) 111184676(PLA2G4A)
PCAD: 102983188(PLA2G4D) 102983681(PLA2G4F) 102984239(PLA2G4E) 102985111(PLA2G4A) 102990390
ECB: 100033889(PLA2G4A) 100071016(PLA2G4F) 100071025(PLA2G4D) 100071038(PLA2G4E) 100071062(PLA2G4B)
EPZ: 103549946(PLA2G4D) 103549947(PLA2G4E) 103549950(PLA2G4B) 103549953(PLA2G4F) 103560072(PLA2G4A)
EAI: 106841342(PLA2G4F) 106841343(PLA2G4D) 106841344(PLA2G4E) 106841348(PLA2G4B) 106846782(PLA2G4A)
MYB: 102241902(PLA2G4D) 102242502(PLA2G4F) 102259120(PLA2G4A) 102260953(PLA2G4E)
MYD: 102754320(PLA2G4D) 102754611(PLA2G4E) 102771796(PLA2G4F) 102772466(JMJD7) 102774327(PLA2G4A)
MMYO: 118650182(PLA2G4B) 118650204(PLA2G4E) 118650220(PLA2G4F) 118664483(PLA2G4D) 118673123(PLA2G4A)
MNA: 107536544(PLA2G4D) 107536549(PLA2G4F) 107536550(PLA2G4E) 107536561 107546298(PLA2G4A)
HAI: 109379089(PLA2G4A) 109383984(PLA2G4E) 109384003(PLA2G4F) 109384004(PLA2G4D) 109384055(PLA2G4B)
DRO: 112296687(PLA2G4A) 112311060(PLA2G4D) 112311538(PLA2G4E) 112311539(PLA2G4F)
SHON: 118979140(PLA2G4A)
AJM: 119059728(PLA2G4A) 119061268(PLA2G4B) 119061284(PLA2G4E) 119061309(PLA2G4F) 119061310(PLA2G4D)
MMF: 118628856(PLA2G4B) 118634813(PLA2G4E) 118637733(PLA2G4F) 118638018(PLA2G4A) 118641275(PLA2G4D)
PALE: 102883421(PLA2G4F) 102883684(PLA2G4E) 102886310(PLA2G4A) 102887778(PLA2G4D) 102888274
RAY: 107510914(PLA2G4E) 107510922 107510924(PLA2G4F) 107510925(PLA2G4D) 107514503 107521615(PLA2G4A)
MJV: 108385404(PLA2G4D) 108385409(PLA2G4B) 108385414(PLA2G4E) 108402518(PLA2G4F) 108410188(PLA2G4A)
TOD: 119237913(PLA2G4D) 119237914(PLA2G4F) 119238524(PLA2G4B) 119239548(PLA2G4E) 119241195(PLA2G4A)
LAV: 100658490(PLA2G4A) 100667057(PLA2G4E) 100675131(PLA2G4D) 100675410(PLA2G4F) 111753010(PLA2G4B)
MDO: 100009808(PLA2G4E) 100024859(PLA2G4A) 100029983(PLA2G4C) 100029998 100030037 100620032(PLA2G4D)
SHR: 100913647(PLA2G4E) 100914602(PLA2G4B) 100917893(PLA2G4D) 100918158(PLA2G4F) 100927005(PLA2G4C) 100927268(PLA2G4A)
PCW: 110206877(PLA2G4A) 110219868(PLA2G4C) 110223640(PLA2G4D) 110223689 110223735(PLA2G4F) 110223736(PLA2G4E)
OAA: 100085563 100086135(PLA2G4A) 100086783 100088450(PLA2G4E) 100088466(PLA2G4D) 100681775(PLA2G4F)
GGA: 101749229(PLA2G4B) 396394(PLA2G4A) 423226(PLA2G4EL7) 423227(PLA2G4EL6) 423229(PLA2G4EL1) 428870(PLA2G4EL3) 428871(PLA2G4F) 771552(PLA2G4EL5) 771560(PLA2G4EL4) 771574(PLA2G4EL2)
FPG: 101915779(PLA2G4C) 101918580(PLA2G4A) 101920043 101922121 101922643(PLA2G4B) 101924845 101925011(PLA2G4E) 101925028(PLA2G4F)
AMJ: 102564564(PLA2G4A) 102568256(PLA2G4B) 102568705(PLA2G4F.1) 102570036(PLA2G4C) 102571167 102571708 102571930 102572385 102572619(PLA2G4E) 102572848(PLA2G4D) 102573092 102573324(PLA2G4F) 106736657
XLA: 108698978(jmjd7-pla2g4b.L) 108699173 108699245(pla2g4f.L) 108699264 108700467 380561(pla2g4a.L)
XTR: 100145731(pla2g4a) 100485430(jmjd7-pla2g4b) 100497525(pla2g4f) 105948093(pla2g4d)
NPR: 108789293(PLA2G4F) 108789917 108793921 108798704(PLA2G4A)
DRE: 100148581 100148818(si:ch73-55i23.1) 30554(pla2g4aa) 492789(zgc:101699) 559087(pla2g4ab) 565386(pla2g4f.2) 798864(pla2g4f.1)
AMEX: 103030644(pla2g4f) 103034242 103034573
NCC: 104955131(pla2g4a)
ELY: 117254190(pla2g4ab) 117268534
PLEP: 121957031 121966943(pla2g4ab)
ECRA: 117951142(pla2g4ab) 117957742 117960725
GAT: 120823990(pla2g4ab) 120828307
MSAM: 119882257 119896422 119900432(pla2g4ab)
OAU: 116312169 116312178 116335050(pla2g4ab)
OLA: 101156151(pla2g4c) 101172400(pla2g4a)
OML: 112150852(pla2g4ab)
XMA: 102235312(pla2g4a) 111611546(pla2g4c)
XCO: 114148573(pla2g4c) 114150820(pla2g4a)
XHE: 116726166(pla2g4a) 116735519(pla2g4c)
PRET: 103468160(pla2g4c) 103468245(pla2g4a)
CVG: 107085950(pla2g4a) 107102418
CTUL: 119784228(zmp:0000000629) 119787730(pla2g4ab)
NFU: 107391550(pla2g4c) 107392886(pla2g4a)
KMR: 108238355(pla2g4ab) 108245365
ALIM: 106516826(pla2g4a) 106529930 106529932
AOCE: 111585764(pla2g4a) 111586157 111586158
CSEM: 103393578(pla2g4c) 103395269(pla2g4a)
POV: 109636707(pla2g4a) 109641948
SDU: 111217737(pla2g4c) 111232269(pla2g4a)
SLAL: 111645380(pla2g4a) 111669721(pla2g4c)
XGL: 120790859(pla2g4ab) 120796120
BPEC: 110162475 110167951(pla2g4a) 110169133
MALB: 109961725(pla2g4a) 109973708
SALP: 111971555 111975415(pla2g4a) 111978689(pla2g4f) 111979756
ELS: 105028802 105029083(pla2g4a)
LCM: 102351206 102352898(PLA2G4A) 102356324(PLA2G4F) 102360293
CMK: 103179984(pla2g4a) 103189875
RTP: 109933766(pla2g4a) 109936792
BFO: 118421715
PVM: 113801269
HAME: 121854357
CSCU: 111618634
PTEP: 107457549
SDM: 118194069
BGT: 106074668
OBI: 106876643
NVE: 5519297
ATEN: 116302301
HMG: 100200456
PXB: 103942742
NCR: NCU08298
NTE: NEUTE1DRAFT60205(NEUTE1DRAFT_60205)
MGR: MGG_01523
SSCK: SPSK_00697
MAW: MAC_06783
MAJ: MAA_01120
CMT: CCM_02980
MBE: MBM_02873
ANI: AN6211.2
ANG: ANI_1_2450024(An02g04040)
CIM: CIMG_11529(CIMG05408)
PBL: PAAG_11047(PAAG_00099)
PBN: PADG_12248(PADG_07163)
ABE: ARB_00638
TVE: TRV_05103
PTE: PTT_15862
MGL: MGL_1512
MRT: MRET_3847
 » show all
Reference
  Authors
Schaloske RH, Dennis EA
  Title
The phospholipase A2 superfamily and its group numbering system.
  Journal
Biochim Biophys Acta 1761:1246-59 (2006)
DOI:10.1016/j.bbalip.2006.07.011
Reference
  Authors
Ghosh M, Loper R, Gelb MH, Leslie CC
  Title
Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes.
  Journal
J Biol Chem 281:16615-24 (2006)
DOI:10.1074/jbc.M601770200
Reference
  Authors
Song C, Chang XJ, Bean KM, Proia MS, Knopf JL, Kriz RW
  Title
Molecular characterization of cytosolic phospholipase A2-beta.
  Journal
J Biol Chem 274:17063-7 (1999)
DOI:10.1074/jbc.274.24.17063
  Sequence
[hsa:100137049]
LinkDB

DBGET integrated database retrieval system