KEGG   ORTHOLOGY: K19886
Entry
K19886            Tight     KO                                     

Name
rebC
Definition
flavin-dependent monooxygenase RebC [EC:1.13.12.17]
Pathway
ko00404  Staurosporine biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00789  Rebeccamycin biosynthesis, tryptophan => rebeccamycin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K19886  rebC; flavin-dependent monooxygenase RebC
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.17  dichloroarcyriaflavin A synthase
     K19886  rebC; flavin-dependent monooxygenase RebC
Other DBs
RN: R09567
COG: COG0654
Genes
AG: BAC10676(rebC)
Reference
  Authors
Nishizawa T, Aldrich CC, Sherman DH
  Title
Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243.
  Journal
J Bacteriol 187:2084-92 (2005)
DOI:10.1128/JB.187.6.2084-2092.2005
  Sequence
Reference
  Authors
Groom K, Bhattacharya A, Zechel DL
  Title
Rebeccamycin and staurosporine biosynthesis: insight into the mechanisms of the flavin-dependent monooxygenases RebC and StaC.
  Journal
Chembiochem 12:396-400 (2011)
DOI:10.1002/cbic.201000580
LinkDB

KEGG   ORTHOLOGY: K19887
Entry
K19887            Tight     KO                                     

Name
rebP
Definition
cytochrome P450 RebP [EC:1.13.12.17]
Pathway
ko00404  Staurosporine biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00789  Rebeccamycin biosynthesis, tryptophan => rebeccamycin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K19887  rebP; cytochrome P450 RebP
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.17  dichloroarcyriaflavin A synthase
     K19887  rebP; cytochrome P450 RebP
Other DBs
RN: R09567
COG: COG2124
Genes
AG: BAC10677(rebP)
Reference
  Authors
Nishizawa T, Aldrich CC, Sherman DH
  Title
Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243.
  Journal
J Bacteriol 187:2084-92 (2005)
DOI:10.1128/JB.187.6.2084-2092.2005
  Sequence
Reference
  Authors
Howard-Jones AR, Walsh CT
  Title
Nonenzymatic oxidative steps accompanying action of the cytochrome P450 enzymes StaP and RebP in the biosynthesis of staurosporine and rebeccamycin.
  Journal
J Am Chem Soc 129:11016-7 (2007)
DOI:10.1021/ja0743801
LinkDB

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