KEGG   ORTHOLOGY: K18660Help
Entry
K18660                      KO                                     

Name
ACSF3
Definition
malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.-]
Pathway
ko00061  Fatty acid biosynthesis
ko00280  Valine, leucine and isoleucine degradation
ko01100  Metabolic pathways
ko01212  Fatty acid metabolism
Module
M00873  Fatty acid biosynthesis in mitochondria, animals
Disease
H02109  Combined malonic and methylmalonic aciduria
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00061 Fatty acid biosynthesis
    K18660  ACSF3; malonyl-CoA/methylmalonyl-CoA synthetase
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K18660  ACSF3; malonyl-CoA/methylmalonyl-CoA synthetase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.-  
     K18660  ACSF3; malonyl-CoA/methylmalonyl-CoA synthetase
BRITE hierarchy
Other DBs
RN: R03383 R12300
COG: COG0318
GO: 0090409
Genes
HSA: 197322(ACSF3)
PTR: 454311(ACSF3)
PPS: 100993031(ACSF3)
GGO: 101148664(ACSF3)
PON: 100459097(ACSF3)
NLE: 100584583(ACSF3)
MCC: 106995123(ACSF3)
MCF: 102124170(ACSF3)
CSAB: 103233469(ACSF3)
RRO: 104655975(ACSF3)
RBB: 108520197(ACSF3)
CJC: 100389759(ACSF3)
SBQ: 101045750(ACSF3)
MMU: 257633(Acsf3)
MCAL: 110299939(Acsf3)
MPAH: 110337582(Acsf3)
RNO: 498962(Acsf3)
MUN: 110545227(Acsf3)
CGE: 100764604(Acsf3)
NGI: 103739998(Acsf3)
HGL: 101708737(Acsf3)
CCAN: 109692748(Acsf3)
TUP: 102494496(ACSF3)
CFA: 100683704(ACSF3)
VVP: 112924630(ACSF3)
AML: 100468387(ACSF3)
UMR: 103673852(ACSF3)
UAH: 113252139(ACSF3)
ORO: 101380436(ACSF3)
FCA: 101099921(ACSF3)
PTG: 102952439(ACSF3)
PPAD: 109245531(ACSF3)
AJU: 106973497(ACSF3)
BTA: 509209(ACSF3)
BOM: 102268238(ACSF3)
BIU: 109572849(ACSF3)
BBUB: 102404462(ACSF3)
CHX: 102169989(ACSF3)
OAS: 101109383(ACSF3)
SSC: 100739500(ACSF3)
CFR: 102514930(ACSF3)
CDK: 105104336(ACSF3)
BACU: 103006350(ACSF3)
LVE: 103069795(ACSF3)
OOR: 101272385(ACSF3)
DLE: 111179387(ACSF3)
PCAD: 102978174(ACSF3)
ECB: 100051639(ACSF3)
EPZ: 103562086(ACSF3)
EAI: 106828244(ACSF3)
MYB: 102264099(ACSF3)
MYD: 102757514(ACSF3)
MNA: 107543506(ACSF3)
HAI: 109389204(ACSF3)
DRO: 112300687(ACSF3)
PALE: 102888559(ACSF3)
RAY: 107502352(ACSF3)
MJV: 108398345(ACSF3)
LAV: 100665435(ACSF3)
TMU: 101348352
MDO: 100026661(ACSF3)
SHR: 100934834(ACSF3)
PCW: 110210298(ACSF3)
OAA: 100080846(ACSF3)
GGA: 427561(ACSF3)
MGP: 104913064(ACSF3)
CJO: 107319518(ACSF3)
NMEL: 110404322(ACSF3)
APLA: 101789434(ACSF3)
ACYG: 106046510(ACSF3)
TGU: 100226659(ACSF3)
LSR: 110468775(ACSF3)
SCAN: 103816762(ACSF3)
GFR: 102043804(ACSF3)
FAB: 101810484(ACSF3)
PHI: 102101860(ACSF3)
PMAJ: 107209950(ACSF3)
CCAE: 111934399(ACSF3)
CCW: 104691853(ACSF3)
ETL: 114068202(ACSF3)
FPG: 101914803(ACSF3)
FCH: 102048057(ACSF3)
CLV: 102096424(ACSF3)
EGZ: 104127039(ACSF3)
NNI: 104023568(ACSF3)
ACUN: 113484628(ACSF3)
PADL: 103913407(ACSF3)
AAM: 106489294(ACSF3)
ASN: 102375874(ACSF3)
AMJ: 102560749(ACSF3)
PSS: 102445720(ACSF3)
CMY: 102929679(ACSF3)
CPIC: 101930814 101938726(ACSF3)
ACS: 100568268(acsf3)
PVT: 110076304(ACSF3)
PBI: 103058003(ACSF3)
PMUR: 107283518(ACSF3)
PMUA: 114602140(ACSF3)
GJA: 107106555(ACSF3)
XLA: 444743(acsf3.S)
XTR: 100158470(acsf3)
NPR: 108787714(ACSF3)
DRE: 562292(acsf3)
SRX: 107730180(acsf3)
SANH: 107663040
SGH: 107561460
CCAR: 109099865
IPU: 108259686(acsf3)
AMEX: 103034152(acsf3)
EEE: 113575703(acsf3)
TRU: 101063367(acsf3)
LCO: 104922786(acsf3)
NCC: 104951573(acsf3)
MZE: 101468267(acsf3)
ONL: 100707810(acsf3)
OLA: 101170745(acsf3)
XMA: 102230562(acsf3)
XCO: 114143356(acsf3)
PRET: 103462378(acsf3)
CVG: 107091333(acsf3)
NFU: 107381230(acsf3)
KMR: 108250104(acsf3)
ALIM: 106513917(acsf3)
AOCE: 111588400(acsf3)
CSEM: 103378655(acsf3)
POV: 109624726(acsf3)
LCF: 108887665(acsf3)
SDU: 111238435(acsf3)
SLAL: 111668336(acsf3)
HCQ: 109519728(acsf3)
BPEC: 110173014(acsf3)
MALB: 109965423(acsf3)
SASA: 106562165(acsf3)
OTW: 112249120 112263579(acsf3)
ELS: 105017127(acsf3)
SFM: 108934574(acsf3)
PKI: 111832951(acsf3)
LCM: 102359073(ACSF3)
CMK: 103188085(acsf3)
RTP: 109922101(acsf3)
CIN: 100175199
SPU: 579933
APLC: 110973722
DME: Dmel_CG18155(CG18155)
DER: 6551437
DSI: Dsimw501_GD16841(Dsim_GD16841)
DSR: 110183531
DWI: 6637694
DAZ: 108620017
DNV: 115565182
DHE: 111602856
MDE: 101893765
LCQ: 111677053
AAG: 5578522
NVI: 100123908
CSOL: 105363664
MDL: 103575693
TCA: 664439
ATD: 109595780
NVL: 108559274
BMOR: 101739309
PMAC: 106718666
PRAP: 111000397
HAW: 110377632
TNL: 113494291
API: 100168625
DNX: 107165065
AGS: 114121417
RMD: 113547994
BTAB: 109042193
CLEC: 106664913
ZNE: 110829175
FCD: 110841952
PVM: 113810650
PTEP: 107437889
PCAN: 112576533
CRG: 105342284
MYI: 110449900
OBI: 106874666
LAK: 106151525
EPA: 110241051
AMIL: 114969610
PDAM: 113673905
SPIS: 111323410
ATH: AT3G16170(AAE13)
CRB: 17893307
THJ: 104817978
CIT: 102619243
TCC: 18595956
GRA: 105776753
GAB: 108483454
DZI: 111278937
EGR: 104423091
VRA: 106774327
VAR: 108320665
VUN: 114167163
CCAJ: 109808002
LJA: Lj3g3v2312070.1(Lj3g3v2312070.1)
ADU: 107464053
AIP: 107618487
FVE: 101313429
RCN: 112187693
PPER: 18782111
PAVI: 110769490
PXB: 103944850
ZJU: 107405227
CSV: 101208501
CMO: 103493370
MCHA: 111020569
CMAX: 111494602
CMOS: 111464352
CPEP: 111779370
RCU: 8273830
JCU: 105635019
HBR: 110639934
MESC: 110627022
POP: 18094769
VVI: 100258310
SLY: 101245036
SPEN: 107007252
SOT: 102592845
SIND: 105157654
OEU: 111366194
CCAV: 112510212
DCR: 108196830
BVG: 104904717
SOE: 110801728
NNU: 104595150
OSA: 4327020
DOSA: Os01t0761300-01(Os01g0761300)
OBR: 102703440
BDI: 100830101
ATS: 109753580(LOC109753580)
SBI: 110433879
ZMA: 100282439(cl30761_1)
SITA: 101773389
MUS: 103975964
DCT: 110091939
PEQ: 110020552
AOF: 109848382
MNG: MNEG_8922
APRO: F751_6027
CNB: CNBC3980
DFA: DFA_09639
SMIN: v1.2.017530.t1(symbB.v1.2.017530.t1) v1.2.017530.t2(symbB.v1.2.017530.t2) v1.2.017530.t3(symbB.v1.2.017530.t3)
SCL: sce7641(fadD4)
SFU: Sfum_0297
GVI: glr1122
SGN: SGRA_2823
SLI: Slin_1553
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Sloan JL, Johnston JJ, Manoli I, Chandler RJ, Krause C, Carrillo-Carrasco N, Chandrasekaran SD, Sysol JR, O'Brien K, Hauser NS, Sapp JC, Dorward HM, Huizing M, Barshop BA, Berry SA, James PM, Champaigne NL, de Lonlay P, Valayannopoulos V, Geschwind MD, Gavrilov DK, Nyhan WL, Biesecker LG, Venditti CP
  Title
Exome sequencing identifies ACSF3 as a cause of combined malonic and methylmalonic aciduria.
  Journal
Nat Genet 43:883-6 (2011)
DOI:10.1038/ng.908
  Sequence
[hsa:197322]
Reference
  Authors
Chen H, Kim HU, Weng H, Browse J
  Title
Malonyl-CoA synthetase, encoded by ACYL ACTIVATING ENZYME13, is essential for growth and development of Arabidopsis.
  Journal
Plant Cell 23:2247-62 (2011)
DOI:10.1105/tpc.111.086140
  Sequence
[ath:AT3G16170]
Reference
  Authors
Witkowski A, Thweatt J, Smith S
  Title
Mammalian ACSF3 protein is a malonyl-CoA synthetase that supplies the chain extender units for mitochondrial fatty acid synthesis.
  Journal
J Biol Chem 286:33729-36 (2011)
DOI:10.1074/jbc.M111.291591
LinkDB All DBs

KEGG   REACTION: R12300Help
Entry
R12300                      Reaction                               

Name
malonate:CoA ligase (AMP-forming)
Definition
ATP + Malonate + CoA <=> AMP + Diphosphate + Malonyl-CoA
Equation
Enzyme
6.2.1.-
Pathway
rn00061  Fatty acid biosynthesis
rn01100  Metabolic pathways
rn01212  Fatty acid metabolism
Orthology
K18660  malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.-]
LinkDB All DBs

DBGET integrated database retrieval system