KEGG   ORTHOLOGY: K18317
Entry
K18317                      KO                                     

Name
cpmB, carB
Definition
carboxymethylproline synthase [EC:2.3.1.226]
Pathway
ko00332  Carbapenem biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko02024  Quorum sensing
Module
M00675  Carbapenem-3-carboxylate biosynthesis, pyrroline-5-carboxylate + malonyl-CoA => carbapenem-3-carboxylate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18317  cpmB, carB; carboxymethylproline synthase
 09140 Cellular Processes
  09145 Cellular community - prokaryotes
   02024 Quorum sensing
    K18317  cpmB, carB; carboxymethylproline synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.226  carboxymethylproline synthase
     K18317  cpmB, carB; carboxymethylproline synthase
Other DBs
RN: R10485
COG: COG1024
Genes
SERA: Ser39006_009925
SERQ: CWC46_09920
DZE: Dd1591_0212
DAQ: DAQ1742_04175(cpmB)
PAO: Pat9b_5316
PLU: plu0183(cpmB)
PLUM: A4R40_00885
PTT: VY86_09610
PRG: RB151_027390(echA8)
BGP: BGL_2c27610
PFT: JBW_01239
 » show all
Reference
  Authors
Stapon A, Li R, Townsend CA
  Title
Carbapenem biosynthesis: confirmation of stereochemical assignments and the role of CarC in the ring stereoinversion process from L-proline.
  Journal
J Am Chem Soc 125:8486-93 (2003)
DOI:10.1021/ja034248a
LinkDB

KEGG   ORTHOLOGY: K18583
Entry
K18583                      KO                                     

Name
thnE
Definition
carboxymethylproline synthase [EC:2.3.1.226]
Pathway
ko00332  Carbapenem biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18583  thnE; carboxymethylproline synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.226  carboxymethylproline synthase
     K18583  thnE; carboxymethylproline synthase
Other DBs
RN: R10485
COG: COG1024
Genes
SCT: SCAT_p0824(thnE)
SCY: SCATT_p09110
SFA: Sfla_0164
STRP: F750_6857
Reference
  Authors
Rodriguez M, Nunez LE, Brana AF, Mendez C, Salas JA, Blanco G
  Title
Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya.
  Journal
Antimicrob Agents Chemother 55:1638-49 (2011)
DOI:10.1128/AAC.01366-10
  Sequence
Reference
  Authors
Hamed RB, Batchelar ET, Mecinovic J, Claridge TD, Schofield CJ
  Title
Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline.
  Journal
Chembiochem 10:246-50 (2009)
DOI:10.1002/cbic.200800652
Reference
  Authors
Bodner MJ, Li R, Phelan RM, Freeman MF, Moshos KA, Lloyd EP, Townsend CA
  Title
Definition of the common and divergent steps in carbapenem beta-lactam antibiotic biosynthesis.
  Journal
Chembiochem 12:2159-65 (2011)
DOI:10.1002/cbic.201100366
LinkDB

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