KEGG   ORTHOLOGY: K16431Help
Entry
K16431                      KO                                     

Name
cepH, sgcC3, mdpC3, kedY3
Definition
FAD-dependent halogenase [EC:1.14.19.-]
Pathway
ko01055  Biosynthesis of vancomycin group antibiotics
ko01059  Biosynthesis of enediyne antibiotics
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00827  C-1027 beta-amino acid moiety biosynthesis, tyrosine => 3-chloro-4,5-dihydroxy-beta-phenylalanyl-PCP
M00832  Kedarcidin 2-aza-3-chloro-beta-tyrosine moiety biosynthesis, azatyrosine => 2-aza-3-chloro-beta-tyrosyl-PCP
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K16431  cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase
   01055 Biosynthesis of vancomycin group antibiotics
    K16431  cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.-  
     K16431  cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase
BRITE hierarchy
Other DBs
RN: R11368 R11393
COG: COG0644
Genes
NTP: CRH09_30915
GPO: GPOL_c23630
GOM: D7316_00962(lodB)
SGB: WQO_33760
SBH: SBI_00676
SRC: M271_00350 M271_09130
STRE: GZL_07290
SPAV: Spa2297_32975
STRT: A8713_00440
SLS: SLINC_7264
SFK: KY5_1050c
STRR: EKD16_14345(lodB)
ACTI: UA75_18105
ACAD: UA74_17580
SAQ: Sare_2119
AG: ABY66006(mdpC3) AFV52210(kedY3)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W
  Title
Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.
  Journal
BMC Genomics 15:363 (2014)
DOI:10.1186/1471-2164-15-363
  Sequence
[aoi:AORI_1485]
Reference
  Authors
Lin S, Van Lanen SG, Shen B
  Title
Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
J Am Chem Soc 129:12432-8 (2007)
DOI:10.1021/ja072311g
Reference
PMID:12183628 (sgcC3)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_33760]
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