KEGG   ORTHOLOGY: K18123
Entry
K18123                      KO                                     

Name
HOGA1
Definition
4-hydroxy-2-oxoglutarate aldolase [EC:4.1.3.16]
Pathway
ko00330  Arginine and proline metabolism
ko00630  Glyoxylate and dicarboxylate metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    K18123  HOGA1; 4-hydroxy-2-oxoglutarate aldolase
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K18123  HOGA1; 4-hydroxy-2-oxoglutarate aldolase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.16  4-hydroxy-2-oxoglutarate aldolase
     K18123  HOGA1; 4-hydroxy-2-oxoglutarate aldolase
Other DBs
RN: R00470 R00471
GO: 0008700
Genes
HSA: 112817(HOGA1)
PTR: 742884(HOGA1)
PPS: 103782784(HOGA1)
GGO: 101154009(HOGA1)
PON: 100171598(HOGA1)
NLE: 100589206(HOGA1)
MCC: 706661(HOGA1)
MCF: 102126728(HOGA1)
CSAB: 103216345(HOGA1)
RRO: 104682808(HOGA1)
RBB: 108534698(HOGA1)
CJC: 103796777(HOGA1)
SBQ: 104650492(HOGA1)
MMU: 67432(Hoga1)
MCAL: 110285310(Hoga1)
MPAH: 110333903(Hoga1)
RNO: 293949(Hoga1)
MUN: 110564114(Hoga1)
CGE: 100759109(Hoga1)
NGI: 103733196(Hoga1)
HGL: 101700602(Hoga1)
CCAN: 109695304(Hoga1)
OCU: 100344505(HOGA1)
TUP: 102486364(HOGA1)
CFA: 608755(HOGA1)
VVP: 112914409(HOGA1)
AML: 100478059(HOGA1)
UMR: 103674087(HOGA1)
UAH: 113251791(HOGA1)
ORO: 101385318(HOGA1)
ELK: 111145298
FCA: 101101417(HOGA1)
PTG: 102965487(HOGA1)
PPAD: 109272717(HOGA1)
AJU: 106966929(HOGA1)
BTA: 506001(HOGA1)
BOM: 102265621(HOGA1)
BIU: 109552999(HOGA1)
BBUB: 102398601(HOGA1)
CHX: 102173994(HOGA1)
OAS: 101114573(HOGA1)
SSC: 100153961(HOGA1)
CFR: 102512614(HOGA1)
CDK: 105084288(HOGA1)
BACU: 103004258(HOGA1)
LVE: 103077167 103089444(HOGA1)
OOR: 101271753(HOGA1)
DLE: 111172427(HOGA1)
PCAD: 102979032(HOGA1)
ECB: 100070689(HOGA1)
EPZ: 103558701(HOGA1)
EAI: 106844960(HOGA1)
MYB: 102246939(HOGA1)
MYD: 102768587(HOGA1)
MNA: 107542604(HOGA1)
HAI: 109379716(HOGA1)
DRO: 112307109(HOGA1)
PALE: 102884382(HOGA1)
RAY: 107520438(HOGA1)
MJV: 108399750(HOGA1)
LAV: 100670230(HOGA1)
TMU: 101355404
MDO: 100021876(HOGA1)
SHR: 100929176(HOGA1)
PCW: 110215427(HOGA1)
OAA: 100088274(HOGA1)
GGA: 770036(HOGA1)
MGP: 100548398(HOGA1)
CJO: 107316003(HOGA1)
NMEL: 110400352(HOGA1)
ACYG: 106036839(HOGA1)
TGU: 100231472(HOGA1)
LSR: 110473597(HOGA1)
SCAN: 103813888(HOGA1)
GFR: 102042170(HOGA1)
FAB: 101806953(HOGA1)
PHI: 102112987(HOGA1)
PMAJ: 107206698(HOGA1)
CCAE: 111931229(HOGA1)
CCW: 104695887(HOGA1)
ETL: 114070777(HOGA1)
FPG: 101920952(HOGA1)
FCH: 102052298(HOGA1)
CLV: 102097409(HOGA1)
EGZ: 104132255(HOGA1)
NNI: 104012772(HOGA1)
ACUN: 113481407(HOGA1)
PADL: 103916280(HOGA1)
ASN: 102382587(HOGA1)
AMJ: 102563093(HOGA1)
CPIC: 103307603(HOGA1)
ACS: 100566929(hoga1)
PVT: 110089167(HOGA1)
PBI: 103053263(HOGA1)
PMUR: 107295219(HOGA1)
TSR: 106549035(HOGA1)
PMUA: 114597588(HOGA1)
GJA: 107114457(HOGA1)
XLA: 495193(hoga1.L)
XTR: 496669(hoga1)
NPR: 108792933(HOGA1)
DRE: 405806(hoga1)
SRX: 107706114
SANH: 107663482(hoga1)
SGH: 107551368 107588470(hoga1)
CCAR: 109069442
IPU: 108259603(hoga1)
PHYP: 113546731(hoga1)
AMEX: 103023796(hoga1)
EEE: 113577699(hoga1)
TRU: 101061435(hoga1)
LCO: 104930035(hoga1)
NCC: 104953008(hoga1)
MZE: 101479315(hoga1)
ONL: 100690946(hoga1)
OLA: 101161460(hoga1)
XMA: 102230783(hoga1)
XCO: 114145238(hoga1)
PRET: 103470116(hoga1)
CVG: 107081958(hoga1)
NFU: 107382406(hoga1)
KMR: 108247450(hoga1)
ALIM: 106537034(hoga1)
AOCE: 111580411(hoga1)
CSEM: 103383203(hoga1)
POV: 109645371
LCF: 108880833(hoga1)
SDU: 111235845(hoga1)
SLAL: 111665639(hoga1)
HCQ: 109511381(hoga1)
BPEC: 110155940(hoga1)
MALB: 109952000(hoga1)
SASA: 106591168(hoga1) 106591313
SALP: 112079381(hoga1)
ELS: 105006876(hoga1)
SFM: 108924852(hoga1)
PKI: 111848362(hoga1)
LCM: 102362318(HOGA1)
CMK: 103172525(hoga1)
RTP: 109921722(hoga1)
CIN: 100181036
SPU: 579934
APLC: 110981286
SKO: 100372772
VEM: 105569390
API: 100570569
DNX: 107163989
AGS: 114132054
RMD: 113549091
ZNE: 110831450
FCD: 110856855
PVM: 113818492
CSCU: 111618478
PTEP: 107438884
PCAN: 112565420
MYI: 110455405
OBI: 106884306
LAK: 106170963
NVE: 5520994
EPA: 110231654
ADF: 107337820
AMIL: 114962597
PDAM: 113686876
SPIS: 111324439
DGT: 114515751
HMG: 100199549
QSU: 111991330
NTE: NEUTE1DRAFT148948(NEUTE1DRAFT_148948) NEUTE1DRAFT48910(NEUTE1DRAFT_48910)
MBE: MBM_05778
ANI: AN1503.2
ANG: ANI_1_1446134(An15g04230) ANI_1_1986144(An16g07700) ANI_1_26174(An10g00330)
CNE: CNC03990
CNB: CNBC3190
TASA: A1Q1_07016
ABP: AGABI1DRAFT111212(AGABI1DRAFT_111212) AGABI1DRAFT114952(AGABI1DRAFT_114952)
ABV: AGABI2DRAFT190432(AGABI2DRAFT_190432) AGABI2DRAFT191181(AGABI2DRAFT_191181)
LIP: LI0108(dapA)
LIR: LAW_00107(dapA_1)
DHD: Dhaf_1978
TFR: BR63_09785(dapA)
TMR: Tmar_1165
THX: Thet_1017
TIT: Thit_1575
STI: Sthe_0488
TRA: Trad_0621
TSC: TSC_c08910(dapA1)
MRB: Mrub_2327
ACA: ACP_0327
ABAS: ACPOL_6664
SUS: Acid_1067
ABAC: LuPra_06084(dapA_3)
TLI: Tlie_1310
GAU: GAU_0904
GBA: J421_2804
 » show all
Reference
  Authors
Riedel TJ, Johnson LC, Knight J, Hantgan RR, Holmes RP, Lowther WT
  Title
Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria.
  Journal
PLoS One 6:e26021 (2011)
DOI:10.1371/journal.pone.0026021
  Sequence
[hsa:112817]
LinkDB

KEGG   ENZYME: 4.1.3.16
Entry
EC 4.1.3.16                 Enzyme                                 

Name
4-hydroxy-2-oxoglutarate aldolase;
2-oxo-4-hydroxyglutarate aldolase;
hydroxyketoglutaric aldolase;
4-hydroxy-2-ketoglutaric aldolase;
2-keto-4-hydroxyglutaric aldolase;
4-hydroxy-2-ketoglutarate aldolase;
2-keto-4-hydroxyglutarate aldolase;
2-oxo-4-hydroxyglutaric aldolase;
DL-4-hydroxy-2-ketoglutarate aldolase;
hydroxyketoglutarate aldolase;
2-keto-4-hydroxybutyrate aldolase;
4-hydroxy-2-oxoglutarate glyoxylate-lyase;
KHGA
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
Sysname
4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
Reaction(IUBMB)
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate [RN:R00470]
Reaction(KEGG)
R00470 > R00471 R10283
Substrate
4-hydroxy-2-oxoglutarate [CPD:C01127]
Product
pyruvate [CPD:C00022];
glyoxylate [CPD:C00048]
Comment
The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. cf. EC 4.1.3.42, (4S)-4-hydroxy-2-oxoglutarate aldolase.
History
EC 4.1.3.16 created 1972 (EC 4.1.2.1 created 1961, incorporated 1972, EC 4.1.2.31 created 1978, incorporated 1982)
Pathway
ec00330  Arginine and proline metabolism
ec00630  Glyoxylate and dicarboxylate metabolism
ec01100  Metabolic pathways
Orthology
K18123  4-hydroxy-2-oxoglutarate aldolase
Genes
HSA: 112817(HOGA1)
PTR: 742884(HOGA1)
PPS: 103782784(HOGA1)
GGO: 101154009(HOGA1)
PON: 100171598(HOGA1)
NLE: 100589206(HOGA1)
MCC: 706661(HOGA1)
MCF: 102126728(HOGA1)
CSAB: 103216345(HOGA1)
RRO: 104682808(HOGA1)
RBB: 108534698(HOGA1)
CJC: 103796777(HOGA1)
SBQ: 104650492(HOGA1)
MMU: 67432(Hoga1)
MCAL: 110285310(Hoga1)
MPAH: 110333903(Hoga1)
RNO: 293949(Hoga1)
MUN: 110564114(Hoga1)
CGE: 100759109(Hoga1)
NGI: 103733196(Hoga1)
HGL: 101700602(Hoga1)
CCAN: 109695304(Hoga1)
OCU: 100344505(HOGA1)
TUP: 102486364(HOGA1)
CFA: 608755(HOGA1)
VVP: 112914409(HOGA1)
AML: 100478059(HOGA1)
UMR: 103674087(HOGA1)
UAH: 113251791(HOGA1)
ORO: 101385318(HOGA1)
ELK: 111145298
FCA: 101101417(HOGA1)
PTG: 102965487(HOGA1)
PPAD: 109272717(HOGA1)
AJU: 106966929(HOGA1)
BTA: 506001(HOGA1)
BOM: 102265621(HOGA1)
BIU: 109552999(HOGA1)
BBUB: 102398601(HOGA1)
CHX: 102173994(HOGA1)
OAS: 101114573(HOGA1)
SSC: 100153961(HOGA1)
CFR: 102512614(HOGA1)
CDK: 105084288(HOGA1)
BACU: 103004258(HOGA1)
LVE: 103077167 103089444(HOGA1)
OOR: 101271753(HOGA1)
DLE: 111172427(HOGA1)
PCAD: 102979032(HOGA1)
ECB: 100070689(HOGA1)
EPZ: 103558701(HOGA1)
EAI: 106844960(HOGA1)
MYB: 102246939(HOGA1)
MYD: 102768587(HOGA1)
MNA: 107542604(HOGA1)
HAI: 109379716(HOGA1)
DRO: 112307109(HOGA1)
PALE: 102884382(HOGA1)
RAY: 107520438(HOGA1)
MJV: 108399750(HOGA1)
LAV: 100670230(HOGA1)
TMU: 101355404
MDO: 100021876(HOGA1)
SHR: 100929176(HOGA1)
PCW: 110215427(HOGA1)
OAA: 100088274(HOGA1)
GGA: 770036(HOGA1)
MGP: 100548398(HOGA1)
CJO: 107316003(HOGA1)
NMEL: 110400352(HOGA1)
ACYG: 106036839(HOGA1)
TGU: 100231472(HOGA1)
LSR: 110473597(HOGA1)
SCAN: 103813888(HOGA1)
GFR: 102042170(HOGA1)
FAB: 101806953(HOGA1)
PHI: 102112987(HOGA1)
PMAJ: 107206698(HOGA1)
CCAE: 111931229(HOGA1)
CCW: 104695887(HOGA1)
ETL: 114070777(HOGA1)
FPG: 101920952(HOGA1)
FCH: 102052298(HOGA1)
CLV: 102097409(HOGA1)
EGZ: 104132255(HOGA1)
NNI: 104012772(HOGA1)
ACUN: 113481407(HOGA1)
PADL: 103916280(HOGA1)
ASN: 102382587(HOGA1)
AMJ: 102563093(HOGA1)
CPIC: 103307603(HOGA1)
ACS: 100566929(hoga1)
PVT: 110089167(HOGA1)
PBI: 103053263(HOGA1)
PMUR: 107295219(HOGA1)
TSR: 106549035(HOGA1)
PMUA: 114597588(HOGA1)
GJA: 107114457(HOGA1)
XLA: 495193(hoga1.L)
XTR: 496669(hoga1)
NPR: 108792933(HOGA1)
DRE: 405806(hoga1)
SRX: 107706114
SANH: 107663482(hoga1)
SGH: 107551368 107588470(hoga1)
CCAR: 109069442
IPU: 108259603(hoga1)
PHYP: 113546731(hoga1)
AMEX: 103023796(hoga1)
EEE: 113577699(hoga1)
TRU: 101061435(hoga1)
LCO: 104930035(hoga1)
NCC: 104953008(hoga1)
MZE: 101479315(hoga1)
ONL: 100690946(hoga1)
OLA: 101161460(hoga1)
XMA: 102230783(hoga1)
XCO: 114145238(hoga1)
PRET: 103470116(hoga1)
CVG: 107081958(hoga1)
NFU: 107382406(hoga1)
KMR: 108247450(hoga1)
ALIM: 106537034(hoga1)
AOCE: 111580411(hoga1)
CSEM: 103383203(hoga1)
POV: 109645371
LCF: 108880833(hoga1)
SDU: 111235845(hoga1)
SLAL: 111665639(hoga1)
HCQ: 109511381(hoga1)
BPEC: 110155940(hoga1)
MALB: 109952000(hoga1)
SASA: 106591168(hoga1) 106591313
SALP: 112079381(hoga1)
ELS: 105006876(hoga1)
SFM: 108924852(hoga1)
PKI: 111848362(hoga1)
LCM: 102362318(HOGA1)
CMK: 103172525(hoga1)
RTP: 109921722(hoga1)
CIN: 100181036
SPU: 579934
APLC: 110981286
SKO: 100372772
VEM: 105569390
API: 100570569
DNX: 107163989
AGS: 114132054
RMD: 113549091
ZNE: 110831450
FCD: 110856855
PVM: 113818492
CSCU: 111618478
PTEP: 107438884
PCAN: 112565420
MYI: 110455405
OBI: 106884306
LAK: 106170963
NVE: 5520994
EPA: 110231654
ADF: 107337820
AMIL: 114962597
PDAM: 113686876
SPIS: 111324439
DGT: 114515751
HMG: 100199549
QSU: 111991330
NTE: NEUTE1DRAFT148948(NEUTE1DRAFT_148948) NEUTE1DRAFT48910(NEUTE1DRAFT_48910)
MBE: MBM_05778
ANI: AN1503.2
ANG: ANI_1_1446134(An15g04230) ANI_1_1986144(An16g07700) ANI_1_26174(An10g00330)
CNE: CNC03990
CNB: CNBC3190
TASA: A1Q1_07016
ABP: AGABI1DRAFT111212(AGABI1DRAFT_111212) AGABI1DRAFT114952(AGABI1DRAFT_114952)
ABV: AGABI2DRAFT190432(AGABI2DRAFT_190432) AGABI2DRAFT191181(AGABI2DRAFT_191181)
LIP: LI0108(dapA)
LIR: LAW_00107(dapA_1)
DHD: Dhaf_1978
TFR: BR63_09785(dapA)
TMR: Tmar_1165
THX: Thet_1017
TIT: Thit_1575
STI: Sthe_0488
TRA: Trad_0621
TSC: TSC_c08910(dapA1)
MRB: Mrub_2327
ACA: ACP_0327
ABAS: ACPOL_6664
SUS: Acid_1067
ABAC: LuPra_06084(dapA_3)
TLI: Tlie_1310
GAU: GAU_0904
GBA: J421_2804
 » show all
Reference
1  [PMID:14089442]
  Authors
KURATOMI K, FUKUNAGA K.
  Title
THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT LIVER. I. ENZYMIC SYNTHESIS OF GAMMA-HYDROXY-ALPHA-KETOGLUTARATE FROM PYRUVATE AND GLYOXYLATE.
  Journal
Biochim Biophys Acta 78:617-28 (1963)
DOI:10.1016/0006-3002(63)91027-8
Reference
2  [PMID:5780845]
  Authors
Kobes RD, Dekker EE
  Title
2-Keto-4-hydroxyglutarate aldolase of bovine liver. Purification, criteria of purity, and general properties.
  Journal
J Biol Chem 244:1919-25 (1969)
Reference
3  [PMID:5580656]
  Authors
Lane RS, Shapley A, Dekker EE.
  Title
2-keto-4-hydroxybutyrate aldolase. Identification as 2-keto-4-hydroxyglutarate aldolase, catalytic properties, and role in the mammalian metabolism of L-homoserine.
  Journal
Biochemistry 10:1353-64 (1971)
DOI:10.1021/bi00784a013
Reference
4  [PMID:3942759]
  Authors
Scholtz JM, Schuster SM
  Title
Regulation of rat liver 4-hydroxy-2-ketoglutarate aldolase.
  Journal
Biochim Biophys Acta 869:192-6 (1986)
DOI:10.1016/0167-4838(86)90294-3
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.16
IUBMB Enzyme Nomenclature: 4.1.3.16
ExPASy - ENZYME nomenclature database: 4.1.3.16
BRENDA, the Enzyme Database: 4.1.3.16
CAS: 9030-81-3
LinkDB

KEGG   REACTION: R00470
Entry
R00470                      Reaction                               

Name
4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
Definition
4-Hydroxy-2-oxoglutarate <=> Pyruvate + Glyoxylate
Equation
Reaction class
RC00307  C00022_C01127
RC00308  C00048_C01127
Enzyme
4.1.3.16        4.1.3.42
Pathway
rn00630  Glyoxylate and dicarboxylate metabolism
rn01100  Metabolic pathways
Orthology
K01625  2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42]
K18123  4-hydroxy-2-oxoglutarate aldolase [EC:4.1.3.16]
Other DBs
RHEA: 18172
LinkDB

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