KEGG   ORTHOLOGY: K17398
Entry
K17398                      KO                                     

Name
DNMT3A
Definition
DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
Pathway
ko00270  Cysteine and methionine metabolism
ko01100  Metabolic pathways
ko05206  MicroRNAs in cancer
Module
M00035  Methionine degradation
Disease
H01481  Myelodysplastic syndrome
H01892  Peripheral T cell lymphoma
H02294  Tatton-Brown-Rahman syndrome
H02410  Myelodysplastic/myeloproliferative neoplasms
H02411  Chronic myelomonocytic leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    K17398  DNMT3A; DNA (cytosine-5)-methyltransferase 3A
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K17398  DNMT3A; DNA (cytosine-5)-methyltransferase 3A
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K17398  DNMT3A; DNA (cytosine-5)-methyltransferase 3A
   03032 DNA replication proteins
    K17398  DNMT3A; DNA (cytosine-5)-methyltransferase 3A
   03036 Chromosome and associated proteins
    K17398  DNMT3A; DNA (cytosine-5)-methyltransferase 3A
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.37  DNA (cytosine-5-)-methyltransferase
     K17398  DNMT3A; DNA (cytosine-5)-methyltransferase 3A
Transcription factors [BR:ko03000]
 Eukaryotic type
  Zinc finger
   Cys4 GATA-factors
    K17398  DNMT3A; DNA (cytosine-5)-methyltransferase 3A
DNA replication proteins [BR:ko03032]
 Eukaryotic type
  DNA Replication Termination Factors
   DNA methylation enzymes
    K17398  DNMT3A; DNA (cytosine-5)-methyltransferase 3A
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    K17398  DNMT3A; DNA (cytosine-5)-methyltransferase 3A
Other DBs
RN: R04858
GO: 0003886
Genes
HSA: 1788(DNMT3A)
PTR: 739139(DNMT3A)
PPS: 100973478(DNMT3A)
GGO: 101149451(DNMT3A)
PON: 100459471(DNMT3A)
NLE: 100594618(DNMT3A)
MCC: 694822(DNMT3A)
MCF: 102123287(DNMT3A)
CSAB: 103220651(DNMT3A)
RRO: 104677880(DNMT3A)
RBB: 108532669(DNMT3A)
CJC: 100413373(DNMT3A)
SBQ: 101042504(DNMT3A)
MMU: 13435(Dnmt3a)
MCAL: 110307282(Dnmt3a)
MPAH: 110324204(Dnmt3a)
RNO: 444984(Dnmt3a)
MUN: 110555188(Dnmt3a)
CGE: 100771064(Dnmt3a)
NGI: 103746385(Dnmt3a)
HGL: 101718745(Dnmt3a)
CCAN: 109685692(Dnmt3a)
OCU: 100344715(DNMT3A)
TUP: 102497213(DNMT3A)
CFA: 482996(DNMT3A)
VVP: 112908462(DNMT3A)
AML: 100481405(DNMT3A)
UMR: 103671927(DNMT3A)
UAH: 113270642(DNMT3A)
ORO: 101366930(DNMT3A)
ELK: 111154048
FCA: 100510798(DNMT3A)
PTG: 102951977(DNMT3A)
PPAD: 109267474(DNMT3A)
AJU: 106967901(DNMT3A)
BTA: 359716(DNMT3A)
BOM: 102284316(DNMT3A)
BIU: 109566324(DNMT3A)
BBUB: 102411368(DNMT3A)
CHX: 102190884(DNMT3A)
OAS: 100500776(DNMT3A)
SSC: 100037301(DNMT3A)
CFR: 102513850(DNMT3A)
CDK: 105100034(DNMT3A)
BACU: 102998753(DNMT3A)
LVE: 103077720
OOR: 101285073(DNMT3A)
DLE: 111174996(DNMT3A)
PCAD: 102986976(DNMT3A)
ECB: 100055881(DNMT3A)
EPZ: 103547819(DNMT3A)
EAI: 106841074(DNMT3A)
MYB: 102260433(DNMT3A)
MNA: 107534125(DNMT3A)
HAI: 109384340(DNMT3A)
DRO: 112297754(DNMT3A)
PALE: 102887578(DNMT3A)
RAY: 107498522(DNMT3A)
MJV: 108391589(DNMT3A)
TMU: 101350464
MDO: 100030681(DNMT3A)
SHR: 100926710(DNMT3A)
PCW: 110206518(DNMT3A)
OAA: 100077964(DNMT3A)
GGA: 421991(DNMT3A)
MGP: 100548727(DNMT3A)
CJO: 107312403(DNMT3A)
NMEL: 110395923(DNMT3A)
TGU: 115494592(DNMT3A)
FAB: 101822230(DNMT3A)
PHI: 102103159(DNMT3A)
PMAJ: 107198691(DNMT3A)
ETL: 114069985(DNMT3A)
FPG: 101914320(DNMT3A)
FCH: 102056931(DNMT3A)
CLV: 102097066(DNMT3A)
NNI: 104015768(DNMT3A)
ASN: 102368302(DNMT3A)
AMJ: 102561346(DNMT3A)
CMY: 102939867(DNMT3A)
CPIC: 101946629(DNMT3A)
ACS: 100529107(dnmt3a)
PVT: 110086977(DNMT3A)
PMUR: 107295539
PMUA: 114594993(DNMT3A)
GJA: 107113771(DNMT3A)
XTR: 100492187 100496503(dnmt3a)
DRE: 553187(dnmt3aa) 553189(dnmt3ab)
IPU: 108257425(dnmt3a) 108270301
PHYP: 113528792(dnmt3a) 113539015
AMEX: 103043892(dnmt3a) 103045261
EEE: 113586543
NCC: 104942372(dnmt3a)
MZE: 101471420(dnmt3a) 101476133
OLA: 101158497(dnmt3a)
XCO: 114134496(dnmt3a) 114158467
PRET: 103457275 103458376(dnmt3a)
CVG: 107082872 107095834(dnmt3a)
NFU: 107377776 107392003(dnmt3a)
KMR: 108233456 108239073(dnmt3a)
AOCE: 111569486(dnmt3a) 111588989
CSEM: 103380388(dnmt3a) 103381119
MALB: 109962317 109964554(dnmt3a)
SASA: 106603656
OTW: 112261530
SALP: 112068054(dnmt3a)
SFM: 108922141
PKI: 111857940
LCM: 102358591(DNMT3A)
CIN: 100176613
SPU: 582367
AME: 410798(Dnmt3)
NVI: 100114044
API: 100572675
TSP: Tsp_09280
NVE: 5505382
HMG: 100209870
AQU: 100642138
ATH: AT5G27650
CRB: 17884584
CCAJ: 109796175
CAM: 101500730
FVE: 101313815
CSV: 101211600
VVI: 100259614
SLY: 101248143
SPEN: 107007748
SOT: 102596406
OSA: 4337816
DOSA: Os05t0149200-01(Os05g0149200)
BDI: 100833788
SITA: 101781565
RCH: RUM_20080
 » show all
Reference
  Authors
Jurkowski TP, Jeltsch A
  Title
On the evolutionary origin of eukaryotic DNA methyltransferases and Dnmt2.
  Journal
PLoS One 6:e28104 (2011)
DOI:10.1371/journal.pone.0028104
Reference
  Authors
Ponger L, Li WH
  Title
Evolutionary diversification of DNA methyltransferases in eukaryotic genomes.
  Journal
Mol Biol Evol 22:1119-28 (2005)
DOI:10.1093/molbev/msi098
Reference
  Authors
Okano M, Bell DW, Haber DA, Li E
  Title
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
  Journal
Cell 99:247-57 (1999)
DOI:10.1016/S0092-8674(00)81656-6
  Sequence
[mmu:13435]
LinkDB

DBGET integrated database retrieval system