KEGG   ORTHOLOGY: K19280
Entry
K19280                      KO                                     

Name
mct
Definition
succinyl-CoA:mesaconate CoA transferase [EC:2.8.3.26]
Pathway
ko00630  Glyoxylate and dicarboxylate metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00740  Methylaspartate cycle
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    K19280  mct; succinyl-CoA:mesaconate CoA transferase
Enzymes [BR:ko01000]
 2. Transferases
  2.8  Transferring sulfur-containing groups
   2.8.3  CoA-transferases
    2.8.3.26  succinyl-CoA:mesaconate CoA transferase
     K19280  mct; succinyl-CoA:mesaconate CoA transferase
Other DBs
RN: R10904
COG: COG1804
Genes
HMA: rrnAC0683
HHI: HAH_1336(caiB)
HHN: HISP_06840
HAB: SG26_14685
HTA: BVU17_06510
HALJ: G9465_08560
HMU: Hmuk_2979
HALZ: E5139_02170
HALL: LC1Hm_2316(mct)
HRR: HZS55_20010
HTU: Htur_1595
NMG: Nmag_3333(mct)
NAT: NJ7G_3294
SALI: L593_04685
 » show all
Reference
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
  Sequence
[hma:rrnAC0683]
LinkDB

KEGG   ENZYME: 2.8.3.26
Entry
EC 2.8.3.26                 Enzyme                                 

Name
succinyl-CoA:mesaconate CoA transferase;
mct (gene name)
Class
Transferases;
Transferring sulfur-containing groups;
CoA-transferases
Sysname
succinyl-CoA:mesaconate CoA transferase
Reaction(IUBMB)
succinyl-CoA + mesaconate = 2-methylfumaryl-CoA + succinate [RN:R10904]
Reaction(KEGG)
R10904
Substrate
succinyl-CoA [CPD:C00091];
mesaconate [CPD:C01732]
Product
2-methylfumaryl-CoA [CPD:C06028];
succinate [CPD:C00042]
Comment
The enzyme participates in the methylaspartate cycle, an anaplerotic pathway that operates in some members of the haloarchaea and forms malate from acetyl-CoA.
History
EC 2.8.3.26 created 2020
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K19280  succinyl-CoA:mesaconate CoA transferase
Genes
HMA: rrnAC0683
HHI: HAH_1336(caiB)
HHN: HISP_06840
HAB: SG26_14685
HTA: BVU17_06510
HALJ: G9465_08560
HMU: Hmuk_2979
HALZ: E5139_02170
HALL: LC1Hm_2316(mct)
HRR: HZS55_20010
HTU: Htur_1595
NMG: Nmag_3333(mct)
NAT: NJ7G_3294
SALI: L593_04685
 » show all
Reference
1  [PMID:21252347]
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA.
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
  Sequence
[hma:rrnAC0683]
Reference
2  [PMID:28932214]
  Authors
Borjian F, Johnsen U, Schonheit P, Berg IA
  Title
Succinyl-CoA:Mesaconate CoA-Transferase and Mesaconyl-CoA Hydratase, Enzymes of the Methylaspartate Cycle in Haloarcula hispanica.
  Journal
Front Microbiol 8:1683 (2017)
DOI:10.3389/fmicb.2017.01683
  Sequence
[hhi:HAH_1336]
Other DBs
ExplorEnz - The Enzyme Database: 2.8.3.26
IUBMB Enzyme Nomenclature: 2.8.3.26
ExPASy - ENZYME nomenclature database: 2.8.3.26
BRENDA, the Enzyme Database: 2.8.3.26
LinkDB

KEGG   REACTION: R10904
Entry
R10904                      Reaction                               

Name
succinyl-CoA:mesaconate CoA-transferase
Definition
Succinyl-CoA + Mesaconate <=> Succinate + 2-Methylfumaryl-CoA
Equation
Reaction class
RC00014  C00042_C00091
RC00978  C01732_C06028
Enzyme
Pathway
rn00630  Glyoxylate and dicarboxylate metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00740  Methylaspartate cycle
Orthology
K19280  succinyl-CoA:mesaconate CoA transferase [EC:2.8.3.26]
LinkDB

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