KEGG   ORTHOLOGY: K18316
Entry
K18316                      KO                                     

Name
cpmA, carA
Definition
carbapenam-3-carboxylate synthase [EC:6.3.3.6]
Pathway
ko00332  Carbapenem biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko02024  Quorum sensing
Module
M00675  Carbapenem-3-carboxylate biosynthesis, pyrroline-5-carboxylate + malonyl-CoA => carbapenem-3-carboxylate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18316  cpmA, carA; carbapenam-3-carboxylate synthase
 09140 Cellular Processes
  09145 Cellular community - prokaryotes
   02024 Quorum sensing
    K18316  cpmA, carA; carbapenam-3-carboxylate synthase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.6  carbapenam-3-carboxylate synthase
     K18316  cpmA, carA; carbapenam-3-carboxylate synthase
Other DBs
RN: R10556
COG: COG0367
Genes
SERA: Ser39006_009920
SERQ: CWC46_09915
DZE: Dd1591_0213
DAQ: DAQ1742_04174(cpmA)
PAO: Pat9b_5317
PLU: plu0182(cpmA)
PLUM: A4R40_00880
PTT: VY86_09615
PRG: RB151_027380(carA_2)
BGP: BGL_2c27620
AG: AAD38229(carA)
 » show all
Reference
  Authors
Raber ML, Arnett SO, Townsend CA
  Title
A conserved tyrosyl-glutamyl catalytic dyad in evolutionarily linked enzymes: carbapenam synthetase and beta-lactam synthetase.
  Journal
Biochemistry 48:4959-71 (2009)
DOI:10.1021/bi900432n
  Sequence
LinkDB

KEGG   ORTHOLOGY: K18582
Entry
K18582                      KO                                     

Name
thnM
Definition
carbapenam-3-carboxylate synthase [EC:6.3.3.6]
Pathway
ko00332  Carbapenem biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18582  thnM; carbapenam-3-carboxylate synthase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.6  carbapenam-3-carboxylate synthase
     K18582  thnM; carbapenam-3-carboxylate synthase
Other DBs
RN: R10556
COG: COG0367
Genes
SCT: SCAT_p0832(thnM)
SCY: SCATT_p09030
SFA: Sfla_0156
STRP: F750_6865
Reference
  Authors
Rodriguez M, Nunez LE, Brana AF, Mendez C, Salas JA, Blanco G
  Title
Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya.
  Journal
Antimicrob Agents Chemother 55:1638-49 (2011)
DOI:10.1128/AAC.01366-10
  Sequence
Reference
  Authors
Bodner MJ, Li R, Phelan RM, Freeman MF, Moshos KA, Lloyd EP, Townsend CA
  Title
Definition of the common and divergent steps in carbapenem beta-lactam antibiotic biosynthesis.
  Journal
Chembiochem 12:2159-65 (2011)
DOI:10.1002/cbic.201100366
LinkDB

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