KEGG   ORTHOLOGY: K18689
Entry
K18689                      KO                                     

Name
E2.7.1.185
Definition
mevalonate-3-kinase [EC:2.7.1.185]
Pathway
ko00900  Terpenoid backbone biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K18689  E2.7.1.185; mevalonate-3-kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.185  mevalonate 3-kinase
     K18689  E2.7.1.185; mevalonate-3-kinase
Other DBs
RN: R10779
COG: COG3407
Genes
TAC: Ta1305
TVO: TVG0327166(TVG0327166)
PTO: PTO1356
FAC: FACI_IFERC01G1817
FAI: FAD_0787
CDIV: CPM_0451
MARH: Mia14_0537
Reference
  Authors
Vinokur JM, Korman TP, Cao Z, Bowie JU
  Title
Evidence of a novel mevalonate pathway in archaea.
  Journal
Biochemistry 53:4161-8 (2014)
DOI:10.1021/bi500566q
  Sequence
[tac:Ta1305]
LinkDB

KEGG   ENZYME: 2.7.1.185
Entry
EC 2.7.1.185                Enzyme                                 

Name
mevalonate 3-kinase;
ATP:(R)-MVA 3-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:(R)-mevalonate 3-phosphotransferase
Reaction(IUBMB)
ATP + (R)-mevalonate = ADP + (R)-3-phosphomevalonate [RN:R10779]
Reaction(KEGG)
R10779
Substrate
ATP [CPD:C00002];
(R)-mevalonate [CPD:C00418]
Product
ADP [CPD:C00008];
(R)-3-phosphomevalonate [CPD:C20847]
Comment
Mevalonate 3-kinase and mevalonate-3-phosphate-5-kinase (EC 2.7.1.186) act sequentially in an alternate mevalonate pathway in the archaeon Thermoplasma acidophilum. Mevalonate 3-kinase is different from mevalonate kinase, EC 2.7.1.36, which transfers phosphate to position 5 of (R)-mevalonate and is part of the classical mevalonate pathway in eukaryotes and archaea.
History
EC 2.7.1.185 created 2014
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01100  Metabolic pathways
Orthology
K18689  mevalonate-3-kinase
Genes
TAC: Ta1305
TVO: TVG0327166(TVG0327166)
PTO: PTO1356
FAC: FACI_IFERC01G1817
FAI: FAD_0787
CDIV: CPM_0451
MARH: Mia14_0537
Reference
1  [PMID:24914732]
  Authors
Vinokur JM, Korman TP, Cao Z, Bowie JU.
  Title
Evidence of a novel mevalonate pathway in archaea.
  Journal
Biochemistry 53:4161-8 (2014)
DOI:10.1021/bi500566q
  Sequence
[tac:Ta1305]
Reference
2  [PMID:24755225]
  Authors
Azami Y, Hattori A, Nishimura H, Kawaide H, Yoshimura T, Hemmi H.
  Title
(R)-mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum.
  Journal
J Biol Chem 289:15957-67 (2014)
DOI:10.1074/jbc.M114.562686
  Sequence
[tac:Ta1305]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.185
IUBMB Enzyme Nomenclature: 2.7.1.185
ExPASy - ENZYME nomenclature database: 2.7.1.185
BRENDA, the Enzyme Database: 2.7.1.185
LinkDB

KEGG   REACTION: R10779
Entry
R10779                      Reaction                               

Name
ATP:(R)-mevalonate 3-phosphotransferase
Definition
(R)-Mevalonate + ATP <=> (R)-Mevalonate 3-phosphate + ADP
Equation
Reaction class
RC00002  C00002_C00008
RC01439  C00418_C20847
Enzyme
Pathway
rn00900  Terpenoid backbone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Orthology
K18689  mevalonate-3-kinase [EC:2.7.1.185]
Other DBs
RHEA: 42887
LinkDB

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