KEGG   ORTHOLOGY: K16421
Entry
K16421                      KO                                     

Name
hmaS, nocF
Definition
4-hydroxymandelate synthase [EC:1.13.11.46]
Pathway
ko00261  Monobactam biosynthesis
ko01055  Biosynthesis of vancomycin group antibiotics
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01055 Biosynthesis of vancomycin group antibiotics
    K16421  hmaS, nocF; 4-hydroxymandelate synthase
  09110 Biosynthesis of other secondary metabolites
   00261 Monobactam biosynthesis
    K16421  hmaS, nocF; 4-hydroxymandelate synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.46  4-hydroxymandelate synthase
     K16421  hmaS, nocF; 4-hydroxymandelate synthase
Other DBs
RN: R06632
GO: 0050585
Genes
MSD: MYSTI_03600
AGE: AA314_04078
CFUS: CYFUS_002913
THAA: CFI11_12525
NTP: CRH09_30890(hppD)
SCO: SCO3229(SCE63.04)
SVL: Strvi_8789
SBH: SBI_01126
SRC: M271_09160 M271_27680
SALU: DC74_563
SALL: SAZ_03310
STRE: GZL_08687
SLAU: SLA_6884
SKY: D0C37_28235(hppD)
SCYA: EJ357_01680(hppD)
SKA: CP970_03010(hppD) CP970_07050(hppD) CP970_09760(hppD)
KFL: Kfla_6066
SRO: Sros_6970
AOI: AORI_1495(hppD)
AMI: Amir_4590
SSYI: EKG83_29580(hppD) EKG83_30955(hppD)
KAL: KALB_6132
ACTI: UA75_15380
ACAD: UA74_14810
ACTA: C1701_23410(hppD)
SAQ: Sare_2673
MIL: ML5_4909
MTUA: CSH63_07635(hppD)
MICH: FJK98_16440(hppD)
MTEM: GCE86_13405(hppD)
MCAB: HXZ27_18210(hppD)
CAI: Caci_3256
HAU: Haur_1888
AG: AAT09803(nocF) CAA11761(hmaS)
 » show all
Reference
  Authors
Hubbard BK, Thomas MG, Walsh CT
  Title
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
  Journal
Chem Biol 7:931-42 (2000)
DOI:10.1016/S1074-5521(00)00043-0
  Sequence
Reference
  Authors
Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J
  Title
Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor.
  Journal
Chem Biol 9:1175-87 (2002)
DOI:10.1016/S1074-5521(02)00252-1
  Sequence
[sco:SCO3229]
Reference
  Authors
Gunsior M, Breazeale SD, Lind AJ, Ravel J, Janc JW, Townsend CA
  Title
The biosynthetic gene cluster for a monocyclic beta-lactam antibiotic, nocardicin A.
  Journal
Chem Biol 11:927-38 (2004)
DOI:10.1016/j.chembiol.2004.04.012
  Sequence
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