KEGG   ORTHOLOGY: K18690
Entry
K18690                      KO                                     

Name
E2.7.1.186
Definition
mevalonate-3-phosphate-5-kinase [EC:2.7.1.186]
Pathway
ko00900  Terpenoid backbone biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K18690  E2.7.1.186; mevalonate-3-phosphate-5-kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.186  mevalonate-3-phosphate 5-kinase
     K18690  E2.7.1.186; mevalonate-3-phosphate-5-kinase
Other DBs
RN: R10780
COG: COG2074
Genes
TAC: Ta0762
TVO: TVG0885910(TVG0885910)
PTO: PTO0479
FAC: FACI_IFERC01G0924
FAI: FAD_1810(pgk2)
CDIV: CPM_0343
MARH: Mia14_0536
Reference
  Authors
Vinokur JM, Korman TP, Cao Z, Bowie JU
  Title
Evidence of a novel mevalonate pathway in archaea.
  Journal
Biochemistry 53:4161-8 (2014)
DOI:10.1021/bi500566q
  Sequence
[tac:Ta0762]
LinkDB

KEGG   ENZYME: 2.7.1.186
Entry
EC 2.7.1.186                Enzyme                                 

Name
mevalonate-3-phosphate 5-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:(R)-3-phosphomevalonate 5-phosphotransferase
Reaction(IUBMB)
ATP + (R)-3-phosphomevalonate = ADP + (R)-3,5-bisphosphomevalonate [RN:R10780]
Reaction(KEGG)
R10780
Substrate
ATP [CPD:C00002];
(R)-3-phosphomevalonate [CPD:C20847]
Product
ADP [CPD:C00008];
(R)-3,5-bisphosphomevalonate [CPD:C20848]
Comment
Mevalonate 3-kinase (EC 2.7.1.185) and mevalonate-3-phosphate-5-kinase act sequentially in an alternate mevalonate pathway in the archaeon Thermoplasma acidophilum.
History
EC 2.7.1.186 created 2014
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01100  Metabolic pathways
Orthology
K18690  mevalonate-3-phosphate-5-kinase
Genes
TAC: Ta0762
TVO: TVG0885910(TVG0885910)
PTO: PTO0479
FAC: FACI_IFERC01G0924
FAI: FAD_1810(pgk2)
CDIV: CPM_0343
MARH: Mia14_0536
Reference
1  [PMID:24914732]
  Authors
Vinokur JM, Korman TP, Cao Z, Bowie JU.
  Title
Evidence of a novel mevalonate pathway in archaea.
  Journal
Biochemistry 53:4161-8 (2014)
DOI:10.1021/bi500566q
  Sequence
[tac:Ta0762]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.186
IUBMB Enzyme Nomenclature: 2.7.1.186
ExPASy - ENZYME nomenclature database: 2.7.1.186
BRENDA, the Enzyme Database: 2.7.1.186
LinkDB

KEGG   REACTION: R10780
Entry
R10780                      Reaction                               

Name
ATP:(R)-3-phosphomevalonate 5-phosphotransferase
Definition
(R)-Mevalonate 3-phosphate + ATP <=> (R)-Mevalonate 3,5-bisphosphate + ADP
Equation
Reaction class
RC00002  C00002_C00008
RC00017  C20847_C20848
Enzyme
Pathway
rn00900  Terpenoid backbone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Orthology
K18690  mevalonate-3-phosphate-5-kinase [EC:2.7.1.186]
Other DBs
RHEA: 42891
LinkDB

DBGET integrated database retrieval system