KEGG   ORTHOLOGY: K18386
Entry
K18386                      KO                                     

Name
PAXM, ATMM, LTMM
Definition
FAD dependent monooxygenase [EC:1.14.13.-]
Pathway
ko00403  Indole diterpene alkaloid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00661  Paspaline biosynthesis, geranylgeranyl-PP + indoleglycerol phosphate => paspaline
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00403 Indole diterpene alkaloid biosynthesis
    K18386  PAXM, ATMM, LTMM; FAD dependent monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-  
     K18386  PAXM, ATMM, LTMM; FAD dependent monooxygenase
Other DBs
RN: R10350 R10351
Genes
FGR: FGSG_04595
FPU: FPSE_10836
MAW: MAC_08211
MAJ: MAA_00078 MAA_07499
ANI: AN8140.2
AFM: AFUA_6G13970 AFUA_8G02380
ACT: ACLA_008510
NFI: NFIA_096050 NFIA_100480
AOR: AO090113000174
ANG: ANI_1_1734094(An11g02480)
 » show all
Reference
  Authors
Nicholson MJ, Koulman A, Monahan BJ, Pritchard BL, Payne GA, Scott B
  Title
Identification of two aflatrem biosynthesis gene loci in Aspergillus flavus and metabolic engineering of Penicillium paxilli to elucidate their function.
  Journal
Appl Environ Microbiol 75:7469-81 (2009)
DOI:10.1128/AEM.02146-08
  Sequence
Reference
  Authors
Young C, McMillan L, Telfer E, Scott B
  Title
Molecular cloning and genetic analysis of an indole-diterpene gene cluster from Penicillium paxilli.
  Journal
Mol Microbiol 39:754-64 (2001)
DOI:10.1046/j.1365-2958.2001.02265.x
Reference
  Authors
Tagami K, Liu C, Minami A, Noike M, Isaka T, Fueki S, Shichijo Y, Toshima H, Gomi K, Dairi T, Oikawa H
  Title
Reconstitution of biosynthetic machinery for indole-diterpene paxilline in Aspergillus oryzae.
  Journal
J Am Chem Soc 135:1260-3 (2013)
DOI:10.1021/ja3116636
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