KEGG   ORTHOLOGY: K17725
Entry
K17725                      KO                                     

Name
ETHE1
Definition
sulfur dioxygenase [EC:1.13.11.18]
Pathway
ko00920  Sulfur metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Disease
H01249  Ethylmalonic encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K17725  ETHE1; sulfur dioxygenase
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K17725  ETHE1; sulfur dioxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.18  persulfide dioxygenase
     K17725  ETHE1; sulfur dioxygenase
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial protein import machinery
  Matrix
   Other matrix factors
    K17725  ETHE1; sulfur dioxygenase
Other DBs
RN: R08678
GO: 0050313
Genes
HSA: 23474(ETHE1)
PTR: 456093(ETHE1)
GGO: 115931646(ETHE1)
PON: 100458034(ETHE1)
NLE: 100607326(ETHE1)
MCC: 718089(ETHE1)
MCF: 102135821(ETHE1)
CSAB: 103234782(ETHE1)
RRO: 104669456(ETHE1) 115892008
RBB: 108538048(ETHE1)
CJC: 100392539(ETHE1)
SBQ: 101049584(ETHE1)
MMU: 66071(Ethe1)
MCAL: 110299108(Ethe1)
MPAH: 110336911(Ethe1)
RNO: 292710(Ethe1)
MUN: 110539763(Ethe1)
CGE: 100769786(Ethe1)
NGI: 103749149(Ethe1)
HGL: 101700567(Ethe1)
CCAN: 109691867(Ethe1)
OCU: 100340123(ETHE1)
TUP: 102495095(ETHE1)
CFA: 612416(ETHE1)
VVP: 112931344(ETHE1)
AML: 100470121(ETHE1)
UMR: 103657004(ETHE1)
UAH: 113243498(ETHE1)
ORO: 101379540(ETHE1)
ELK: 111139525
FCA: 101092565(ETHE1)
PTG: 102966568(ETHE1)
PPAD: 109258021(ETHE1)
AJU: 106973678(ETHE1)
BTA: 509150(ETHE1)
BOM: 102274866(ETHE1)
BIU: 109572865(ETHE1)
BBUB: 102405140(ETHE1)
CHX: 102183356(ETHE1)
OAS: 101108154(ETHE1)
SSC: 106504117(ETHE1)
CFR: 102515553(ETHE1)
CDK: 105090237(ETHE1)
BACU: 103015695(ETHE1)
LVE: 103088914(ETHE1)
OOR: 101277675(ETHE1)
DLE: 111180790(ETHE1)
PCAD: 102979940(ETHE1)
ECB: 100146195(ETHE1)
EPZ: 103550890(ETHE1)
EAI: 106848399(ETHE1)
MYB: 102243740(ETHE1)
MYD: 102751781(ETHE1)
MNA: 107542254(ETHE1)
HAI: 109372823(ETHE1)
DRO: 112312868(ETHE1)
PALE: 102885174(ETHE1)
RAY: 107512297(ETHE1)
MJV: 108407776(ETHE1)
LAV: 100654574(ETHE1)
TMU: 101349750
SHR: 100919768(ETHE1)
PCW: 110219860(ETHE1)
OAA: 107546927(ETHE1)
CJO: 107307773(ETHE1)
TGU: 115492925(ETHE1)
LSR: 110481566(ETHE1)
SCAN: 115483956(ETHE1)
PHI: 106628866(ETHE1)
CLV: 102084440
ASN: 102372675(ETHE1)
AMJ: 102565248(ETHE1)
CMY: 102948016
CPIC: 101936154 101940172(ETHE1)
ACS: 100561649(ethe1)
PVT: 110089614(ETHE1)
PBI: 103054622
PMUR: 107293232(ETHE1)
TSR: 106548103(ETHE1)
PMUA: 114603420(ETHE1)
XLA: 108704965(ethe1.S) 379091(ethe1.L)
XTR: 448221(ethe1)
NPR: 108785537(ETHE1)
DRE: 405865(ethe1)
SRX: 107724764(ethe1)
SANH: 107673323(ethe1)
CCAR: 109091107
IPU: 108278065(ethe1)
PHYP: 113525561(ethe1)
AMEX: 111197379(ethe1)
EEE: 113574425
TRU: 101079181(ethe1)
LCO: 104930280(ethe1)
NCC: 104950320(ethe1)
OLA: 101159221(ethe1)
ALIM: 106530059 106530060(ethe1)
AOCE: 111572512(ethe1)
CSEM: 103388847(ethe1)
POV: 109633148(ethe1)
LCF: 108899420(ethe1)
SDU: 111235762(ethe1)
SLAL: 111654733(ethe1)
HCQ: 109513105(ethe1)
BPEC: 110168222(ethe1)
SASA: 106582613(ETHE1) 106605166
ELS: 105008890(ethe1)
SFM: 108919204(ethe1)
PKI: 111851915(ethe1)
LCM: 102365540(ETHE1)
RTP: 109925668 109926037(ethe1)
SPU: 585574
APLC: 110988524
DME: Dmel_CG30022(CG30022) Dmel_CG30023(sprt)
DSE: 116800439
DSI: Dsimw501_GD25902(Dsim_GD25902) Dsimw501_GD28368(Dsim_GD28368)
DAN: 26514905
DVI: 26531904
AALB: 109402833
PXY: 105388838
DPTE: 113797480
CSCU: 111640980
PTEP: 107452201
CEL: CELE_C33A12.7(ethe-1)
CBR: CBG20009
TSP: Tsp_12937
PCAN: 112569058
CRG: 105329868
MYI: 110443462
OBI: 106871303
SHX: MS3_00676
EGL: EGR_05903
ADF: 107343924
AMIL: 114964258
PDAM: 113668438
SPIS: 111331608
DGT: 114519290
HMG: 100205916
ATH: AT1G53580(GLY3)
ALY: 9327824
CRB: 17897233
THJ: 104822594
CPAP: 110812511
CIT: 102607739
GAB: 108480258
GMX: 100780846(GMGLYII-6) 100796796(GMGLYII-10)
VRA: 106759670
VAR: 108332369
VUN: 114185979
CCAJ: 109813775
CAM: 101498546
LJA: Lj0g3v0131669.1(Lj0g3v0131669.1) Lj2g3v3224400.1(Lj2g3v3224400.1)
ADU: 107459807
AIP: 107613512
FVE: 101313434
RCN: 112190919
PPER: 18782019
PMUM: 103328924
PAVI: 110765908
CSV: 101221943
CMO: 103501765
MCHA: 111012255
RCU: 8277795
HBR: 110663464
MESC: 110609577
JRE: 109019225
QSU: 112036259
INI: 109150563
SIND: 105165531
HAN: 110885953
LSV: 111904482
CCAV: 112516959
DCR: 108223439
BVG: 104907336
SOE: 110775567
OSA: 4326319
DOSA: Os01t0667200-01(Os01g0667200)
OBR: 102722159
BDI: 100826131
ATS: 109778914(LOC109778914)
SBI: 8060399
ZMA: 100283164(IDP546)
SITA: 101785668
DCT: 110101845
ATR: 18437340
MNG: MNEG_3639
SMIN: v1.2.004789.t1(symbB.v1.2.004789.t1) v1.2.008370.t1(symbB.v1.2.008370.t1) v1.2.020192.t1(symbB.v1.2.020192.t1) v1.2.025153.t1(symbB.v1.2.025153.t1)
PTI: PHATRDRAFT_16707(GLO_1)
PSES: PSCI_0030
PALL: UYA_21250
MAQ: Maqu_1405
LOK: Loa_01823
LCD: clem_09270(blh)
LSS: NCTC12082_00079(pksB)
METL: U737_21730
MMAI: sS8_2766
FTQ: RO31_1669
FTC: DA46_43
FTV: CH67_953
FTZ: CH68_687
FTX: AW25_612
FTD: AS84_1120
FTY: CH70_550
FPT: BZ13_705
FPI: BF30_1545(ethe1)
FPM: LA56_882
FPX: KU46_14
FPZ: LA55_1579
FPJ: LA02_955
FRC: KX01_1164
HMAR: HVMH_1014
TEE: Tel_15535
TVR: TVD_10990
SVA: SVA_0968
CGD: CR3_1292 CR3_2791(gloB)
BVE: AK36_3116(ethe1)
BCEN: DM39_5202(ethe1)
BCEW: DM40_3259(ethe1)
BCEO: I35_6562
BMK: DM80_4694(ethe1)
BMUL: NP80_3228(ethe1)
BCED: DM42_5309(ethe1)
BDL: AK34_3221(eTHE1)
BCON: NL30_17130
BUB: BW23_3850(eTHE1)
BLAT: WK25_28880
BTEI: WS51_10045
BSEM: WJ12_33245
BPSL: WS57_01000
BMEC: WJ16_31690
BSTG: WT74_32100
BFN: OI25_2781(ethe1) OI25_7880 OI25_8246(ethe1)
CABA: SBC2_41690(blh_1) SBC2_43200(gloB_4) SBC2_52500(blh_2)
HPSE: HPF_03375(blh1) HPF_22135(blh2)
CBAA: SRAA_0536
NIM: W01_12700(gly3)
SPLB: SFPGR_32480(gly3)
SNIV: SFSGTM_21040(gly3_1) SFSGTM_22010(gly3_2)
EAD: OV14_3417
SMAZ: LH19_06300
SPHT: K426_25465
ALB: AEB_P2623
SHUM: STHU_18830
AFR: AFE_0956
ACU: Atc_2279
ATX: GCD22_01295(ethe1)
HHG: XM38_017830(blh)
MPK: VL20_2736
GLJ: GKIL_2375(gloB)
CALH: IJ00_07550
CEO: ETSB_1094
NJA: NSJP_3718
 » show all
Reference
  Authors
Kabil O, Banerjee R
  Title
Characterization of patient mutations in human persulfide dioxygenase (ETHE1) involved in H2S catabolism.
  Journal
J Biol Chem 287:44561-7 (2012)
DOI:10.1074/jbc.M112.407411
  Sequence
[hsa:23474]
LinkDB

KEGG   ENZYME: 1.13.11.18
Entry
EC 1.13.11.18               Enzyme                                 

Name
persulfide dioxygenase;
sulfur oxygenase (incorrect);
sulfur:oxygen oxidoreductase (incorrect);
sulfur dioxygenase (incorrect)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
S-sulfanylglutathione:oxygen oxidoreductase
Reaction(IUBMB)
S-sulfanylglutathione + O2 + H2O = glutathione + sulfite + 2 H+ (overall reaction) [RN:R08678];
(1a) S-sulfanylglutathione + O2 = S-sulfinatoglutathione + H+ [RN:R11946];
(1b) S-sulfinatoglutathione + H2O = glutathione + sulfite + H+ (spontaneous) [RN:R11947]
Reaction(KEGG)
Substrate
S-sulfanylglutathione [CPD:C17267];
O2 [CPD:C00007];
H2O [CPD:C00001];
S-sulfinatoglutathione [CPD:C21787]
Product
glutathione [CPD:C00051];
sulfite [CPD:C00094];
H+ [CPD:C00080];
S-sulfinatoglutathione [CPD:C21787]
Comment
An iron protein. Perthiols, formed spontaneously by interactions between thiols and elemental sulfur or sulfide, are the only acceptable substrate to the enzyme. The sulfite that is formed by the enzyme can be further converted into sulfate, thiosulfate or S-sulfoglutathione (GSSO3-) non-enzymically [2].
History
EC 1.13.11.18 created 1972, modified 2015
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K17725  sulfur dioxygenase
Genes
HSA: 23474(ETHE1)
PTR: 456093(ETHE1)
GGO: 115931646(ETHE1)
PON: 100458034(ETHE1)
NLE: 100607326(ETHE1)
MCC: 718089(ETHE1)
MCF: 102135821(ETHE1)
CSAB: 103234782(ETHE1)
RRO: 104669456(ETHE1) 115892008
RBB: 108538048(ETHE1)
CJC: 100392539(ETHE1)
SBQ: 101049584(ETHE1)
MMU: 66071(Ethe1)
MCAL: 110299108(Ethe1)
MPAH: 110336911(Ethe1)
RNO: 292710(Ethe1)
MUN: 110539763(Ethe1)
CGE: 100769786(Ethe1)
NGI: 103749149(Ethe1)
HGL: 101700567(Ethe1)
CCAN: 109691867(Ethe1)
OCU: 100340123(ETHE1)
TUP: 102495095(ETHE1)
CFA: 612416(ETHE1)
VVP: 112931344(ETHE1)
AML: 100470121(ETHE1)
UMR: 103657004(ETHE1)
UAH: 113243498(ETHE1)
ORO: 101379540(ETHE1)
ELK: 111139525
FCA: 101092565(ETHE1)
PTG: 102966568(ETHE1)
PPAD: 109258021(ETHE1)
AJU: 106973678(ETHE1)
BTA: 509150(ETHE1)
BOM: 102274866(ETHE1)
BIU: 109572865(ETHE1)
BBUB: 102405140(ETHE1)
CHX: 102183356(ETHE1)
OAS: 101108154(ETHE1)
SSC: 106504117(ETHE1)
CFR: 102515553(ETHE1)
CDK: 105090237(ETHE1)
BACU: 103015695(ETHE1)
LVE: 103088914(ETHE1)
OOR: 101277675(ETHE1)
DLE: 111180790(ETHE1)
PCAD: 102979940(ETHE1)
ECB: 100146195(ETHE1)
EPZ: 103550890(ETHE1)
EAI: 106848399(ETHE1)
MYB: 102243740(ETHE1)
MYD: 102751781(ETHE1)
MNA: 107542254(ETHE1)
HAI: 109372823(ETHE1)
DRO: 112312868(ETHE1)
PALE: 102885174(ETHE1)
RAY: 107512297(ETHE1)
MJV: 108407776(ETHE1)
LAV: 100654574(ETHE1)
TMU: 101349750
SHR: 100919768(ETHE1)
PCW: 110219860(ETHE1)
OAA: 107546927(ETHE1)
CJO: 107307773(ETHE1)
TGU: 115492925(ETHE1)
LSR: 110481566(ETHE1)
SCAN: 115483956(ETHE1)
PHI: 106628866(ETHE1)
CLV: 102084440
ASN: 102372675(ETHE1)
AMJ: 102565248(ETHE1)
CMY: 102948016
CPIC: 101936154 101940172(ETHE1)
ACS: 100561649(ethe1)
PVT: 110089614(ETHE1)
PBI: 103054622
PMUR: 107293232(ETHE1)
TSR: 106548103(ETHE1)
PMUA: 114603420(ETHE1)
XLA: 108704965(ethe1.S) 379091(ethe1.L)
XTR: 448221(ethe1)
NPR: 108785537(ETHE1)
DRE: 405865(ethe1)
SRX: 107724764(ethe1)
SANH: 107673323(ethe1)
CCAR: 109091107
IPU: 108278065(ethe1)
PHYP: 113525561(ethe1)
AMEX: 111197379(ethe1)
EEE: 113574425
TRU: 101079181(ethe1)
LCO: 104930280(ethe1)
NCC: 104950320(ethe1)
OLA: 101159221(ethe1)
ALIM: 106530059 106530060(ethe1)
AOCE: 111572512(ethe1)
CSEM: 103388847(ethe1)
POV: 109633148(ethe1)
LCF: 108899420(ethe1)
SDU: 111235762(ethe1)
SLAL: 111654733(ethe1)
HCQ: 109513105(ethe1)
BPEC: 110168222(ethe1)
SASA: 106582613(ETHE1) 106605166
ELS: 105008890(ethe1)
SFM: 108919204(ethe1)
PKI: 111851915(ethe1)
LCM: 102365540(ETHE1)
RTP: 109925668 109926037(ethe1)
SPU: 585574
APLC: 110988524
DME: Dmel_CG30022(CG30022) Dmel_CG30023(sprt)
DSE: 116800439
DSI: Dsimw501_GD25902(Dsim_GD25902) Dsimw501_GD28368(Dsim_GD28368)
DAN: 26514905
DVI: 26531904
AALB: 109402833
PXY: 105388838
DPTE: 113797480
CSCU: 111640980
PTEP: 107452201
CEL: CELE_C33A12.7(ethe-1)
CBR: CBG20009
TSP: Tsp_12937
PCAN: 112569058
CRG: 105329868
MYI: 110443462
OBI: 106871303
SHX: MS3_00676
EGL: EGR_05903
ADF: 107343924
AMIL: 114964258
PDAM: 113668438
SPIS: 111331608
DGT: 114519290
HMG: 100205916
ATH: AT1G53580(GLY3)
ALY: 9327824
CRB: 17897233
THJ: 104822594
CPAP: 110812511
CIT: 102607739
GAB: 108480258
GMX: 100780846(GMGLYII-6) 100796796(GMGLYII-10)
VRA: 106759670
VAR: 108332369
VUN: 114185979
CCAJ: 109813775
CAM: 101498546
LJA: Lj0g3v0131669.1(Lj0g3v0131669.1) Lj2g3v3224400.1(Lj2g3v3224400.1)
ADU: 107459807
AIP: 107613512
FVE: 101313434
RCN: 112190919
PPER: 18782019
PMUM: 103328924
PAVI: 110765908
CSV: 101221943
CMO: 103501765
MCHA: 111012255
RCU: 8277795
HBR: 110663464
MESC: 110609577
JRE: 109019225
QSU: 112036259
INI: 109150563
SIND: 105165531
HAN: 110885953
LSV: 111904482
CCAV: 112516959
DCR: 108223439
BVG: 104907336
SOE: 110775567
OSA: 4326319
DOSA: Os01t0667200-01(Os01g0667200)
OBR: 102722159
BDI: 100826131
ATS: 109778914(LOC109778914)
SBI: 8060399
ZMA: 100283164(IDP546)
SITA: 101785668
DCT: 110101845
ATR: 18437340
MNG: MNEG_3639
SMIN: v1.2.004789.t1(symbB.v1.2.004789.t1) v1.2.008370.t1(symbB.v1.2.008370.t1) v1.2.020192.t1(symbB.v1.2.020192.t1) v1.2.025153.t1(symbB.v1.2.025153.t1)
PTI: PHATRDRAFT_16707(GLO_1)
PSES: PSCI_0030
PALL: UYA_21250
MAQ: Maqu_1405
LOK: Loa_01823
LCD: clem_09270(blh)
LSS: NCTC12082_00079(pksB)
METL: U737_21730
MMAI: sS8_2766
FTQ: RO31_1669
FTC: DA46_43
FTV: CH67_953
FTZ: CH68_687
FTX: AW25_612
FTD: AS84_1120
FTY: CH70_550
FPT: BZ13_705
FPI: BF30_1545(ethe1)
FPM: LA56_882
FPX: KU46_14
FPZ: LA55_1579
FPJ: LA02_955
FRC: KX01_1164
HMAR: HVMH_1014
TEE: Tel_15535
TVR: TVD_10990
SVA: SVA_0968
CGD: CR3_1292 CR3_2791(gloB)
BVE: AK36_3116(ethe1)
BCEN: DM39_5202(ethe1)
BCEW: DM40_3259(ethe1)
BCEO: I35_6562
BMK: DM80_4694(ethe1)
BMUL: NP80_3228(ethe1)
BCED: DM42_5309(ethe1)
BDL: AK34_3221(eTHE1)
BCON: NL30_17130
BUB: BW23_3850(eTHE1)
BLAT: WK25_28880
BTEI: WS51_10045
BSEM: WJ12_33245
BPSL: WS57_01000
BMEC: WJ16_31690
BSTG: WT74_32100
BFN: OI25_2781(ethe1) OI25_7880 OI25_8246(ethe1)
CABA: SBC2_41690(blh_1) SBC2_43200(gloB_4) SBC2_52500(blh_2)
HPSE: HPF_03375(blh1) HPF_22135(blh2)
CBAA: SRAA_0536
NIM: W01_12700(gly3)
SPLB: SFPGR_32480(gly3)
SNIV: SFSGTM_21040(gly3_1) SFSGTM_22010(gly3_2)
EAD: OV14_3417
SMAZ: LH19_06300
SPHT: K426_25465
ALB: AEB_P2623
SHUM: STHU_18830
AFR: AFE_0956
ACU: Atc_2279
ATX: GCD22_01295(ethe1)
HHG: XM38_017830(blh)
MPK: VL20_2736
GLJ: GKIL_2375(gloB)
CALH: IJ00_07550
CEO: ETSB_1094
NJA: NSJP_3718
 » show all
Reference
1  [PMID:5968172]
  Authors
Suzuki I, Silver M.
  Title
The initial product and properties of the sulfur-oxidizing enzyme of thiobacilli.
  Journal
Biochim Biophys Acta 122:22-33 (1966)
DOI:10.1016/0926-6593(66)90088-9
Reference
2  [PMID:12855721]
  Authors
Rohwerder T, Sand W.
  Title
The sulfane sulfur of persulfides is the actual substrate of the sulfur-oxidizing enzymes from Acidithiobacillus and Acidiphilium spp.
  Journal
Microbiology 149:1699-710 (2003)
DOI:10.1099/mic.0.26212-0
Reference
3  [PMID:24389926]
  Authors
Liu H, Xin Y, Xun L
  Title
Distribution, diversity, and activities of sulfur dioxygenases in heterotrophic bacteria.
  Journal
Appl Environ Microbiol 80:1799-806 (2014)
DOI:10.1128/AEM.03281-13
Reference
4  [PMID:22786886]
  Authors
Holdorf MM, Owen HA, Lieber SR, Yuan L, Adams N, Dabney-Smith C, Makaroff CA
  Title
Arabidopsis ETHE1 encodes a sulfur dioxygenase that is essential for embryo and endosperm development.
  Journal
Plant Physiol 160:226-36 (2012)
DOI:10.1104/pp.112.201855
  Sequence
[ath:AT1G53580]
Reference
5  [PMID:25596185]
  Authors
Pettinati I, Brem J, McDonough MA, Schofield CJ
  Title
Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy.
  Journal
Hum Mol Genet 24:2458-69 (2015)
DOI:10.1093/hmg/ddv007
  Sequence
[hsa:23474]
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.18
IUBMB Enzyme Nomenclature: 1.13.11.18
ExPASy - ENZYME nomenclature database: 1.13.11.18
BRENDA, the Enzyme Database: 1.13.11.18
CAS: 37256-58-9
LinkDB

KEGG   REACTION: R08678
Entry
R08678                      Reaction                               

Name
S-sulfanylglutathione:oxygen oxidoreductase
Definition
S-Sulfanylglutathione + Oxygen + H2O <=> Glutathione + Sulfite
Equation
Comment
two-step reaction (see R11946+R11947)
Reaction class
RC02313  C00051_C17267
Enzyme
Pathway
rn00920  Sulfur metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K17725  sulfur dioxygenase [EC:1.13.11.18]
Other DBs
RHEA: 12984
LinkDB

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